TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients

Neurology

Volumn 56, Issue 7, 2001, Pages 890-896

  Pirmohamed, Munir ^a   Lin, Ke ^a   Chadwick, David ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; HLA DQ ANTIGEN; HLA DR3 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DRUG HYPERSENSITIVITY; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; ALLELE; GENETICS; MIDDLE AGED; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CARBAMAZEPINE; CHILD; CHILD, PRESCHOOL; DRUG HYPERSENSITIVITY; GENOTYPE; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MIDDLE AGED; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035836342     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.56.7.890     Document Type: Article

References (41)

1. Carbamazepine: Clinical use
2. Carbamazepine side effects in children and adults
3. Drugs 5 years later: Carbamazepine
4. Anticonvulsant hypersensitivity syndrome: In vitro risk assessment
5. Carbamazepine (Tegretol) and toxic epidermal necrolysis: Report of three cases with histopathologic observations
6. Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine
7. Familial occurrence of hypersensitivity to phenytoin
8. Concordance of primary generalised epilepsy and carbamazepine hypersensitivity in monozygotic twins
9. Metabolism of carbamazepine
10. Bioactivation of carbamazepine in the rat in vivo - Evidence for the formation of reactive arene oxide(s)
11. Protein-reactive metabolites of carbamazepine in mouse liver microsomes
12. The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes
13. Predisposition to phenytoin hepatotoxicity assessed in vitro
14. Carbamazepine hypersensitivity: Assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine
15. Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions
16. Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity
17. Detection of an autoantibody directed against a human liver microsomal protein in a patient with carbamazepine hypersensitivity
18. Human anticytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions
19. Activation of drug-specific CD4(+) and CD8(+) T-cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine
20. In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10-11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity
21. An allelic polymorphism within the human tumor-necrosis-factor-alpha promoter region is strongly associated with HLA-A1, HLA-B8, and HLA-DR3 alleles
22. Complete sequence and gene map of a human major histocompatibility complex
23. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria
24. Polymorphism in tumor-necrosis-factor genes associated with mucocutaneous leishmaniasis
25. TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype
26. Carbamazepine hypersensitivity and the use of lymphocyte proliferation responses
27. Novel genetic association between ulcerative-colitis and the antiinflammatory cytokine interleukin-1 receptor antagonist
28. Association of a tumour necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis
29. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours - An alternative to serological DR typing in clinical-practice including donor-recipient matching in cadaveric transplantation
30. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours
31. A genetic association between systemic lupus-erythematosus and tumornecrosis-factor-alpha
32. A polymorphic variation in a putative regulation box of the TNFA promoter region
33. Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection
34. What's wrong with Bonferroni adjustments?
35. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
36. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation
37. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: Relevance to genetic predisposition to systemic lupus erythematosus
38. Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis
39. Soluble fractions of tumor necrosis factor-alpha, interleukin-6 and of their receptors in toxic epidermal necrolysis: A comparison with second-degree burns
40. The biology of cachectin/TNF - A primary mediator of the host response
41. Tumor necrosis factor