Wnt and notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation

Stem Cells

Volumn 29, Issue 4, 2011, Pages 678-688

  Shahi, Payam ^a   Seethammagari, Mamatha R ^a   Valdez, Joseph M ^a   Xin, Li ^a   Spencer, David M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Catenin; Notch; p63; Prostate stem cell; Wnt

Indexed keywords

ATAXIN 1; CYTOKERATIN; CYTOKERATIN 5; CYTOKERATIN 8; NOTCH RECEPTOR; NOTCH1 RECEPTOR; WNT PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; BASAL CELL; CARCINOMA CELL; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DOWN REGULATION; EPITHELIUM BASAL CELL; EXPERIMENT; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROSTATE; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION;

ADULT STEM CELLS; ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MICE; PHOSPHOPROTEINS; PROSTATE; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELLS; TRANS-ACTIVATORS; WNT PROTEINS;

EID: 79953780101     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.606     Document Type: Article

References (56)

1. Jemal A, Siegel R, Xu J et al. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
2. Chesire DR, Ewing CM, Sauvageot J et al. Detection and analysis of beta-catenin mutations in prostate cancer. Prostate 2000;45: 323-334.
3. Chesire DR, Isaacs WB. Beta-catenin signaling in prostate cancer: An early perspective. Endocr Relat Cancer 2003;10:537-560. (Pubitemid 38094890)
4. Huang L, Pu Y, Hu WY et al. The role of Wnt5a in prostate gland development. Dev Biol 2009;328:188-199.
5. Wang BE, Wang XD, Ernst JA et al. Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling. PLoS One 2008;3:e2186.
6. Yu X, Wang Y, Jiang M et al. Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate 2009;69:249-262.
7. Chesire DR, Ewing CM, Gage WR et al. In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis. Oncogene 2002;21:2679-2694.
8. Chen G, Shukeir N, Potti A et al. Up-regulation of Wnt-1 and betacatenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications. Cancer 2004;101:1345-1356. (Pubitemid 39180390)
9. Mulholland DJ, Cheng H, Reid K et al. The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli. J Biol Chem 2002;277:17933-17943. (Pubitemid 34967604)
10. Pawlowski JE, Ertel JR, Allen MP et al. Liganded androgen receptor interaction with beta-catenin: Nuclear co-localization and modulation of transcriptional activity in neuronal cells. J Biol Chem 2002;277: 20702-20710. (Pubitemid 34967374)
11. Verras M, Brown J, Li X et al. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res 2004;64:8860-8866. (Pubitemid 39665490)
12. Winston JT, Strack P, Beer-Romero P et al. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 1999;13:270-283. (Pubitemid 29095799)
13. Eastman Q, Grosschedl R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 1999;11:233-240. (Pubitemid 29164039)
14. Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002;297:365-369. (Pubitemid 34790759)
15. Pinto D, Gregorieff A, Begthel H et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 2003;17:1709-1713. (Pubitemid 36870334)
16. Reya T. Regulation of hematopoietic stem cell self-renewal. Recent Prog Horm Res 2003;58:283-295. (Pubitemid 37339314)
17. Duncan AW, Rattis FM, DiMascio LN et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 2005;6:314-322. (Pubitemid 41724769)
18. Mumm JS, Schroeter EH, Saxena MT et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell 2000;5:197-206. (Pubitemid 30628079)
19. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998;393:382-386. (Pubitemid 28269713)
20. Kopan R, Ilagan MX. The canonical Notch signaling pathway: Unfolding the activation mechanism. Cell 2009;137:216-233.
21. Mumm JS, Kopan R. Notch signaling: From the outside in. Dev Biol 2000;228:151-165. (Pubitemid 32011983)
22. Pannequin J, Bonnans C, Delaunay N et al. The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res 2009;69:6065-6073.
23. Rodilla V, Villanueva A, Obrador-Hevia A et al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci USA 2009;106:6315-6320.
24. Isaacs JT, Coffey DS. Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl 1989;2:33-50. (Pubitemid 20075619)
25. Leong KG, Wang BE, Johnson L et al. Generation of a prostate from a single adult stem cell. Nature 2008;456:804-808.
26. Lawson DA, Xin L, Lukacs RU et al. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci USA 2007;104:181-186. (Pubitemid 46068005)
27. Xin L, Lukacs RU, Lawson DA et al. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells 2007;25:2760-2769. (Pubitemid 350127860)
28. Lawson DA, Zong Y, Memarzadeh S et al. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci USA 2010;107:2610-2615.
29. Wang X, Kruithof-de Julio M, Economides KD et al. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 2009;461:495-500.
30. Shou J, Ross S, Koeppen H et al. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res 2001; 61:7291-7297. (Pubitemid 32951774)
31. Whelan JT, Kellogg A, Shewchuk BM et al. Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression. J Cell Biochem 2009;107:992-1001.
32. Barth AI, Stewart DB, Nelson WJ. T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin. Proc Natl Acad Sci USA 1999; 96:4947-4952. (Pubitemid 29214516)
33. Carlesso N, Aster JC, Sklar J et al. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood 1999;93:838-848. (Pubitemid 29067848)
34. Zong Y, Panikkar A, Xu J et al. Notch signaling controls liver development by regulating biliary differentiation. Development 2009;136: 1727-1739.
35. Xin L, Ide H, Kim Y et al. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proc Natl Acad Sci USA 2003;100(suppl 1): 11896-11903.
36. Signoretti S, Waltregny D, Dilks J et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000; 157:1769-1775.
37. Seethammagari MR, Xie X, Greenberg NM et al. EZC-prostate models offer high sensitivity and specificity for noninvasive imaging of prostate cancer progression and androgen receptor action. Cancer Res 2006;66:6199-6209.
38. Gilles C, Polette M, Mestdagt M et al. Transactivation of vimentin by beta-catenin in human breast cancer cells. Cancer Res 2003;63: 2658-2664. (Pubitemid 36605210)
39. Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/ LEF-1 signaling pathway in induction of EMT. Cell Biol Int 2002;26: 463-476.
40. Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn 2006;235:3404-3412. (Pubitemid 44888206)
41. Yook JI, Li XY, Ota I et al. A Wnt-axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006;8: 1398-1406. (Pubitemid 44835115)
42. Wang XD, Shou J, Wong P et al. Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement. J Biol Chem 2004;279:24733-24744. (Pubitemid 38725341)
43. Orr B, Grace OC, Vanpoucke G et al. A role for notch signaling in stromal survival and differentiation during prostate development. Endocrinology 2009;150:463-472.
44. Wang XD, Leow CC, Zha J et al. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol 2006;290:66-80. (Pubitemid 43083604)
45. Wallberg AE, Pedersen K, Lendahl U et al. p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol 2002;22: 7812-7819. (Pubitemid 35217292)
46. Bisson I, Prowse DM. WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 2009;19:683-697.
47. Goldstein AS, Huang J, Guo C et al. Identification of a cell of origin for human prostate cancer. Science 2010;329:568-571.
48. Pannuti A, Foreman K, Rizzo P et al. Targeting Notch to target cancer stem cells. Clin Cancer Res 2010;16:3141-3152.
49. Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: Can we safely eradicate cancer stem cells? Clin Cancer Res 2010;16: 3153-3162.
50. Nakamura T, Tsuchiya K, Watanabe M. Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol 2007;42:705-710. (Pubitemid 47456757)
51. Morrison SJ, Perez SE, Qiao Z et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell 2000;101:499-510.
52. Nguyen BC, Lefort K, Mandinova A et al. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 2006;20:1028-1042.
53. Estrach S, Ambler CA, Lo Celso C et al. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 2006;133:4427-4438. (Pubitemid 46017818)
54. Dalrymple S, Antony L, Xu Y et al. Role of Notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells. Cancer Res 2005;65:9269-9279. (Pubitemid 41507993)
55. Pece S, Serresi M, Santolini E et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004;167:215-221. (Pubitemid 39435065)
56. Weng AP, Nam Y, Wolfe MS et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003;23:655-664. (Pubitemid 36050558)