Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

Cancer Research

Volumn 67, Issue 17, 2007, Pages 8131-8138

  Liao, Mai Jing ^a   Cheng, Cheng Zhang ^a,d   Zhou, Beiyan ^a   Zimonjic, Drazen B ^c   Mani, Sendurai A ^a   Kaba, Megan ^a   Gifford, Ann ^a   Reinhardt, Ferenc ^a,b   Popescu, Nicholas C ^c   Guo, Wenjun ^a   Elinor, Ng Eaton ^a   Lodish, Harvey F ^a,b   Weinberg, Robert A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CELL; BREAST DEVELOPMENT; CANCER CELL CULTURE; CELL ISOLATION; CELL POPULATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENOMIC INSTABILITY; IMMUNOPHENOTYPING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ADULT STEM CELLS; ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; FEMALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGANOIDS;

EID: 34548569038     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4493     Document Type: Article

References (21)

1. Daniel CW, De Ome KB, Young JT, Blair PB, Faulkin LJ, Jr. The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. Proc Natl Acad Sci U S A 1968;61:53-60.
2. Kordon EC, Smith GH. An entire functional mammary gland may comprise the progeny from a single cell. Development 1998;125:1921-30.
3. Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003;36 Suppl 1:59-72.
4. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003;100:3983-8.
5. Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol 2002;245:42-56.
6. Sleeman KE, Kendrick H, Ashworth A, Isacke CM, Smalley MJ. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res 2006;8:R7.
7. Stingl J, Eirew P, Ricketson I, et al. Purification and unique properties of mammary epithelial stem cells. Nature 2006;439:993-7.
8. Shackleton M, Vaillant F, Simpson KJ, et al. Generation of a functional mammary gland from a single stem cell. Nature 2006;439:84-8.
9. Stingl J, Raouf A, Emerman JT, Eaves CJ. Epithelial progenitors in the normal human mammary gland. J Mammary Gland Biol Neoplasia 2005;10:49-59.
10. Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253-70.
11. Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66:6063-71.
12. Chen CZ, Li L, Li M, Lodish HF. The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity 2003;19:525-33.
13. Zhang CC, Steele AD, Lindquist S, Lodish HF. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A 2006;103:2184-9.
14. Brisken C, Socolovsky M, Lodish HF, Weinberg R. The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A 2002;99:14241-5.
15. Zimonjic DB, Popescu NC. An improved procedure for chromosome preparations from solid tumors. Cancer Genet Cytogenet 1994;72:161.
16. Zimonjic D, Brooks MW, Popescu N, Weinberg RA, Hahn WC. Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res 2001;61:8838-44.
17. Yin AH, Miraglia S, Zanjani ED, et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 1997;90:5002-12.
18. Mani SA, Yang J, Brooks M, et al. Mesenchyme Forkhead1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A 2007;104:10069-74.
19. Zhang CC, Lodish HF. Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood 2005;105:4314-20.
20. Ligios C, Sigurdson CJ, Santucciu C, et al. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med 2005;11:1137-8.
21. Hanson C, Caisander G. Human embryonic stem cells and chromosome stability. APMIS 2005;113:751-5.