메뉴 건너뛰기




Volumn 13, Issue 4, 2011, Pages 282-288

Mineralocorticoid receptor blockade in chronic kidney disease

Author keywords

Aldosterone; Aldosterone breakthrough; Bioimpedance; Chronic kidney disease; CKD; Extracellular volume; Hyperkalemia; Hypertension; Mineralocorticoid blockade; Tissue inflammation

Indexed keywords

ALDOSTERONE; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; EPLERENONE; FUROSEMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LISINOPRIL; LOSARTAN; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; PLACEBO; SPIRONOLACTONE; TRICHLORMETHIAZIDE;

EID: 80052567801     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0202-2     Document Type: Article
Times cited : (20)

References (62)
  • 1
    • 34548163060 scopus 로고    scopus 로고
    • The incidence and implications of aldosterone breakthrough
    • DOI 10.1038/ncpneph0575, PII NCPNEPH0575
    • Bomback AS, Klemmer PJ. The incidence and implications of aldosterone breakthrough. Nat Clin Pract Nephrol. 2007;3:486-92. (Pubitemid 47313030)
    • (2007) Nature Clinical Practice Nephrology , vol.3 , Issue.9 , pp. 486-492
    • Bomback, A.S.1    Klemmer, P.J.2
  • 2
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • DOI 10.1056/NEJM199909023411001
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341:709-17. (Pubitemid 29407370)
    • (1999) New England Journal of Medicine , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 4
    • 0016682588 scopus 로고
    • Blood pressure sodium intake and sodium related hormones in the Yanomamo Indians a "nosalt" culture
    • Oliver WJ, Cohen EL, Neel JV. Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "nosalt" culture. Circulation. 1975;52:146-51.
    • (1975) Circulation , vol.52 , pp. 146-151
    • Oliver, W.J.1    Cohen, E.L.2    Neel, J.V.3
  • 6
    • 73349089382 scopus 로고    scopus 로고
    • Disordered aldosterone-volume relationship in end-stage kidney disease
    • The results of this pilot study suggest that hemodialysis patients are unable to suppress their aldosterone appropriately in response to volume expansion (i.e., a state of relative hyperaldosteronism)
    • Bomback AS, Kshirsagar AV, Ferris ME, Klemmer PJ: Disordered aldosterone-volume relationship in end-stage kidney disease. J Renin Angiotensin Aldosterone Syst 2009, 10:230236.The results of this pilot study suggest that hemodialysis patients are unable to suppress their aldosterone appropriately in response to volume expansion (i.e., a state of relative hyperaldosteronism)
    • (2009) J Renin Angiotensin Aldosterone Syst , vol.10 , pp. 230-236
    • Bomback, A.S.1    Kshirsagar, A.V.2    Ferris, M.E.3    Klemmer, P.J.4
  • 7
    • 42349091319 scopus 로고    scopus 로고
    • Aldosterone and metabolic syndrome: Is increased aldosterone in metabolic syndrome patients an additional risk factor?
    • DOI 10.1161/HYPERTENSIONAHA.107.109439, PII 0000426820080500000002
    • Krug AW, Ehrhart-Bornstein M. Aldosterone and metabolic syndrome: is increased aldosterone in metabolic syndrome patients an additional risk factor? Hypertension. 2008;51:1252-8. (Pubitemid 351555932)
    • (2008) Hypertension , vol.51 , Issue.5 , pp. 1252-1258
    • Krug, A.W.1    Ehrhart-Bornstein, M.2
  • 8
    • 77649291571 scopus 로고    scopus 로고
    • Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension
    • Whaley-Connell A, Johnson MS, Sowers JR. Aldosterone: role in the cardiometabolic syndrome and resistant hypertension. Prog Cardiovasc Dis. 2010;52:401-9.
    • (2010) Prog Cardiovasc Dis , vol.52 , pp. 401-409
    • Whaley-Connell, A.1    Johnson, M.S.2    Sowers, J.R.3
  • 9
    • 66549130863 scopus 로고    scopus 로고
    • Narrative review: The emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
    • Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009;150:776-83.
    • (2009) Ann Intern Med , vol.150 , pp. 776-783
    • Sowers, J.R.1    Whaley-Connell, A.2    Epstein, M.3
  • 10
    • 77953298335 scopus 로고    scopus 로고
    • Aldosterone: Role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome
    • Schrier RW, Masoumi A, Elhassan E. Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome. Clin J Am Soc Nephrol. 2010;5:1132-40.
    • (2010) Clin J Am Soc Nephrol , Issue.5 , pp. 1132-1140
    • Schrier, R.W.1    Masoumi, A.2    Elhassan, E.3
  • 11
    • 0026458472 scopus 로고
    • Membrane receptors for aldosterone: A novel pathway for mineralocorticoid action
    • Wehling M, Christ M, Theisen K. Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Am J Physiol. 1992;263:E974-9.
    • (1992) Am J Physiol , vol.263
    • Wehling, M.1    Christ, M.2    Theisen, K.3
  • 12
    • 3042635831 scopus 로고    scopus 로고
    • Aldosterone-induced organ damage: Plasma aldosterone level and inappropriate salt status
    • DOI 10.1291/hypres.27.303
    • Sato A, Saruta T. Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status. Hypertens Res. 2004;27:303-10. (Pubitemid 38832669)
    • (2004) Hypertension Research , vol.27 , Issue.5 , pp. 303-310
    • Sato, A.1    Saruta, T.2
  • 13
    • 0343356941 scopus 로고
    • Pathologic changes induced in various species by overdosage with desoxycorticosterone
    • Selye H, Hall C. Pathologic changes induced in various species by overdosage with desoxycorticosterone. Arch Pathol. 1943;36:19-31
    • (1943) Arch Pathol , vol.36 , pp. 19-31
    • Selye, H.1    Hall, C.2
  • 16
    • 73349131138 scopus 로고    scopus 로고
    • Benefits of dietary sodium restriction in the management of chronic kidney disease
    • Krikken JA, Laverman GD, Navis G. Benefits of dietary sodium restriction in the management of chronic kidney disease. Curr Opin Nephrol Hypertens. 2009;18:531-8.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , pp. 531-538
    • Krikken, J.A.1    Laverman, G.D.2    Navis, G.3
  • 17
    • 44049101711 scopus 로고    scopus 로고
    • Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    • In this crossover study, reduction of ECV (via diuretics and/or salt restriction) enhances the antiproteinuric effect of RAAS blockade
    • Vogt L, Waanders F, Boomsma F, De ZD, Navis G: Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol 2008, 19:999-1007. In this crossover study, reduction of ECV (via diuretics and/or salt restriction) enhances the antiproteinuric effect of RAAS blockade.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 999-1007
    • Vogt, L.1    Waanders, F.2    Boomsma, F.3    De, Z.D.4    Navis, G.5
  • 18
    • 38549083146 scopus 로고    scopus 로고
    • Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension
    • DOI 10.1161/HYPERTENSIONAHA.107.100701, PII 0000426820080200000029
    • Pimenta E, Gaddam KK, Pratt-Ubunama MN, Nishizaka MK, Aban I, Oparil S, et al. Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension. Hypertension. 2008;51:339-44. (Pubitemid 351159948)
    • (2008) Hypertension , vol.51 , Issue.2 , pp. 339-344
    • Pimenta, E.1    Gaddam, K.K.2    Pratt-Ubunama, M.N.3    Nishizaka, M.K.4    Aban, I.5    Oparil, S.6    Calhoun, D.A.7
  • 19
    • 0142249392 scopus 로고    scopus 로고
    • Role of excess volume in the pathophysiology of hypertension in chronic kidney disease
    • DOI 10.1046/j.1523-1755.2003.00273.x
    • Vasavada N, Agarwal R. Role of excess volume in the pathophysiology of hypertension in chronic kidney disease. Kidney Int. 2003;64:1772-9. (Pubitemid 37323706)
    • (2003) Kidney International , vol.64 , Issue.5 , pp. 1772-1779
    • Vasavada, N.1    Agarwal, R.2
  • 20
    • 0023663143 scopus 로고
    • Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons of the rat
    • Mathie A, Cull-Candy SG, Colquhoun D. Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons of the rat. Proc R Soc Lond B Biol Sci. 1987;232:239-48.
    • (1987) Proc R Soc Lond B Biol Sci , vol.232 , pp. 239-248
    • Mathie, A.1    Cull-Candy, S.G.2    Colquhoun, D.3
  • 21
    • 58849122659 scopus 로고    scopus 로고
    • Bioimpedance analysis in dialysis: State of the art and what we can expect
    • Tattersall J. Bioimpedance analysis in dialysis: state of the art and what we can expect. Blood Purif. 2009;27:70-4.
    • (2009) Blood Purif , vol.27 , pp. 70-74
    • Tattersall, J.1
  • 22
    • 58849150742 scopus 로고    scopus 로고
    • Importance of wholebody bioimpedance spectroscopy for the management of fluid balance
    • Wabel P, Chamney P, Moissl U, Jirka T. Importance of wholebody bioimpedance spectroscopy for the management of fluid balance. Blood Purif. 2009;27:75-80.
    • (2009) Blood Purif , vol.27 , pp. 75-80
    • Wabel, P.1    Chamney, P.2    Moissl, U.3    Jirka, T.4
  • 23
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • DOI 10.1016/S0092-8674(01)00241-0
    • Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545-56. (Pubitemid 32201949)
    • (2001) Cell , vol.104 , Issue.4 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 25
    • 45149100695 scopus 로고    scopus 로고
    • Characterization of resistant hypertension: Association between resistant hypertension, aldosterone, and persistent intravascular volume expansion
    • DOI 10.1001/archinte.168.11.1159
    • Gaddam KK, Nishizaka MK, Pratt-Ubunama MN, Pimenta E, Aban I, Oparil S, Calhoun DA: Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion. Arch Intern Med 2008, 168:1159-1164. This study documents the importance of a disordered aldosterone-ECV relationship in patients with resistant hypertension. (Pubitemid 351831398)
    • (2008) Archives of Internal Medicine , vol.168 , Issue.11 , pp. 1159-1164
    • Gaddam, K.K.1    Nishizaka, M.K.2    Pratt-Ubunama, M.N.3    Pimenta, E.4    Aban, I.5    Oparil, S.6    Calhoun, D.A.7
  • 26
    • 60649111919 scopus 로고    scopus 로고
    • Sleep apnea, aldosterone, and resistant hypertension
    • Pimenta E, Calhoun DA, Oparil S. Sleep apnea, aldosterone, and resistant hypertension. Prog Cardiovasc Dis. 2009;51:371-80.
    • (2009) Prog Cardiovasc Dis , vol.51 , pp. 371-380
    • Pimenta, E.1    Calhoun, D.A.2    Oparil, S.3
  • 28
    • 33847048251 scopus 로고    scopus 로고
    • Association of adrenal steroids with hypertension and the metabolic syndrome in blacks
    • Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, et al. Association of adrenal steroids with hypertension and the metabolic syndrome in blacks. Hypertension. 2007;49:704-11.
    • (2007) Hypertension , vol.49 , pp. 704-711
    • Kidambi, S.1    Kotchen, J.M.2    Grim, C.E.3    Raff, H.4    Mao, J.5    Singh, R.J.6
  • 29
    • 70450225065 scopus 로고    scopus 로고
    • Aldosterone contributes to blood pressure variance and to likelihood of hypertension in normal-weight and overweight African Americans
    • Kidambi S, Kotchen JM, Krishnaswami S, Grim CE, Kotchen TA. Aldosterone contributes to blood pressure variance and to likelihood of hypertension in normal-weight and overweight African Americans. Am J Hypertens. 2009;22:1303-8.
    • (2009) Am J Hypertens , vol.22 , pp. 1303-1308
    • Kidambi, S.1    Kotchen, J.M.2    Krishnaswami, S.3    Grim, C.E.4    Kotchen, T.A.5
  • 30
    • 73849110168 scopus 로고    scopus 로고
    • Salt-sensitive hypertension in circadian clockdeficient cry-null mice involves dysregulated adrenal Hsd3b6
    • Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, et al. Salt-sensitive hypertension in circadian clockdeficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med. 2010;16:67-74.
    • (2010) Nat Med , vol.16 , pp. 67-74
    • Doi, M.1    Takahashi, Y.2    Komatsu, R.3    Yamazaki, F.4    Yamada, H.5    Haraguchi, S.6
  • 32
    • 20544445158 scopus 로고    scopus 로고
    • Effect of spironolactone on blood pressure and the renin-angiotensin- aldosterone system in oligo-anuric hemodialysis patients
    • DOI 10.1053/j.ajkd.2005.03.005, PII S0272638605004324
    • Gross E, Rothstein M, Dombek S, Juknis HI. Effect of spironolactone on blood pressure and the renin-angiotensinaldosterone system in oligo-anuric hemodialysis patients. Am J Kidney Dis. 2005;46:94-101. (Pubitemid 40848437)
    • (2005) American Journal of Kidney Diseases , vol.46 , Issue.1 , pp. 94-101
    • Gross, E.1    Rothstein, M.2    Dombek, S.3    Juknis, H.I.4
  • 33
    • 1442338287 scopus 로고    scopus 로고
    • Resistant hypertension, obesity, sleep apnea, and aldosterone: Theory and therapy
    • DOI 10.1161/01.HYP.0000116223.97436.e5
    • Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension. 2004;43:518-24. (Pubitemid 38282420)
    • (2004) Hypertension , vol.43 , Issue.3 , pp. 518-524
    • Goodfriend, T.L.1    Calhoun, D.A.2
  • 34
    • 33845238078 scopus 로고    scopus 로고
    • Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: Possible contribution of fat-derived factors
    • DOI 10.1681/ASN.2006080944
    • Nagase M, Yoshida S, Shibata S, Nagase T, Gotoda T, Ando K, et al. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol. 2006;17:3438-46. (Pubitemid 44865286)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.12 , pp. 3438-3446
    • Nagase, M.1    Yoshida, S.2    Shibata, S.3    Nagase, T.4    Gotoda, T.5    Ando, K.6    Fujita, T.7
  • 37
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: A systematic review
    • Bomback AS, Kshirsagar AV, Amamoo MA, Klemmer PJ. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis. 2008;51:199-211.
    • (2008) Am J Kidney Dis , vol.51 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Amamoo, M.A.3    Klemmer, P.J.4
  • 38
    • 66149131479 scopus 로고    scopus 로고
    • Aldosterone antagonists for preventing the progression of chronic kidney disease: A systematic review and meta-analysis
    • This is one of two systematic reviews on the use of aldosterone blockade in CKD. In nearly all studies, spironolactone or eplerenone was added to ACE inhibitor or ARB therapy with relatively low risk of hyperkalemia
    • Navaneethan SD, Nigwekar SU, Sehgal AR, Strippoli GF: Aldosterone antagonists for preventing the progression of chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol 2009, 4:542-551. This is one of two systematic reviews on the use of aldosterone blockade in CKD. In nearly all studies, spironolactone or eplerenone was added to ACE inhibitor or ARB therapy with relatively low risk of hyperkalemia.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 542-551
    • Navaneethan, S.D.1    Nigwekar, S.U.2    Sehgal, A.R.3    Strippoli, G.F.4
  • 39
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibi-tion in diabetic nephropathy
    • Mehdi UF, Adams-Huet B, Raskin P, Vega GL, Toto RD. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibi-tion in diabetic nephropathy. J Am Soc Nephrol. 2009;20:2641-50
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3    Vega, G.L.4    Toto, R.D.5
  • 41
    • 77949655427 scopus 로고    scopus 로고
    • Intensive versus conventional therapy to slow the progression of idiopathic glomerular diseases
    • Bianchi S, Bigazzi R, Campese VM. Intensive versus conventional therapy to slow the progression of idiopathic glomerular diseases. Am J Kidney Dis. 2010;55:671-81.
    • (2010) Am J Kidney Dis , vol.55 , pp. 671-681
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 42
    • 40149090641 scopus 로고    scopus 로고
    • Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: Addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker
    • DOI 10.1291/hypres.31.59
    • Furumatsu Y, Nagasawa Y, Tomida K, Mikami S, Kaneko T, Okada N, et al. Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker. Hypertens Res. 2008;31:59-67. (Pubitemid 351325616)
    • (2008) Hypertension Research , vol.31 , Issue.1 , pp. 59-67
    • Furumatsu, Y.1    Nagasawa, Y.2    Tomida, K.3    Mikami, S.4    Kaneko, T.5    Okada, N.6    Tsubakihara, Y.7    Imai, E.8    Shoji, T.9
  • 43
    • 0035870772 scopus 로고    scopus 로고
    • Lifethreatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: An analysis of 25 cases
    • Schepkens H, Vanholder R, Billiouw JM, Lameire N. Lifethreatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: An analysis of 25 cases. Am J Med. 2001;110:438-41.
    • (2001) Am J Med , vol.110 , pp. 438-441
    • Schepkens, H.1    Vanholder, R.2    Billiouw, J.M.3    Lameire, N.4
  • 44
    • 69749100645 scopus 로고    scopus 로고
    • Predictors of hyperkalemia risk following hypertension control with aldosterone blockade
    • Khosla N, Kalaitzidis R, Bakris GL. Predictors of hyperkalemia risk following hypertension control with aldosterone blockade. Am J Nephrol. 2009;30:418-24.
    • (2009) Am J Nephrol , vol.30 , pp. 418-424
    • Khosla, N.1    Kalaitzidis, R.2    Bakris, G.L.3
  • 45
    • 58849115865 scopus 로고    scopus 로고
    • Extracellular volume and aldosterone interaction in chronic kidney disease
    • Klemmer PJ, Bomback AS: Extracellular volume and aldosterone interaction in chronic kidney disease. Blood Purif. 2009, 27:92-98.
    • (2009) Blood Purif , vol.27 , pp. 92-98
    • Klemmer, P.J.1    Bomback, A.S.2
  • 46
    • 0020067313 scopus 로고
    • Disorders of body fluids, sodium and potassium in chronic renal failure
    • Mitch WE, Wilcox CS. Disorders of body fluids, sodium and potassium in chronic renal failure. Am J Med. 1982;72:536-50 (Pubitemid 12188689)
    • (1982) American Journal of Medicine , vol.72 , Issue.3 , pp. 536-550
    • Mitch, W.E.1    Wilcox, C.S.2
  • 48
    • 0032885976 scopus 로고    scopus 로고
    • Involvement of aldosterone in left ventricular hypertrophy of patients with end-stage renal failure treated with hemodialysis
    • DOI 10.1016/S0895-7061(99)00066-7, PII S0895706199000667
    • Sato A, Funder JW, Saruta T. Involvement of aldosterone in left ventricular hypertrophy of patients with end-stage renal failure treated with hemodialysis. Am J Hypertens. 1999;12:867-73. (Pubitemid 29469939)
    • (1999) American Journal of Hypertension , vol.12 , Issue.9 , pp. 867-873
    • Sato, A.1    Funder, J.W.2    Saruta, T.3
  • 50
    • 73649103775 scopus 로고    scopus 로고
    • The association between left ventricular hypertrophy and biomarkers in patients on continuous ambulatory peritoneal dialysis
    • Park SH, Lee SW, Lee SJ, Shin WY, Jin DK, Gil HW, et al. The association between left ventricular hypertrophy and biomarkers in patients on continuous ambulatory peritoneal dialysis. Korean Circ J. 2009;39:488-93.
    • (2009) Korean Circ J , vol.39 , pp. 488-493
    • Park, S.H.1    Lee, S.W.2    Lee, S.J.3    Shin, W.Y.4    Jin, D.K.5    Gil, H.W.6
  • 51
    • 66049135092 scopus 로고    scopus 로고
    • Peritoneal mesothelial cells as a target of local aldosterone action: Upregulation of connective tissue growth factor expression via serum- and glucocorticoid-inducible protein kinase 1
    • Okazaki A, Mori Y, Nakata M, Kimura T, Sonomura K, Sakoda C, et al. Peritoneal mesothelial cells as a target of local aldosterone action: upregulation of connective tissue growth factor expression via serum- and glucocorticoid-inducible protein kinase 1. Kidney Blood Press Res. 2009;32:151-60.
    • (2009) Kidney Blood Press Res , vol.32 , pp. 151-160
    • Okazaki, A.1    Mori, Y.2    Nakata, M.3    Kimura, T.4    Sonomura, K.5    Sakoda, C.6
  • 52
    • 77953687629 scopus 로고    scopus 로고
    • The renin-angiotensinaldosterone system in peritoneal dialysis: Is what is good for the kidney also good for the peritoneum
    • Nessim SJ, Perl J, Bargman JM. The renin-angiotensinaldosterone system in peritoneal dialysis: is what is good for the kidney also good for the peritoneum? Kidney Int. 2010;78:23-8.
    • (2010) Kidney Int , vol.78 , pp. 23-28
    • Nessim, S.J.1    Perl, J.2    Bargman, J.M.3
  • 55
    • 63349097399 scopus 로고    scopus 로고
    • Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients
    • In this study, low-dose spironolactone was administered to 61 hemodialysis patients for 6 months without any episodes of severe hyperkalemia. Half of the patients were receiving concurrent therapy with an ACE inhibitor and/or ARB
    • Matsumoto Y, Kageyama S, Yakushigawa T, Arihara K, Sugiyama T, Mori Y, Sugiyama H, Ohmura H, Shio N: Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology 2009, 114:32-38. In this study, low-dose spironolactone was administered to 61 hemodialysis patients for 6 months without any episodes of severe hyperkalemia. Half of the patients were receiving concurrent therapy with an ACE inhibitor and/or ARB.
    • (2009) Cardiology , vol.114 , pp. 32-38
    • Matsumoto, Y.1    Kageyama, S.2    Yakushigawa, T.3    Arihara, K.4    Sugiyama, T.5    Mori, Y.6    Sugiyama, H.7    Ohmura, H.8    Shio, N.9
  • 56
    • 0031992191 scopus 로고    scopus 로고
    • Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure
    • Hatch M, Freel RW, Vaziri ND. Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure. Am J Physiol. 1998;274:F275-82.
    • (1998) Am J Physiol , vol.274
    • Hatch, M.1    Freel, R.W.2    Vaziri, N.D.3
  • 57
    • 4644313400 scopus 로고    scopus 로고
    • + homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients
    • DOI 10.1111/j.1523-1755.2004.00931.x
    • Michea L, Vukusich A, Gonzalez M, Zehnder C, Marusic ET. Effect of spironolactone on K(+) homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients. Kidney Int. 2004;66:1647-53. (Pubitemid 39298401)
    • (2004) Kidney International , vol.66 , Issue.4 , pp. 1647-1653
    • Michea, L.1    Vukusich, A.2    Gonzalez, M.3    Zehnder, C.4    Marusic, E.T.5
  • 58
    • 0023686337 scopus 로고
    • The role of aldosterone in potassium tolerance: Studies in anephric humans
    • Sugarman A, Brown RS. The role of aldosterone in potassium tolerance: studies in anephric humans. Kidney Int. 1988;34:397-403.
    • (1988) Kidney Int , vol.34 , pp. 397-403
    • Sugarman, A.1    Brown, R.S.2
  • 59
    • 0036842148 scopus 로고    scopus 로고
    • Aldactone therapy in a peritoneal dialysis patient with decreased left ventricular function [4]
    • Hausmann MJ, Liel-Cohen N. Aldactone therapy in a peritoneal dialysis patient with decreased left ventricular function. Nephrol Dial Transplant. 2002;17:2035-6. (Pubitemid 35277114)
    • (2002) Nephrology Dialysis Transplantation , vol.17 , Issue.11 , pp. 2035-2036
    • Hausmann, M.J.1    Liel-Cohen, N.2
  • 62
    • 12144252958 scopus 로고    scopus 로고
    • Aldosterone escape during blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate
    • DOI 10.1007/s00125-004-1542-0
    • Schjoedt KJ, Andersen S, Rossing P, Tarnow L, Parving HH. Aldosterone escape during blockade of the renin-angiotensinaldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate. Diabetologia. 2004;47:1936-9. (Pubitemid 40110201)
    • (2004) Diabetologia , vol.47 , Issue.11 , pp. 1936-1939
    • Schjoedt, K.J.1    Andersen, S.2    Rossing, P.3    Tarnow, L.4    Parving, H.-H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.