Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease

Nature Medicine

Volumn 14, Issue 12, 2008, Pages 1370-1376

  Shibata, Shigeru ^a   Nagase, Miki ^a   Yoshida, Shigetaka ^a   Kawarazaki, Wakako ^a   Kurihara, Hidetake ^b   Tanaka, Hirotoshi ^c   Miyoshi, Jun ^d   Takai, Yoshimi ^e   Fujita, Toshiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ALDOSTERONE; EPLERENONE; MINERALOCORTICOID RECEPTOR; P21 ACTIVATED KINASE; RAC1 PROTEIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY INJURY; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEINURIA; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION;

AMINOQUINOLINES; ANIMALS; CELL LINE; HUMANS; KIDNEY DISEASES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; PROTEINURIA; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RECEPTORS, MINERALOCORTICOID; SIGNAL TRANSDUCTION;

MUS;

EID: 57349168398     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1879     Document Type: Article

References (34)

1. Chrysostomou, A. & Becker, G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N. Engl. J. Med. 345, 925-926 (2001).
2. Williams, G.H. et al. Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am. J. Cardiol. 93, 990-996 (2004).
3. Togawa, A. et al. Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene 18, 5373-5380 (1999).
4. Gao, Y., Dickerson, J.B., Guo, F., Zheng, J. & Zheng, Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl Acad. Sci. USA 101, 7618-7623 (2004).
5. Cancelas, J.A. et al. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med. 11, 886-891 (2005).
6. Kato, S. et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270, 1491-1494 (1995).
7. Tronche, F. et al. Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev. 18, 492-497 (2004).
8. Takai, Y., Sasaki, T. & Matozaki, T. Small GTP-binding proteins. Physiol. Rev. 81, 153-208 (2001).
9. Tzima, E. et al. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J. 21, 6791-6800 (2002).
10. Rubino, D. et al. Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene 16, 2513-2526 (1998).
11. Su, L.F., Knoblauch, R. & Garabedian, M.J. Rho GTPases as modulators of the estrogen receptor transcriptional response. J. Biol. Chem. 276, 3231-3237 (2001).
12. Kino, T. et al. Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. J. Biol. Chem. 281, 9118-9126 (2006).
13. Le Menuet, D. et al. Alteration of cardiac and renal functions in transgenic mice overexpressing human mineralocorticoid receptor. J. Biol. Chem. 276, 38911-38920 (2001).
14. Massaad, C., Houard, N., Lombes, M. & Barouki, R. Modulation of human mineralocorticoid receptor function by protein kinase A. Mol. Endocrinol. 13, 57-65 (1999).
15. Funder, J.W. Is aldosterone bad for the heart? Trends Endocrinol. Metab. 15, 139-142 (2004).
16. Nagase, M., Matsui, H., Shibata, S., Gotoda, T. & Fujita, T. Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 50, 877-883 (2007).
17. Burridge, K. & Wennerberg, K. Rho and Rac take center stage. Cell 116, 167-179 (2004).
18. Edwards, D.C., Sanders, L.C., Bokoch, G.M. & Gill, G.N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1, 253-259 (1999).
19. Wang, R.A., Mazumdar, A., Vadlamudi, R.K. & Kumar, R. P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J. 21, 5437-5447 (2002).
20. Zhao, L. et al. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat. Neurosci. 9, 234-242 (2006).
21. Shibata, S., Nagase, M. & Fujita, T. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J. Am. Soc. Nephrol. 17, 754-764 (2006).
22. Shibata, S., Nagase, M., Yoshida, S., Kawachi, H. & Fujita, T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 49, 355-364 (2007).
23. Nagase, M. et al. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 47, 1084-1093 (2006).
24. Brown, N.J. et al. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int. 58, 1219-1227 (2000).
25. Niranjan, T. et al. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat. Med. 14, 290-298 (2008).
26. Isermann, B. et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat. Med. 13, 1349-1358 (2007).
27. Pitt, B. & Leopold, J.A. A role for mineralocorticoid receptor blockade in the prevention of apoptosis. J. Mol. Cell. Cardiol. 39, 415-417 (2005).
28. Wu, X. et al. Rac1 activation controls nuclear localization ofβ-catenin during canonical Wnt signaling. Cell 133, 340-353 (2008).
29. Liu, W.F., Nelson, C.M., Tan, J.L. & Chen, C.S. Cadherins, RhoA and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ. Res. 101, e44-e52 (2007).
30. Takenaka, T., Forster, H., De Micheli, A. & Epstein, M. Impaired myogenic responsiveness of renal microvessels in Dahl salt-sensitive rats. Circ. Res. 71, 471-480 (1992).
31. Eto, N. et al. Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression. Kidney Int. 72, 455-463 (2007).
32. 2+-dependent exocytosis from PC12 cells. Genes Cells 1, 943-951 (1996).
33. Diekmann, D. et al. Bcr encodes a GTPase-activating protein for p21rac. Nature 351, 400-402 (1991).
34. Iida, T. et al. Functional modulation of the mineralocorticoid receptor by cis-diamminedichloroplatinum (II). Kidney Int. 58, 1450-1460 (2000).