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Volumn 9, Issue 7, 2014, Pages

Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; RECOMBINANT PROTEIN; RETINOID RELATED ORPHAN RECEPTOR BETA; STRESS ACTIVATED PROTEIN KINASE; WNT PROTEIN; WNT1 PROTEIN; WNT3A PROTEIN; WNT5A PROTEIN; DKK1 PROTEIN, MOUSE; SIGNAL PEPTIDE; WNT1 PROTEIN, MOUSE; WNT3A PROTEIN, MOUSE;

EID: 84904246120     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101800     Document Type: Article
Times cited : (34)

References (87)
  • 1
    • 0014330153 scopus 로고
    • The in vivo life span of normal and preneoplastic mouse mammary glands: A serial transplantation study
    • Daniel CW, Ome KBD, Young JT, Blair PB, Faulkin LJ (1968) The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. PNAS 61: 53-60.
    • (1968) PNAS , vol.61 , pp. 53-60
    • Daniel, C.W.1    Ome, K.B.D.2    Young, J.T.3    Blair, P.B.4    Faulkin, L.J.5
  • 2
    • 0031748344 scopus 로고    scopus 로고
    • An entire functional mammary gland may comprise the progeny from a single cell
    • Kordon EC, Smith GH (1998) An entire functional mammary gland may comprise the progeny from a single cell. Development 125: 1921-1930.
    • (1998) Development , vol.125 , pp. 1921-1930
    • Kordon, E.C.1    Smith, G.H.2
  • 5
    • 84867575877 scopus 로고    scopus 로고
    • Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland
    • De Visser KE, Ciampricotti M, Michalak E, Wei-Min Tan D, Speksnijder EN, et al. (2012) Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland. The Journal of Pathology 228: 300-309.
    • (2012) The Journal of Pathology , vol.228 , pp. 300-309
    • De Visser, K.E.1    Ciampricotti, M.2    Michalak, E.3    Wei-Min Tan, D.4    Speksnijder, E.N.5
  • 6
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, et al. (2011) Distinct stem cells contribute to mammary gland development and maintenance. Nature 479: 189-193.
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1    Rocha, A.S.2    Ousset, M.3    Beck, B.4    Bouvencourt, G.5
  • 7
    • 84894267586 scopus 로고    scopus 로고
    • In situ identification of bipotent stem cells in the mammary gland
    • Rios AC, Fu NY, Lindeman GJ, Visvader JE (2014) In situ identification of bipotent stem cells in the mammary gland. Nature 506: 322-327.
    • (2014) Nature , vol.506 , pp. 322-327
    • Rios, A.C.1    Fu, N.Y.2    Lindeman, G.J.3    Visvader, J.E.4
  • 9
    • 79953780101 scopus 로고    scopus 로고
    • Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation
    • Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM (2011) Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells 29: 678-688.
    • (2011) Stem Cells , vol.29 , pp. 678-688
    • Shahi, P.1    Seethammagari, M.R.2    Valdez, J.M.3    Xin, L.4    Spencer, D.M.5
  • 10
    • 33847034841 scopus 로고    scopus 로고
    • Strengths and limitations of the neurosphere culture system
    • Jensen JB, Parmar M (2006) Strengths and limitations of the neurosphere culture system. Mol Neurobiol 34: 153-161.
    • (2006) Mol Neurobiol , vol.34 , pp. 153-161
    • Jensen, J.B.1    Parmar, M.2
  • 14
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S, Dontu G, Mantle ID, Patel S, Ahn N, et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66: 6063-6071.
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.5
  • 15
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, et al. (2008) Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68: 4674-4682.
    • (2008) Cancer Res , vol.68 , pp. 4674-4682
    • Zhang, M.1    Behbod, F.2    Atkinson, R.L.3    Landis, M.D.4    Kittrell, F.5
  • 16
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya H, Paulson A, Iovino F, Wicha MS (2008) HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 27: 6120-6130.
    • (2008) Oncogene , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3    Wicha, M.S.4
  • 17
    • 84874715117 scopus 로고    scopus 로고
    • Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential
    • Dong Q, Wang D, Bandyopadhyay A, Gao H, Gorena KM, et al. (2013) Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential. Stem Cell Res 10: 396-404.
    • (2013) Stem Cell Res , vol.10 , pp. 396-404
    • Dong, Q.1    Wang, D.2    Bandyopadhyay, A.3    Gao, H.4    Gorena, K.M.5
  • 18
    • 55749106963 scopus 로고    scopus 로고
    • Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
    • Grimshaw MJ, Cooper L, Papazisis K, Coleman JA, Bohnenkamp HR, et al. (2008) Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 10: R52.
    • (2008) Breast Cancer Res , vol.10
    • Grimshaw, M.J.1    Cooper, L.2    Papazisis, K.3    Coleman, J.A.4    Bohnenkamp, H.R.5
  • 19
    • 84879826154 scopus 로고    scopus 로고
    • Wnt pathway activity in breast cancer sub-types and stem-like cells
    • Lamb R, Ablett MP, Spence K, Landberg G, Sims AH, et al. (2013) Wnt pathway activity in breast cancer sub-types and stem-like cells. PLoS ONE 8: e67811.
    • (2013) PLoS ONE , vol.8
    • Lamb, R.1    Ablett, M.P.2    Spence, K.3    Landberg, G.4    Sims, A.H.5
  • 20
    • 4444368563 scopus 로고    scopus 로고
    • Wnt proteins in mammary development and cancer
    • DOI 10.1023/B:JOMG.0000037157.94207.33, Embryonic Genes in Mammary Gland Development and Tumorigenesis
    • Brennan KR, Brown AMC (2004) Wnt proteins in mammary development and cancer. J Mammary Gland Biol Neoplasia 9: 119-131. (Pubitemid 39177498)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.2 , pp. 119-131
    • Brennan, K.R.1    Brown, A.M.C.2
  • 21
    • 84873554856 scopus 로고    scopus 로고
    • Mammary stem cells and cancer: Roles of Wnt signaling in plain view
    • Many AM, Brown AMC (2010) Mammary stem cells and cancer: roles of Wnt signaling in plain view. Breast Cancer Res 12: 313.
    • (2010) Breast Cancer Res , vol.12 , pp. 313
    • Many, A.M.1    Brown, A.M.C.2
  • 22
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-Catenin Signaling and Disease
    • Clevers H, Nusse R (2012) Wnt/β-Catenin Signaling and Disease. Cell 149: 1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 23
  • 26
    • 33846193290 scopus 로고    scopus 로고
    • The many ways of Wnt in cancer
    • Polakis P (2007) The many ways of Wnt in cancer. Curr Opin Genet Dev 17: 45-51.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 45-51
    • Polakis, P.1
  • 27
    • 0034696336 scopus 로고    scopus 로고
    • Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
    • Li Y, Hively WP, Varmus HE (2000) Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 19: 1002-1009. (Pubitemid 30153783)
    • (2000) Oncogene , vol.19 , Issue.8 , pp. 1002-1009
    • Li, Y.1    Hively, W.P.2    Varmus, H.E.3
  • 30
    • 79960857043 scopus 로고    scopus 로고
    • Key signaling nodes in mammary gland development and cancer: β-catenin
    • Incassati A, Chandramouli A, Eelkema R, Cowin P (2010) Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res 12: 213.
    • (2010) Breast Cancer Res , vol.12 , pp. 213
    • Incassati, A.1    Chandramouli, A.2    Eelkema, R.3    Cowin, P.4
  • 32
    • 84887212573 scopus 로고    scopus 로고
    • MMTV-Wnt1 and ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
    • Teissedre B, Pinderhughes A, Incassati A, Hatsell SJ, Hiremath M, et al. (2009) MMTV-Wnt1 and ΔN89β-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS ONE 4: e4537.
    • (2009) PLoS ONE , vol.4
    • Teissedre, B.1    Pinderhughes, A.2    Incassati, A.3    Hatsell, S.J.4    Hiremath, M.5
  • 33
    • 68949154567 scopus 로고    scopus 로고
    • The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage
    • Badders NM, Goel S, Clark RJ, Klos KS, Kim S, et al. (2009) The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS ONE 4: e6594.
    • (2009) PLoS ONE , vol.4
    • Badders, N.M.1    Goel, S.2    Clark, R.J.3    Klos, K.S.4    Kim, S.5
  • 34
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE (1988) Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55: 619-625.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1    Grosschedl, R.2    Guzman, R.C.3    Parslow, T.4    Varmus, H.E.5
  • 35
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • Zeng YA, Nusse R (2010) Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6: 568-577.
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 36
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/β-catenin- responsive stem cells in the mammary gland
    • Van Amerongen R, Bowman AN, Nusse R (2012) Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11: 387-400.
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • Van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 37
    • 36849055111 scopus 로고    scopus 로고
    • SnapShot: Wnt/β-catenin signaling
    • Macdonald BT, Semenov MV, He X (2007) SnapShot: Wnt/β-catenin signaling. Cell 131: 1204.
    • (2007) Cell , vol.131 , pp. 1204
    • Macdonald, B.T.1    Semenov, M.V.2    He, X.3
  • 39
    • 37349025355 scopus 로고    scopus 로고
    • SnapShot: Noncanonical Wnt Signaling Pathways
    • Semenov MV, Habas R, Macdonald BT, He X (2007) SnapShot: Noncanonical Wnt Signaling Pathways. Cell 131: 1378.
    • (2007) Cell , vol.131 , pp. 1378
    • Semenov, M.V.1    Habas, R.2    Macdonald, B.T.3    He, X.4
  • 41
    • 17644424645 scopus 로고    scopus 로고
    • The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts
    • DOI 10.1128/MCB.25.9.3475-3482.2005
    • Liu G, Bafico A, Aaronson SA (2005) The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts. Mol Cell Biol 25: 3475-3482. (Pubitemid 40559556)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.9 , pp. 3475-3482
    • Liu, G.1    Bafico, A.2    Aaronson, S.A.3
  • 43
    • 78349276165 scopus 로고    scopus 로고
    • Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
    • Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, et al. (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev 24: 2517-2530.
    • (2010) Genes Dev , vol.24 , pp. 2517-2530
    • Grumolato, L.1    Liu, G.2    Mong, P.3    Mudbhary, R.4    Biswas, R.5
  • 44
    • 2442680430 scopus 로고    scopus 로고
    • Wnt proteins induce dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize β-catenin
    • DOI 10.1128/MCB.24.11.4757-4768.2004
    • Gonzalez-Sancho JM, Brennan KR, Castelo-Soccio LA, Brown AMC (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize β-catenin. Mol Cell Biol 24: 4757-4768. (Pubitemid 38668042)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.11 , pp. 4757-4768
    • Gonzalez-Sancho, J.M.1    Brennan, K.R.2    Castelo-Soccio, L.A.3    Brown, A.M.C.4
  • 45
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald SL, Silver A (2009) The opposing roles of Wnt-5a in cancer. Br J Cancer 101: 209-214.
    • (2009) Br J Cancer , vol.101 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 46
    • 36549025433 scopus 로고    scopus 로고
    • Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth
    • DOI 10.1242/dev.008250
    • Roarty K, Serra R (2007) Wnt5a is required for proper mammary gland development and TGFβ-mediated inhibition of ductal growth. Development 134: 3929-3939. (Pubitemid 350187351)
    • (2007) Development , vol.134 , Issue.21 , pp. 3929-3939
    • Roarty, K.1    Serra, R.2
  • 47
    • 68349123821 scopus 로고    scopus 로고
    • Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype
    • Roarty K, Baxley SE, Crowley MR, Frost AR, Serra R (2009) Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res 11: R19.
    • (2009) Breast Cancer Res , vol.11
    • Roarty, K.1    Baxley, S.E.2    Crowley, M.R.3    Frost, A.R.4    Serra, R.5
  • 49
    • 77949587674 scopus 로고    scopus 로고
    • Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway
    • Fuerer C, Nusse R (2010) Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway. PLoS ONE 5: e9370.
    • (2010) PLoS ONE , vol.5
    • Fuerer, C.1    Nusse, R.2
  • 50
    • 84867198093 scopus 로고    scopus 로고
    • Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury
    • Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS (2012) Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science 338: 108-113.
    • (2012) Science , vol.338 , pp. 108-113
    • Miyoshi, H.1    Ajima, R.2    Luo, C.T.3    Yamaguchi, T.P.4    Stappenbeck, T.S.5
  • 51
    • 79955046668 scopus 로고    scopus 로고
    • An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
    • Gonsalves FC, Klein K, Carson BB, Katz S, Ekas LA, et al. (2011) An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proceedings of the National Academy of Sciences 108: 5954-5963.
    • (2011) Proceedings of the National Academy of Sciences , vol.108 , pp. 5954-5963
    • Gonsalves, F.C.1    Klein, K.2    Carson, B.B.3    Katz, S.4    Ekas, L.A.5
  • 53
    • 67651109145 scopus 로고    scopus 로고
    • Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture
    • Dey D, Saxena M, Paranjape AN, Krishnan V, Giraddi R, et al. (2009) Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture. PLoS One 4: e5329.
    • (2009) PLoS One , vol.4
    • Dey, D.1    Saxena, M.2    Paranjape, A.N.3    Krishnan, V.4    Giraddi, R.5
  • 54
    • 79651473318 scopus 로고    scopus 로고
    • Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity
    • Tao L, Roberts AL, Dunphy KA, Bigelow C, Yan H, et al. (2011) Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity. Stem Cells 29: 119-127.
    • (2011) Stem Cells , vol.29 , pp. 119-127
    • Tao, L.1    Roberts, A.L.2    Dunphy, K.A.3    Bigelow, C.4    Yan, H.5
  • 55
    • 34247398806 scopus 로고    scopus 로고
    • Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    • DOI 10.1242/dev.02797
    • Moraes RC, Zhang X, Harrington N, Fung JY, Wu M-F, et al. (2007) Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 134: 1231-1242. (Pubitemid 46630090)
    • (2007) Development , vol.134 , Issue.6 , pp. 1231-1242
    • Moraes, R.C.1    Zhang, X.2    Harrington, N.3    Fung, J.Y.4    Wu, M.-F.5    Hilsenbeck, S.G.6    Allred, D.C.7    Lewis, M.T.8
  • 56
    • 59649100796 scopus 로고    scopus 로고
    • Wnt signaling controls the fate of mesenchymal stem cells
    • Ling L, Nurcombe V, Cool SM (2009) Wnt signaling controls the fate of mesenchymal stem cells. Gene 433: 1-7.
    • (2009) Gene , vol.433 , pp. 1-7
    • Ling, L.1    Nurcombe, V.2    Cool, S.M.3
  • 58
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 11: 951-961.
    • (2001) Curr Biol , vol.11 , pp. 951-961
    • Semënov, M.V.1    Tamai, K.2    Brott, B.K.3    Kühl, M.4    Sokol, S.5
  • 59
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • DOI 10.1038/35083081
    • Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA (2001) Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 3: 683-686. (Pubitemid 32624426)
    • (2001) Nature Cell Biology , vol.3 , Issue.7 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 60
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • DOI 10.1038/35077108
    • Mao B, Wu W, Li Y, Hoppe D, Stannek P, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411: 321-325. (Pubitemid 32467039)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 61
    • 84855416391 scopus 로고    scopus 로고
    • Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells
    • Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin JS (2012) Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS ONE 7: e29455.
    • (2012) PLoS ONE , vol.7
    • Baljinnyam, B.1    Klauzinska, M.2    Saffo, S.3    Callahan, R.4    Rubin, J.S.5
  • 62
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context
    • Mikels AJ, Nusse R (2006) Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. PLoS Biol 4: e115.
    • (2006) PLoS Biol , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 64
    • 84864352822 scopus 로고    scopus 로고
    • Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development
    • Van Amerongen R, Fuerer C, Mizutani M, Nusse R (2012) Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol 369: 101-114.
    • (2012) Dev Biol , vol.369 , pp. 101-114
    • Van Amerongen, R.1    Fuerer, C.2    Mizutani, M.3    Nusse, R.4
  • 65
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation
    • DOI 10.1083/jcb.200303158
    • Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J Cell Biol 162: 899-908. (Pubitemid 37087729)
    • (2003) Journal of Cell Biology , vol.162 , Issue.5 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3    Garrett-Beal, L.4    Carolan, P.J.5    Yang, Y.6
  • 66
    • 34547925581 scopus 로고    scopus 로고
    • Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation
    • DOI 10.1002/jcb.21097
    • Baksh D, Boland GM, Tuan RS (2007) Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. J Cell Biochem 101: 1109-1124. (Pubitemid 47253714)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.5 , pp. 1109-1124
    • Baksh, D.1    Boland, G.M.2    Tuan, R.S.3
  • 68
    • 79958228344 scopus 로고    scopus 로고
    • Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture
    • Pavlovich AL, Boghaert E, Nelson CM (2011) Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture. Exp Cell Res 317: 1872-1884.
    • (2011) Exp Cell Res , vol.317 , pp. 1872-1884
    • Pavlovich, A.L.1    Boghaert, E.2    Nelson, C.M.3
  • 69
    • 0030941498 scopus 로고    scopus 로고
    • A member of the frizzled protein family mediating axis induction by Wnt- 5A
    • DOI 10.1126/science.275.5306.1652
    • He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275: 1652-1654. (Pubitemid 27120542)
    • (1997) Science , vol.275 , Issue.5306 , pp. 1652-1654
    • He, X.1    Saint-Jeannet, J.-P.2    Wang, Y.3    Nathans, J.4    Dawid, I.5    Varmus, H.6
  • 70
    • 77954365864 scopus 로고    scopus 로고
    • Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization
    • Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, et al. (2010) Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol Cell Biol 30: 3610-3619.
    • (2010) Mol Cell Biol , vol.30 , pp. 3610-3619
    • Nishita, M.1    Itsukushima, S.2    Nomachi, A.3    Endo, M.4    Wang, Z.5
  • 71
    • 73849123750 scopus 로고    scopus 로고
    • The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
    • O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, et al. (2010) The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29: 34-44.
    • (2010) Oncogene , vol.29 , pp. 34-44
    • O'Connell, M.P.1    Fiori, J.L.2    Xu, M.3    Carter, A.D.4    Frank, B.P.5
  • 72
    • 54249099723 scopus 로고    scopus 로고
    • Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
    • Nomachi A, Nishita M, Inaba D, Enomoto M, Hamasaki M, et al. (2008) Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem. 283: 27973-27981.
    • (2008) J Biol Chem. , vol.283 , pp. 27973-27981
    • Nomachi, A.1    Nishita, M.2    Inaba, D.3    Enomoto, M.4    Hamasaki, M.5
  • 76
    • 77957266335 scopus 로고    scopus 로고
    • Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
    • Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, et al. (2010) Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc Natl Acad Sci USA 107: 15473-15478.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15473-15478
    • Ettenberg, S.A.1    Charlat, O.2    Daley, M.P.3    Liu, S.4    Vincent, K.J.5
  • 77
    • 34347254641 scopus 로고    scopus 로고
    • The soluble Wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo
    • DOI 10.1158/0008-5472.CAN-07-0266
    • DeAlmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, et al. (2007) The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res 67: 5371-5379. (Pubitemid 46997277)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5371-5379
    • DeAlmeida, V.I.1    Miao, L.2    Ernst, J.A.3    Koeppen, H.4    Polakis, P.5    Rubinfeld, B.6
  • 79
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson M, Dejmek J, Bendahl PO, Andersson T (2002) Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res 62: 409-416. (Pubitemid 34106413)
    • (2002) Cancer Research , vol.62 , Issue.2 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.-O.3    Andersson, T.4
  • 80
    • 27144450534 scopus 로고    scopus 로고
    • Wnt-5a protein expression in primary Dukes B colon cancers identifies a subgroup of patients with good prognosis
    • DOI 10.1158/0008-5472.CAN-05-1710
    • Dejmek J, Dejmek A, Säfholm A, Sjölander A, Andersson T (2005) Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 65: 9142-9146. (Pubitemid 41507974)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9142-9146
    • Dejmek, J.1    Dejmek, A.2    Safholm, A.3    Sjolander, A.4    Andersson, T.5
  • 81
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH-J, Chaffer CL, Reinhardt F, et al. (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145: 926-940.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.-J.3    Chaffer, C.L.4    Reinhardt, F.5
  • 82
    • 79960201532 scopus 로고    scopus 로고
    • Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells
    • Yeh JR, Zhang X, Nagano MC (2011) Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells. Journal of Cell Science 124: 2357-2366.
    • (2011) Journal of Cell Science , vol.124 , pp. 2357-2366
    • Yeh, J.R.1    Zhang, X.2    Nagano, M.C.3
  • 83
    • 84870252814 scopus 로고    scopus 로고
    • The complex world of WNT receptor signalling
    • Niehrs C (2012) The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 13: 767-779.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 84
    • 55749102279 scopus 로고    scopus 로고
    • Alternative wnt signaling is initiated by distinct receptors
    • Van Amerongen R, Mikels A, Nusse R (2008) Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1: re9.
    • (2008) Sci Signal , vol.1
    • Van Amerongen, R.1    Mikels, A.2    Nusse, R.3
  • 85
    • 84873131410 scopus 로고    scopus 로고
    • Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
    • Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, et al. (2013) Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis. Cell Rep 3: 70-78.
    • (2013) Cell Rep , vol.3 , pp. 70-78
    • Plaks, V.1    Brenot, A.2    Lawson, D.A.3    Linnemann, J.R.4    Van Kappel, E.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.