Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: Correlation among phenotype, genotype, and mRNA expression

Pharmacogenetics and Genomics

Volumn 18, Issue 11, 2008, Pages 989-998

  Kwan, Patrick ^a,c   Poon, Wai Sang ^b   Ng, Ho Keung ^c   Kang, David E ^h   Wong, Virginia ^e   Ng, Ping Wing ^f   Lui, Colin H T ^g   Sin, Ngai Chuen ^d,i   Wong, Ka S ^a   Baum, Larry ^a  

^a Department of Medicine and Therapeutics

^b Division of Neurosurgery

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f United Christian Hospital

^g QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ HOSPITAL AUTHORITY   (Hong Kong)

Author keywords

Antiepileptic drug; Drug resistance; Epilepsy; Pharmacogenetic; Sodium channel

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; MESSENGER RNA; OXCARBAZEPINE; PHENYTOIN; RNA; SODIUM CHANNEL; TOPIRAMATE;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BLOOD; BLOOD SAMPLING; BRAIN; EPILEPSY; EXON; FEMALE; GENE; GENE EXPRESSION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCN1A GENE; SCN2A GENE; SCN3A GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

ANTICONVULSANTS; BASE SEQUENCE; COHORT STUDIES; DRUG RESISTANCE, MULTIPLE; EPILEPSY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRONS; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SODIUM CHANNELS;

EID: 56149108008     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283117d67     Document Type: Article

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