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Volumn 28, Issue 5, 2010, Pages 863-873

The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate

Author keywords

Embryonic stem cell; Pluripotency; Self renewal; Signaling; SMAD4; Transforming growth factor

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; BONE MORPHOGENETIC PROTEIN 4; DOXYCYCLINE; SHORT HAIRPIN RNA; SMAD4 PROTEIN;

EID: 77952345331     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.409     Document Type: Article
Times cited : (38)

References (53)
  • 1
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • DOI 10.1038/74447
    • Reubinoff BE, Pera MF, Fong CY et al. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol 2000;18:399-404. (Pubitemid 30217526)
    • (2000) Nature Biotechnology , vol.18 , Issue.4 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.-Y.3    Trounson, A.4    Bongso, A.5
  • 2
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3
  • 4
    • 0034669082 scopus 로고    scopus 로고
    • Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
    • Amit M, Carpenter MK, Inokuma MS et al. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 2000;227:271-278.
    • (2000) Dev Biol , vol.227 , pp. 271-278
    • Amit, M.1    Carpenter, M.K.2    Inokuma, M.S.3
  • 5
    • 1242276404 scopus 로고    scopus 로고
    • Feeder Layer- and Serum-Free Culture of Human Embryonic Stem Cells
    • DOI 10.1095/biolreprod.103.021147
    • Amit M, Shariki C, Margulets V et al. Feeder layer- and serum-free culture of human embryonic stem cells. Biol Reprod 2004;70:837-845. (Pubitemid 38233724)
    • (2004) Biology of Reproduction , vol.70 , Issue.3 , pp. 837-845
    • Amit, M.1    Shariki, C.2    Margulets, V.3    Itskovitz-Eldor, J.4
  • 7
    • 7244240749 scopus 로고    scopus 로고
    • Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3
    • DOI 10.1074/jbc.M404979200
    • Besser D. Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. J Biol Chem 2004;279:45076-45084. (Pubitemid 39430922)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 45076-45084
    • Besser, D.1
  • 8
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • DOI 10.1242/dev.01706
    • James D, Levine AJ, Besser D et al. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005;132:1273-1282. (Pubitemid 40528787)
    • (2005) Development , vol.132 , Issue.6 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3    Hemmati-Brivanlou, A.4
  • 9
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • DOI 10.1038/nm979
    • Sato N, Meijer L, Skaltsounis L et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10:55-63. (Pubitemid 38524699)
    • (2004) Nature Medicine , vol.10 , Issue.1 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 10
    • 27644486756 scopus 로고    scopus 로고
    • Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
    • DOI 10.1242/jcs.02553
    • Vallier L, Alexander M, Pedersen RA. Activin/nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci 2005;118:4495-4509. (Pubitemid 41556347)
    • (2005) Journal of Cell Science , vol.118 , Issue.19 , pp. 4495-4509
    • Vallier, L.1    Alexander, M.2    Pedersen, R.A.3
  • 11
    • 14244262504 scopus 로고    scopus 로고
    • Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway
    • DOI 10.1016/j.ydbio.2004.08.031
    • Vallier L, Reynolds D, Pedersen RA. Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev Biol 2004;275:403-421. (Pubitemid 40288095)
    • (2004) Developmental Biology , vol.275 , Issue.2 , pp. 403-421
    • Vallier, L.1    Reynolds, D.2    Pedersen, R.A.3
  • 12
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells
    • Xiao L, Yuan X, Sharkis SJ. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 2006;24:1476-1486.
    • (2006) Stem Cells , vol.24 , pp. 1476-1486
    • Xiao, L.1    Yuan, X.2    Sharkis, S.J.3
  • 13
    • 18744375483 scopus 로고    scopus 로고
    • Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
    • Xu RH, Peck RM, Li DS et al. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods 2005;2:185-190.
    • (2005) Nat Methods , vol.2 , pp. 185-190
    • Xu, R.H.1    Peck, R.M.2    Li, D.S.3
  • 14
    • 48149098004 scopus 로고    scopus 로고
    • NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs
    • Xu RH, Sampsell-Barron TL, Gu F et al. NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 2008;3:196-206.
    • (2008) Cell Stem Cell , vol.3 , pp. 196-206
    • Xu, R.H.1    Sampsell-Barron, T.L.2    Gu, F.3
  • 16
    • 33845996144 scopus 로고    scopus 로고
    • Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
    • McLean AB, D'Amour KA, Jones KL et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007;25:29-38.
    • (2007) Stem Cells , vol.25 , pp. 29-38
    • McLean, A.B.1    D'Amour, K.A.2    Jones, K.L.3
  • 17
    • 43149101280 scopus 로고    scopus 로고
    • A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies
    • DOI 10.1038/nprot.2008.42, PII NPROT.2008.42
    • Ng ES, Davis R, Stanley EG et al. A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies. Nat Protoc 2008;3:768-776. (Pubitemid 351639021)
    • (2008) Nature Protocols , vol.3 , Issue.5 , pp. 768-776
    • Ng, E.S.1    Davis, R.2    Stanley, E.G.3    Elefanty, A.G.4
  • 18
    • 33646474117 scopus 로고    scopus 로고
    • Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions
    • Yao S, Chen S, Clark J et al. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci USA 2006;103:6907-6912.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6907-6912
    • Yao, S.1    Chen, S.2    Clark, J.3
  • 19
    • 16444373230 scopus 로고    scopus 로고
    • Activin a maintains pluripotency of human embryonic stem cells in the absence of feeder layers
    • DOI 10.1634/stemcells.2004-0279
    • Beattie GM, Lopez AD, Bucay N et al. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells 2005;23:489-495. (Pubitemid 40478488)
    • (2005) Stem Cells , vol.23 , Issue.4 , pp. 489-495
    • Beattie, G.M.1    Lopez, A.D.2    Bucay, N.3    Hinton, A.4    Firpo, M.T.5    King, C.C.6    Hayek, A.7
  • 23
    • 69249153489 scopus 로고    scopus 로고
    • Smad, PI3K/Akt, and Wnt-dependent signaling pathways are involved in BMP-4-induced Esc self-renewal
    • Lee MY, Lim HW, Lee SH et al. Smad, PI3K/Akt, And Wnt-dependent signaling pathways are involved in BMP-4-induced Esc self-renewal. Stem Cells 2009;27:1858-1868.
    • (2009) Stem Cells , vol.27 , pp. 1858-1868
    • Lee, M.Y.1    Lim, H.W.2    Lee, S.H.3
  • 24
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • DOI 10.1016/S0092-8674(03)00847-X
    • Ying QL, Nichols J, Chambers I et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003;115:281-292. (Pubitemid 37487702)
    • (2003) Cell , vol.115 , Issue.3 , pp. 281-292
    • Ying, Q.-L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 25
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 28
    • 65649139046 scopus 로고    scopus 로고
    • Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference
    • Zafarana G, Avery SR, Avery K et al. Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference. Stem Cells 2009;27:776-782.
    • (2009) Stem Cells , vol.27 , pp. 776-782
    • Zafarana, G.1    Avery, S.R.2    Avery, K.3
  • 29
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • DOI 10.1016/S0092-8674(03)00392-1
    • Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655. (Pubitemid 36694189)
    • (2003) Cell , vol.113 , Issue.5 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 30
    • 34547117857 scopus 로고    scopus 로고
    • Transient and stable transgene expression in human embryonic stem cells
    • DOI 10.1634/stemcells.2006-0634
    • Liew CG, Draper JS, Walsh J et al. Transient and stable transgene expression in human embryonic stem cells. Stem Cells 2007;25:1521-1528. (Pubitemid 47106021)
    • (2007) Stem Cells , vol.25 , Issue.6 , pp. 1521-1528
    • Liew, C.-G.1    Draper, J.S.2    Walsh, J.3    Moore, H.4    Andrews, P.W.5
  • 32
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 33
    • 0020368488 scopus 로고
    • Monoclonal antibody to murine embryos defines a stage-specific embryonic antigen expressed on mouse embryos and human teratocarcinoma cells
    • Shevinsky LH, Knowles BB, Damjanov I et al. Monoclonal antibody to murine embryos defines a stage-specific embryonic antigen expressed on mouse embryos and human teratocarcinoma cells. Cell 1982;30:697-705. (Pubitemid 13204659)
    • (1982) Cell , vol.30 , Issue.3 , pp. 697-705
    • Hamburger Shevinsky, L.1    Knowles, B.B.2    Damjanov, I.3    Solter, D.4
  • 34
    • 0021745096 scopus 로고
    • Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells
    • Andrews PW, Banting G, Damjanov I et al. Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hybridoma 1984;3:347-361. (Pubitemid 15126239)
    • (1984) Hybridoma , vol.3 , Issue.4 , pp. 347-361
    • Andrews, P.W.1    Banting, G.2    Damjanov, I.3
  • 35
    • 0036244901 scopus 로고    scopus 로고
    • Surface antigens of human embryonic stem cells: Changes upon differentiation in culture
    • DOI 10.1046/j.1469-7580.2002.00030.x
    • Draper JS, Pigott C, Thomson JA et al. Surface antigens of human embryonic stem cells: Changes upon differentiation in culture. J Anat 2002;200:249-258. (Pubitemid 34467317)
    • (2002) Journal of Anatomy , vol.200 , Issue.3 , pp. 249-258
    • Draper, J.S.1    Pigott, C.2    Thomson, J.A.3    Andrews, P.W.4
  • 36
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 1991;19:2499.
    • (1991) Nucleic Acids Res , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 37
    • 0035710746 scopus 로고    scopus 로고
    • -deltadeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001;25:402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 54049152426 scopus 로고    scopus 로고
    • Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells
    • Wu Z, Zhang W, Chen G et al. Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem 2008;283:24991-25002.
    • (2008) J Biol Chem , vol.283 , pp. 24991-25002
    • Wu, Z.1    Zhang, W.2    Chen, G.3
  • 39
    • 1442313955 scopus 로고    scopus 로고
    • Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
    • DOI 10.1038/sj.emboj.7600067
    • Maeda S, Hayashi M, Komiya S et al. Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J 2004;23:552-563. (Pubitemid 38282387)
    • (2004) EMBO Journal , vol.23 , Issue.3 , pp. 552-563
    • Maeda, S.1    Hayashi, M.2    Komiya, S.3    Imamura, T.4    Miyazono, K.5
  • 40
    • 37549002155 scopus 로고    scopus 로고
    • Nanog safeguards pluripotency and mediates germline development
    • Chambers I, Silva J, Colby D et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007;450:1230-1234.
    • (2007) Nature , vol.450 , pp. 1230-1234
    • Chambers, I.1    Silva, J.2    Colby, D.3
  • 41
    • 67650096520 scopus 로고    scopus 로고
    • Activin/nodal signalling maintains pluripotency by controlling Nanog expression
    • Vallier L, Mendjan S, Brown S et al. Activin/nodal signalling maintains pluripotency by controlling Nanog expression. Development 2009;136:1339-1349.
    • (2009) Development , vol.136 , pp. 1339-1349
    • Vallier, L.1    Mendjan, S.2    Brown, S.3
  • 43
    • 33745256758 scopus 로고    scopus 로고
    • Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
    • DOI 10.1016/j.ydbio.2006.03.047, PII S0012160606002582
    • Camus A, Perea-Gomez A, Moreau A et al. Absence of nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol 2006;295:743-755. (Pubitemid 43927707)
    • (2006) Developmental Biology , vol.295 , Issue.2 , pp. 743-755
    • Camus, A.1    Perea-Gomez, A.2    Moreau, A.3    Collignon, J.4
  • 45
    • 0035025619 scopus 로고    scopus 로고
    • Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism
    • DOI 10.1016/S0896-6273(01)00263-X
    • Tropepe V, Hitoshi S, Sirard C et al. Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 2001;30:65-78. (Pubitemid 32441677)
    • (2001) Neuron , vol.30 , Issue.1 , pp. 65-78
    • Tropepe, V.1    Hitoshi, S.2    Sirard, C.3    Mak, T.W.4    Rossant, J.5    Van Der Kooy, D.6
  • 46
    • 37349052866 scopus 로고    scopus 로고
    • Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
    • DOI 10.1016/j.ydbio.2007.10.003, PII S0012160607014145
    • Smith JR, Vallier L, Lupo G et al. Inhibition of activin/nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol 2008;313:107-117. (Pubitemid 350298306)
    • (2008) Developmental Biology , vol.313 , Issue.1 , pp. 107-117
    • Smith, J.R.1    Vallier, L.2    Lupo, G.3    Alexander, M.4    Harris, W.A.5    Pedersen, R.A.6
  • 47
    • 19744364989 scopus 로고    scopus 로고
    • Neural induction: Old problem, new findings, yet more questions
    • Stern CD. Neural induction: Old problem, new findings, yet more questions. Development 2005;132:2007-2021.
    • (2005) Development , vol.132 , pp. 2007-2021
    • Stern, C.D.1
  • 48
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • DOI 10.1038/nbt780
    • Ying QL, Stavridis M, Griffiths D et al. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 2003;21:183-186. (Pubitemid 36188218)
    • (2003) Nature Biotechnology , vol.21 , Issue.2 , pp. 183-186
    • Ying, Q.-L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 49
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 52
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006;38:431-440.
    • (2006) Nat Genet , vol.38 , pp. 431-440
    • Loh, Y.H.1    Wu, Q.2    Chew, J.L.3


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