메뉴 건너뛰기




Volumn 34, Issue 3, 2014, Pages 307-322

Aldosterone blockade in chronic kidney disease

Author keywords

Aldosterone; Chronic kidney disease; Proteinuria; Spironolactone

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; CONNECTIVE TISSUE GROWTH FACTOR; CREATININE; CYCLOOXYGENASE 2; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; LOSARTAN; MINERALOCORTICOID RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SPIRONOLACTONE; TELMISARTAN; TRANSFORMING GROWTH FACTOR BETA1; ALDOSTERONE; MINERALOCORTICOID ANTAGONIST;

EID: 84903993734     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2014.04.006     Document Type: Review
Times cited : (22)

References (167)
  • 1
    • 0033745021 scopus 로고    scopus 로고
    • Aldosterone: a mediator of myocardial necrosis and renal arteriopathy
    • Rocha R., Stier C.T., Kifor I., et al. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 2000, 141:3871-3878.
    • (2000) Endocrinology , vol.141 , pp. 3871-3878
    • Rocha, R.1    Stier, C.T.2    Kifor, I.3
  • 3
    • 0042320418 scopus 로고    scopus 로고
    • Aldosterone in chronic kidney and cardiac disease
    • Hostetter T.H., Ibrahim H.N. Aldosterone in chronic kidney and cardiac disease. J Am Soc Nephrol 2003, 14:2395-2401.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2395-2401
    • Hostetter, T.H.1    Ibrahim, H.N.2
  • 4
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B., Zannad F., Remme W.J., et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999, 341:709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 5
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B., Remme W., Zannad F., et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003, 348:1309-1321.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 6
    • 84874656078 scopus 로고    scopus 로고
    • Clinical practice guideline for the evaluation and management of chronic kidney disease
    • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012
    • clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2012, 2:337-414. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012.
    • (2012) Kidney Int Suppl , vol.2 , pp. 337-414
  • 7
    • 84874644599 scopus 로고    scopus 로고
    • Clinical practice guideline for the evaluation and management of chronic kidney disease
    • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012
    • clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013, 3:1-150. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012.
    • (2013) Kidney Int Suppl , vol.3 , pp. 1-150
  • 8
    • 0030604561 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy
    • The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia)
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 1997, 349:1857-1863. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia).
    • (1997) Lancet , vol.349 , pp. 1857-1863
  • 9
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner B.M., Cooper M.E., de Zeeuw D., et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001, 345:861-869.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3
  • 10
    • 4344621497 scopus 로고    scopus 로고
    • Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
    • de Zeeuw D., Remuzzi G., Parving H.-H., et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation 2004, 110:921-927.
    • (2004) Circulation , vol.110 , pp. 921-927
    • de Zeeuw, D.1    Remuzzi, G.2    Parving, H.-H.3
  • 11
  • 13
    • 0027081410 scopus 로고
    • Mineralocorticoid excess, dietary sodium, and myocardial fibrosis
    • Brilla C.G., Weber K.T. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 1992, 120:893-901.
    • (1992) J Lab Clin Med , vol.120 , pp. 893-901
    • Brilla, C.G.1    Weber, K.T.2
  • 14
    • 0027227646 scopus 로고
    • Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism
    • Brilla C.G., Matsubara L.S., Weber K.T. Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J Mol Cell Cardiol 1993, 25:563-575.
    • (1993) J Mol Cell Cardiol , vol.25 , pp. 563-575
    • Brilla, C.G.1    Matsubara, L.S.2    Weber, K.T.3
  • 15
    • 0029810416 scopus 로고    scopus 로고
    • Role of aldosterone in the remnant kidney model in the rat
    • Greene E.L., Kren S., Hostetter T.H. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest 1996, 98:1063-1068.
    • (1996) J Clin Invest , vol.98 , pp. 1063-1068
    • Greene, E.L.1    Kren, S.2    Hostetter, T.H.3
  • 16
    • 0031600240 scopus 로고    scopus 로고
    • Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats
    • Rocha R., Chander P.N., Khanna K., Zuckerman A., Stier C.T. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 1998, 31:451-458.
    • (1998) Hypertension , vol.31 , pp. 451-458
    • Rocha, R.1    Chander, P.N.2    Khanna, K.3    Zuckerman, A.4    Stier, C.T.5
  • 17
    • 0036838616 scopus 로고    scopus 로고
    • Aldosterone induces a vascular inflammatory phenotype in the rat heart
    • Rocha R., Rudolph A.E., Frierdich G.E., et al. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol 2002, 283:H1802-H1810.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Rocha, R.1    Rudolph, A.E.2    Frierdich, G.E.3
  • 19
    • 67349208215 scopus 로고    scopus 로고
    • New aspects of rapid aldosterone signaling
    • Grossmann C., Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol 2009, 308:53-62.
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 53-62
    • Grossmann, C.1    Gekle, M.2
  • 20
    • 3042635831 scopus 로고    scopus 로고
    • Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status
    • Sato A., Saruta T. Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status. Hypertens Res 2004, 27:303-310.
    • (2004) Hypertens Res , vol.27 , pp. 303-310
    • Sato, A.1    Saruta, T.2
  • 21
    • 21244458789 scopus 로고    scopus 로고
    • Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation
    • Joffe H.V., Adler G.K. Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation. Heart Fail Rev 2005, 10:31-37.
    • (2005) Heart Fail Rev , vol.10 , pp. 31-37
    • Joffe, H.V.1    Adler, G.K.2
  • 22
    • 0032921738 scopus 로고    scopus 로고
    • Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats
    • Rocha R., Chander P.N., Zuckerman A., Stier C.T. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension 1999, 33:232-237.
    • (1999) Hypertension , vol.33 , pp. 232-237
    • Rocha, R.1    Chander, P.N.2    Zuckerman, A.3    Stier, C.T.4
  • 23
    • 35848952953 scopus 로고    scopus 로고
    • Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress
    • Nagase M., Matsui H., Shibata S., Gotoda T., Fujita T. Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 2007, 50:877-883.
    • (2007) Hypertension , vol.50 , pp. 877-883
    • Nagase, M.1    Matsui, H.2    Shibata, S.3    Gotoda, T.4    Fujita, T.5
  • 24
    • 3242737409 scopus 로고    scopus 로고
    • Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways
    • Mano A., Tatsumi T., Shiraishi J., et al. Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways. Circulation 2004, 110:317-323.
    • (2004) Circulation , vol.110 , pp. 317-323
    • Mano, A.1    Tatsumi, T.2    Shiraishi, J.3
  • 25
    • 22244431527 scopus 로고    scopus 로고
    • Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo
    • Burniston J.G., Saini A., Tan L.-B., Goldspink D.F. Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo. J Mol Cell Cardiol 2005, 39:395-399.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 395-399
    • Burniston, J.G.1    Saini, A.2    Tan, L.-B.3    Goldspink, D.F.4
  • 26
    • 33846210660 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
    • Pérez-Rojas J., Blanco J.A., Cruz C., et al. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 2007, 292:F131-F139.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Pérez-Rojas, J.1    Blanco, J.A.2    Cruz, C.3
  • 27
    • 39749157059 scopus 로고    scopus 로고
    • Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis
    • Iwazu Y., Muto S., Fujisawa G., et al. Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis. Hypertension 2008, 51:749-754.
    • (2008) Hypertension , vol.51 , pp. 749-754
    • Iwazu, Y.1    Muto, S.2    Fujisawa, G.3
  • 28
    • 0033849916 scopus 로고    scopus 로고
    • Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo
    • Brown N.J., Nakamura S., Ma L., et al. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int 2000, 58:1219-1227.
    • (2000) Kidney Int , vol.58 , pp. 1219-1227
    • Brown, N.J.1    Nakamura, S.2    Ma, L.3
  • 29
    • 12144286297 scopus 로고    scopus 로고
    • Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats
    • Nishiyama A., Yao L., Nagai Y., et al. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004, 43:841-848.
    • (2004) Hypertension , vol.43 , pp. 841-848
    • Nishiyama, A.1    Yao, L.2    Nagai, Y.3
  • 30
    • 33744981628 scopus 로고    scopus 로고
    • Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker
    • Nagase M., Shibata S., Yoshida S., Nagase T., Gotoda T., Fujita T. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006, 47:1084-1093.
    • (2006) Hypertension , vol.47 , pp. 1084-1093
    • Nagase, M.1    Shibata, S.2    Yoshida, S.3    Nagase, T.4    Gotoda, T.5    Fujita, T.6
  • 31
    • 20144365498 scopus 로고    scopus 로고
    • Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability
    • Nishiyama A., Yao L., Fan Y., et al. Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension 2005, 45:710-716.
    • (2005) Hypertension , vol.45 , pp. 710-716
    • Nishiyama, A.1    Yao, L.2    Fan, Y.3
  • 32
    • 33846443625 scopus 로고    scopus 로고
    • Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1
    • Shibata S., Nagase M., Yoshida S., Kawachi H., Fujita T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 2007, 49:355-364.
    • (2007) Hypertension , vol.49 , pp. 355-364
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3    Kawachi, H.4    Fujita, T.5
  • 33
    • 24744454626 scopus 로고    scopus 로고
    • Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria
    • Quinkler M., Zehnder D., Eardley K.S., et al. Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation 2005, 112:1435-1443.
    • (2005) Circulation , vol.112 , pp. 1435-1443
    • Quinkler, M.1    Zehnder, D.2    Eardley, K.S.3
  • 34
    • 33744954417 scopus 로고    scopus 로고
    • Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy
    • Takebayashi K., Matsumoto S., Aso Y., Inukai T. Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy. J Clin Endocrinol Metab 2006, 91:2214-2217.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2214-2217
    • Takebayashi, K.1    Matsumoto, S.2    Aso, Y.3    Inukai, T.4
  • 36
    • 71049170852 scopus 로고    scopus 로고
    • Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes
    • Nemeth Z., Kokeny G., Godo M., et al. Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes. Nephrol Dial Transplant 2009, 24:3640-3651.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3640-3651
    • Nemeth, Z.1    Kokeny, G.2    Godo, M.3
  • 37
    • 4644245230 scopus 로고    scopus 로고
    • Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats
    • Fujisawa G., Okada K., Muto S., et al. Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats. Kidney Int 2004, 66:1493-1502.
    • (2004) Kidney Int , vol.66 , pp. 1493-1502
    • Fujisawa, G.1    Okada, K.2    Muto, S.3
  • 38
    • 79961096910 scopus 로고    scopus 로고
    • Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production
    • Toyonaga J., Tsuruya K., Ikeda H., et al. Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production. Nephrol Dial Transplant 2011, 26:2475-2484.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 2475-2484
    • Toyonaga, J.1    Tsuruya, K.2    Ikeda, H.3
  • 39
    • 36349013809 scopus 로고    scopus 로고
    • Beneficial effects of spironolactone on glomerular injury in streptozotocin-induced diabetic rats
    • Yuan J., Jia R., Bao Y. Beneficial effects of spironolactone on glomerular injury in streptozotocin-induced diabetic rats. J Renin Angiotensin Aldosterone Syst 2007, 8:118-126.
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , pp. 118-126
    • Yuan, J.1    Jia, R.2    Bao, Y.3
  • 40
    • 84862986085 scopus 로고    scopus 로고
    • Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats
    • Banki N.F., Ver A., Wagner L.J., et al. Aldosterone antagonists in monotherapy are protective against streptozotocin-induced diabetic nephropathy in rats. PLoS One 2012, 7:e39938.
    • (2012) PLoS One , vol.7
    • Banki, N.F.1    Ver, A.2    Wagner, L.J.3
  • 41
    • 33646366660 scopus 로고    scopus 로고
    • Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
    • Han S.-Y., Kim C.-H., Kim H.-S., et al. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. J Am Soc Nephrol 2006, 17:1362-1372.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1362-1372
    • Han, S.-Y.1    Kim, C.-H.2    Kim, H.-S.3
  • 42
    • 33745683630 scopus 로고    scopus 로고
    • Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats
    • Han K.H., Kang Y.S., Han S.-Y., et al. Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney Int 2006, 70:111-120.
    • (2006) Kidney Int , vol.70 , pp. 111-120
    • Han, K.H.1    Kang, Y.S.2    Han, S.-Y.3
  • 43
    • 58049209809 scopus 로고    scopus 로고
    • Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats
    • Kang Y.S., Ko G.J., Lee M.H., et al. Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats. Nephrol Dial Transplant 2009, 24:73-84.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 73-84
    • Kang, Y.S.1    Ko, G.J.2    Lee, M.H.3
  • 44
    • 28544451946 scopus 로고    scopus 로고
    • Role of aldosterone in diabetic nephropathy
    • Cha D.R., Kang Y.S., Han S.Y., et al. Role of aldosterone in diabetic nephropathy. Nephrology 2005, 10(Suppl):S37-S39.
    • (2005) Nephrology , vol.10 , Issue.SUPPL
    • Cha, D.R.1    Kang, Y.S.2    Han, S.Y.3
  • 45
    • 84885103855 scopus 로고    scopus 로고
    • Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults
    • Cooper J.N., Fried L., Tepper P., et al. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults. Hypertens Res 2013, 36:895-901.
    • (2013) Hypertens Res , vol.36 , pp. 895-901
    • Cooper, J.N.1    Fried, L.2    Tepper, P.3
  • 46
    • 0346157984 scopus 로고    scopus 로고
    • Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration
    • de Paula R.B., da Silva A.A., Hall J.E. Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension 2004, 43:41-47.
    • (2004) Hypertension , vol.43 , pp. 41-47
    • de Paula, R.B.1    da Silva, A.A.2    Hall, J.E.3
  • 47
    • 33845238078 scopus 로고    scopus 로고
    • Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors
    • Nagase M., Yoshida S., Shibata S., et al. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 2006, 17:3438-3446.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3438-3446
    • Nagase, M.1    Yoshida, S.2    Shibata, S.3
  • 48
    • 20144369870 scopus 로고    scopus 로고
    • Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis
    • Asai M., Monkawa T., Marumo T., et al. Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis. Hypertens Res 2004, 27:971-978.
    • (2004) Hypertens Res , vol.27 , pp. 971-978
    • Asai, M.1    Monkawa, T.2    Marumo, T.3
  • 49
    • 41149157892 scopus 로고    scopus 로고
    • Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome
    • Nakhoul F., Khankin E., Yaccob A., et al. Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. Am J Physiol Renal Physiol 2008, 294:F628-F637.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Nakhoul, F.1    Khankin, E.2    Yaccob, A.3
  • 50
    • 84868662652 scopus 로고    scopus 로고
    • Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
    • McCurley A., Pires P.W., Bender S.B., et al. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med 2012, 18:1429-1433.
    • (2012) Nat Med , vol.18 , pp. 1429-1433
    • McCurley, A.1    Pires, P.W.2    Bender, S.B.3
  • 52
    • 84873371137 scopus 로고    scopus 로고
    • Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice
    • Voelkl J., Alesutan I., Leibrock C.B., et al. Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice. J Clin Invest 2013, 123:812-822.
    • (2013) J Clin Invest , vol.123 , pp. 812-822
    • Voelkl, J.1    Alesutan, I.2    Leibrock, C.B.3
  • 54
    • 0041318968 scopus 로고    scopus 로고
    • Nongenomic vascular action of aldosterone in the glomerular microcirculation
    • Arima S., Kohagura K., Xu H.-L., et al. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol 2003, 14:2255-2263.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2255-2263
    • Arima, S.1    Kohagura, K.2    Xu, H.-L.3
  • 55
    • 34548029979 scopus 로고    scopus 로고
    • New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone
    • Bobadilla N.A., Gamba G. New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone. Am J Physiol Renal Physiol 2007, 293:F2-F9.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Bobadilla, N.A.1    Gamba, G.2
  • 56
    • 6444245944 scopus 로고    scopus 로고
    • Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity
    • Feria I., Pichardo I., Juárez P., et al. Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity. Kidney Int 2003, 63:43-52.
    • (2003) Kidney Int , vol.63 , pp. 43-52
    • Feria, I.1    Pichardo, I.2    Juárez, P.3
  • 57
    • 26844546641 scopus 로고    scopus 로고
    • Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity
    • Pérez-Rojas J.M., Derive S., Blanco J.A., et al. Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 2005, 289:F1020-F1030.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Pérez-Rojas, J.M.1    Derive, S.2    Blanco, J.A.3
  • 60
  • 61
    • 84871765500 scopus 로고    scopus 로고
    • Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury
    • Barrera-Chimal J., Pérez-Villalva R., Rodríguez-Romo R., et al. Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury. Kidney Int 2013, 83:93-103.
    • (2013) Kidney Int , vol.83 , pp. 93-103
    • Barrera-Chimal, J.1    Pérez-Villalva, R.2    Rodríguez-Romo, R.3
  • 62
    • 0029986554 scopus 로고    scopus 로고
    • Salt restriction inhibits renal growth and stabilizes injury in rats with established renal disease
    • Dworkin L.D., Benstein J.A., Tolbert E., Feiner H.D. Salt restriction inhibits renal growth and stabilizes injury in rats with established renal disease. J Am Soc Nephrol 1996, 7:437-442.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 437-442
    • Dworkin, L.D.1    Benstein, J.A.2    Tolbert, E.3    Feiner, H.D.4
  • 63
    • 2442692854 scopus 로고    scopus 로고
    • Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet
    • Wang Q., Clement S., Gabbiani G., et al. Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet. Am J Physiol Renal Physiol 2004, 286:F1178-F1184.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Wang, Q.1    Clement, S.2    Gabbiani, G.3
  • 64
    • 0032497921 scopus 로고    scopus 로고
    • Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats
    • Yu H.C., Burrell L.M., Black M.J., et al. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 1998, 98:2621-2628.
    • (1998) Circulation , vol.98 , pp. 2621-2628
    • Yu, H.C.1    Burrell, L.M.2    Black, M.J.3
  • 65
    • 0033035240 scopus 로고    scopus 로고
    • High salt intake potentiates the renal vascular and glomerular damage caused by low doses of angiotensin II in uni-nephrectomized rats
    • Hirawa N., Uehara Y., Kawabata Y., et al. High salt intake potentiates the renal vascular and glomerular damage caused by low doses of angiotensin II in uni-nephrectomized rats. J Hypertens 1999, 17:923-932.
    • (1999) J Hypertens , vol.17 , pp. 923-932
    • Hirawa, N.1    Uehara, Y.2    Kawabata, Y.3
  • 66
    • 79958167599 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats
    • Kawarazaki H., Ando K., Fujita M., et al. Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats. Am J Physiol Renal Physiol 2011, 300:F1402-F1409.
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Kawarazaki, H.1    Ando, K.2    Fujita, M.3
  • 67
    • 4644300219 scopus 로고    scopus 로고
    • Sodium intake affects urinary albumin excretion especially in overweight subjects
    • Verhave J.C., Hillege H.L., Burgerhof J.G.M., et al. Sodium intake affects urinary albumin excretion especially in overweight subjects. J Intern Med 2004, 256:324-330.
    • (2004) J Intern Med , vol.256 , pp. 324-330
    • Verhave, J.C.1    Hillege, H.L.2    Burgerhof, J.G.M.3
  • 68
    • 33745282934 scopus 로고    scopus 로고
    • Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample
    • Fox C.S., Larson M.G., Hwang S.-J., et al. Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample. Kidney Int 2006, 69:2064-2069.
    • (2006) Kidney Int , vol.69 , pp. 2064-2069
    • Fox, C.S.1    Larson, M.G.2    Hwang, S.-J.3
  • 69
    • 0031885506 scopus 로고    scopus 로고
    • Salt intake and renal outcome in patients with progressive renal disease
    • Cianciaruso B., Bellizzi V., Minutolo R., et al. Salt intake and renal outcome in patients with progressive renal disease. Miner Electrolyte Metab 1998, 24:296-301.
    • (1998) Miner Electrolyte Metab , vol.24 , pp. 296-301
    • Cianciaruso, B.1    Bellizzi, V.2    Minutolo, R.3
  • 70
    • 38549083146 scopus 로고    scopus 로고
    • Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension
    • Pimenta E., Gaddam K.K., Pratt-Ubunama M.N., et al. Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension. Hypertension 2008, 51:339-344.
    • (2008) Hypertension , vol.51 , pp. 339-344
    • Pimenta, E.1    Gaddam, K.K.2    Pratt-Ubunama, M.N.3
  • 71
    • 79960972766 scopus 로고    scopus 로고
    • Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway
    • Shibata S., Mu S., Kawarazaki H., et al. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest 2011, 121:3233-3243.
    • (2011) J Clin Invest , vol.121 , pp. 3233-3243
    • Shibata, S.1    Mu, S.2    Kawarazaki, H.3
  • 72
    • 0037386904 scopus 로고    scopus 로고
    • Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat
    • Farjah M., Roxas B.P., Geenen D.L., Danziger R.S. Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension 2003, 41:874-878.
    • (2003) Hypertension , vol.41 , pp. 874-878
    • Farjah, M.1    Roxas, B.P.2    Geenen, D.L.3    Danziger, R.S.4
  • 73
    • 84873106278 scopus 로고    scopus 로고
    • Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease
    • Nagase M., Fujita T. Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease. Nat Rev Nephrol 2013, 9:86-98.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 86-98
    • Nagase, M.1    Fujita, T.2
  • 74
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
    • Shibata S., Nagase M., Yoshida S., et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 2008, 14:1370-1376.
    • (2008) Nat Med , vol.14 , pp. 1370-1376
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3
  • 75
    • 84861832781 scopus 로고    scopus 로고
    • Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation
    • Kawarazaki W., Nagase M., Yoshida S., et al. Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation. J Am Soc Nephrol 2012, 23:997-1007.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 997-1007
    • Kawarazaki, W.1    Nagase, M.2    Yoshida, S.3
  • 76
    • 0018084033 scopus 로고
    • Role of aldosterone in the control of sodium excretion in patients with advanced chronic renal failure
    • Berl T., Katz F.H., Henrich W.L., de Torrente A., Schrier RW. Role of aldosterone in the control of sodium excretion in patients with advanced chronic renal failure. Kidney Int 1978, 14:228-235.
    • (1978) Kidney Int , vol.14 , pp. 228-235
    • Berl, T.1    Katz, F.H.2    Henrich, W.L.3    de Torrente, A.4    Schrier, R.W.5
  • 77
    • 0020045293 scopus 로고
    • Plasma aldosterone concentrations in chronic renal disease
    • Hené R.J., Boer P., Koomans H.A., Mees E.J. Plasma aldosterone concentrations in chronic renal disease. Kidney Int 1982, 21:98-101.
    • (1982) Kidney Int , vol.21 , pp. 98-101
    • Hené, R.J.1    Boer, P.2    Koomans, H.A.3    Mees, E.J.4
  • 78
    • 0022982344 scopus 로고
    • Effect of enalapril in subjects with hypertension associated with moderate to severe renal dysfunction
    • Reams G.P., Bauer J.H. Effect of enalapril in subjects with hypertension associated with moderate to severe renal dysfunction. Arch Intern Med 1986, 146:2145-2148.
    • (1986) Arch Intern Med , vol.146 , pp. 2145-2148
    • Reams, G.P.1    Bauer, J.H.2
  • 79
    • 84856037918 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade in chronic kidney disease
    • Bomback A.S., Klemmer P.J. Mineralocorticoid receptor blockade in chronic kidney disease. Blood Purif 2012, 33:119-124.
    • (2012) Blood Purif , vol.33 , pp. 119-124
    • Bomback, A.S.1    Klemmer, P.J.2
  • 81
    • 62449278945 scopus 로고    scopus 로고
    • Interaction of aldosterone and extracellular volume in the pathogenesis of obesity-associated kidney disease: a narrative review
    • Bomback A.S., Klemmer P.J. Interaction of aldosterone and extracellular volume in the pathogenesis of obesity-associated kidney disease: a narrative review. Am J Nephrol 2009, 30:140-146.
    • (2009) Am J Nephrol , vol.30 , pp. 140-146
    • Bomback, A.S.1    Klemmer, P.J.2
  • 82
    • 84863721734 scopus 로고    scopus 로고
    • Plasma aldosterone is increased in class 2 and 3 obese essential hypertensive patients despite drug treatment
    • Sarzani R., Guerra F., Mancinelli L., Buglioni A., Franchi E., Dessì-Fulgheri P. Plasma aldosterone is increased in class 2 and 3 obese essential hypertensive patients despite drug treatment. Am J Hypertens 2012, 25:818-826.
    • (2012) Am J Hypertens , vol.25 , pp. 818-826
    • Sarzani, R.1    Guerra, F.2    Mancinelli, L.3    Buglioni, A.4    Franchi, E.5    Dessì-Fulgheri, P.6
  • 84
    • 77953298335 scopus 로고    scopus 로고
    • Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome
    • Schrier R.W., Masoumi A., Elhassan E. Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome. Clin J Am Soc Nephrol 2010, 5:1132-1140.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1132-1140
    • Schrier, R.W.1    Masoumi, A.2    Elhassan, E.3
  • 85
    • 84874580180 scopus 로고    scopus 로고
    • Aldosterone and mortality in hemodialysis patients: role of volume overload
    • Hung S.-C., Lin Y.-P., Huang H.-L., Pu H.-F., Tarng D.-C. Aldosterone and mortality in hemodialysis patients: role of volume overload. PLoS One 2013, 8:e57511.
    • (2013) PLoS One , vol.8
    • Hung, S.-C.1    Lin, Y.-P.2    Huang, H.-L.3    Pu, H.-F.4    Tarng, D.-C.5
  • 86
    • 80052567801 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade in chronic kidney disease
    • Volk M.J., Bomback A.S., Klemmer P.J. Mineralocorticoid receptor blockade in chronic kidney disease. Curr Hypertens Rep 2011, 13:282-288.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 282-288
    • Volk, M.J.1    Bomback, A.S.2    Klemmer, P.J.3
  • 87
    • 58849115865 scopus 로고    scopus 로고
    • Extracellular volume and aldosterone interaction in chronic kidney disease
    • Klemmer P.J., Bomback A.S. Extracellular volume and aldosterone interaction in chronic kidney disease. Blood Purif 2009, 27:92-98.
    • (2009) Blood Purif , vol.27 , pp. 92-98
    • Klemmer, P.J.1    Bomback, A.S.2
  • 88
    • 77953184636 scopus 로고    scopus 로고
    • Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria
    • Ando K., Ohtsu H., Arakawa Y., et al. Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria. Hypertens Res 2010, 33:616-621.
    • (2010) Hypertens Res , vol.33 , pp. 616-621
    • Ando, K.1    Ohtsu, H.2    Arakawa, Y.3
  • 89
    • 68349094014 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation in obesity hypertension
    • Nagase M., Fujita T. Mineralocorticoid receptor activation in obesity hypertension. Hypertens Res 2009, 32:649-657.
    • (2009) Hypertens Res , vol.32 , pp. 649-657
    • Nagase, M.1    Fujita, T.2
  • 90
    • 44049101711 scopus 로고    scopus 로고
    • De Zeeuw D, Navis G. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    • Vogt L., Waanders F., Boomsma F. de Zeeuw D, Navis G. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol 2008, 19:999-1007.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 999-1007
    • Vogt, L.1    Waanders, F.2    Boomsma, F.3
  • 91
    • 73349131138 scopus 로고    scopus 로고
    • Benefits of dietary sodium restriction in the management of chronic kidney disease
    • Krikken J.A., Laverman G.D., Navis G. Benefits of dietary sodium restriction in the management of chronic kidney disease. Curr Opin Nephrol Hypertens 2009, 18:531-538.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , pp. 531-538
    • Krikken, J.A.1    Laverman, G.D.2    Navis, G.3
  • 92
    • 0036314951 scopus 로고    scopus 로고
    • Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats
    • Naruse M., Tanabe A., Sato A., et al. Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats. Hypertension 2002, 40:28-33.
    • (2002) Hypertension , vol.40 , pp. 28-33
    • Naruse, M.1    Tanabe, A.2    Sato, A.3
  • 94
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • Sato A., Hayashi K., Naruse M., Saruta T. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 2003, 41:64-68.
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3    Saruta, T.4
  • 95
    • 33749128531 scopus 로고    scopus 로고
    • Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy
    • Horita Y., Taura K., Taguchi T., Furusu A., Kohno S. Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy. Nephrology 2006, 11:462-466.
    • (2006) Nephrology , vol.11 , pp. 462-466
    • Horita, Y.1    Taura, K.2    Taguchi, T.3    Furusu, A.4    Kohno, S.5
  • 96
    • 34548163060 scopus 로고    scopus 로고
    • The incidence and implications of aldosterone breakthrough
    • Bomback A.S., Klemmer P.J. The incidence and implications of aldosterone breakthrough. Nat Clin Pract Nephrol 2007, 3:486-492.
    • (2007) Nat Clin Pract Nephrol , vol.3 , pp. 486-492
    • Bomback, A.S.1    Klemmer, P.J.2
  • 97
    • 0030096265 scopus 로고    scopus 로고
    • Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure
    • Struthers A.D. Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure. J Card Fail 1996, 2:47-54.
    • (1996) J Card Fail , vol.2 , pp. 47-54
    • Struthers, A.D.1
  • 98
    • 0642373665 scopus 로고    scopus 로고
    • RAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease
    • Lakkis J., Lu W.X., Weir M.R. RAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease. Curr Hypertens Rep 2003, 5:408-417.
    • (2003) Curr Hypertens Rep , vol.5 , pp. 408-417
    • Lakkis, J.1    Lu, W.X.2    Weir, M.R.3
  • 99
    • 12144252958 scopus 로고    scopus 로고
    • Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate
    • Schjoedt K.J., Andersen S., Rossing P., Tarnow L., Parving H.H. Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate. Diabetologia 2004, 47:1936-1939.
    • (2004) Diabetologia , vol.47 , pp. 1936-1939
    • Schjoedt, K.J.1    Andersen, S.2    Rossing, P.3    Tarnow, L.4    Parving, H.H.5
  • 100
    • 0028914059 scopus 로고
    • "Escape" of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: implications for therapy
    • Pitt B. "Escape" of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: implications for therapy. Cardiovasc Drugs Ther 1995, 9:145-149.
    • (1995) Cardiovasc Drugs Ther , vol.9 , pp. 145-149
    • Pitt, B.1
  • 101
    • 78650399880 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms
    • Zannad F., McMurray J.J., Krum H., et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011, 364:11-21.
    • (2011) N Engl J Med , vol.364 , pp. 11-21
    • Zannad, F.1    McMurray, J.J.2    Krum, H.3
  • 102
    • 62949146402 scopus 로고    scopus 로고
    • Aldosterone and long-term outcome after myocardial infarction: a substudy of the French nationwide Observatoire sur la Prise en charge hospitalière, l[U+05F3]Evolution à un an et les caRactéristiques de patients présentant un infArctus du myocarde avec ou sans onde Q (OPERA) study
    • Beygui F., Montalescot G., Vicaut E., et al. Aldosterone and long-term outcome after myocardial infarction: a substudy of the French nationwide Observatoire sur la Prise en charge hospitalière, l[U+05F3]Evolution à un an et les caRactéristiques de patients présentant un infArctus du myocarde avec ou sans onde Q (OPERA) study. Am Heart J 2009, 157:680-687.
    • (2009) Am Heart J , vol.157 , pp. 680-687
    • Beygui, F.1    Montalescot, G.2    Vicaut, E.3
  • 103
    • 0037083216 scopus 로고    scopus 로고
    • Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    • Cicoira M., Zanolla L., Franceschini L., et al. Relation of aldosterone "escape" despite angiotensin-converting enzyme inhibitor administration to impaired exercise capacity in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2002, 89:403-407.
    • (2002) Am J Cardiol , vol.89 , pp. 403-407
    • Cicoira, M.1    Zanolla, L.2    Franceschini, L.3
  • 104
    • 0035124068 scopus 로고    scopus 로고
    • Late escape from the antiproteinuric effect of ace inhibitors in nondiabetic renal disease
    • Shiigai T., Shichiri M. Late escape from the antiproteinuric effect of ace inhibitors in nondiabetic renal disease. Am J Kidney Dis 2001, 37:477-483.
    • (2001) Am J Kidney Dis , vol.37 , pp. 477-483
    • Shiigai, T.1    Shichiri, M.2
  • 105
    • 57049133582 scopus 로고    scopus 로고
    • The effects of spironolactone on nephron function in patients with diabetic nephropathy
    • Ustundag A., Tugrul A., Ustundag S., Sut N., Demirkan B. The effects of spironolactone on nephron function in patients with diabetic nephropathy. Ren Fail 2008, 30:982-991.
    • (2008) Ren Fail , vol.30 , pp. 982-991
    • Ustundag, A.1    Tugrul, A.2    Ustundag, S.3    Sut, N.4    Demirkan, B.5
  • 106
    • 20544465842 scopus 로고    scopus 로고
    • Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study
    • Bianchi S., Bigazzi R., Campese V.M. Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis 2005, 46:45-51.
    • (2005) Am J Kidney Dis , vol.46 , pp. 45-51
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 107
    • 33845302661 scopus 로고    scopus 로고
    • Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease
    • Bianchi S., Bigazzi R., Campese V.M. Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int 2006, 70:2116-2123.
    • (2006) Kidney Int , vol.70 , pp. 2116-2123
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 108
    • 0034745049 scopus 로고    scopus 로고
    • Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in essential hypertensive patients with left ventricular hypertrophy
    • Sato A., Saruta T. Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in essential hypertensive patients with left ventricular hypertrophy. J Int Med Res 2001, 29:13-21.
    • (2001) J Int Med Res , vol.29 , pp. 13-21
    • Sato, A.1    Saruta, T.2
  • 109
    • 71449110620 scopus 로고    scopus 로고
    • Low-dose spironolactone, added to long-term ACE inhibitor therapy, reduces blood pressure and urinary albumin excretion in obese patients with hypertensive target organ damage
    • Bomback A.S., Muskala P., Bald E., Chwatko G., Nowicki M. Low-dose spironolactone, added to long-term ACE inhibitor therapy, reduces blood pressure and urinary albumin excretion in obese patients with hypertensive target organ damage. Clin Nephrol 2009, 72:449-456.
    • (2009) Clin Nephrol , vol.72 , pp. 449-456
    • Bomback, A.S.1    Muskala, P.2    Bald, E.3    Chwatko, G.4    Nowicki, M.5
  • 110
    • 84885216371 scopus 로고    scopus 로고
    • Determinants and changes associated with aldosterone breakthrough after angiotensin II receptor blockade in patients with type 2 diabetes with overt nephropathy
    • Moranne O., Bakris G., Fafin C., Favre G., Pradier C., Esnault VLM. Determinants and changes associated with aldosterone breakthrough after angiotensin II receptor blockade in patients with type 2 diabetes with overt nephropathy. Clin J Am Soc Nephrol 2013, 8:1694-1701.
    • (2013) Clin J Am Soc Nephrol , vol.8 , pp. 1694-1701
    • Moranne, O.1    Bakris, G.2    Fafin, C.3    Favre, G.4    Pradier, C.5    Esnault, V.L.M.6
  • 111
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review
    • Bomback A.S., Kshirsagar A.V., Amamoo M.A., Klemmer P.J. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis 2008, 51:199-211.
    • (2008) Am J Kidney Dis , vol.51 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Amamoo, M.A.3    Klemmer, P.J.4
  • 112
    • 0035922443 scopus 로고    scopus 로고
    • Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease
    • Chrysostomou A., Becker G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N Engl J Med 2001, 345:925-926.
    • (2001) N Engl J Med , vol.345 , pp. 925-926
    • Chrysostomou, A.1    Becker, G.2
  • 113
    • 19244378076 scopus 로고    scopus 로고
    • Distinct responses of membranoproliferative glomerulonephritis-related proteinuria to spironolactone with and without angiotensin II blockade
    • Yonemura K., Yasuda H., Hishida A. Distinct responses of membranoproliferative glomerulonephritis-related proteinuria to spironolactone with and without angiotensin II blockade. Ann Intern Med 2003, 139:W79.
    • (2003) Ann Intern Med , vol.139
    • Yonemura, K.1    Yasuda, H.2    Hishida, A.3
  • 114
    • 76249089792 scopus 로고    scopus 로고
    • Successful effect of triple blockade of renin-angiotensin-aldosterone system on massive proteinuria in a patient with chronic kidney disease
    • Kuriyama S., Sugano N., Ueda H., Otsuka Y., Kanzaki G., Hosoya T. Successful effect of triple blockade of renin-angiotensin-aldosterone system on massive proteinuria in a patient with chronic kidney disease. Clin Exp Nephrol 2009, 13:663-666.
    • (2009) Clin Exp Nephrol , vol.13 , pp. 663-666
    • Kuriyama, S.1    Sugano, N.2    Ueda, H.3    Otsuka, Y.4    Kanzaki, G.5    Hosoya, T.6
  • 115
    • 33750993170 scopus 로고    scopus 로고
    • The effect of aldosterone blockade in patients with Alport syndrome
    • Kaito H., Nozu K., Iijima K., et al. The effect of aldosterone blockade in patients with Alport syndrome. Pediatr Nephrol 2006, 21:1824-1829.
    • (2006) Pediatr Nephrol , vol.21 , pp. 1824-1829
    • Kaito, H.1    Nozu, K.2    Iijima, K.3
  • 116
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study
    • Pitt B., Reichek N., Willenbrock R., et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003, 108:1831-1838.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 117
    • 1842688311 scopus 로고    scopus 로고
    • Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension
    • Williams G.H., Burgess E., Kolloch R.E., et al. Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am J Cardiol 2004, 93:990-996.
    • (2004) Am J Cardiol , vol.93 , pp. 990-996
    • Williams, G.H.1    Burgess, E.2    Kolloch, R.E.3
  • 118
    • 13244298395 scopus 로고    scopus 로고
    • Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease
    • Sato A., Hayashi K., Saruta T. Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease. Am J Hypertens 2005, 18:44-49.
    • (2005) Am J Hypertens , vol.18 , pp. 44-49
    • Sato, A.1    Hayashi, K.2    Saruta, T.3
  • 119
    • 0030887031 scopus 로고    scopus 로고
    • A short-term antihypertensive treatment-induced fall in glomerular filtration rate predicts long-term stability of renal function
    • Apperloo A.J., de Zeeuw D., de Jong P.E. A short-term antihypertensive treatment-induced fall in glomerular filtration rate predicts long-term stability of renal function. Kidney Int 1997, 51:793-797.
    • (1997) Kidney Int , vol.51 , pp. 793-797
    • Apperloo, A.J.1    de Zeeuw, D.2    de Jong, P.E.3
  • 120
    • 79960407033 scopus 로고    scopus 로고
    • An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function
    • Holtkamp F.A., de Zeeuw D., Thomas M.C., et al. An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function. Kidney Int 2011, 80:282-287.
    • (2011) Kidney Int , vol.80 , pp. 282-287
    • Holtkamp, F.A.1    de Zeeuw, D.2    Thomas, M.C.3
  • 121
    • 33746558934 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotensin II receptor blocker
    • Chrysostomou A., Pedagogos E., MacGregor L., Becker GJ. Double-blind placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotensin II receptor blocker. Clin J Am Soc Nephrol 2006, 1:256-262.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 256-262
    • Chrysostomou, A.1    Pedagogos, E.2    MacGregor, L.3    Becker, G.J.4
  • 122
    • 84856997580 scopus 로고    scopus 로고
    • The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease
    • Edwards N.C., Steeds R.P., Chue C.D., Stewart P.M., Ferro C.J., Townend J.N. The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease. Br J Clin Pharmacol 2012, 73:447-454.
    • (2012) Br J Clin Pharmacol , vol.73 , pp. 447-454
    • Edwards, N.C.1    Steeds, R.P.2    Chue, C.D.3    Stewart, P.M.4    Ferro, C.J.5    Townend, J.N.6
  • 123
    • 40149090641 scopus 로고    scopus 로고
    • Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker
    • Furumatsu Y., Nagasawa Y., Tomida K., et al. Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker. Hypertens Res 2008, 31:59-67.
    • (2008) Hypertens Res , vol.31 , pp. 59-67
    • Furumatsu, Y.1    Nagasawa, Y.2    Tomida, K.3
  • 124
    • 49749125234 scopus 로고    scopus 로고
    • Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial
    • Tylicki L., Rutkowski P., Renke M., et al. Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial. Am J Kidney Dis 2008, 52:486-493.
    • (2008) Am J Kidney Dis , vol.52 , pp. 486-493
    • Tylicki, L.1    Rutkowski, P.2    Renke, M.3
  • 125
    • 84859998982 scopus 로고    scopus 로고
    • The long-term antiproteinuric effect of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease
    • Tsuboi N., Kawamura T., Okonogi H., Ishii T., Hosoya T. The long-term antiproteinuric effect of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease. J Renin Angiotensin Aldosterone Syst 2012, 13:113-117.
    • (2012) J Renin Angiotensin Aldosterone Syst , vol.13 , pp. 113-117
    • Tsuboi, N.1    Kawamura, T.2    Okonogi, H.3    Ishii, T.4    Hosoya, T.5
  • 126
    • 80455145142 scopus 로고    scopus 로고
    • Moderate antiproteinuric effect of add-on aldosterone blockade with eplerenone in non-diabetic chronic kidney disease. A randomized cross-over study
    • Boesby L., Elung-Jensen T., Klausen T.W., Strandgaard S., Kamper A.-L. Moderate antiproteinuric effect of add-on aldosterone blockade with eplerenone in non-diabetic chronic kidney disease. A randomized cross-over study. PLoS One 2011, 6:e26904.
    • (2011) PLoS One , vol.6
    • Boesby, L.1    Elung-Jensen, T.2    Klausen, T.W.3    Strandgaard, S.4    Kamper, A.-L.5
  • 127
    • 84874521311 scopus 로고    scopus 로고
    • Renoprotective effects of mineralocorticoid receptor blockers in patients with proteinuric kidney diseases
    • Morales E., Millet V.G., Rojas-Rivera J., et al. Renoprotective effects of mineralocorticoid receptor blockers in patients with proteinuric kidney diseases. Nephrol Dial Transplant 2013, 28:405-412.
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 405-412
    • Morales, E.1    Millet, V.G.2    Rojas-Rivera, J.3
  • 128
    • 73649110263 scopus 로고    scopus 로고
    • Effect of spironolactone on urinary protein excretion in patients with chronic kidney disease
    • Sengul E., Sahin T., Sevin E., Yilmaz A. Effect of spironolactone on urinary protein excretion in patients with chronic kidney disease. Ren Fail 2009, 31:928-932.
    • (2009) Ren Fail , vol.31 , pp. 928-932
    • Sengul, E.1    Sahin, T.2    Sevin, E.3    Yilmaz, A.4
  • 129
    • 33745209933 scopus 로고    scopus 로고
    • Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor
    • Ogawa S., Takeuchi K., Mori T., Nako K., Ito S. Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor. Clin Exp Pharmacol Physiol 2006, 33:477-479.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 477-479
    • Ogawa, S.1    Takeuchi, K.2    Mori, T.3    Nako, K.4    Ito, S.5
  • 130
    • 33750274950 scopus 로고    scopus 로고
    • Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function
    • van den Meiracker A.H., Baggen R.G., Pauli S., et al. Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function. J Hypertens 2006, 24:2285-2292.
    • (2006) J Hypertens , vol.24 , pp. 2285-2292
    • van den Meiracker, A.H.1    Baggen, R.G.2    Pauli, S.3
  • 131
    • 24144495285 scopus 로고    scopus 로고
    • Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study
    • Rossing K., Schjoedt K.J., Smidt U.M., Boomsma F., Parving H.-H. Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study. Diabetes Care 2005, 28:2106-2112.
    • (2005) Diabetes Care , vol.28 , pp. 2106-2112
    • Rossing, K.1    Schjoedt, K.J.2    Smidt, U.M.3    Boomsma, F.4    Parving, H.-H.5
  • 132
    • 65849248674 scopus 로고    scopus 로고
    • Effect of spironolactone therapy on albuminuria in patients with type 2 diabetes treated with angiotensin-converting enzyme inhibitors
    • Davidson M.B., Wong A., Hamrahian A.H., Stevens M., Siraj E.S. Effect of spironolactone therapy on albuminuria in patients with type 2 diabetes treated with angiotensin-converting enzyme inhibitors. Endocr Pract 2008, 14:985-992.
    • (2008) Endocr Pract , vol.14 , pp. 985-992
    • Davidson, M.B.1    Wong, A.2    Hamrahian, A.H.3    Stevens, M.4    Siraj, E.S.5
  • 133
    • 33746566456 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
    • Schjoedt K.J., Rossing K., Juhl T.R., et al. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int 2006, 70:536-542.
    • (2006) Kidney Int , vol.70 , pp. 536-542
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 134
    • 58149125532 scopus 로고    scopus 로고
    • Effects of additive therapy with spironolactone on proteinuria in diabetic patients already on ACE inhibitor or ARB therapy: results of a randomized, placebo-controlled, double-blind, crossover trial
    • Saklayen M.G., Gyebi L.K., Tasosa J., Yap J. Effects of additive therapy with spironolactone on proteinuria in diabetic patients already on ACE inhibitor or ARB therapy: results of a randomized, placebo-controlled, double-blind, crossover trial. J Invest Med 2008, 56:714-719.
    • (2008) J Invest Med , vol.56 , pp. 714-719
    • Saklayen, M.G.1    Gyebi, L.K.2    Tasosa, J.3    Yap, J.4
  • 135
    • 32844467281 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone in diabetic nephropathy
    • Schjoedt K.J., Rossing K., Juhl T.R., et al. Beneficial impact of spironolactone in diabetic nephropathy. Kidney Int 2005, 68:2829-2836.
    • (2005) Kidney Int , vol.68 , pp. 2829-2836
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 136
    • 84864023693 scopus 로고    scopus 로고
    • Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study
    • Nielsen S.E., Persson F., Frandsen E., et al. Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study. Diabet Med 2012, 29:e184-e190.
    • (2012) Diabet Med , vol.29
    • Nielsen, S.E.1    Persson, F.2    Frandsen, E.3
  • 137
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • Mehdi U.F., Adams-Huet B., Raskin P., Vega G.L., Toto R.D. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 2009, 20:2641-2650.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3    Vega, G.L.4    Toto, R.D.5
  • 138
    • 84890086278 scopus 로고    scopus 로고
    • Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: a randomized clinical trial
    • Esteghamati A., Noshad S., Jarrah S., Mousavizadeh M., Khoee S.H., Nakhjavani M. Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: a randomized clinical trial. Nephrol Dial Transplant 2013, 28:2823-2833.
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 2823-2833
    • Esteghamati, A.1    Noshad, S.2    Jarrah, S.3    Mousavizadeh, M.4    Khoee, S.H.5    Nakhjavani, M.6
  • 139
    • 33750331264 scopus 로고    scopus 로고
    • Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes
    • Epstein M., Williams G.H., Weinberger M., et al. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 2006, 1:940-951.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 940-951
    • Epstein, M.1    Williams, G.H.2    Weinberger, M.3
  • 140
    • 69749100645 scopus 로고    scopus 로고
    • Predictors of hyperkalemia risk following hypertension control with aldosterone blockade
    • Khosla N., Kalaitzidis R., Bakris G.L. Predictors of hyperkalemia risk following hypertension control with aldosterone blockade. Am J Nephrol 2009, 30:418-424.
    • (2009) Am J Nephrol , vol.30 , pp. 418-424
    • Khosla, N.1    Kalaitzidis, R.2    Bakris, G.L.3
  • 141
    • 84863869088 scopus 로고    scopus 로고
    • Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease
    • Pisoni R., Acelajado M.C., Cartmill F.R., et al. Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease. J Human Hypertens 2012, 26:502-506.
    • (2012) J Human Hypertens , vol.26 , pp. 502-506
    • Pisoni, R.1    Acelajado, M.C.2    Cartmill, F.R.3
  • 142
    • 79952220553 scopus 로고    scopus 로고
    • Efficacy of low dose spironolactone in chronic kidney disease with resistant hypertension
    • Abolghasmi R., Taziki O. Efficacy of low dose spironolactone in chronic kidney disease with resistant hypertension. Saudi J Kidney Dis Transpl 2011, 22:75-78.
    • (2011) Saudi J Kidney Dis Transpl , vol.22 , pp. 75-78
    • Abolghasmi, R.1    Taziki, O.2
  • 143
    • 20544445158 scopus 로고    scopus 로고
    • Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients
    • Gross E., Rothstein M., Dombek S., Juknis H.I. Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients. Am J Kidney Dis 2005, 46:94-101.
    • (2005) Am J Kidney Dis , vol.46 , pp. 94-101
    • Gross, E.1    Rothstein, M.2    Dombek, S.3    Juknis, H.I.4
  • 144
    • 82155196012 scopus 로고    scopus 로고
    • Effect of eplerenone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric chronic hemodialysis patients - a pilot study
    • Shavit L., Neykin D., Lifschitz M., Slotki I. Effect of eplerenone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric chronic hemodialysis patients - a pilot study. Clin Nephrol 2011, 76:388-395.
    • (2011) Clin Nephrol , vol.76 , pp. 388-395
    • Shavit, L.1    Neykin, D.2    Lifschitz, M.3    Slotki, I.4
  • 145
    • 84868574835 scopus 로고    scopus 로고
    • Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: insights from RALES (Randomized Aldactone Evaluation Study)
    • Vardeny O., Wu D.H., Desai A., et al. Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: insights from RALES (Randomized Aldactone Evaluation Study). J Am Coll Cardiol 2012, 60:2082-2089.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2082-2089
    • Vardeny, O.1    Wu, D.H.2    Desai, A.3
  • 146
    • 67651048925 scopus 로고    scopus 로고
    • Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial
    • Edwards N.C., Steeds R.P., Stewart P.M., Ferro C.J., Townend J.N. Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial. J Am Coll Cardiol 2009, 54:505-512.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 505-512
    • Edwards, N.C.1    Steeds, R.P.2    Stewart, P.M.3    Ferro, C.J.4    Townend, J.N.5
  • 147
    • 0032885976 scopus 로고    scopus 로고
    • Involvement of aldosterone in left ventricular hypertrophy of patients with end-stage renal failure treated with hemodialysis
    • Sato A., Funder J.W., Saruta T. Involvement of aldosterone in left ventricular hypertrophy of patients with end-stage renal failure treated with hemodialysis. Am J Hypertens 1999, 12:867-873.
    • (1999) Am J Hypertens , vol.12 , pp. 867-873
    • Sato, A.1    Funder, J.W.2    Saruta, T.3
  • 148
    • 34247164635 scopus 로고    scopus 로고
    • Role of aldosterone in left ventricular hypertrophy among African-American patients with end-stage renal disease on hemodialysis
    • Steigerwalt S., Zafar A., Mesiha N., Gardin J., Provenzano R. Role of aldosterone in left ventricular hypertrophy among African-American patients with end-stage renal disease on hemodialysis. Am J Nephrol 2007, 27:159-163.
    • (2007) Am J Nephrol , vol.27 , pp. 159-163
    • Steigerwalt, S.1    Zafar, A.2    Mesiha, N.3    Gardin, J.4    Provenzano, R.5
  • 149
    • 67649770575 scopus 로고    scopus 로고
    • Spironolactone in chronic hemodialysis patients improves cardiac function
    • Taheri S., Mortazavi M., Shahidi S., et al. Spironolactone in chronic hemodialysis patients improves cardiac function. Saudi J Kidney Dis Transpl 2009, 20:392-397.
    • (2009) Saudi J Kidney Dis Transpl , vol.20 , pp. 392-397
    • Taheri, S.1    Mortazavi, M.2    Shahidi, S.3
  • 150
    • 84862697216 scopus 로고    scopus 로고
    • A prospective double-blind randomized placebo-controlled clinical trial to evaluate the safety and efficacy of spironolactone in patients with advanced congestive heart failure on continuous ambulatory peritoneal dialysis
    • Taheri S., Mortazavi M., Pourmoghadas A., Seyrafian S., Alipour Z., Karimi S. A prospective double-blind randomized placebo-controlled clinical trial to evaluate the safety and efficacy of spironolactone in patients with advanced congestive heart failure on continuous ambulatory peritoneal dialysis. Saudi J Kidney Dis Transpl 2012, 23:507-512.
    • (2012) Saudi J Kidney Dis Transpl , vol.23 , pp. 507-512
    • Taheri, S.1    Mortazavi, M.2    Pourmoghadas, A.3    Seyrafian, S.4    Alipour, Z.5    Karimi, S.6
  • 151
    • 0037316834 scopus 로고    scopus 로고
    • Prognostic value of heart rate variability in patients with end-stage renal disease on chronic haemodialysis
    • Fukuta H., Hayano J., Ishihara S., et al. Prognostic value of heart rate variability in patients with end-stage renal disease on chronic haemodialysis. Nephrol Dial Transplant 2003, 18:318-325.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 318-325
    • Fukuta, H.1    Hayano, J.2    Ishihara, S.3
  • 152
    • 84877583563 scopus 로고    scopus 로고
    • Spironolactone improves endothelial and cardiac autonomic function in non heart failure hemodialysis patients
    • Flevari P., Kalogeropoulou S., Drakou A., et al. Spironolactone improves endothelial and cardiac autonomic function in non heart failure hemodialysis patients. J Hypertens 2013, 31:1239-1244.
    • (2013) J Hypertens , vol.31 , pp. 1239-1244
    • Flevari, P.1    Kalogeropoulou, S.2    Drakou, A.3
  • 153
    • 0242317726 scopus 로고    scopus 로고
    • Aldosterone blockade and vascular calcification in hemodialysis patients
    • Nitta K., Akiba T., Nihei H. Aldosterone blockade and vascular calcification in hemodialysis patients. Am J Med 2003, 115:250.
    • (2003) Am J Med , vol.115 , pp. 250
    • Nitta, K.1    Akiba, T.2    Nihei, H.3
  • 154
    • 77955728969 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of spironolactone on carotid intima-media thickness in nondiabetic hemodialysis patients
    • Vukusich A., Kunstmann S., Varela C., et al. A randomized, double-blind, placebo-controlled trial of spironolactone on carotid intima-media thickness in nondiabetic hemodialysis patients. Clin J Am Soc Nephrol 2010, 5:1380-1387.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1380-1387
    • Vukusich, A.1    Kunstmann, S.2    Varela, C.3
  • 156
    • 84870432435 scopus 로고    scopus 로고
    • Management of hyperkalaemia consequent to mineralocorticoid-receptor antagonist therapy
    • Roscioni S.S., de Zeeuw D., Bakker SJL, Lambers Heerspink H.J. Management of hyperkalaemia consequent to mineralocorticoid-receptor antagonist therapy. Nat Rev Nephrol 2012, 8:691-699.
    • (2012) Nat Rev Nephrol , vol.8 , pp. 691-699
    • Roscioni, S.S.1    de Zeeuw, D.2    Bakker, S.J.L.3    Lambers Heerspink, H.J.4
  • 157
    • 78349303033 scopus 로고    scopus 로고
    • Spironolactone use in heart failure patients with end-stage renal disease on hemodialysis: is it safe?
    • Chua D., Lo A., Lo C. Spironolactone use in heart failure patients with end-stage renal disease on hemodialysis: is it safe?. Clin Cardiol 2010, 33:604-608.
    • (2010) Clin Cardiol , vol.33 , pp. 604-608
    • Chua, D.1    Lo, A.2    Lo, C.3
  • 158
    • 84862259587 scopus 로고    scopus 로고
    • Safety of mineralocorticoid receptor antagonists in patients receiving hemodialysis
    • Baker W.L., White W.B. Safety of mineralocorticoid receptor antagonists in patients receiving hemodialysis. Ann Pharmacother 2012, 46:889-894.
    • (2012) Ann Pharmacother , vol.46 , pp. 889-894
    • Baker, W.L.1    White, W.B.2
  • 159
    • 84873135573 scopus 로고    scopus 로고
    • Mineralocorticoid receptor-associated hypertension and target organ damage: clinical relevance for resistant hypertension in end stage renal disease
    • Rekhtman Y. Mineralocorticoid receptor-associated hypertension and target organ damage: clinical relevance for resistant hypertension in end stage renal disease. Curr Hypertens Rev 2012, 8:267-275.
    • (2012) Curr Hypertens Rev , vol.8 , pp. 267-275
    • Rekhtman, Y.1
  • 160
    • 0036842148 scopus 로고    scopus 로고
    • Aldactone therapy in a peritoneal dialysis patient with decreased left ventricular function
    • Hausmann M.J., Liel-Cohen N. Aldactone therapy in a peritoneal dialysis patient with decreased left ventricular function. Nephrol Dial Transplant 2002, 17:2035-2036.
    • (2002) Nephrol Dial Transplant , vol.17 , pp. 2035-2036
    • Hausmann, M.J.1    Liel-Cohen, N.2
  • 161
    • 0036202848 scopus 로고    scopus 로고
    • Spironolactone therapy in older patients--the impact of renal dysfunction
    • Butler J.V., McAvoy H., McEnroy D., Mulkerrin E.C. Spironolactone therapy in older patients--the impact of renal dysfunction. Arch Gerontol Geriatr 2002, 35:45-49.
    • (2002) Arch Gerontol Geriatr , vol.35 , pp. 45-49
    • Butler, J.V.1    McAvoy, H.2    McEnroy, D.3    Mulkerrin, E.C.4
  • 162
    • 77958563925 scopus 로고    scopus 로고
    • Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone
    • discussion 6
    • Erden I., Yalcin S., Ozhan H. Syncope caused by hyperkalemia during use of a combined therapy with the angiotensin-converting enzyme inhibitor and spironolactone. Kardiol Pol 2010, 68:1043-1045. discussion 6.
    • (2010) Kardiol Pol , vol.68 , pp. 1043-1045
    • Erden, I.1    Yalcin, S.2    Ozhan, H.3
  • 163
    • 0035870772 scopus 로고    scopus 로고
    • Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: an analysis of 25 cases
    • Schepkens H., Vanholder R., Billiouw J.M., Lameire N. Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: an analysis of 25 cases. Am J Med 2001, 110:438-441.
    • (2001) Am J Med , vol.110 , pp. 438-441
    • Schepkens, H.1    Vanholder, R.2    Billiouw, J.M.3    Lameire, N.4
  • 164
    • 84903964942 scopus 로고    scopus 로고
    • Evaluation of spironolactone plus hydrochlorothiazide in reducing proteinuria in type 2 diabetic nephropathy
    • Epub ahead of print.
    • Momeni A, Behradmanesh MS, Kheiri S, Horestani MK. Evaluation of spironolactone plus hydrochlorothiazide in reducing proteinuria in type 2 diabetic nephropathy. J Renin Angiotensin Aldosterone Syst. 2013. Epub ahead of print.
    • (2013) J Renin Angiotensin Aldosterone Syst.
    • Momeni, A.1    Behradmanesh, M.S.2    Kheiri, S.3    Horestani, M.K.4
  • 165
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • ONTARGET Investigators
    • Yusuf S., Teo K.K., et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008, 358:1547-1559. ONTARGET Investigators.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2
  • 166
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
    • Mann J.F.E., Schmieder R.E., McQueen M., et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008, 372:547-553.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.E.1    Schmieder, R.E.2    McQueen, M.3
  • 167
    • 59049107132 scopus 로고    scopus 로고
    • Renal aspirin: will all patients with chronic kidney disease one day take spironolactone?
    • Bomback A.S., Kshirsagar A.V., Klemmer P.J. Renal aspirin: will all patients with chronic kidney disease one day take spironolactone?. Nat Clin Pract Nephrol 2009, 5:74-75.
    • (2009) Nat Clin Pract Nephrol , vol.5 , pp. 74-75
    • Bomback, A.S.1    Kshirsagar, A.V.2    Klemmer, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.