Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles

Expert Opinion on Drug Delivery

Volumn 7, Issue 6, 2010, Pages 705-719

  Peltonen, Leena ^a   Valo, Hanna ^a   Kolakovic, Ruzica ^a   Laaksonen, Timo ^a   Hirvonen, Jouni ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Drug nanoparticles; Electrospraying; Liquid atomization; Nanostructured microparticles; Spray drying

Indexed keywords

AMIFOSTINE; AMPICILLIN; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CLARITHROMYCIN; DICLOFENAC; DOXORUBICIN; GLIMEPIRIDE; INDOMETACIN; INSULIN; KETOPROFEN; NANOPARTICLE; NAPROXEN; PACLITAXEL; PARACETAMOL; RECOMBINANT GROWTH HORMONE; SALBUTAMOL SULFATE; THEOPHYLLINE; VERAPAMIL;

AEROSOL; CONTROLLED DRUG RELEASE; DRY POWDER; ELECTRIC CONDUCTIVITY; ELECTROSPRAY; EMULSION; FLOW RATE; MICROENCAPSULATION; MOLECULAR WEIGHT; NANOPHARMACEUTICS; NEBULIZATION; PARTICLE SIZE; PROCESS OPTIMIZATION; REVIEW; SPRAY DRYING; VAPOR PRESSURE;

CHEMISTRY, PHARMACEUTICAL; NANOPARTICLES;

EID: 77952698655     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425241003716802     Document Type: Review

References (117)

1. Ferrari M. Nanogeometry - Beyond drug delivery. Nat Nanotechnol 2008;3:131-132
2. Jiang W, Kim BYS, Rutka JT, Chan WCW. Nanoparticle-mediated cellular response is size-dependent. Nature Nanotech 2008;3:145-150
3. Torchilin VP. Nanoparticulates as drug carriers. Imperial College Press, London, UK; 2006
4. Merisko-Liversidge E, Liversidge G. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol Pathol 2008;36:43-138
5. Liversidge GG, Cundy KC. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int J Pharm 1995;125:91-97
6. Wu Y, Loperb A, Landisb E, et al. The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a beagle dog model predicts improved bioavailability and diminished food effect on absorption in human. Int J Pharm 2004;285:135-146
7. Kipp JE. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm 2004;284:109-122
8. Thassu D, Deleers M, Pathak Y. Nanoparticulate drug delivery systems. Informa Healthcare USA, Inc., New York, USA; 2007
9. Guterres SS, Fessi H, Barratt G, et al. Poly (D, L-lactide) nanocapsules containig diclofenac I. Formulation and stability study. Int J Pharm 1995;113:57-63
10. Okuyama K, Abdullah M, Lenggoro IW, Iskandar F. Preparation of functional nanostructured particles by spray drying. Adv Powder Technol 2006;17:587-611
11. Krohn Jensen DT, Cun D, Maltesen MJ, et al. Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation. J Control Release 2010;142(1):138-145
12. Muller CR, Bassani VL, Pohlmann AR, et al. Preparation and characterization of spray-dried polymeric nanocapsules. Drug Dev Ind Pharm 2000;26:343-347
13. Chaubal MV, Popescu C. Conversion of nanosuspensions into dry powders by spray drying: a case study. Pharm Res 2008;25:2302-2308
14. Schaffazick SR, Pohlmann AR, Mezzalira G. Development of nanocapsule suspension and nanocapsule spray-dried powders containing melatonin. J Braz Chem Soc 2006;17:562-569
15. Pohlmann AR, Weiss V, Mertins O, et al. Spray-dried indomethacin-loaded polyester nanocapsules and nanospheres: development, stability evaluation and nanostructure models. Eur J Pharm Sci 2002;16:305-312
16. Guterres SS, Beck RCR, Pohlmann AR. Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview. Braz J Phys 2009;39:205-209
17. Eerikäinen H, Kauppinen EI, Kansikas J. Polymeric drug nanoparticles by an aerosol flow reactor method. Pharm Res 2004;21:136-143
18. Jaworek A. Electrostatic micro- and nanoencapsulation and electroemulsification: a brief review. J Microencapsul 2008;25:443-468
19. Jaworek A, Sobczyk AT. Electrospraying route to nanotechnology: an overview. J Electrostatics 2008;66:197-219
20. Teo WE, Ramakrishna S. A review on electrospinning design and nanofibre assemblies. Nanotechnology 2006;17:R89-106
21. Chang SJ, Niu GCC, Kuo SM, et al. Preparation of nano-sized particles from collagen II by a high-voltage electrostatic field system. IEEE Proc Nanotechnol 2006;153:1-6
22. Cavallari C, Luppi B, Pietra AM, et al. Enhanced release of indomethacin from PVP/stearic acid microcapsules prepared coupling co-freeze-drying and ultrasound assisted spray-congealing process. Pharm Res 2007;24:521-529
23. Yubing X, Castracane J. High-voltage, electric field-driven micro/ nanofabrication for polymeric drug delivery systems. IEEE Eng Med Biol Mag 2009;28:23-30
24. Canals JMA, Hernandis V. Behaviour of the thermospray nebulizer as a system for the introduction of organic solutions in flame atomic absorption spectrometry. Spectrochim Acta B 1996;51:1535-1549
25. Plasma Science Committee, Board on Physics and Astronomy, Committee on Physical Sciences, Mathematics and Applications, National Research Council. Plasma science from fundamental research to technological applications. Chapter 5. Beams, accelerators, and coherent radiation sources. The National Academies, 1995
26. Taylor GI. Disintegration of water drops in an electric field. Proc R Soc London Ser A 1964;280:383-397
27. Rohner TC, Lion N, Girault HH. Electrochemical and theoretical aspects of electrospray ionization. Phys Chem Chem Phys 2004;6:3056-3068
28. Chen D, Pui DYH, Kaufman SL. Electrospraying of conducting liquids for monodisperse aerosol generation in the 4 nm to 1.8 μ diameter range. J Aerosol Sci 1995;26:963-977
29. Xie J, Lim LK, Phua Y, et al. Electrohydrodynamic atomization for biodegradable polymeric particle production. J Colloid Interface Sci 2006;302:103-112
30. Jaworek A. Micro- and nanoparticle production by electrospraying. Powder Technol 2007;176:18-35
31. Chakraborty S, Liao I, Adler A, Leong KW. Electrohydrodynamics: A facile technique to fabricate drug delivery systems. Adv Drug Deliv Rev 2009;61:1043-1054
32. Barichello JM, Morishita M, Takayama K, Nagai T. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev Ind Pharm 1999;25:471-476
33. Bilati U, Allémann E, Doelker E. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur J Pharm Sci 2005;24:67-75
34. El-Baseir MM, Kellaway IW. Poly(-lactic acid) microspheres for pulmonary drug delivery: release kinetics and aerosolization studies. Int J Pharm 1998;175:135-145
35. Hong Y, Hu FQ, Yuan H. Effect of PEG2000 on drug delivery characterization from solid lipid nanoparticles. Pharmazie 2006;61:312-315
36. Freytag T, Dashevsky A, Tillman L, Hardee GE. Bodmeier, R. Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. J Control Release 2000;69:197-207
37. Delie F, Berton M, Allémann E, Gurny R. Comparison of two methods of encapsulation of an oligonucleotide into poly(-lactic acid) particles. Int J Pharm 2001;214:25-30
38. Zambaux MF, Bonneaux F, Gref R, et al. Preparation and characterization of protein C-loaded PLA nanoparticles. J Control Release 1999;60:179-188
39. Valo H, Peltonen L, Vehviläinen S, et al. Electrospray encapsulation of hydrophilic and hydrophobic drugs in poly(L-lactic acid) nanoparticles. Small 2009;5:1791-1798
40. Ciach T. Microencapsulation of drugs by electro-hydro-dynamic atomization. Int J Pharm 2006;324:51-55
41. Xu Y, Hanna MA. Electrospray encapsulation of water-soluble protein with polylactide - effects of formulations on morphology, encapsulation efficiency and release profile of particles. Int J Pharm 2006;320:30-36 (Pubitemid 44128701)
42. Xie J, Tan JC, Wang C. Biodegradable films developed by electrospray deposition for sustained drug delivery. J Pharm Sci 2008;97:3109-3122
43. Xie J, Ng WJ, Lee LY, Wang C. Encapsulation of protein drugs in biodegradable microparticles by co-axial electrospray. J Colloid Interface Sci 2008;317:469-476
44. Meng F, Jiang Y, Sun Z, et al. Electrohydrodynamic liquid atomization of biodegradable polymer microparticles: effect of electrohydrodynamic liquid atomization variables on microparticles. J Appl Polym Sci 2009;113:526-534
45. Yao J, Kuang Lim L, Xie J, Hua J. Wang C. Characterization of electrospraying process for polymeric particle fabrication. J Aerosol Sci 2008;39:987-1002
46. Xie J, Wang C. Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor cone-jet mode. Biotechnol Bioeng 2007;97:1278-1290
47. Ding L, Lee T, Wang C. Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization. J Control Release 2005;102:395-413
48. Arya N, Chakraborty S, Dube N, Katti DS. Electrospraying: A facile technique for synthesis of chitosan-based micro/nanospheres for drug delivery applications. J Biomed Mater Res B Appl Biomater 2009;88:17-31
49. Wu Y, MacKay JA, McDaniel JR, et al. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules 2009;10:19-24
50. Schipper NGM, Olsson S, Hoogstraate JA, et al. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res 1997;14:923-929
51. Meyer DE, Chilkoti A. Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides. Biomacromolecules 2004;5:846-851
52. Prabaharan M. Chitosan derivatives as promising materials for controlled drug delivery. J Biomater Appl 2008;1:5-36
53. Mi F, Tan Y, Liang H, Sung H. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials 2002;23:181-191
54. Chilkoti A, Dreher MR, Meyer DE. Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Adv Drug Deliv Rev 2002;54:1093-1111
55. Jayasinghe SN, Edirisinghe MJ. Effect of viscosity on the size of relics produced by electrostatic atomization. J Aerosol Sci 2002;33:1379-1388
56. Xu Y, Hanna MA. Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules: synthesis and characterization. J Microencapsul 2007;24:143-151
57. Gomez A, Bingham D, Juan LD, Tang K. Production of protein nanoparticles by electrospray drying. J Aerosol Sci 1998;29:561-574
58. Paine MD, Alexander MS, Stark JPW. Nozzle and liquid effects on the spray modes in nanoelectrospray. J Colloid Interface Sci 2007;305:111-123
59. Lewinska D, Rosinski S, Werynski A. Influence of process conditions during impulsed electrostatic formation on size distribution of hydrogel beads. Artif Cells Blood Substit Immobil Biotechnol 2004;32:41-53
60. Xie J, Wang C. Electrospray in the dripping mode for cell microencapsulation. J Colloid Interface Sci 2007;312:247-255
61. Grenha A, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 2005;25:427-437
62. Gómez-Gaete C, Fattal E, Silva L, et al. Dexamethasone acetate encapsulation into Trojan particles. J Control Release 2008;128:41-49
63. Jafari SM, Assadpoor E, Bhandari B, He Y. Nano-particle encapsulation of fish oil by spray drying. Food Res Int 2008;41:172-183
64. Pamujula S, Graves RA, Freeman T, et al. Oral delivery of spray dried PLGA/amifostine nanoparticles. J Pharm Pharmacol 2004;56:1119-1125
65. Elversson J, Millqvist-Fureby A, Alderborn G, Elofsson U. Droplet and particle size relationship and shell thickness of inhalable lactose particles during spray drying. J Pharm Sci 2003;92:900-910
66. Elversson J, Millqvist-Fureby A. Particle size and density in spray drying - effects of carbohydrate properties. J Pharm Sci 2005;94:2049-2060
67. Huang LX, Kumar K, Mujumdar AS. A comparative study of a spray dryer with rotary disc atomizer and pressure nozzle using computational fluid dynamic simulations. Chem Eng Process 2006;45:461-470
68. Christensen KL, Pedersen GP, Kristensen HG. Preparation of redispersable dry emulsion by spray drying. Int J Pharm 2001;212:187-194
69. Dunbar CA, Concessio NM, Hickey AJ. Evaluation of atomizer performance in production of respirable spray-dried particles. Pharm Dev Technol 1998;3:433-441
70. Iskandar F, Gradon L, Okuyama K. Control of the morphology of nanostructured particles prepared by the spray drying of a nanoparticle sol. J Colloid Interface Sci 2003;265:296-303
71. Wu HM, Tu JP, Yang YZ, Shi DQ. Spray-drying process for synthesis of nanosized LiMn2O4 cathode. J Mater Sci 2006;41:4247-4250
72. Hadinoto K, Zhu K, Tan RB. Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery. Int J Pharm 2007;341:195-206
73. Oyabu T, Ogami A, Morimoto Y, et al. Biopersistence of inhaled nickel oxide nanoparticles in rat lung. Inhal Toxicol 2007;19:55-58
74. Lindeløv JS, Wahlberg M. Spray drying for processing of nanomaterials. J Phys Conf Ser 2009;170:1-7
75. Mosen K, Bäckstrom K, Thalberg K, et al. Particle formation and capture during spray drying of inhalable particles. Pharm Dev Technol 2004;9:409-417
76. Corrigan DO, Corrigan OI, Healy AM. Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems. Int J Pharm 2004;273:171-182
77. Corrigan DO, Corrigan OI, Healy AM. Physicochemical and in vitro deposition properties of salbutamol sulphate/ ipratropium bromide and salbutamol sulphate/excipient spray dried mixtures for use in dry powder inhalers. Int J Pharm 2006;322:22-30
78. Ståhl K, Claesson M, Lilliehorn P, et al. The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation. Int J Pharm 2002;233:227-237
79. Broadhead J, Rouan SK, Hau I, Rhodes CT. The effect of process and formulation variables on the properties of the spray-dried beta-galactosidase. J Pharm Pharmacol 1994;46:458-467
80. Gilani K, Najafabadi AR, Barghi M, Rafiee-Tehrani M. The effect of water to ethanol feed ratio on physical properties and aerosolization behavior of spray dried cromolyn sodium particles. J Pharm Sci 2005;94:1048-1059
81. Rabbani NR, Seville PC. The influence of formulation components on the aerosolization properties of spray-dried powders. J Control Release 2005;110:130-140
82. Klingler C, Müller BW, Steckel H. Insulin-micro- and nanoparticles for pulmonary delivery. Int J Pharm 2009;377:173-179
83. Maury M, Murphy K, Kumar S, et al. Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-drier. Eur J Pharm Biopharm 2005;59:565-573
84. Margulis-Goshen K, Netivi HD, Major DT, et al. Formation of organic nanoparticles from volatile microemulsions. J Colloid Interface Sci 2010;342(2):283-292
85. Freitas C, Müller RH. Spray-drying of solid lipid nanoparticles (SLN™). Eur J Pharm Biopharm 1998;46:145-151
86. Broadhead J, Edmond Rouan SK, Rhodes CT. The spray drying of pharmaceutics. Drug Dev Ind Pharm 1992;18:1169-1206
87. Zhang X, Pan W, Gan L, et al. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamphothecin by spray-drying. Chem Pharm Bull 2008;56:1645-1650
88. Chow LC, Sun L, Hockey B. Properties of nanostructured hydroxyapatite prepared by spray drying technique. J Res Natl Inst Stand Technol 2004;109:543-551
89. Sun L, Chow LC. Preparation and properties of nano-sized calcium fluoride for dental applications. Dent Mater 2008;24:111-116
90. Lind A, von Hohenesche CF, Smått J-H, et al. Spherical silica agglomerates possessing hierarchical porosity prepared by spray drying of MCM-41 and MCM-48 nanospheres. Microporous Mesoporous Mater 2003;66:219-227
91. Urata C, Yamauchi Y, Aoyama Y, et al. Fabrication of hierarchically porous spherical particles by assembling mesoporous silica nanoparticles via spray drying. J Nanosci Nanotechnol 2008;8:3101-3105
92. Wang Y, Tian W, Yang Y. Preparation and characterization of rare earth modified nanocrystalline Al2O3/13 wt% TiO2 feedstock for plasma spraying. J Nanosci Nanotechnol 2009;9:1445-1448
93. Mizoe T, Ozeki T, Okada H. Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms. J Control Release 2007;122:10-15
94. Grenha A, Seijo B, Serra C, Remuñán-López C. Chitosan-nanoparticle loaded mannitol microspheres: structure and surface characterization. Biomacromolecules 2007;8:2072-2079
95. Yang Y, Coradin T. A green route to silica nanoparticles with tunable size and structure. Green Chem 2008;10:183-190
96. Hadinoto K, Cheow WS. Hollow spherical nanoparticulate aggregates as potential ultrasound contrast agent: shell thickness characterization. Drug Dev Ind Pharm 2009;35:1167-1179
97. Tomoda K, Ohkoshi T, Hirota K, et al. Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer. Colloids Surf B Biointerfaces 2009;71:177-182
98. Sen D, Spalla O, Taché O, et al. Slow drying of a spray of nanoparticles dispersion. In situ SAXS investigation. Langmuir 2007;23:4296-4302
99. Sham JO-H, Zhang Y, Finlay WH, et al. Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int J Pharm 2004;269:457-467
100. Lyonnard S, Bartlett JR, Sizgek E, et al. Role of interparticle potential in controlling the morphology of spray-dried powders from aqueous nanoparticle sols. Langmuir 2002;18:10386-10397
101. Maa YF, Nguyen PA, Hsu SW. Spray-drying of air-liquid interface sensitive recombinant human growth hormone. J Pharm Sci 1998;87:152-159
102. Adler M, Unger M, Lee G. Surface composition of spraydried particles of bovine serum albumin/trehalose/ surfactant. Pharm Res 2000;17:863-870
103. Millqvist-Fureby A, Malmsten M, Bergenstahl B. Spray-drying of trypsin - surface characterisation and activity preservation. Int J Pharm 1999;188:243-253
104. Velev OD, Lenhoff AM, Kaler EW. A class of microstructured particles through colloidal crystallization. Science 2000;287:2240-2243
105. Eerikäinen H, Peltonen L, Raula J, et al. Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. AAPS PharmSciTech 2004;5:e68
106. Ilic I, Dreu R, Burjak M, et al. Microparticle size control and glimepiride microencapsulation using spray congealing technique. Int J Pharm 2009;381:176-183
107. Albertini B, Mezzena M, Passerini N, et al. Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzone. J Pharm Sci 2009;98:2759-2769
108. McCarron PA, Donnelly RF, Al-Kassas R. Comparison of a novel spray congealing procedure with emulsion-based methods for the miro-encapsulation of water-soluble drugs in low melting point triglycerides. J Microencapsul 2008;25:365-378
109. Maschke A, Becker C, Eyrich D, et al. Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof. Eur J Pharm Biopharm 2007;65:175-187
110. Mackaplow MB, Zarraga IE, Morros JF. Rotaryspray congealing of a suspension: effect of disk speed and dispersed particle properties. J Microencapsul 2006;23:793-809
111. Bosquillon C, Lombry C, Preat V, Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J Control Release 2001;70:329-339
112. Yajima T, Umeki N, Itai S. Optimum spray congealing conditions for masking the bitter taste of clarithromycin in wax matrix. Chem Pharm Bull 1999;47:220-225
113. Albertini B, Passerini N, Gonzalez-Rodriguez ML, et al. Effect of Aerosil™ on the properties of lipid controlled release microparticles. J Control Release 2004;100:233-246
114. Cavallari C, Rodriguez L, Albertini B, et al. Thermal and fractal analysis of diclofenac/gelucire 50/13 microparticles obtained by ultrasound-assisted atomization. J Pharm Sci 2005;94:1124-1134
115. Passerini N, Perissutti B, Albertini B, et al. Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing. J Control Release 2003;88:263-275
116. Fini A, Rodriguez L, Cavallari C, et al. Ultrasound-compacted and spray-congealed indomethacin/ polyethyleneglycol systems. Int J Pharm 2002;247:11-22
117. Linders LJM, Meerdink G, van't Riet K. Influence of temperature and drying rate on the dehydration inactivation of Lactobacillus plantarum. Trans IChemE Part C 1996;74:110-114