메뉴 건너뛰기




Volumn 811, Issue , 2014, Pages 183-206

Preparation of nanoscale pulmonary drug delivery formulations by spray drying

Author keywords

Aerosol; Cell culture models; Isolated lung technique; Nano embedded microparticles; Nanoparticles; Pulmonary drug delivery; Spray drying

Indexed keywords

DRUG; LUNG SURFACTANT; NANOPARTICLE;

EID: 84904309907     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-94-017-8739-0_10     Document Type: Article
Times cited : (25)

References (84)
  • 1
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67-74
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 2
    • 84881377924 scopus 로고    scopus 로고
    • Pulmonary drug delivery: From generating aerosols to overcoming biological barriers -therapeutic possibilities and technological challenges
    • Ruge CA, Kirch J, Lehr CM (2013) Pulmonary drug delivery: from generating aerosols to overcoming biological barriers -therapeutic possibilities and technological challenges. Lancet Respir Med 1:402-413
    • (2013) Lancet Respir Med , vol.1 , pp. 402-413
    • Ruge, C.A.1    Kirch, J.2    Lehr, C.M.3
  • 3
    • 60149103022 scopus 로고    scopus 로고
    • Extracellular barriers in respiratory gene therapy
    • Sanders N, Rudolph C, Braeckmans K et al (2009) Extracellular barriers in respiratory gene therapy. Adv Drug Deliv Rev 61:115-127
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 115-127
    • Sanders, N.1    Rudolph, C.2    Braeckmans, K.3
  • 5
    • 78650225640 scopus 로고    scopus 로고
    • The particle has landed -characterizing the fate of inhaled pharmaceuticals
    • Patton JS, Brain JD, Davies LA et al (2010) The particle has landed -characterizing the fate of inhaled pharmaceuticals. J Aerosol Med 23:S71-S87
    • (2010) J Aerosol Med , vol.23 , pp. S71-S87
    • Patton, J.S.1    Brain, J.D.2    Davies, L.A.3
  • 6
    • 42649125889 scopus 로고    scopus 로고
    • Inhaled nanoparticles -a current review
    • Yang W, Peters JI, Williams RO 3rd (2008) Inhaled nanoparticles -a current review. Int J Pharm 356:239-247
    • (2008) Int J Pharm , vol.356 , pp. 239-247
    • Yang, W.1    Peters, J.I.2    Williams, R.O.3
  • 7
    • 77952698655 scopus 로고    scopus 로고
    • Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles
    • Peltonen L, Valo H, Kolakovic R et al (2010) Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles. Expert Opin Drug Deliv 7:705-719
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 705-719
    • Peltonen, L.1    Valo, H.2    Kolakovic, R.3
  • 8
    • 0017879956 scopus 로고
    • The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity
    • Gehr P, Bachofen M, Weibel ER (1978) The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 32:121-140
    • (1978) Respir Physiol , vol.32 , pp. 121-140
    • Gehr, P.1    Bachofen, M.2    Weibel, E.R.3
  • 9
    • 0015609534 scopus 로고
    • Morphological basis of alveolarcapillary gas exchange
    • Weibel ER (1973) Morphological basis of alveolarcapillary gas exchange. Physiol Rev 53:419-495
    • (1973) Physiol Rev , vol.53 , pp. 419-495
    • Weibel, E.R.1
  • 10
    • 70549107968 scopus 로고    scopus 로고
    • Clara cell: Progenitor for the bronchiolar epithelium
    • Reynolds SD, Malkinson AM (2010) Clara cell: progenitor for the bronchiolar epithelium. Int J Biochem Cell Biol 42:1-4
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1-4
    • Reynolds, S.D.1    Malkinson, A.M.2
  • 11
    • 21344471653 scopus 로고    scopus 로고
    • Cell culture models of the respiratory tract relevant to pulmonary drug delivery
    • Steimer A, Haltner E, Lehr CM (2005) Cell culture models of the respiratory tract relevant to pulmonary drug delivery. J Aerosol Med 18:137-182
    • (2005) J Aerosol Med , vol.18 , pp. 137-182
    • Steimer, A.1    Haltner, E.2    Lehr, C.M.3
  • 12
    • 73649135001 scopus 로고    scopus 로고
    • Airway regeneration: The role of the Clara cell secretory protein and the cells that express it
    • Wong AP, Keating A, Waddell TK (2009) Airway regeneration: the role of the Clara cell secretory protein and the cells that express it. Cytotherapy 11:676-687
    • (2009) Cytotherapy , vol.11 , pp. 676-687
    • Wong, A.P.1    Keating, A.2    Waddell, T.K.3
  • 13
    • 0019977498 scopus 로고
    • Cell number and cell characteristics of the normal human lung
    • Crapo JD, Barry BE, Gehr P et al (1982) Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 126:332-337
    • (1982) Am Rev Respir Dis , vol.126 , pp. 332-337
    • Crapo, J.D.1    Barry, B.E.2    Gehr, P.3
  • 14
    • 0031740674 scopus 로고    scopus 로고
    • Pulmonary surfactant: Functions and molecular composition
    • Goerke J (1998) Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta 1408:79-89
    • (1998) Biochim Biophys Acta , vol.1408 , pp. 79-89
    • Goerke, J.1
  • 15
    • 77955440267 scopus 로고    scopus 로고
    • Update on macrophage clearance of inhaled micro-and nanoparticles
    • Geiser M (2010) Update on macrophage clearance of inhaled micro-and nanoparticles. J Aerosol Med 23:207-217
    • (2010) J Aerosol Med , vol.23 , pp. 207-217
    • Geiser, M.1
  • 16
    • 0026813472 scopus 로고
    • Allometric relationships of cell numbers and size in the mammalian lung
    • Stone KC, Mercer RR, Gehr P et al (1992) Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6:235-243
    • (1992) Am J Respir Cell Mol Biol , vol.6 , pp. 235-243
    • Stone, K.C.1    Mercer, R.R.2    Gehr, P.3
  • 17
    • 1642502969 scopus 로고    scopus 로고
    • Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer
    • Geiser M, Schuerch S, Gehr P (2003) Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer. J Appl Physiol 94:1793-1801
    • (2003) J Appl Physiol , vol.94 , pp. 1793-1801
    • Geiser, M.1    Schuerch, S.2    Gehr, P.3
  • 18
    • 0025307779 scopus 로고
    • Surfactant displaces particles toward the epithelium in airways and alveoli
    • Schuerch S, Gehr P, Im Hof V et al (1990) Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 80:17-32
    • (1990) Respir Physiol , vol.80 , pp. 17-32
    • Schuerch, S.1    Gehr, P.2    Im Hof, V.3
  • 19
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone RA (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61:75-85
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 75-85
    • Cone, R.A.1
  • 20
    • 36348985545 scopus 로고    scopus 로고
    • Functional imaging of mucociliary phenomena: High-speed digital reflection contrast microscopy
    • Ryser M, Burn A, Wessel T et al (2007) Functional imaging of mucociliary phenomena: high-speed digital reflection contrast microscopy. Eur Biophys J 37:35-54
    • (2007) Eur Biophys J , vol.37 , pp. 35-54
    • Ryser, M.1    Burn, A.2    Wessel, T.3
  • 21
    • 84875196483 scopus 로고    scopus 로고
    • Pulmonary drug metabolism, clearance, and absorption
    • Smyth HDC, Hickey AJ (eds), Springer, New York
    • Olsson B, Bondesson E, Borgstroem L (2011) Pulmonary drug metabolism, clearance, and absorption. In: Smyth HDC, Hickey AJ (eds) Controlled pulmonary drug delivery, 1st edn. Springer, New York, pp 21-50
    • (2011) Controlled pulmonary drug delivery, 1st edn , pp. 21-50
    • Olsson, B.1    Bondesson, E.2    Borgstroem, L.3
  • 22
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • Patton JS (1996) Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev 19:3-36
    • (1996) Adv Drug Deliv Rev , vol.19 , pp. 3-36
    • Patton, J.S.1
  • 23
    • 84878663137 scopus 로고    scopus 로고
    • Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues
    • Ensign LM, Henning A, Schneider CS et al (2013) Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues. Mol Pharm 10:2176-2182
    • (2013) Mol Pharm , vol.10 , pp. 2176-2182
    • Ensign, L.M.1    Henning, A.2    Schneider, C.S.3
  • 24
    • 84868599371 scopus 로고    scopus 로고
    • Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
    • Kirch J, Schneider A, Abou B et al (2012) Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc Natl Acad Sci U S A 109:18355-18360
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 18355-18360
    • Kirch, J.1    Schneider, A.2    Abou, B.3
  • 25
    • 57049085726 scopus 로고    scopus 로고
    • Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
    • Wang YY, Lai SK, Suk JS et al (2008) Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew Chem Int Ed Engl 47:9726-9729
    • (2008) Angew Chem Int Ed Engl , vol.47 , pp. 9726-9729
    • Wang, Y.Y.1    Lai, S.K.2    Suk, J.S.3
  • 26
    • 0028856079 scopus 로고
    • Alveolar lining layer is thin and continuous: Low-temperature scanning electron microscopy of rat lung
    • Bastacky J, Lee CY, Goerke J et al (1995) Alveolar lining layer is thin and continuous: low-temperature scanning electron microscopy of rat lung. J Appl Physiol 79:1615-1628
    • (1995) J Appl Physiol , vol.79 , pp. 1615-1628
    • Bastacky, J.1    Lee, C.Y.2    Goerke, J.3
  • 27
    • 34250832707 scopus 로고    scopus 로고
    • Biochemical and pharmacological differences between preparations of exogenous natural surfactant used to treat Respiratory Distress Syndrome: Role of the different components in an efficient pulmonary surfactant
    • Blanco O, Perez-Gil J (2007) Biochemical and pharmacological differences between preparations of exogenous natural surfactant used to treat Respiratory Distress Syndrome: role of the different components in an efficient pulmonary surfactant. Eur J Pharmacol 568:1-15
    • (2007) Eur J Pharmacol , vol.568 , pp. 1-15
    • Blanco, O.1    Perez-Gil, J.2
  • 28
    • 0034973011 scopus 로고    scopus 로고
    • Surfactant regulation of host defense function in the lung: A question of balance
    • Phelps DS (2001) Surfactant regulation of host defense function in the lung: a question of balance. Pediatr Pathol Mol Med 20:269-292
    • (2001) Pediatr Pathol Mol Med , vol.20 , pp. 269-292
    • Phelps, D.S.1
  • 29
    • 82255191648 scopus 로고    scopus 로고
    • Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A
    • Ruge CA, Kirch J, Canadas O et al (2011) Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine 7:690-693
    • (2011) Nanomedicine , vol.7 , pp. 690-693
    • Ruge, C.A.1    Kirch, J.2    Canadas, O.3
  • 30
    • 84863678205 scopus 로고    scopus 로고
    • The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles
    • Ruge CA, Schaefer UF, Herrmann J et al (2012) The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One 7:e40775
    • (2012) PLoS One , vol.7
    • Ruge, C.A.1    Schaefer, U.F.2    Herrmann, J.3
  • 31
    • 4544383493 scopus 로고    scopus 로고
    • Nanosuspensions in drug delivery
    • Rabinow BE (2004) Nanosuspensions in drug delivery. Nat Rev Drug Discov 3:785-796
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 785-796
    • Rabinow, B.E.1
  • 32
    • 77952686740 scopus 로고    scopus 로고
    • Generation and sizing of particles for aerosol-based nanotechnology
    • Biskos G, Vons V, Yurteri CU et al (2008) Generation and sizing of particles for aerosol-based nanotechnology. KONA Powder Part J 26:13-35
    • (2008) KONA Powder Part J , vol.26 , pp. 13-35
    • Biskos, G.1    Vons, V.2    Yurteri, C.U.3
  • 33
    • 74049124897 scopus 로고    scopus 로고
    • Spray drying technique. I. Hardware and process parameters
    • Cal K, Sollohub K (2010) Spray drying technique. I. Hardware and process parameters. J Pharm Sci 99:575-586
    • (2010) J Pharm Sci , vol.99 , pp. 575-586
    • Cal, K.1    Sollohub, K.2
  • 34
    • 74049124464 scopus 로고    scopus 로고
    • Spray drying technique: II. Current applications in pharmaceutical technology
    • Sollohub K, Cal K (2010) Spray drying technique: II. Current applications in pharmaceutical technology. J Pharm Sci 99:587-597
    • (2010) J Pharm Sci , vol.99 , pp. 587-597
    • Sollohub, K.1    Cal, K.2
  • 36
    • 42049094490 scopus 로고    scopus 로고
    • Pharmaceutical particle engineering via spray drying
    • Vehring R (2008) Pharmaceutical particle engineering via spray drying. Pharm Res 25:999-1022
    • (2008) Pharm Res , vol.25 , pp. 999-1022
    • Vehring, R.1
  • 37
    • 0037295176 scopus 로고    scopus 로고
    • Preparation of nanoparticles via spray route
    • Okuyama K, Lenggoro IW (2003) Preparation of nanoparticles via spray route. Chem Eng Sci 58: 537-547
    • (2003) Chem Eng Sci , vol.58 , pp. 537-547
    • Okuyama, K.1    Lenggoro, I.W.2
  • 38
    • 79651473099 scopus 로고    scopus 로고
    • Progress in developing spray-drying methods for the production of controlled morphology particles: From the nanometer to submicrometer size ranges
    • Nandiyanto ABD, Okuyama K (2011) Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges. Adv Powder Technol 22:1-19
    • (2011) Adv Powder Technol , vol.22 , pp. 1-19
    • Nandiyanto, A.B.D.1    Okuyama, K.2
  • 40
    • 78650179651 scopus 로고    scopus 로고
    • Nano spray drying: A novel method for preparing protein nanoparticles for protein therapy
    • Lee SH, Heng D, Ng WK et al (2011) Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy. Int J Pharm 403:192-200
    • (2011) Int J Pharm , vol.403 , pp. 192-200
    • Lee, S.H.1    Heng, D.2    Ng, W.K.3
  • 41
    • 33750842699 scopus 로고    scopus 로고
    • Powder formation by atmospheric spray-freeze-drying
    • Wang Z, Finlay WH, Peppler M et al (2006) Powder formation by atmospheric spray-freeze-drying. Powder Technol 170:45-52
    • (2006) Powder Technol , vol.170 , pp. 45-52
    • Wang, Z.1    Finlay, W.H.2    Peppler, M.3
  • 42
    • 0015566617 scopus 로고
    • Ultrasonic atomization-a photographic study of the mechanism of disintegration
    • Topp MN (1973) Ultrasonic atomization-a photographic study of the mechanism of disintegration. J Aerosol Sci 4:17-25
    • (1973) J Aerosol Sci , vol.4 , pp. 17-25
    • Topp, M.N.1
  • 43
    • 79952937096 scopus 로고    scopus 로고
    • Producing pharmaceutical particles via electrospraying with an emphasis on nano and nano structured particles -a review
    • Yurteri CU, Hartman RPA, Marijnissen JCM (2010) Producing pharmaceutical particles via electrospraying with an emphasis on nano and nano structured particles -a review. KONA Powder Part J 28:91-115
    • (2010) KONA Powder Part J , vol.28 , pp. 91-115
    • Yurteri, C.U.1    Hartman, R.P.A.2    Marijnissen, J.C.M.3
  • 44
    • 0036374126 scopus 로고    scopus 로고
    • Spray freeze-drying -the process of choice for low water soluble drugs?
    • Leuenberger H (2002) Spray freeze-drying -the process of choice for low water soluble drugs? J Nanopart Res 4:111-119
    • (2002) J Nanopart Res , vol.4 , pp. 111-119
    • Leuenberger, H.1
  • 45
    • 78650677959 scopus 로고    scopus 로고
    • Spray-freezedrying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery: Effect of freeze-drying adjuvants
    • Cheow WS, Ng ML, Kho K et al (2011) Spray-freezedrying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery: effect of freeze-drying adjuvants. Int J Pharm 404:289-300
    • (2011) Int J Pharm , vol.404 , pp. 289-300
    • Cheow, W.S.1    Ng, M.L.2    Kho, K.3
  • 46
    • 33747092689 scopus 로고    scopus 로고
    • Straightforward biodegradable nanoparticle generation through megahertz-order ultrasonic atomization
    • Forde G, Friend J, Williamson T (2006) Straightforward biodegradable nanoparticle generation through megahertz-order ultrasonic atomization. Appl Phys Lett 89:064105-064105-3
    • (2006) Appl Phys Lett , vol.89
    • Forde, G.1    Friend, J.2    Williamson, T.3
  • 47
    • 0032903845 scopus 로고    scopus 로고
    • Ultrasonic atomization for spray drying: A versatile technique for the preparation of protein loaded biodegradable microspheres
    • Bittner B, Kissel T (1999) Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres. J Microencapsul 16:325-341
    • (1999) J Microencapsul , vol.16 , pp. 325-341
    • Bittner, B.1    Kissel, T.2
  • 48
    • 0033230727 scopus 로고    scopus 로고
    • Strategies for particle design using supercritical fluid technologies
    • York P (1999) Strategies for particle design using supercritical fluid technologies. Pharm Sci Technol Today 2:430-440
    • (1999) Pharm Sci Technol Today , vol.2 , pp. 430-440
    • York, P.1
  • 49
    • 1442348833 scopus 로고    scopus 로고
    • Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods
    • Sethia S, Squillante E (2004) Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm 272:1-10
    • (2004) Int J Pharm , vol.272 , pp. 1-10
    • Sethia, S.1    Squillante, E.2
  • 50
    • 39149086684 scopus 로고    scopus 로고
    • Nanoparticles synthesis using supercritical fluid technology -towards biomedical applications
    • Byrappa K, Ohara S, Adschiri T (2008) Nanoparticles synthesis using supercritical fluid technology -towards biomedical applications. Adv Drug Deliv Rev 60:299-327
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 299-327
    • Byrappa, K.1    Ohara, S.2    Adschiri, T.3
  • 51
    • 34447114484 scopus 로고    scopus 로고
    • Micro-and nanoparticle production by electrospraying
    • Jaworek A (2007) Micro-and nanoparticle production by electrospraying. Powder Technol 176:18-35
    • (2007) Powder Technol , vol.176 , pp. 18-35
    • Jaworek, A.1
  • 52
    • 0033180937 scopus 로고    scopus 로고
    • The surface charge in electrospraying: Its nature and its universal scaling laws
    • Ganan-Calvo AM (1999) The surface charge in electrospraying: its nature and its universal scaling laws. J Aerosol Sci 30:863-872
    • (1999) J Aerosol Sci , vol.30 , pp. 863-872
    • Ganan-Calvo, A.M.1
  • 53
    • 39849090289 scopus 로고    scopus 로고
    • Electrospraying route to nanotechnology: An overview
    • Jaworek A, Sobczyk AT (2008) Electrospraying route to nanotechnology: an overview. J Electrostat 66:197-219
    • (2008) J Electrostat , vol.66 , pp. 197-219
    • Jaworek, A.1    Sobczyk, A.T.2
  • 54
    • 79958033399 scopus 로고    scopus 로고
    • Nanoparticles in medicine and environment: Inhalation and health effects
    • Marijnissen JCM, Gradon L (2010) Nanoparticles in medicine and environment: inhalation and health effects. J Aerosol Med 23:339-341
    • (2010) J Aerosol Med , vol.23 , pp. 339-341
    • Marijnissen, J.C.M.1    Gradon, L.2
  • 55
    • 77950518265 scopus 로고    scopus 로고
    • One-step electrohydrodynamic production of drug-loaded micro-and nanoparticles
    • Enayati M, Ahmad Z, Stride E et al (2010) One-step electrohydrodynamic production of drug-loaded micro-and nanoparticles. J R Soc Interface 7:667-675
    • (2010) J R Soc Interface , vol.7 , pp. 667-675
    • Enayati, M.1    Ahmad, Z.2    Stride, E.3
  • 56
    • 69049088947 scopus 로고    scopus 로고
    • Electrospray encapsulation of hydrophilic and hydrophobic drugs in poly(L-lactic acid) nanoparticles
    • Valo H, Peltonen L, Vehvilaeinen S et al (2009) Electrospray encapsulation of hydrophilic and hydrophobic drugs in poly(L-lactic acid) nanoparticles. Small 5:1791-1798
    • (2009) Small , vol.5 , pp. 1791-1798
    • Valo, H.1    Peltonen, L.2    Vehvilaeinen, S.3
  • 57
    • 0022889862 scopus 로고
    • Deposition of particles in the human respiratory tract in the size range 0.005-15 μm
    • Heyder J, Gebhardt J, Rudolf G et al (1986) Deposition of particles in the human respiratory tract in the size range 0.005-15 μm. J Aerosol Sci 17:811-825
    • (1986) J Aerosol Sci , vol.17 , pp. 811-825
    • Heyder, J.1    Gebhardt, J.2    Rudolf, G.3
  • 58
    • 18144385104 scopus 로고    scopus 로고
    • Novel sustained release microspheres for pulmonary drug delivery
    • Cook RO, Pannu RK, Kellaway IW (2005) Novel sustained release microspheres for pulmonary drug delivery. J Control Release 104:79-90
    • (2005) J Control Release , vol.104 , pp. 79-90
    • Cook, R.O.1    Pannu, R.K.2    Kellaway, I.W.3
  • 59
    • 34548014773 scopus 로고    scopus 로고
    • Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms
    • Mizoe T, Ozeki T, Okada H (2007) Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms. J Control Release 122:10-15
    • (2007) J Control Release , vol.122 , pp. 10-15
    • Mizoe, T.1    Ozeki, T.2    Okada, H.3
  • 60
    • 33847261116 scopus 로고    scopus 로고
    • Effervescent dry powder for respiratory drug delivery
    • Ely L, Roa W, Finlay WH et al (2007) Effervescent dry powder for respiratory drug delivery. Eur J Pharm Biopharm 65:346-353
    • (2007) Eur J Pharm Biopharm , vol.65 , pp. 346-353
    • Ely, L.1    Roa, W.2    Finlay, W.H.3
  • 61
    • 34547554369 scopus 로고    scopus 로고
    • Engineering of poly(DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system
    • Yamamoto H, Hoshina W, Kurashima H et al (2007) Engineering of poly(DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system. Adv Powder Technol 18:215-228
    • (2007) Adv Powder Technol , vol.18 , pp. 215-228
    • Yamamoto, H.1    Hoshina, W.2    Kurashima, H.3
  • 62
    • 33745904988 scopus 로고    scopus 로고
    • Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles
    • Azarmi S, Tao X, Chen H et al (2006) Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles. Int J Pharm 319:155-161
    • (2006) Int J Pharm , vol.319 , pp. 155-161
    • Azarmi, S.1    Tao, X.2    Chen, H.3
  • 63
    • 20744434748 scopus 로고    scopus 로고
    • Microencapsulated chitosan nanoparticles for lung protein delivery
    • Grenha A, Seijo B, Remunan-Lopez C (2005) Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 25:427-437
    • (2005) Eur J Pharm Sci , vol.25 , pp. 427-437
    • Grenha, A.1    Seijo, B.2    Remunan-Lopez, C.3
  • 64
    • 0347360189 scopus 로고    scopus 로고
    • Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung
    • Sham JOH, Zhang Y, Finlay WH et al (2004) Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int J Pharm 269:457-467
    • (2004) Int J Pharm , vol.269 , pp. 457-467
    • Sham, J.O.H.1    Zhang, Y.2    Finlay, W.H.3
  • 65
    • 34447637784 scopus 로고    scopus 로고
    • Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery
    • Hadinoto K, Zhu K, Tan RBH (2007) Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery. Int J Pharm 341:195-206
    • (2007) Int J Pharm , vol.341 , pp. 195-206
    • Hadinoto, K.1    Zhu, K.2    Tan, R.B.H.3
  • 66
    • 76749153731 scopus 로고    scopus 로고
    • Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation
    • Jensen DMK, Cun D, Maltesen MJ et al (2010) Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation. J Control Release 142:138-145
    • (2010) J Control Release , vol.142 , pp. 138-145
    • Jensen, D.M.K.1    Cun, D.2    Maltesen, M.J.3
  • 67
    • 0037126053 scopus 로고    scopus 로고
    • Trojan particles: Large porous carriers of nanoparticles for drug delivery
    • Tsapis N, Bennett D, Jackson B et al (2002) Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc Natl Acad Sci U S A 99:12001-12005
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12001-12005
    • Tsapis, N.1    Bennett, D.2    Jackson, B.3
  • 68
    • 26944474854 scopus 로고    scopus 로고
    • Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery
    • Heyder J (2004) Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 1:315-320
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 315-320
    • Heyder, J.1
  • 69
    • 84862668679 scopus 로고    scopus 로고
    • Controlled pulmonary drug and gene delivery using polymeric nano-carriers
    • Beck-Broichsitter M, Merkel OM, Kissel T (2012) Controlled pulmonary drug and gene delivery using polymeric nano-carriers. J Control Release 161:214-224
    • (2012) J Control Release , vol.161 , pp. 214-224
    • Beck-Broichsitter, M.1    Merkel, O.M.2    Kissel, T.3
  • 70
    • 84858704235 scopus 로고    scopus 로고
    • Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery
    • Beck-Broichsitter M, Schweiger C, Schmehl T et al (2012) Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery. J Control Release 158:329-335
    • (2012) J Control Release , vol.158 , pp. 329-335
    • Beck-Broichsitter, M.1    Schweiger, C.2    Schmehl, T.3
  • 71
    • 85027934512 scopus 로고    scopus 로고
    • Following the concentration of polymeric nanoparticles during nebulization
    • Beck-Broichsitter M, Knuedeler MC, Schmehl T et al (2013) Following the concentration of polymeric nanoparticles during nebulization. Pharm Res 30:16-24
    • (2013) Pharm Res , vol.30 , pp. 16-24
    • Beck-Broichsitter, M.1    Knuedeler, M.C.2    Schmehl, T.3
  • 72
    • 52149103782 scopus 로고    scopus 로고
    • Current therapies and technological advances in aqueous aerosol drug delivery
    • Watts AB, McConville JT, Williams RO III (2008) Current therapies and technological advances in aqueous aerosol drug delivery. Drug Dev Ind Pharm 34:913-922
    • (2008) Drug Dev Ind Pharm , vol.34 , pp. 913-922
    • Watts, A.B.1    McConville, J.T.2    Williams, R.O.3
  • 74
    • 20444378183 scopus 로고    scopus 로고
    • Human respiratory epithelial cell culture for drug delivery applications
    • Forbes B, Ehrhardt C (2005) Human respiratory epithelial cell culture for drug delivery applications. Eur J Pharm Biopharm 60:193-205
    • (2005) Eur J Pharm Biopharm , vol.60 , pp. 193-205
    • Forbes, B.1    Ehrhardt, C.2
  • 75
    • 79952310806 scopus 로고    scopus 로고
    • An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier
    • Lehmann A, Daum N, Bur M et al (2011) An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier. Eur J Pharm Biopharm 77:398-406
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 398-406
    • Lehmann, A.1    Daum, N.2    Bur, M.3
  • 76
    • 58949098172 scopus 로고    scopus 로고
    • A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles
    • Rothen-Rutishauser B, Mueller L, Blank F et al (2008) A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles. ALTEX 25:191-196
    • (2008) ALTEX , vol.25 , pp. 191-196
    • Rothen-Rutishauser, B.1    Mueller, L.2    Blank, F.3
  • 77
    • 79960510296 scopus 로고    scopus 로고
    • In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung -a dialog between aerosol science and biology
    • Paur HR, Cassee FR, Teeguarden JG et al (2011) In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung -a dialog between aerosol science and biology. J Aerosol Sci 42:668-692
    • (2011) J Aerosol Sci , vol.42 , pp. 668-692
    • Paur, H.R.1    Cassee, F.R.2    Teeguarden, J.G.3
  • 78
    • 77955222448 scopus 로고    scopus 로고
    • A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles
    • Lenz A, Karg E, Lentner B et al (2009) A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles. Part Fibre Toxicol 6:32
    • (2009) Part Fibre Toxicol , vol.6 , pp. 32
    • Lenz, A.1    Karg, E.2    Lentner, B.3
  • 79
    • 78650715310 scopus 로고    scopus 로고
    • A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations
    • Hein S, Bur M, Schaefer UF et al (2011) A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations. Eur J Pharm Biopharm 77:132-138
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 132-138
    • Hein, S.1    Bur, M.2    Schaefer, U.F.3
  • 80
    • 79952160334 scopus 로고    scopus 로고
    • Evaluating the controlled release properties of inhaled nanoparticles using isolated, perfused, and ventilated lung models
    • article ID 163791
    • Beck-Broichsitter M, Schmehl T, Seeger W et al (2011) Evaluating the controlled release properties of inhaled nanoparticles using isolated, perfused, and ventilated lung models. J Nanomaterials 2011:1-16, article ID 163791
    • (2011) J Nanomaterials , vol.2011 , pp. 1-16
    • Beck-Broichsitter, M.1    Schmehl, T.2    Seeger, W.3
  • 81
    • 33750845387 scopus 로고    scopus 로고
    • In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery
    • Sakagami M (2006) In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev 58:1030-1060
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1030-1060
    • Sakagami, M.1
  • 82
    • 58249113936 scopus 로고    scopus 로고
    • Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model
    • Beck-Broichsitter M, Gauss J, Packhaeuser CB et al (2009) Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model. Int J Pharm 367:169-178
    • (2009) Int J Pharm , vol.367 , pp. 169-178
    • Beck-Broichsitter, M.1    Gauss, J.2    Packhaeuser, C.B.3
  • 83
    • 76649145422 scopus 로고    scopus 로고
    • Pulmonary targeting with biodegradable salbutamolloaded nanoparticles
    • Beck-Broichsitter M, Gauss J, Gessler T et al (2010) Pulmonary targeting with biodegradable salbutamolloaded nanoparticles. J Aerosol Med 23:47-57
    • (2010) J Aerosol Med , vol.23 , pp. 47-57
    • Beck-Broichsitter, M.1    Gauss, J.2    Gessler, T.3
  • 84
    • 70849084242 scopus 로고    scopus 로고
    • In vitro and in vivo performance of biocompatible negativelycharged salbutamol-loaded nanoparticles
    • Rytting E, Bur M, Cartier R et al (2010) In vitro and in vivo performance of biocompatible negativelycharged salbutamol-loaded nanoparticles. J Control Release 141:101-107
    • (2010) J Control Release , vol.141 , pp. 101-107
    • Rytting, E.1    Bur, M.2    Cartier, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.