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Volumn 29, Issue 2, 2014, Pages 67-79

Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response

Author keywords

Adverse drug reaction; Carbamazepine; Drug resistance; Genetic polymorphism; Human leukocyte antigen (HLA); Pharmacogenetics

Indexed keywords

BIOLOGICAL MARKER; CARBAMAZEPINE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GLUCURONOSYLTRANSFERASE 2B7; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; ABC TRANSPORTER; ANTICONVULSIVE AGENT; CYTOCHROME P450; GENETIC MARKER;

EID: 84904208935     PISSN: 07925077     EISSN: 21910162     Source Type: Journal    
DOI: 10.1515/dmdi-2013-0046     Document Type: Review
Times cited : (17)

References (98)
  • 1
    • 0030794555 scopus 로고    scopus 로고
    • Established antiepileptic drugs
    • DOI 10.1016/S1059-1311(97)80001-5
    • Brodie MJ, Dichter MA. Established antiepileptic drugs. Seizure 1997;6:159-74. (Pubitemid 27290303)
    • (1997) Seizure , vol.6 , Issue.3 , pp. 159-174
    • Brodie, M.J.1    Dichter, M.A.2
  • 2
    • 0036213855 scopus 로고    scopus 로고
    • Practice guideline for the treatment of patients with bipolar disorder
    • American Psychiatric Association
    • American Psychiatric Association. Practice guideline for the treatment of patients with bipolar disorder. Am J Psychiatry 2002;159(Suppl):S1-50.
    • (2002) Am J Psychiatry , vol.159 , Issue.SUPPL.
  • 3
    • 0033643622 scopus 로고    scopus 로고
    • Investigation of phenobarbital-carbamazepinevalproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: An overview
    • Yukawa E. Investigation of phenobarbital-carbamazepinevalproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview. Drug Metabol Drug Interact 2000;16:86-98.
    • (2000) Drug Metabol Drug Interact , vol.16 , pp. 86-98
    • Yukawa, E.1
  • 4
    • 77951908870 scopus 로고    scopus 로고
    • Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays
    • McMillin GA, Juenke JM, Tso G, Dasgupta A. Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays. Am J Clin Pathol 2010;133:728-36.
    • (2010) Am J Clin Pathol , vol.133 , pp. 728-736
    • McMillin, G.A.1    Juenke, J.M.2    Tso, G.3    Dasgupta, A.4
  • 5
    • 0027499718 scopus 로고
    • Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils
    • DOI 10.1016/0006-2952(93)90279-6
    • Furst S, Uetrecht J. Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils. Biochem Pharmacol 1993;45:1267-75. (Pubitemid 23098324)
    • (1993) Biochemical Pharmacology , vol.45 , Issue.6 , pp. 1267-1275
    • Furst, S.M.1    Uetrecht, J.P.2
  • 6
    • 0032912536 scopus 로고    scopus 로고
    • Detection of 2-hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate
    • Ju C, Uetrecht JP. Detection of 2-Hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate. J Pharmacol Exp Ther 1999;288:51-6. (Pubitemid 29113472)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.288 , Issue.1 , pp. 51-56
    • Ju, C.1    Uetrecht, J.P.2    Van Koppen, C.J.3
  • 8
    • 0026724265 scopus 로고
    • Autoinduction and steady-state pharmacokinetics of carbamazepine and its major metabolites
    • Kudriakova TB, Sirota LA, Rozova GI, Gorkov VA. Autoinduction and steady-state pharmacokinetics of carbamazepine and its major metabolites. Br J Clin Pharmacol 1992; 33:611-5.
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 611-615
    • Kudriakova, T.B.1    Sirota, L.A.2    Rozova, G.I.3    Gorkov, V.A.4
  • 9
    • 78549242650 scopus 로고    scopus 로고
    • Antiepileptic drug interactions -principles and clinical implications
    • Johannessen S, Johanessen C. Antiepileptic drug interactions -Principles and clinical implications. Current Neuropharmacol 2010;8:254-7.
    • (2010) Current Neuropharmacol , vol.8 , pp. 254-257
    • Johannessen, S.1    Johanessen, C.2
  • 10
    • 0025055648 scopus 로고
    • Enzyme induction in the cytochrome P-450 system
    • DOI 10.1016/0163-7258(90)90030-6
    • Okey AB. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 1990;45:241-98. (Pubitemid 20008908)
    • (1990) Pharmacology and Therapeutics , vol.45 , Issue.2 , pp. 241-298
    • Okey, A.B.1
  • 11
    • 0029057901 scopus 로고
    • Antiepileptic drug mechanisms of action
    • Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia 1995;36(Suppl):S2-12.
    • (1995) Epilepsia , vol.36 , Issue.SUPPL.
    • Macdonald, R.L.1    Kelly, K.M.2
  • 12
    • 84883193885 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for hla-b genotype and carbamazepine dosing
    • May 21. doi: 10.1038/clpt.2013.103 [Epub ahead of print]
    • Leckband SG, Kelsoe JR, Dunnenberger HM, George AL, Tran E, Berger R, et al. Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther 2013;May 21. doi: 10.1038/clpt.2013.103 [Epub ahead of print].
    • (2013) Clin Pharmacol Ther
    • Leckband, S.G.1    Kelsoe, J.R.2    Dunnenberger, H.M.3    George, A.L.4    Tran, E.5    Berger, R.6
  • 13
    • 84875978896 scopus 로고    scopus 로고
    • Effect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals
    • Shastry CS, Shafeeque AA, Ashwathnarayana BJ. Effect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals. Indian J Pharmacol 2013;45:121-5.
    • (2013) Indian J Pharmacol , vol.45 , pp. 121-125
    • Shastry, C.S.1    Shafeeque, A.A.2    Ashwathnarayana, B.J.3
  • 14
    • 84863096504 scopus 로고    scopus 로고
    • Adverse drug reactions
    • Ferner RE, Butt TF. Adverse drug reactions. Medicine 2012;40:366-70.
    • (2012) Medicine , vol.40 , pp. 366-370
    • Ferner, R.E.1    Butt, T.F.2
  • 17
    • 84895433853 scopus 로고    scopus 로고
    • Factors affecting the development of adverse drug reactions
    • [article in press].
    • Jamal MA. Factors affecting the development of adverse drug reactions. Saudi Pharmaceutical J 2013;[article in press]. http://dx.doi.org/10.1016/j. jsps.2013.02.003.
    • (2013) Saudi Pharmaceutical J
    • Jamal, M.A.1
  • 18
    • 0021160565 scopus 로고
    • A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients
    • Perucca E, Hedges A, Makki KA, Ruprah M, Wilson JF, Richens A. A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol 1984;18:401-10. (Pubitemid 14033827)
    • (1984) British Journal of Clinical Pharmacology , vol.18 , Issue.3 , pp. 401-410
    • Perucca, E.1    Hedges, A.2    Makki, K.A.3
  • 19
    • 49949090275 scopus 로고    scopus 로고
    • The role of ethnicity in variability in response to drugs: Focus on clinical pharmacology studies
    • Yasuda SU, Zhang L, Huang SM. The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies. Clin Pharmacol Ther 2008;84:417-23.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 417-423
    • Yasuda, S.U.1    Zhang, L.2    Huang, S.M.3
  • 21
    • 84863769832 scopus 로고    scopus 로고
    • Genetic polymorphisms affecting drug metabolism: Recent advances and clinical aspects
    • Daly AK. Genetic polymorphisms affecting drug metabolism: recent advances and clinical aspects. Adv Pharmacol 2012;63:137-67.
    • (2012) Adv Pharmacol , vol.63 , pp. 137-167
    • Daly, A.K.1
  • 22
    • 84862868517 scopus 로고    scopus 로고
    • Exanthematous drug eruptions
    • Stern R. Exanthematous drug eruptions. N Engl J Med 2012;366:2492-501.
    • (2012) N Engl J Med , vol.366 , pp. 2492-2501
    • Stern, R.1
  • 23
    • 77949600882 scopus 로고    scopus 로고
    • Common risk allele in aromatic antiepileptic-drug induced stevens-johnson syndrome and toxic epidermal necrolysis in han chinese
    • Hung SI, Chung WH, Liu ZS, Chen CH, Hsih MS, Hui RC, et al. Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics 2010;11:349-56.
    • (2010) Pharmacogenomics , vol.11 , pp. 349-356
    • Hung, S.I.1    Chung, W.H.2    Liu, Z.S.3    Chen, C.H.4    Hsih, M.S.5    Hui, R.C.6
  • 24
    • 84869494804 scopus 로고    scopus 로고
    • Hla genotype and carbamazepine-induced cutaneous adverse drug reactions: A systematic review
    • Yip VL, Marson AG, Jorgensen AL, Pirmohamed M, Alfirevic A. HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. Clin Pharmacol Ther 2012;92:757-65.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 757-765
    • Yip, V.L.1    Marson, A.G.2    Jorgensen, A.L.3    Pirmohamed, M.4    Alfirevic, A.5
  • 25
    • 34248589506 scopus 로고    scopus 로고
    • Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    • DOI 10.1111/j.1528-1167.2007.01022.x
    • Man C, Kwan P, Baum L, Yu E, Lau KM, Cheng A, et al. Association between HLA-B 1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 2007;48:1015-8. (Pubitemid 46763406)
    • (2007) Epilepsia , vol.48 , Issue.5 , pp. 1015-1018
    • Man, C.B.L.1    Kwan, P.2    Baum, L.3    Yu, E.4    Lau, K.M.5    Cheng, A.S.H.6    Ng, M.H.L.7
  • 26
    • 79952010199 scopus 로고    scopus 로고
    • Pharmacogenetics of cutaneous adverse drug reactions
    • Ahijara M. Pharmacogenetics of cutaneous adverse drug reactions. J Dermatol 2011;38:246-54.
    • (2011) J Dermatol , vol.38 , pp. 246-254
    • Ahijara, M.1
  • 28
    • 84904153343 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. FDA Safety Alerts for Human Medical Products. Accessed December 2 2013
    • U.S. Food and Drug Administration. FDA Safety Alerts for Human Medical Products. http://www.fda.gov/Safety/MedWatch/SafetyInformation/ SafetyAlertsforHumanMedicalProducts/ucm150841.htm. Accessed December 2, 2013.
  • 30
    • 57449118501 scopus 로고    scopus 로고
    • Carbamazepine and phenytoin induced stevens-johnson syndrome is associated with hla-b 1502 allele in thai population
    • Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, et al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B 1502 allele in Thai population. Epilepsia 2008;49:2087-91.
    • (2008) Epilepsia , vol.49 , pp. 2087-2091
    • Locharernkul, C.1    Loplumlert, J.2    Limotai, C.3    Korkij, W.4    Desudchit, T.5    Tongkobpetch, S.6
  • 31
    • 78650007285 scopus 로고    scopus 로고
    • Hla-b 1511 is a risk factor for carbamazepine-induced stevens johnson syndrome and toxic epidermal necrolysis in japanese patients
    • Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, et al. HLA-B 1511 is a risk factor for carbamazepine-induced Stevens Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia 2010;51:2461-65.
    • (2010) Epilepsia , vol.51 , pp. 2461-2465
    • Kaniwa, N.1    Saito, Y.2    Aihara, M.3    Matsunaga, K.4    Tohkin, M.5    Kurose, K.6
  • 33
    • 81055156142 scopus 로고    scopus 로고
    • Carbamazepine-induced severe cutaneous adverse reactions and hla genotypes in koreans
    • Kim SH, Lee KW, Song WJ, Kim SH, Jee YK, Lee SM, et al. Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans. Epilepsy Res 2011;97:190-7.
    • (2011) Epilepsy Res , vol.97 , pp. 190-197
    • Kim, S.H.1    Lee, K.W.2    Song, W.J.3    Kim, S.H.4    Jee, Y.K.5    Lee, S.M.6
  • 34
    • 79551600984 scopus 로고    scopus 로고
    • Genome-wide association study identifies hla-A 3101 allele as a genetic risk factor for carbamazepineinduced cutaneous adverse drug reactions in japanese population
    • Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, et al. Genome-wide association study identifies HLA-A 3101 allele as a genetic risk factor for carbamazepineinduced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet 2011;20:1034-41.
    • (2011) Hum Mol Genet , vol.20 , pp. 1034-1041
    • Ozeki, T.1    Mushiroda, T.2    Yowang, A.3    Takahashi, A.4    Kubo, M.5    Shirakata, Y.6
  • 35
    • 84883309307 scopus 로고    scopus 로고
    • Predictive markers for carbamazepine and lamotrigine-induced maculopapular exantherma in han chinese
    • S0920-1211(13)00144-7. doi: 10.1016/j.eplepsyres.2013.05.004. [ Epub ahead of print]
    • Li LJ, Hu FY, Wu XT, An DM, Yan B, Zhoy D. Predictive markers for carbamazepine and lamotrigine-induced maculopapular exantherma in Han Chinese. Epilepsy Res 2013; pii: S0920-1211(13)00144-7. doi: 10.1016/j.eplepsyres.2013. 05.004. [Epub ahead of print].
    • (2013) Epilepsy Res
    • Li, L.J.1    Hu, F.Y.2    Wu, X.T.3    An, D.M.4    Yan, B.5    Zhoy, D.6
  • 36
    • 0035836342 scopus 로고    scopus 로고
    • TNF promoter region gene polymorphisms in carbamazepine-hypersensitive patients
    • Pirmohamed M, Lin K, Chadwick D, Park BK. TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients. Neurology 2001;56:890-6. (Pubitemid 32290806)
    • (2001) Neurology , vol.56 , Issue.7 , pp. 890-896
    • Pirmohamed, M.1    Lin, K.2    Chadwick, D.3    Park, B.K.4
  • 37
  • 39
    • 84871405336 scopus 로고    scopus 로고
    • Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy
    • Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, et al. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy. Pharmacogenomics 2013;14:35-45.
    • (2013) Pharmacogenomics , vol.14 , pp. 35-45
    • Puranik, Y.G.1    Birnbaum, A.K.2    Marino, S.E.3    Ahmed, G.4    Cloyd, J.C.5    Remmel, R.P.6
  • 40
    • 70049099656 scopus 로고    scopus 로고
    • Effect of cyp3a5 3 genotype on serum carbamazepine concentrations at steady-state in korean epileptic patients
    • Park PW, Seo YH, Ahn JY, Kim KA, Park JY. Effect of CYP3A5 3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients. J Clin Pharm Ther 2009;34:569-74.
    • (2009) J Clin Pharm Ther , vol.34 , pp. 569-574
    • Park, P.W.1    Seo, Y.H.2    Ahn, J.Y.3    Kim, K.A.4    Park, J.Y.5
  • 41
    • 33646194393 scopus 로고    scopus 로고
    • Effect of cyp3a5 3 on carbamazepine pharmacokinetics in japanese patients with epilepsy
    • Seo T, Nakada N, Ueda N, Hagiwara T, Hashimoto N, Nakagawa K, et al. Effect of CYP3A5 3 on carbamazepine pharmacokinetics in Japanese patients with epilepsy. Clin Pharmacol Ther 2006;79:509-10.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 509-510
    • Seo, T.1    Nakada, N.2    Ueda, N.3    Hagiwara, T.4    Hashimoto, N.5    Nakagawa, K.6
  • 42
    • 84862908341 scopus 로고    scopus 로고
    • Association of polymorphisms in ephx1, ugt2b7, abcb1, abcc2, scn1a and scn2a genes with carbamazepine therapy optimization
    • Hung CC, Chang WL, Ho JL, Tai JJ, Hsieh TJ, Huang HC, et al. Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization. Pharmacogenomics 2012;13:159-69.
    • (2012) Pharmacogenomics , vol.13 , pp. 159-169
    • Hung, C.C.1    Chang, W.L.2    Ho, J.L.3    Tai, J.J.4    Hsieh, T.J.5    Huang, H.C.6
  • 44
    • 77950288089 scopus 로고    scopus 로고
    • Ugt2b7-161c >t polymorphism is associated with lamotrigine concentration-to-dose ratio in a multivariate study
    • Sánchez MB, Herranz JL, Leno C, Arteaga R, Oterino A, Valdizán EM, et al. UGT2B7-161C >T polymorphism is associated with lamotrigine concentration-to-dose ratio in a multivariate study. Ther Drug Monit 2010;32:177-84.
    • (2010) Ther Drug Monit , vol.32 , pp. 177-184
    • Sánchez, M.B.1    Herranz, J.L.2    Leno, C.3    Arteaga, R.4    Oterino, A.5    Valdizán, E.M.6
  • 46
    • 84860846928 scopus 로고    scopus 로고
    • The association of c3435t single-nucleotide polymorphism, pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy
    • Sterjev Z, Trencevska GK, Cvetkovska E, Petrov I, Kuzmanovski I, Ribarska JT, et al. The association of C3435T single-nucleotide polymorphism, Pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy. Neuropsychiatr Dis Treat 2012;8:191-6.
    • (2012) Neuropsychiatr Dis Treat , vol.8 , pp. 191-196
    • Sterjev, Z.1    Trencevska, G.K.2    Cvetkovska, E.3    Petrov, I.4    Kuzmanovski, I.5    Ribarska, J.T.6
  • 47
    • 76349096470 scopus 로고    scopus 로고
    • Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy
    • Sánchez MB, Herranz JL, Leno C, Arteaga R, Oterino A, Valdizán EM, et al. Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy. Seizure 2010;19:93-101.
    • (2010) Seizure , vol.19 , pp. 93-101
    • Sánchez, M.B.1    Herranz, J.L.2    Leno, C.3    Arteaga, R.4    Oterino, A.5    Valdizán, E.M.6
  • 48
    • 85027944328 scopus 로고    scopus 로고
    • A nonsynonymous variation in mrp2/abcc2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy
    • Kim WJ, Lee JH, Yi J, Cho YJ, Heo K, Lee SH, et al. A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. Pharmacogenet Genomics 2010;20: 249-56.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 249-256
    • Kim, W.J.1    Lee, J.H.2    Yi, J.3    Cho, Y.J.4    Heo, K.5    Lee, S.H.6
  • 49
    • 63849243164 scopus 로고    scopus 로고
    • Polymorphism of the mdr1/abcb1 c3435t drug-transporter and resistance to anticonvulsant drugs: A meta-Analysis
    • Bournissen FG, Moretti ME, Juurlink DN, Koren G, Walker M, Finkelstein Y. Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-Analysis. Epilepsia 2009;50:898-903.
    • (2009) Epilepsia , vol.50 , pp. 898-903
    • Bournissen, F.G.1    Moretti, M.E.2    Juurlink, D.N.3    Koren, G.4    Walker, M.5    Finkelstein, Y.6
  • 53
    • 80052772274 scopus 로고    scopus 로고
    • Impact of abcc2 genotype on antiepileptic drug response in caucasian patients with childhood epilepsy
    • Ufer M, von Stülpnagel C, Muhle H, Haenisch S, Remmler C, Majed A, et al. Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy. Pharmacogenet Genomics 2011;21:624-30.
    • (2011) Pharmacogenet Genomics , vol.21 , pp. 624-630
    • Ufer, M.1    Von Stülpnagel, C.2    Muhle, H.3    Haenisch, S.4    Remmler, C.5    Majed, A.6
  • 54
    • 84863533379 scopus 로고    scopus 로고
    • Effects of scn1a and gaba receptor genetic polymorphisms on carbamazepine tolerability and efficacy in chinese patients with partial seizures: 2-year longitudinal clinical follow-up
    • Zhou BT, Zhou QH, Yin JY, Li GL, Qu J, Xu XJ, et al. Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up. CNS Neurosci Ther 2012;18:566-72.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 566-572
    • Zhou, B.T.1    Zhou, Q.H.2    Yin, J.Y.3    Li, G.L.4    Qu, J.5    Xu, X.J.6
  • 57
    • 84877784267 scopus 로고    scopus 로고
    • Scn1aivs5-91g > a polymorphism is associated with susceptibility to epilepsy but not with drug responsiveness
    • Kumari R, Lakhan R, Kumar S, Garg RK, Misra UK, Kalita J, et al. SCN1AIVS5-91G > A polymorphism is associated with susceptibility to epilepsy but not with drug responsiveness. Biochimie 2013;95:1350-3.
    • (2013) Biochimie , vol.95 , pp. 1350-1353
    • Kumari, R.1    Lakhan, R.2    Kumar, S.3    Garg, R.K.4    Misra, U.K.5    Kalita, J.6
  • 58
    • 56149108008 scopus 로고    scopus 로고
    • Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes scn1a, scn2a, and scn3a: Correlation among phenotype, genotype, and mrna expression
    • Kwan P, Poon WS, Ng HK, Kang DE, Wong V, Ng PW, et al. Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression. Pharmacogenet Genomics 2008;18:989-98.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 989-998
    • Kwan, P.1    Poon, W.S.2    Ng, H.K.3    Kang, D.E.4    Wong, V.5    Ng, P.W.6
  • 59
    • 77950594101 scopus 로고    scopus 로고
    • Association of alpha subunit of gabaa receptor subtype gene polymorphisms with epilepsy susceptibility and drug resistance in north indian population
    • Kumari R, Lakhan R, Kalita J, Misra UK, Mittal B. Association of alpha subunit of GABAA receptor subtype gene polymorphisms with epilepsy susceptibility and drug resistance in north Indian population. Seizure 2010;19:237-41.
    • (2010) Seizure , vol.19 , pp. 237-241
    • Kumari, R.1    Lakhan, R.2    Kalita, J.3    Misra, U.K.4    Mittal, B.5
  • 60
    • 79955464225 scopus 로고    scopus 로고
    • Potential role of gabaa receptor subunit
    • GABRA6 GABRB2 And GABRR2 Gene Polymorphisms In Epilepsy Susceptibility And Pharmacotherapy In North Indian Population
    • Kumari R, Lakhan R, Kalita J, Garg RK, Misra UK, Mittal B. Potential role of GABAA receptor subunit; GABRA6, GABRB2 and GABRR2 gene polymorphisms in epilepsy susceptibility and pharmacotherapy in North Indian population. Clin Chim Acta 2011;412:1244-8.
    • (2011) Clin Chim Acta , vol.412 , pp. 1244-1248
    • Kumari, R.1    Lakhan, R.2    Kalita, J.3    Garg, R.K.4    Misra, U.K.5    Mittal, B.6
  • 62
    • 61649088626 scopus 로고    scopus 로고
    • Functional characterization of cyp3a4.16: Catalytic activities toward midazolam and carbamazepine
    • Maekawa K, Yoshimura T, Saito Y, Fujimura Y, Aohara F, Emoto C, et al. Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine. Xenobiotica 2009;39:140-7.
    • (2009) Xenobiotica , vol.39 , pp. 140-147
    • Maekawa, K.1    Yoshimura, T.2    Saito, Y.3    Fujimura, Y.4    Aohara, F.5    Emoto, C.6
  • 63
    • 78649602813 scopus 로고    scopus 로고
    • Cyp3a4 16 and cyp3a4 18 alleles found in east asians exhibit differential catalytic activities for seven cyp3a4 substrate drugs
    • Maekawa K, Harakawa N, Yoshimura T, Kim SR, Fujimura Y, Aohara F, et al. CYP3A4 16 and CYP3A4 18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs. Drug Metab Dispos 2010;38:2100-4.
    • (2010) Drug Metab Dispos , vol.38 , pp. 2100-2104
    • Maekawa, K.1    Harakawa, N.2    Yoshimura, T.3    Kim, S.R.4    Fujimura, Y.5    Aohara, F.6
  • 67
    • 0030968046 scopus 로고    scopus 로고
    • Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry
    • Maggs JL, Pirmohamed M, Kitteringham NR, Park BK. Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography mass spectrometry. Drug Metab Dispos 1997;25:275-80. (Pubitemid 27120571)
    • (1997) Drug Metabolism and Disposition , vol.25 , Issue.3 , pp. 275-280
    • Maggs, J.L.1    Pirmohamed, M.2    Kitteringham, N.R.3    Park, B.K.4
  • 68
    • 0033645752 scopus 로고    scopus 로고
    • Genetic polymorphism of udp-glucuronosyltransferase 2b7 (ugt2b7) at amino acid 268: Ethnic diversity of alleles and potential clinical significance
    • Nov
    • Bhasker CR, McKinnon W, Stone A, Lo AC, Kubota T, Ishizaki T, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics 2000 Nov;10:679.
    • (2000) Pharmacogenetics , vol.10 , pp. 679
    • Bhasker, C.R.1    McKinnon, W.2    Stone, A.3    Lo, A.C.4    Kubota, T.5    Ishizaki, T.6
  • 69
    • 55749107288 scopus 로고    scopus 로고
    • Single nucleotide polymorphism discovery and functional assessment of variation in the udp-glucuronosyltransferase 2b7 gene
    • Innocenti F, Liu W, Fackenthal D, Ramírez J, Chen P, Ye X, et al. Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene. Pharmacogenet Genomics 2008;18:683-97.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 683-697
    • Innocenti, F.1    Liu, W.2    Fackenthal, D.3    Ramírez, J.4    Chen, P.5    Ye, X.6
  • 70
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • DOI 10.1056/NEJM200002033420503
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-9. (Pubitemid 30075244)
    • (2000) New England Journal of Medicine , vol.342 , Issue.5 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 71
    • 79956347733 scopus 로고    scopus 로고
    • Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions
    • Lazarowski A, Czornyj L. Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions. Drug Metabol Drug Interact 2011;26:21-6.
    • (2011) Drug Metabol Drug Interact , vol.26 , pp. 21-26
    • Lazarowski, A.1    Czornyj, L.2
  • 72
    • 33847125762 scopus 로고    scopus 로고
    • Plasticity of antiepileptic drug targets
    • Beck H. Plasticity of antiepileptic drug targets. Epilepsia 2007;48(Suppl):S14-8.
    • (2007) Epilepsia , vol.48 , Issue.SUPPL.
    • Beck, H.1
  • 73
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • DOI 10.1038/nrn1728
    • Löscher W, Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 2005;6:591-602. (Pubitemid 41059334)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.8 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 74
    • 77955325040 scopus 로고    scopus 로고
    • Abcb1 c3435t polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-Analysis
    • Haerian BS, Roslan H, Raymond AA, Tan CT, Lim KS, Zulkifli SZ, et al. ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-Analysis. Seizure 2010;19:339-46.
    • (2010) Seizure , vol.19 , pp. 339-346
    • Haerian, B.S.1    Roslan, H.2    Raymond, A.A.3    Tan, C.T.4    Lim, K.S.5    Zulkifli, S.Z.6
  • 76
    • 0037665280 scopus 로고    scopus 로고
    • Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity
    • DOI 10.1124/jpet.103.049858
    • Potschka H, Fedrowitz M, Löscher W. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. J Pharmacol Exp Ther 2003;306:124-31. (Pubitemid 36734365)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.1 , pp. 124-131
    • Potschka, H.1    Fedrowitz, M.2    Loscher, W.3
  • 77
    • 84878151518 scopus 로고    scopus 로고
    • Linkage disequilibrium between polymorphisms of abcb1 and abcc2 to predict the treatment outcome of malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the kuala lumpur hospital
    • Subenthiran S, Abdullah NR, Joseph JP, Muniandy PK, Mok BT, Kee CC, et al. Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital. PLoS One 2013;8:e64827.
    • (2013) PLoS One , vol.8
    • Subenthiran, S.1    Abdullah, N.R.2    Joseph, J.P.3    Muniandy, P.K.4    Mok, B.T.5    Kee, C.C.6
  • 79
    • 0036224114 scopus 로고    scopus 로고
    • Effect of the mutation (C3435t) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
    • DOI 10.1067/mcp.2002.122055
    • Nakamura T, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Shirakawa T, et al. Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin Pharmacol Ther 2002;71:297-303. (Pubitemid 34311459)
    • (2002) Clinical Pharmacology and Therapeutics , vol.71 , Issue.4 , pp. 297-303
    • Nakamura, T.1    Sakaeda, T.2    Horinouchi, M.3    Tamura, T.4    Aoyama, N.5    Shirakawa, T.6    Matsuo, M.7    Kasuga, M.8    Okumura, K.9
  • 80
    • 37249003692 scopus 로고    scopus 로고
    • Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey
    • DOI 10.1159/000109264
    • Ozgon GO, Bebek N, Gul G, Cine N. Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey. Eur Neurol 2008;59:67-70. (Pubitemid 350277263)
    • (2008) European Neurology , vol.59 , Issue.1-2 , pp. 67-70
    • Ozgon, G.O.1    Bebek, N.2    Gul, G.3    Cine, N.4
  • 81
    • 79955612469 scopus 로고    scopus 로고
    • Effects of abcb1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in chinese patients with epilepsy
    • Meng H, Guo G, Ren J, Zhou H, Ge Y, Guo Y. Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy. Epilepsy Behav 2011;21:27-30.
    • (2011) Epilepsy Behav , vol.21 , pp. 27-30
    • Meng, H.1    Guo, G.2    Ren, J.3    Zhou, H.4    Ge, Y.5    Guo, Y.6
  • 82
    • 67149124051 scopus 로고    scopus 로고
    • Non-response to antiepileptic pharmacotherapy is associated with the abcc2 -24c ?T polymorphism in young and adult patients with epilepsy
    • Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Häsler R, et al. Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C ?T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genomics 2009;19:353-62.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 353-362
    • Ufer, M.1    Mosyagin, I.2    Muhle, H.3    Jacobsen, T.4    Haenisch, S.5    Häsler, R.6
  • 83
    • 80455131313 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms in abcb1, cyp2b6, oprm1, ankk1 and drd2 genes on methadone therapy in han chinese patients
    • Hung CC, Chiou MH, Huang BH, Hsieh YW, Hsieh TJ, Huang CL, et al. Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients. Pharmacogenomics 2011;12:1525-33.
    • (2011) Pharmacogenomics , vol.12 , pp. 1525-1533
    • Hung, C.C.1    Chiou, M.H.2    Huang, B.H.3    Hsieh, Y.W.4    Hsieh, T.J.5    Huang, C.L.6
  • 84
    • 84874682875 scopus 로고    scopus 로고
    • Epilepsy pharmacogenetics: Science or fiction?
    • Depondt C. Epilepsy pharmacogenetics: science or fiction?. Med Sci 2013;29:189-93.
    • (2013) Med Sci , vol.29 , pp. 189-193
    • Depondt, C.1
  • 86
    • 77954896142 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of the newer anti-epilepsy medications
    • Jun
    • Krasowski MD. Therapeutic drug monitoring of the newer anti-epilepsy medications. Pharmaceuticals (Basel) 2010 Jun;3:1909-35.
    • (2010) Pharmaceuticals (Basel , vol.3 , pp. 1909-1935
    • Krasowski, M.D.1
  • 87
    • 35348848498 scopus 로고    scopus 로고
    • Association of polymorphisms in nr1i2 and abcb1 genes with epilepsy treatment responses
    • Hung CC, Jen Tai J, Kao PJ, Lin MS, Liou HH. Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses. Pharmacogenomics 2007;8:1151-8.
    • (2007) Pharmacogenomics , vol.8 , pp. 1151-1158
    • Hung, C.C.1    Jen Tai, J.2    Kao, P.J.3    Lin, M.S.4    Liou, H.H.5
  • 88
    • 79955691266 scopus 로고    scopus 로고
    • Lack of association of abcb1 and pxr polymorphisms with response to treatment in epilepsy
    • Haerian BS, Lim KS, Mohamed EH, Tan HJ, Tan CT, Raymond AA, et al. Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy. Seizure 2011;20:387-94.
    • (2011) Seizure , vol.20 , pp. 387-394
    • Haerian, B.S.1    Lim, K.S.2    Mohamed, E.H.3    Tan, H.J.4    Tan, C.T.5    Raymond, A.A.6
  • 89
    • 0033694833 scopus 로고    scopus 로고
    • From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
    • Catterall WA. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels. Neuron 2000;26:13-25.
    • (2000) Neuron , vol.26 , pp. 13-25
    • Catterall, W.A.1
  • 93
    • 3543030408 scopus 로고    scopus 로고
    • RNA editing generates tissue-specific sodium channels with distinct gating properties
    • DOI 10.1074/jbc.M402392200
    • Song W, Liu Z, Tan J, Nomura Y, Dong K. RNA editing generates tissue-specific sodium channels with distinct gating properties. J Biol Chem 2004;279:32554-61. (Pubitemid 39014711)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.31 , pp. 32554-32561
    • Song, W.1    Liu, Z.2    Tan, J.3    Nomura, Y.4    Dong, K.5
  • 94
    • 44849130765 scopus 로고    scopus 로고
    • A functional polymorphism in the SCN1A gene is not associated with carbamazepine dosages in Austrian patients with epilepsy
    • DOI 10.1111/j.1528-1167.2008.01549-4.x
    • Zimprich F, Stogmann E, Bonelli S, Baumgartner C, Mueller JC, Meitinger T, et al. A functional polymorphism in the SCN1A gene is not associated with carbamazepine dosages in Austrian patients with epilepsy. Epilepsia 2008;49: 1108-9. (Pubitemid 351794005)
    • (2008) Epilepsia , vol.49 , Issue.6 , pp. 1108-1109
    • Zimprich, F.1    Stogmann, E.2    Bonelli, S.3    Baumgartner, C.4    Mueller, J.C.5    Meitinger, T.6    Zimprich, A.7    Strom, T.M.8
  • 95
    • 79955918406 scopus 로고    scopus 로고
    • A functional polymorphism in the scn1a gene does not influence antiepileptic drug responsiveness in italian patients with focal epilepsy
    • Manna I, Gambardella A, Bianchi A, Striano P, Tozzi R, Aguglia U, et al. A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy. Epilepsia 2011;52:40-4.
    • (2011) Epilepsia , vol.52 , pp. 40-44
    • Manna, I.1    Gambardella, A.2    Bianchi, A.3    Striano, P.4    Tozzi, R.5    Aguglia, U.6
  • 96
    • 33645216053 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in the scn2a gene is associated with uncontrolled epilepsy
    • Sills G, Mohanraj R, Butler E. A single-nucleotide polymorphism in the SCN2A gene is associated with uncontrolled epilepsy. Epilepsia 2004;45:(Suppl):S226.
    • (2004) Epilepsia , vol.45 , Issue.SUPPL.
    • Sills, G.1    Mohanraj, R.2    Butler, E.3
  • 97
    • 68449100608 scopus 로고    scopus 로고
    • Differential role of sodium channels scn1a and scn2a gene polymorphisms with epilepsy and multiple drug resistance in the north indian population
    • Lakhan R, Kumari R, Misra UK, Kalita J, Pradhan S, Mittal B. Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Br J Clin Pharmacol 2009;68: 214-20.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 214-220
    • Lakhan, R.1    Kumari, R.2    Misra, U.K.3    Kalita, J.4    Pradhan, S.5    Mittal, B.6
  • 98
    • 77954091119 scopus 로고    scopus 로고
    • Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents
    • Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, et al. Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 2010;30:8489-501.
    • (2010) J Neurosci , vol.30 , pp. 8489-8501
    • Uebachs, M.1    Opitz, T.2    Royeck, M.3    Dickhof, G.4    Horstmann, M.T.5    Isom, L.L.6


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