메뉴 건너뛰기




Volumn 31, Issue 8, 2013, Pages 1488-1497

Polycomb determines responses to Smad2/3 signaling in embryonic stem cell differentiation and in reprogramming

Author keywords

Oct4 Pluripotency; Polycomb; Reprogramming; Smad2 3

Indexed keywords

ACTIVIN; OCTAMER TRANSCRIPTION FACTOR 4; POLYCOMB GROUP PROTEIN; PROTEIN NODAL; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84883324006     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1417     Document Type: Article
Times cited : (7)

References (49)
  • 1
    • 0037093507 scopus 로고    scopus 로고
    • Three habits of highly effective signaling pathways: Principles of transcriptional control by developmental cell signaling
    • Barolo S, Posakony JW. Three habits of highly effective signaling pathways: Principles of transcriptional control by developmental cell signaling. Genes Dev 2002;16:1167-1181.
    • (2002) Genes Dev , vol.16 , pp. 1167-1181
    • Barolo, S.1    Posakony, J.W.2
  • 2
    • 84861529303 scopus 로고    scopus 로고
    • Enhancers as information integration hubs in development: Lessons from genomics
    • Buecker C, Wysocka J. Enhancers as information integration hubs in development: Lessons from genomics. Trends Genet 2012;28:276-284.
    • (2012) Trends Genet , vol.28 , pp. 276-284
    • Buecker, C.1    Wysocka, J.2
  • 3
    • 79959843359 scopus 로고    scopus 로고
    • Polycomb proteins in mammalian cell differentiation and plasticity
    • Prezioso C, Orlando V. Polycomb proteins in mammalian cell differentiation and plasticity. FEBS Lett 2011;585:2067-2077.
    • (2011) FEBS Lett , vol.585 , pp. 2067-2077
    • Prezioso, C.1    Orlando, V.2
  • 4
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing:Knowns and unknowns
    • Simon JA, Kingston RE. Mechanisms of polycomb gene silencing:Knowns and unknowns.Nat RevMol Cell Biol 2009;10:697-708.
    • (2009) Nat RevMol Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 5
    • 64249138238 scopus 로고    scopus 로고
    • Developmental roles of the histone lysine demethylases
    • Nottke A, Colaiacovo MP, Shi Y. Developmental roles of the histone lysine demethylases. Development 2009;136:879-889.
    • (2009) Development , vol.136 , pp. 879-889
    • Nottke, A.1    Colaiacovo, M.P.2    Shi, Y.3
  • 6
    • 77950243286 scopus 로고    scopus 로고
    • Mouse ES cell culture system as a model of development
    • Niwa H. Mouse ES cell culture system as a model of development. Dev Growth Differ 2010;52:275-283.
    • (2010) Dev Growth Differ , vol.52 , pp. 275-283
    • Niwa, H.1
  • 7
    • 79953163994 scopus 로고    scopus 로고
    • Chromatin states in pluripotent, differentiated, and reprogrammed cells
    • Fisher CL, Fisher AG. Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev 2011;21:140-146.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 140-146
    • Fisher, C.L.1    Fisher, A.G.2
  • 8
    • 77956634439 scopus 로고    scopus 로고
    • Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes
    • Dahle O, Kumar A, Kuehn MR. Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. Sci Signal 2010;3:ra48.
    • (2010) Sci Signal , vol.3
    • Dahle, O.1    Kumar, A.2    Kuehn, M.R.3
  • 9
    • 80051537445 scopus 로고    scopus 로고
    • Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
    • Kim SW, Yoon SJ, Chuong E et al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol 2011;357:492-504.
    • (2011) Dev Biol , vol.357 , pp. 492-504
    • Kim, S.W.1    Yoon, S.J.2    Chuong, E.3
  • 10
    • 66049117813 scopus 로고    scopus 로고
    • Naive and primed pluripotent states
    • Nichols J, Smith A. Naive and primed pluripotent states. Cell Stem Cell 2009;4:487-492.
    • (2009) Cell Stem Cell , vol.4 , pp. 487-492
    • Nichols, J.1    Smith, A.2
  • 11
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal
    • Ying QL, Wray J, Nichols J et al. The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-523.
    • (2008) Nature , vol.453 , pp. 519-523
    • Ying, Q.L.1    Wray, J.2    Nichols, J.3
  • 12
    • 42149192008 scopus 로고    scopus 로고
    • Identification and characterization of subpopulations in undifferentiated ES cell culture
    • Toyooka Y, Shimosato D, Murakami K et al. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 2008;135:909-918.
    • (2008) Development , vol.135 , pp. 909-918
    • Toyooka, Y.1    Shimosato, D.2    Murakami, K.3
  • 13
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 15
    • 84860351082 scopus 로고    scopus 로고
    • The transcriptional and epigenomic foundations of ground state pluripotency
    • Marks H, Kalkan T, Menafra R et al. The transcriptional and epigenomic foundations of ground state pluripotency. Cell 2012;149:590-604.
    • (2012) Cell , vol.149 , pp. 590-604
    • Marks, H.1    Kalkan, T.2    Menafra, R.3
  • 16
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D et al. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006;20:1123-1136.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3
  • 17
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    • Mohn F, Weber M, Rebhan M et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 2008;30:755-766.
    • (2008) Mol Cell , vol.30 , pp. 755-766
    • Mohn, F.1    Weber, M.2    Rebhan, M.3
  • 18
    • 84865112255 scopus 로고    scopus 로고
    • The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    • Mansour AA, Gafni O, Weinberger L et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature 2012;488:409-413.
    • (2012) Nature , vol.488 , pp. 409-413
    • Mansour, A.A.1    Gafni, O.2    Weinberger, L.3
  • 19
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • Onder TT, Kara N, Cherry A et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012;483:598-602.
    • (2012) Nature , vol.483 , pp. 598-602
    • Onder, T.T.1    Kara, N.2    Cherry, A.3
  • 20
    • 77953086963 scopus 로고    scopus 로고
    • ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
    • Pereira CF, Piccolo FM, Tsubouchi T et al. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 2010;6:547-556.
    • (2010) Cell Stem Cell , vol.6 , pp. 547-556
    • Pereira, C.F.1    Piccolo, F.M.2    Tsubouchi, T.3
  • 21
    • 79952135845 scopus 로고    scopus 로고
    • PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming
    • Zhang Z, Jones A, Sun CW et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011;29:229-240.
    • (2011) Stem Cells , vol.29 , pp. 229-240
    • Zhang, Z.1    Jones, A.2    Sun, C.W.3
  • 22
    • 70350536767 scopus 로고    scopus 로고
    • A small-molecule inhibitor of Tgf-b signaling replaces Sox2 in reprogramming by inducing Nanog
    • Ichida JK, Blanchard J, Lam K et al. A small-molecule inhibitor of Tgf-b signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 2009;5:491-503.
    • (2009) Cell Stem Cell , vol.5 , pp. 491-503
    • Ichida, J.K.1    Blanchard, J.2    Lam, K.3
  • 23
    • 70350732790 scopus 로고    scopus 로고
    • A chemical platform for improved induction of human iPSCs
    • Lin T, Ambasudhan R, Yuan X et al. A chemical platform for improved induction of human iPSCs. Nat Methods 2009;6:805-808.
    • (2009) Nat Methods , vol.6 , pp. 805-808
    • Lin, T.1    Ambasudhan, R.2    Yuan, X.3
  • 24
    • 70350571742 scopus 로고    scopus 로고
    • Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc
    • Maherali N, Hochedlinger K. Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol 2009; 19:1718-1723.
    • (2009) Curr Biol , vol.19 , pp. 1718-1723
    • Maherali, N.1    Hochedlinger, K.2
  • 25
    • 49449096588 scopus 로고    scopus 로고
    • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
    • Wernig M, Lengner CJ, Hanna J et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol 2008;26:916-924.
    • (2008) Nat Biotechnol , vol.26 , pp. 916-924
    • Wernig, M.1    Lengner, C.J.2    Hanna, J.3
  • 26
    • 79960888524 scopus 로고    scopus 로고
    • Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
    • Brown S, Teo A, Pauklin S et al. Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 2011;29:1176-1185.
    • (2011) Stem Cells , vol.29 , pp. 1176-1185
    • Brown, S.1    Teo, A.2    Pauklin, S.3
  • 27
    • 79959814756 scopus 로고    scopus 로고
    • Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
    • Lee KL, Lim SK, Orlov YL et al. Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet 2011;7:e1002130.
    • (2011) PLoS Genet , vol.7
    • Lee, K.L.1    Lim, S.K.2    Orlov, Y.L.3
  • 28
    • 80155137594 scopus 로고    scopus 로고
    • Master transcription factors determine cell-type-specific responses to TGF-beta signaling
    • Mullen AC, Orlando DA, Newman JJ et al. Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 2011;147:565-576.
    • (2011) Cell , vol.147 , pp. 565-576
    • Mullen, A.C.1    Orlando, D.A.2    Newman, J.J.3
  • 29
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3
  • 30
    • 34248169728 scopus 로고    scopus 로고
    • The polycomb group protein Suz12 is required for embryonic stem cell differentiation
    • Pasini D, Bracken AP, Hansen JB et al. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 2007;27:3769-3779.
    • (2007) Mol Cell Biol , vol.27 , pp. 3769-3779
    • Pasini, D.1    Bracken, A.P.2    Hansen, J.B.3
  • 31
    • 77956202054 scopus 로고    scopus 로고
    • Polycomb group proteins set the stage for early lineage commitment
    • Surface LE, Thornton SR, Boyer LA. Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 2010;7:288-298.
    • (2010) Cell Stem Cell , vol.7 , pp. 288-298
    • Surface, L.E.1    Thornton, S.R.2    Boyer, L.A.3
  • 32
    • 71449109765 scopus 로고    scopus 로고
    • Direct cell reprogramming is a stochastic process amenable to acceleration
    • Hanna J, Saha K, Pando B et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009;462:595-601.
    • (2009) Nature , vol.462 , pp. 595-601
    • Hanna, J.1    Saha, K.2    Pando, B.3
  • 33
    • 69349103956 scopus 로고    scopus 로고
    • The Ink4/Arf locus is a barrier for iPS cell reprogramming
    • Li H, Collado M, Villasante A et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009;460:1136-1139.
    • (2009) Nature , vol.460 , pp. 1136-1139
    • Li, H.1    Collado, M.2    Villasante, A.3
  • 34
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R, Liang J, Ni S et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010;7:51-63.
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 35
    • 84857125590 scopus 로고    scopus 로고
    • Transforming growth factor-beta superfamily in mouse embryonic stem cell self-renewal
    • Galvin-Burgess KE, Vivian JL. Transforming growth factor-beta superfamily in mouse embryonic stem cell self-renewal. Vitam Horm 2011;87:341-365.
    • (2011) Vitam Horm , vol.87 , pp. 341-365
    • Galvin-Burgess, K.E.1    Vivian, J.L.2
  • 36
    • 34447527158 scopus 로고    scopus 로고
    • Derivation of pluripotent epiblast stem cells from mammalian embryos
    • Brons IG, Smithers LE, Trotter MW et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007;448:191-195.
    • (2007) Nature , vol.448 , pp. 191-195
    • Brons, I.G.1    Smithers, L.E.2    Trotter, M.W.3
  • 37
    • 73049085665 scopus 로고    scopus 로고
    • SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells
    • Chng Z, Teo A, Pedersen RA et al. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell 2010;6:59-70.
    • (2010) Cell Stem Cell , vol.6 , pp. 59-70
    • Chng, Z.1    Teo, A.2    Pedersen, R.A.3
  • 38
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • James D, Levine AJ, Besser D et al. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005;132:1273-1282.
    • (2005) Development , vol.132 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3
  • 39
    • 67650810301 scopus 로고    scopus 로고
    • Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs
    • Kashyap V, Rezende NC, Scotland KB et al. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev 2009;18:1093-1108.
    • (2009) Stem Cells Dev , vol.18 , pp. 1093-1108
    • Kashyap, V.1    Rezende, N.C.2    Scotland, K.B.3
  • 40
    • 33746435907 scopus 로고    scopus 로고
    • Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
    • Mesnard D, Guzman-Ayala M, Constam DB. Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development 2006;133:2497-2505.
    • (2006) Development , vol.133 , pp. 2497-2505
    • Mesnard, D.1    Guzman-Ayala, M.2    Constam, D.B.3
  • 41
    • 27644486756 scopus 로고    scopus 로고
    • Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
    • Vallier L, Alexander M, Pedersen RA. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci 2005;118:4495-4509.
    • (2005) J Cell Sci , vol.118 , pp. 4495-4509
    • Vallier, L.1    Alexander, M.2    Pedersen, R.A.3
  • 42
    • 67650096520 scopus 로고    scopus 로고
    • Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
    • Vallier L, Mendjan S, Brown S et al. Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 2009;136:1339-1349.
    • (2009) Development , vol.136 , pp. 1339-1349
    • Vallier, L.1    Mendjan, S.2    Brown, S.3
  • 43
    • 78649847411 scopus 로고    scopus 로고
    • Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells
    • Fei T, Zhu S, Xia K et al. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res 2010;20:1306-1318.
    • (2010) Cell Res , vol.20 , pp. 1306-1318
    • Fei, T.1    Zhu, S.2    Xia, K.3
  • 44
    • 0029865895 scopus 로고    scopus 로고
    • Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
    • Yeom YI, Fuhrmann G, Ovitt CE et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 1996;122:881-894.
    • (1996) Development , vol.122 , pp. 881-894
    • Yeom, Y.I.1    Fuhrmann, G.2    Ovitt, C.E.3
  • 45
    • 79952846468 scopus 로고    scopus 로고
    • Progress in understanding reprogramming to the induced pluripotent state
    • Plath K, Lowry WE. Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet 2011;12:253-265.
    • (2011) Nat Rev Genet , vol.12 , pp. 253-265
    • Plath, K.1    Lowry, W.E.2
  • 46
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFbeta signal transduction
    • Moustakas A, Heldin CH. The regulation of TGFbeta signal transduction. Development 2009;136:3699-3714.
    • (2009) Development , vol.136 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.H.2
  • 47
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado H, Quintanilla M, Cano A. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions. J Biol Chem 2003;278: 21113-21123.
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 48
    • 84862777514 scopus 로고    scopus 로고
    • RAC1 activation mediates Twist1-induced cancer cell migration
    • Yang WH, Lan HY, Huang CH et al. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol 2012;14:366-374.
    • (2012) Nat Cell Biol , vol.14 , pp. 366-374
    • Yang, W.H.1    Lan, H.Y.2    Huang, C.H.3
  • 49
    • 78149485776 scopus 로고    scopus 로고
    • Interpretation of developmental signaling at chromatin: The Polycomb perspective
    • Sawarkar R, Paro R. Interpretation of developmental signaling at chromatin: The Polycomb perspective. Dev Cell 2010;19:651-661.
    • (2010) Dev Cell , vol.19 , pp. 651-661
    • Sawarkar, R.1    Paro, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.