메뉴 건너뛰기




Volumn 28, Issue 11, 2013, Pages 2823-2833

Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: A randomized clinical trial

Author keywords

Blood pressure control; Diabetic nephropathy; Glomerular filtration rate; Mineralocorticoid receptor antagonist; Urinary albumin excretion

Indexed keywords

ALBUMIN; ENALAPRIL; LOSARTAN; POTASSIUM; SPIRONOLACTONE;

EID: 84890086278     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft281     Document Type: Article
Times cited : (55)

References (44)
  • 1
    • 0036515622 scopus 로고    scopus 로고
    • Lifetime costs of complications resulting from type 2 diabetes in the U. S
    • Caro JJ, Ward AJ, O'Brien JA. Lifetime costs of complications resulting from type 2 diabetes in the U.S. Diabetes Care 2002; 25: 476-481
    • (2002) Diabetes Care , vol.25 , pp. 476-481
    • Caro, J.J.1    Ward, A.J.2    O'brien, J.A.3
  • 2
    • 0033552080 scopus 로고    scopus 로고
    • The progressive cost of complications in type 2 diabetes mellitus
    • Brown JB, Pedula KL, Bakst AW. The progressive cost of complications in type 2 diabetes mellitus. Arch Intern Med 1999; 159: 1873-1880
    • (1999) Arch Intern Med , vol.159 , pp. 1873-1880
    • Brown, J.B.1    Pedula, K.L.2    Bakst, A.W.3
  • 3
    • 80055105303 scopus 로고    scopus 로고
    • Cost-ofillness analysis of type 2 diabetes mellitus in Iran
    • Javanbakht M, Baradaran HR, Mashayekhi A et al. Cost-ofillness analysis of type 2 diabetes mellitus in Iran. PLoS One 2011; 6: e26864
    • (2011) PLoS One , vol.6
    • Javanbakht, M.1    Baradaran, H.R.2    Mashayekhi, A.3
  • 4
    • 33748309114 scopus 로고    scopus 로고
    • Risk factors for renal dysfunction in type 2 diabetes
    • Retnakaran R, Cull CA, Thorne KI et al. Risk factors for renal dysfunction in type 2 diabetes. Diabetes 2006; 55: 1832-1839
    • (2006) Diabetes , vol.55 , pp. 1832-1839
    • Retnakaran, R.1    Cull, C.A.2    Thorne, K.I.3
  • 5
    • 84855185039 scopus 로고    scopus 로고
    • Standards of medical care in diabetes- 2012
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes- 2012. Diabetes Care 2012; 35 (Suppl 1): S11-S63
    • (2012) Diabetes Care , vol.35 , Issue.SUPPL. 1
  • 6
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, de Zeeuw D et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-869
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    De Zeeuw, D.3
  • 7
    • 33845501641 scopus 로고    scopus 로고
    • Antihypertensive therapy in the presence of proteinuria
    • Sarafidis PA, Khosla N, Bakris GL. Antihypertensive therapy in the presence of proteinuria. Am J Kidney Dis 2007; 49: 12-26
    • (2007) Am J Kidney Dis , vol.49 , pp. 12-26
    • Sarafidis, P.A.1    Khosla, N.2    Bakris, G.L.3
  • 8
    • 0033620788 scopus 로고    scopus 로고
    • Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with nonnephrotic proteinuria
    • Ruggenenti P, Perna A, Gherardi G et al. Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with nonnephrotic proteinuria. Lancet 1999; 354: 359-364
    • (1999) Lancet , vol.354 , pp. 359-364
    • Ruggenenti, P.1    Perna, A.2    Gherardi, G.3
  • 9
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, doubleblind, controlled trial
    • Mann JFE, Schmieder RE, McQueen M et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, doubleblind, controlled trial. Lancet 2008; 372: 547-553
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.E.1    Schmieder, R.E.2    McQueen, M.3
  • 10
    • 77953298335 scopus 로고    scopus 로고
    • Aldosterone: Role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome
    • Schrier RW, Masoumi A, Elhassan E. Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome. Clin J Am Soc Nephrol 2010; 5: 1132-1140
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1132-1140
    • Schrier, R.W.1    Masoumi, A.2    Elhassan, E.3
  • 11
    • 32844467281 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone in diabetic nephropathy
    • Schjoedt KJ, Rossing K, Juhl TR et al. Beneficial impact of spironolactone in diabetic nephropathy. Kidney Int 2005; 68: 2829-2836
    • (2005) Kidney Int , vol.68 , pp. 2829-2836
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 12
    • 79955622277 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation and blockade: An emerging paradigm in chronic kidney disease
    • Bertocchio JP,Warnock DG, Jaisser F. Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease. Kidney Int 2011; 79: 1051-1060
    • (2011) Kidney Int , vol.79 , pp. 1051-1060
    • Bertocchio, J.P.1    Warnock, D.G.2    Jaisser, F.3
  • 13
    • 33845302661 scopus 로고    scopus 로고
    • Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease
    • Bianchi S, Bigazzi R, Campese VM. Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int 2006; 70: 2116-2123
    • (2006) Kidney Int , vol.70 , pp. 2116-2123
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 14
    • 84864023693 scopus 로고    scopus 로고
    • Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: A randomized placebo-controlled crossover study
    • Nielsen SE, Persson F, Frandsen E et al. Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study. Diabet Med 2012; 29: e184-e190
    • (2012) Diabet Med , vol.29
    • Nielsen, S.E.1    Persson, F.2    Frandsen, E.3
  • 15
    • 24144495285 scopus 로고    scopus 로고
    • Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: A randomized, double-masked, cross-over study
    • Rossing K, Schjoedt KJ, Smidt UM et al. Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study. Diabetes Care 2005; 28: 2106-2112
    • (2005) Diabetes Care , vol.28 , pp. 2106-2112
    • Rossing, K.1    Schjoedt, K.J.2    Smidt, U.M.3
  • 16
    • 84855161991 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2012; 35 (Suppl 1): S64-S71
    • (2012) Diabetes Care , vol.35 , Issue.SUPPL. 1
  • 17
    • 65649142017 scopus 로고    scopus 로고
    • A new equation to estimate glomerular filtration rate
    • Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612
    • (2009) Ann Intern Med , vol.150 , pp. 604-612
    • Levey, A.S.1    Stevens, L.A.2    Schmid, C.H.3
  • 18
    • 0035922443 scopus 로고    scopus 로고
    • Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease
    • Chrysostomou A, Becker G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N Engl J Med 2001; 345: 925-926
    • (2001) N Engl J Med , vol.345 , pp. 925-926
    • Chrysostomou, A.1    Becker, G.2
  • 19
    • 13244298395 scopus 로고    scopus 로고
    • Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease
    • Sato A, Hayashi K, Saruta T. Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease. Am J Hypertens 2005; 18: 44-49
    • (2005) Am J Hypertens , vol.18 , pp. 44-49
    • Sato, A.1    Hayashi, K.2    Saruta, T.3
  • 20
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: A systematic review
    • Bomback AS, Kshirsagar AV, Amamoo MA et al. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis 2008; 51: 199-211
    • (2008) Am J Kidney Dis , vol.51 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Amamoo, M.A.3
  • 21
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • Mehdi UF, Adams-Huet B, Raskin P et al. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2641-2650
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3
  • 22
    • 33746566456 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
    • Schjoedt KJ, Rossing K, Juhl TR et al. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int 2006; 70: 536-542
    • (2006) Kidney Int , vol.70 , pp. 536-542
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 23
    • 33750274950 scopus 로고    scopus 로고
    • Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function
    • van den Meiracker AH, Baggen RG, Pauli S et al. Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function. J Hypertens 2006; 24: 2285-2292
    • (2006) J Hypertens , vol.24 , pp. 2285-2292
    • Van Den Meiracker, A.H.1    Baggen, R.G.2    Pauli, S.3
  • 24
    • 33750331264 scopus 로고    scopus 로고
    • Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes
    • Epstein M, Williams GH, Weinberger M et al. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 2006; 1: 940-951
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 940-951
    • Epstein, M.1    Williams, G.H.2    Weinberger, M.3
  • 25
    • 20544465842 scopus 로고    scopus 로고
    • Antagonists of aldosterone and proteinuria in patients with CKD: An uncontrolled pilot study
    • Bianchi S, Bigazzi R, Campese VM. Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis 2005; 46: 45-51
    • (2005) Am J Kidney Dis , vol.46 , pp. 45-51
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 26
    • 69749100645 scopus 로고    scopus 로고
    • Predictors of hyperkalemia risk following hypertension control with aldosterone blockade
    • Khosla N, Kalaitzidis R, Bakris GL. Predictors of hyperkalemia risk following hypertension control with aldosterone blockade. Am J Nephrol 2009; 30: 418-424
    • (2009) Am J Nephrol , vol.30 , pp. 418-424
    • Khosla, N.1    Kalaitzidis, R.2    Bakris, G.L.3
  • 27
    • 0027517659 scopus 로고
    • The effect of angiotensinconverting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
    • Lewis EJ, Hunsicker LG, Bain RP et al. The effect of angiotensinconverting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993; 329: 1456-1462
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3
  • 28
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Parving HH, Lehnert H, Brochner-Mortensen J et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870-878
    • (2001) N Engl J Med , vol.345 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Brochner-Mortensen, J.3
  • 29
    • 0038455748 scopus 로고    scopus 로고
    • Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: Analysis of 44 cases
    • Wrenger E, Muller R, Moesenthin M et al. Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases. BMJ 2003; 327: 147-149
    • (2003) BMJ , vol.327 , pp. 147-149
    • Wrenger, E.1    Muller, R.2    Moesenthin, M.3
  • 30
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 31
    • 33746558934 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotensin II receptor blocker
    • Chrysostomou A, Pedagogos E, MacGregor L et al. Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotensin II receptor blocker. Clin J Am Soc Nephrol 2006; 1: 256-262
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 256-262
    • Chrysostomou, A.1    Pedagogos, E.2    Macgregor, L.3
  • 32
    • 36349036058 scopus 로고    scopus 로고
    • Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus
    • Yoneda T, Takeda Y, Usukura M et al. Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus. Am J Hypertens 2007; 20: 1329-1333
    • (2007) Am J Hypertens , vol.20 , pp. 1329-1333
    • Yoneda, T.1    Takeda, Y.2    Usukura, M.3
  • 33
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • Sato A, Hayashi K, Naruse M et al. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 2003; 41: 64-68
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3
  • 34
    • 1842474802 scopus 로고    scopus 로고
    • Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model
    • Zhou X, Ono H, Ono Y et al. Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model. Am J Nephrol 2004; 24: 242-249
    • (2004) Am J Nephrol , vol.24 , pp. 242-249
    • Zhou, X.1    Ono, H.2    Ono, Y.3
  • 35
    • 47649085301 scopus 로고    scopus 로고
    • Aldosterone and glomerular podocyte injury
    • Nagase M, Fujita T. Aldosterone and glomerular podocyte injury. Clin Exp Nephrol 2008; 12: 233-242
    • (2008) Clin Exp Nephrol , vol.12 , pp. 233-242
    • Nagase, M.1    Fujita, T.2
  • 36
    • 33846443625 scopus 로고    scopus 로고
    • Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1
    • Shibata S, Nagase M, Yoshida S et al. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 2007; 49: 355-364
    • (2007) Hypertension , vol.49 , pp. 355-364
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3
  • 37
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
    • Leopold JA, Dam A, Maron BA et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 2007; 13: 189-197
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 38
    • 67349208215 scopus 로고    scopus 로고
    • New aspects of rapid aldosterone signaling
    • Grossmann C, Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol 2009; 308: 53-62
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 53-62
    • Grossmann, C.1    Gekle, M.2
  • 39
    • 77956265232 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonists and the metabolic syndrome
    • Tirosh A, Garg R, Adler GK. Mineralocorticoid receptor antagonists and the metabolic syndrome. Curr Hypertens Rep 2010; 12: 252-257
    • (2010) Curr Hypertens Rep , vol.12 , pp. 252-257
    • Tirosh, A.1    Garg, R.2    Adler, G.K.3
  • 40
    • 68149170224 scopus 로고    scopus 로고
    • Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes
    • Ninomiya T, Perkovic V, de Galan BE et al. Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes. J Am Soc Nephrol 2009; 20: 1813-1821
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1813-1821
    • Ninomiya, T.1    Perkovic, V.2    De Galan, B.E.3
  • 41
    • 0034074955 scopus 로고    scopus 로고
    • Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes
    • Estacio RO, Jeffers BW, Gifford N et al. Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes. Diabetes Care 2000; 23 (Suppl 2): B54-B64
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 2
    • Estacio, R.O.1    Jeffers, B.W.2    Gifford, N.3
  • 42
    • 0033055724 scopus 로고    scopus 로고
    • Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: The Steno type 2 randomised study
    • Gaede P, Vedel P, Parving HH et al. Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study. Lancet 1999; 353: 617-622
    • (1999) Lancet , vol.353 , pp. 617-622
    • Gaede, P.1    Vedel, P.2    Parving, H.H.3
  • 43
    • 0028376692 scopus 로고
    • Renal protective effects of enalapril in hypertensive NIDDM: Role of baseline albuminuria
    • Lebovitz HE, Wiegmann TB, Cnaan A et al. Renal protective effects of enalapril in hypertensive NIDDM: role of baseline albuminuria. Kidney Int Suppl 1994; 45: S150-S155
    • (1994) Kidney Int Suppl , vol.45
    • Lebovitz, H.E.1    Wiegmann, T.B.2    Cnaan, A.3
  • 44
    • 0033945051 scopus 로고    scopus 로고
    • Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients
    • Chan JC, Ko GT, Leung DH et al. Long-term effects of angiotensin- converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients. Kidney Int 2000; 57: 590-600
    • (2000) Kidney Int , vol.57 , pp. 590-600
    • Chan, J.C.1    Ko, G.T.2    Leung, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.