Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation

Journal of the American Society of Nephrology

Volumn 23, Issue 6, 2012, Pages 997-1007

  Kawarazaki, Wakako ^a   Nagase, Miki ^a   Yoshida, Shigetaka ^a   Takeuchi, Maki ^a   Ishizawa, Kenichi ^a   Ayuzawa, Nobuhiro ^a   Ueda, Kohei ^a   Fujita, Toshiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; EHT 1864; EPLERENONE; HYDRALAZINE; MINERALOCORTICOID RECEPTOR; RAC1 PROTEIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; URINARY TRACT AGENT;

ADRENALECTOMY; ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; HYPERTENSION; KIDNEY DISEASE; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 84861832781     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011070734     Document Type: Article

References (42)

1. Ruggenenti P,Cravedi P, RemuzziG: The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol 6: 319-330, 2010
2. Parving HH, Lehnert H, Bröchner-Mortensen J, Gomis R, Andersen S, Arner P Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group: The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl JMed 345: 870-878, 2001
3. Brenner BM, Cooper ME, de Zeeuw D, KeaneWF,MitchWE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S RENAAL Study Investigators: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345: 861-869, 2001
4. Kobori H, Nangaku M, Navar LG, Nishiyama A: The intrarenal reninangiotensin system: From physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59: 251-287, 2007 (Pubitemid 47481436)
5. Greene EL, Kren S, Hostetter TH: Role of aldosterone in the remnant kidney model in the rat. J Clin Invest 98: 1063-1068, 1996 (Pubitemid 26293326)
6. Blasi ER, Rocha R, Rudolph AE, Blomme EA, Polly ML, McMahon EG: Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int 63: 1791-1800, 2003 (Pubitemid 36513325)
7. Fiebeler A, Nussberger J, Shagdarsuren E, Rong S, Hilfenhaus G, Al-SaadiN, Dechend R,WellnerM,Meiners S,Maser-Gluth C, Jeng AY, Webb RL, Luft FC, Muller DN: Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 111: 3087-3094, 2005
8. Nagase M: Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome. Clin Exp Nephrol 14: 303-314, 2010
9. Funder JW: Is aldosterone bad for the heart? Trends Endocrinol Metab 15: 139-142, 2004
10. Ritz E, Dikow R, Morath C, Schwenger V: Salt-a potential 'uremic toxin'? Blood Purif 24: 63-66, 2006
11. Hirawa N, Uehara Y, Kawabata Y, Numabe A, Ogawa N, Gomi T, Ikeda T, Goto A, Toyo-oka T, Omata M: High salt intake potentiates the renal vascular and glomerular damage caused by low doses of angiotensin II in uni-nephrectomized rats. J Hypertens 17: 923-932, 1999 (Pubitemid 29322180)
12. Williams GH, Cain JP, Dluhy RG, Underwood RH: Studies of the control of plasma aldosterone concentration in normal man. I. Response to posture, acute and chronic volume depletion, and sodium loading. J Clin Invest 51: 1731-1742, 1972
13. Nagase M, Matsui H, Shibata S, Gotoda T, Fujita T: Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: Role of oxidative stress. Hypertension 50: 877-883, 2007 (Pubitemid 350287529)
14. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T: Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease. Nat Med 14: 1370-1376, 2008
15. Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T: Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest 121: 3233-3243, 2011
16. Fukamizu A, Sugimura K, Takimoto E, Sugiyama F, Seo MS, Takahashi S, Hatae T, Kajiwara N, Yagami K, Murakami K: Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 268: 11617-11621, 1993 (Pubitemid 23168109)
17. Kai T, Kino H, Sugimura K, Shimada S, Kurooka A, Akamatsu K, Takenaka T, Fukamizu A, Murakami K, Ishikawa K, Katori R: Significant role of the increase in renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in double transgenic tsukuba hypertensive mice carrying both human renin and angiotensinogen genes. Clin Exp Hypertens 20: 439-449, 1998 (Pubitemid 28269523)
18. Nishijo N, Sugiyama F, Kimoto K, Taniguchi K, Murakami K, Suzuki S, Fukamizu A, Yagami K: Salt-sensitive aortic aneurysm and rupture in hypertensive transgenic mice that overproduce angiotensin II. Lab Invest 78: 1059-1066, 1998 (Pubitemid 28440822)
19. Sakurabayashi-Kitade S, Aoka Y, Nagashima H, Kasanuki H, Hagiwara N, Kawana M: Aldosterone blockade by Spironolactone improves the hypertensive vascular hypertrophy and remodeling in angiotensin II overproducing transgenic mice. Atherosclerosis 206: 54-60, 2009
20. Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ: Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem 282: 35666-35678, 2007 (Pubitemid 350277149)
21. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT: Aldosteroneinduced inflammation in the rat heart: Role of oxidative stress. Am J Pathol 161: 1773-1781, 2002 (Pubitemid 35265535)
22. Oliver WJ, Cohen EL, Neel JV: Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture. Circulation 52: 146-151, 1975
23. MacGregor G, de Wardener HE: Salt, blood pressure and health. Int J Epidemiol 31: 320-327, 2002
24. Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier BC, Loffing J: In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: Differential effect of corticosteroids along the distal tubule. Am J Physiol Renal Physiol 299: F1473-F1485, 2010
25. Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, JansenM, Schlünz M, Klingel K, Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D: Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 110: 1263-1268, 2002 (Pubitemid 35285752)
26. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F: Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in genetargeted mice lacking SGK1. J Mol Med (Berl) 84: 737-746, 2006 (Pubitemid 44328065)
27. Terada Y, Kuwana H, Kobayashi T, Okado T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S: Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. J AmSoc Nephrol 19: 298-309, 2008 (Pubitemid 351240652)
28. Chander PN, Rocha R, Ranaudo J, Singh G, Zuckerman A, Stier CT Jr: Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSP. J Am Soc Nephrol 14: 1990-1997, 2003 (Pubitemid 36909906)
29. Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, BrownNJ: Aldosterone antagonismor synthase inhibition reduces endorgan damage induced by treatment with angiotensin and high salt. Kidney Int 75: 936-944, 2009
30. Silva GB, Garvin JL: Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb. Am J Physiol Renal Physiol 298: F421-F425, 2010
31. Hsu HH, Hoffmann S, Endlich N, Velic A, Schwab A, Weide T, Schlatter E, Pavenstädt H: Mechanisms of angiotensin II signaling on cytoskeleton of podocytes. J Mol Med (Berl) 86: 1379-1394, 2008
32. Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y: Aldosterone induces superoxide generation via Rac1 activation in endothelial cells. Endocrinology 149: 1009-1014, 2008 (Pubitemid 351397957)
33. Jaffe IZ, Mendelsohn ME: Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res 96: 643-650, 2005 (Pubitemid 40478331)
34. Lemarié CA, Simeone SM, Nikonova A, Ebrahimian T, Deschênes ME, Coffman TM, Paradis P, Schiffrin EL: Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. Circ Res 105: 852-859, 2009
35. Boustany CM, Bharadwaj K, Daugherty A, Brown DR, Randall DC, Cassis LA: Activation of the systemic and adipose renin-angiotensin systemin rats with diet-induced obesity and hypertension.AmJ Physiol Regul Integr Comp Physiol 287: R943-R949, 2004 (Pubitemid 39280483)
36. Engeli S, Böhnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM: Weight loss and the renin-angiotensin-aldosterone system. Hypertension 45: 356-362, 2005 (Pubitemid 40315803)
37. Hao L, Kanno Y, Fukushima R, Watanabe Y, Ishida Y, Suzuki H: Effects of eplerenone on heart and kidney in two-kidney, one-clip rats. Am J Nephrol 24: 54-60, 2004 (Pubitemid 38250486)
38. Fukamizu A, Seo MS, Hatae T, Yokoyama M, Nomura T, Katsuki M, Murakami K: Tissue-specific expression of the human renin gene in transgenic mice. Biochem Biophys Res Commun 165: 826-832, 1989 (Pubitemid 20025596)
39. Takahashi S, Fukamizu A,Hasegawa T, YokoyamaM, Nomura T, Katsuki M, Murakami K: Expression of the human angiotensinogen gene in transgenic mice and transfected cells. Biochem Biophys Res Commun 180: 1103-1109, 1991
40. Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM: Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 115: 1092-1099, 2005 (Pubitemid 40489414)
41. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T,McMahon A, Hummler E, Rossier BC: Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest 112: 554-565, 2003 (Pubitemid 38056340)
42. Shimizu H, Hori Y, Kaname S, Yamada K, Nishiyama N, Matsumoto S, Miyata K, Oba M, Yamada A, Kataoka K, Fujita T: siRNA-based therapy ameliorates glomerulonephritis. J Am SocNephrol 21: 622-633, 2010