Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey

European Neurology

Volumn 59, Issue 1-2, 2007, Pages 67-70

  Ozgon, Gulay Oner ^a   Bebek, Nerses ^a,b   Gul, Gunay ^c   Cine, Naci ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Bakirkoy Hospital for Psychiatric and Neurological Diseases   (Turkey)

Author keywords

Carbamazepine; Drug resistance; Epilepsy; MDR1; Polymorphism

Indexed keywords

CARBAMAZEPINE; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; ALLELE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG RESISTANCE; DRUG RESPONSE; EPILEPSY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MUTANT; PREVALENCE; PRIORITY JOURNAL; PROTEIN VARIANT; TURKEY (REPUBLIC);

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DRUG RESISTANCE; EPILEPSY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; TURKEY;

EID: 37249003692     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000109264     Document Type: Article

References (15)

1. Kwan P, Brodie MJ: Refractory epilepsy: mechanisms and solutions. Expert Rev Neurother 2006;6:397-406.
2. Genton P: The definition of drug resistance: an epileptologist's perspective. Rev Neurol (Paris) 2004;160:3-9.
3. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V: Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 1985;6031:817-819.
4. Borst P, Schinkel AH: What have we learnt thus far from mice with disrupted P-glycoprotein genes? Eur J Cancer 1996;32:985-990.
5. Fromm MF: P-glycoprotein. A defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther 2000;38:69-74.
6. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkman U: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000;97:3473-3478.
7. Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM: Multidrug resistance in epilepsy is associated with polymorphism in ABCB1. N Engl J Med 2003;348:1442-1448.
8. Sills GJ, Mohanraj R, Butler E, McCrindle S, Colier L, Wilson EA, Brodie MJ: Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 2005;46:643-647.
9. Tan NCK, Heron SE, Scheffer IE, Pelekanos JT, McMahon JM, Vears DF, Mulley JC, Berkovic SF: Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Neurology 2004;63:1090-1092.
10. Zimprich F, Sunder-Plassman R, Stogmann E, Gleiss A, Dal-Bianco A, Zimprich A, Plumer S, Baumgartner C, Mannhalter C: Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology 2004;63:1087-1089.
11. Kim DW, Kim M, Lee SK, Kang R, Lee SY: Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy. Seizure 2006;15:344-347.
12. Evans WE, Oellerich M: Therapeutic Drug Monitoring Clinical Guide. Abbott Park, US Abbott Laboratories, 1984, pp 19-88.
13. Kerb R, Aynacioglu AS, Brockmoller J, Schlagenhaufer R, Bauer S, Szekeres T, Hamwi A, Fritzer-Szekeres M, Baumgartner C, Öngen HZ, Güzelbey P, Roots I, Brinkmann U: The predictive value of MDR1, CYP2C9 and CYP2C19 polymorphisms for phenytoin plasma levels. Pharmacogenomics J 2001;1:204-210.
14. Ameway MM, Regateiro F, Li T, Liu X, Tariq M, Mobarek A, Thornton N, Folayan OG, Githang J, Indalo A, Adjei D, Evans D, McLeod H: MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics 2001;11:217-221.
15. Seo T, Ishitsu T, Ueda N, Nakada N, Yurube K, Ueda K, Nakagawa K: ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients. Pharmacogenomics 2006;7:551-561.