Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster

Pharmacogenetics and Genomics

Volumn 16, Issue 4, 2006, Pages 287-296

  Alfirevic, Ana ^a   Mills, Tracy ^b   Harrington, Pauline ^b   Pinel, Tracy ^b   Sherwood, James ^b   Jawaid, Ansar ^b   Smith, John C ^b   March, Ruth E ^b   Barratt, Bryan J ^b   Chadwick, David W ^a   Park, B Kevin ^a   Pirmohamed, Munir ^a,c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c University of Liverpool ^*  (United Kingdom)

Author keywords

Carbamazepine; Drug induced hypersensitivity; HSP70; Pharmacogenetics

Indexed keywords

CARBAMAZEPINE; HEAT SHOCK PROTEIN 70; MICROSATELLITE DNA;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG ERUPTION; DRUG FEVER; DRUG HYPERSENSITIVITY; EOSINOPHILIA; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEPATOSPLENOMEGALY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POPULATION STRUCTURE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CARBAMAZEPINE; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DRUG HYPERSENSITIVITY; HAPLOTYPES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; MULTIGENE FAMILY; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; VARIATION (GENETICS);

EID: 33645065133     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/01.fpc.0000189800.88596.7a     Document Type: Article

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