Predisposition to epilepsy - Does the ABCB1 gene play a role?

Epilepsia

Volumn 51, Issue 9, 2010, Pages 1882-1885

  Nurmohamed, Laila ^a   Garcia Bournissen, Facundo ^a   Buono, Russell J ^b,c   Shannon, Michael W ^d   Finkelstein, Yaron ^a,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

ABCB1 C3435T; Epilepsy; MDR1; Meta analysis; Polymorphism

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 1; ABCB1 PROTEIN, HUMAN; ANTICONVULSIVE AGENT; GENETIC MARKER; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CLINICAL TRIAL; DISEASE PREDISPOSITION; EPILEPSY; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; META ANALYSIS; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; ALLELE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MULTIDRUG RESISTANCE; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK;

ALLELES; ANTICONVULSANTS; DRUG RESISTANCE, MULTIPLE; EPILEPSY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; ODDS RATIO; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; P-GLYCOPROTEINS;

EID: 77956328599     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02588.x     Document Type: Article

References (12)

1. Bournissen FG, Moretti ME, Juurlink DN, Koren G, Walker M, Finkelstein Y 2009) Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia 50 : 898 903.
2. Buono RJ, Sperling MR, Dlugos DJ, Privitera MD, French JA, Lo W, Schachter S, Cossette P, Zhao H, Feng Z, Collins NJ, Scattergood T, Berrettini WH, Ferraro TN 2006) Association between ABCB1 gene variation and response to anti epileptic drugs and seizure susceptibility. Epilepsia 47 : 364 365.
3. Dericioglu N, Babaoglu MO, Yasar U, Bal IB, Bozkurt A, Saygi S 2008) Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene. Epilepsy Res 80 : 42 46.
4. Ebid AH, Ahmed MM, Mohammed SA 2007) Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study. Ther Drug Monit 29 : 305 312.
5. Hung CC, Tai JJ, Lin CJ, Lee MJ, Liou HH 2005) Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response. Pharmacogenomics 6 : 411 417.
6. Kim DW, Kim M, Lee SK, Kang R, Lee SY 2006) Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy. Seizure 15 : 344 347.
7. Kwan P, Baum L, Wong V, Ng PW, Lui CH, Sin NC, Hui AC, Yu E, Wong LK 2007) Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese. Epilepsy Behav 11 : 112 117.
8. Lakhan R, Misra UK, Kalita J, Pradhan S, Gogtay NJ, Singh MK, Mittal B 2009) No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population. Epilepsy Behav 14 : 78 82.
9. Ozgon GO, Bebek N, Gul G, Cine N 2008) Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey. Eur Neurol 59 : 67 70.
10. Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM 2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 348 : 1442 1448.
11. Sills GJ, Mohanraj R, Butler E, McCrindle S, Collier L, Wilson EA, Brodie MJ 2005) Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 46 : 643 647.
12. Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, Faltraco F, Remmler C, von SS, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I 2009) Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genomics 19 : 353 362.