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Volumn 27, Issue 8, 2012, Pages 3160-3169

Recovery from ischemic acute kidney injury by spironolactone administration

Author keywords

AKI treatment; endothelin; renal dysfunction; Rho kinase

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ENDOTHELIN; HEAT SHOCK PROTEIN 72; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PROTEIN; RHO KINASE; SPIRONOLACTONE;

EID: 84864585183     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs014     Document Type: Article
Times cited : (59)

References (61)
  • 1
    • 3242806045 scopus 로고    scopus 로고
    • Inflammatory cells in ischemic acute renal failure
    • Friedewald JJ, Rabb H. Inflammatory cells in ischemic acute renal failure. Kidney Int 2004; 66: 486-491.
    • (2004) Kidney Int , vol.66 , pp. 486-491
    • Friedewald, J.J.1    Rabb, H.2
  • 2
    • 33644834056 scopus 로고    scopus 로고
    • Acute renal failure: Much more than a kidney disease
    • Kelly KJ. Acute renal failure: much more than a kidney disease. Semin Nephrol 2006; 26: 105-113.
    • (2006) Semin Nephrol , vol.26 , pp. 105-113
    • Kelly, K.J.1
  • 3
    • 9544231691 scopus 로고    scopus 로고
    • Epidemiology of acute renal failure: A prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group
    • Liano F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int 1996; 50: 811-818.
    • (1996) Kidney Int , vol.50 , pp. 811-818
    • Liano, F.1    Pascual, J.2
  • 4
    • 33645470533 scopus 로고    scopus 로고
    • Declining mortality in patients with acute renal failure, 1988 to 2002
    • Waikar SS, Curhan GC, Wald R et al. Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 2006; 17: 1143-1150.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1143-1150
    • Waikar, S.S.1    Curhan, G.C.2    Wald, R.3
  • 6
    • 75649098127 scopus 로고    scopus 로고
    • Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults
    • Mosier MJ, Pham TN, Klein MB et al. Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults. J Burn Care Res 2010; 31: 83-92.
    • (2010) J Burn Care Res , vol.31 , pp. 83-92
    • Mosier, M.J.1    Pham, T.N.2    Klein, M.B.3
  • 7
    • 36749046363 scopus 로고    scopus 로고
    • Acute renal failure: Outcomes and risk of chronic kidney disease
    • Block CA, Schoolwerth AC. Acute renal failure: outcomes and risk of chronic kidney disease. Minerva Urol Nefrol 2007; 59: 327-335.
    • (2007) Minerva Urol Nefrol , vol.59 , pp. 327-335
    • Block, C.A.1    Schoolwerth, A.C.2
  • 8
    • 45249111128 scopus 로고    scopus 로고
    • The risk of acute renal failure in patients with chronic kidney disease
    • Hsu CY, Ordonez JD, Chertow GM et al. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int 2008; 74: 101-107.
    • (2008) Kidney Int , vol.74 , pp. 101-107
    • Hsu, C.Y.1    Ordonez, J.D.2    Chertow, G.M.3
  • 9
    • 33644874086 scopus 로고    scopus 로고
    • Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    • Chertow GM, Burdick E, Honour M et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16: 3365-3370.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3365-3370
    • Chertow, G.M.1    Burdick, E.2    Honour, M.3
  • 10
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 11
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309-1321.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 12
    • 0031600240 scopus 로고    scopus 로고
    • Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats
    • Rocha R, Chander PN, Khanna K et al. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 1998; 31: 451-458.
    • (1998) Hypertension , vol.31 , pp. 451-458
    • Rocha, R.1    Chander, P.N.2    Khanna, K.3
  • 13
    • 0032921738 scopus 로고    scopus 로고
    • Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats
    • Rocha R, Chander PN, Zuckerman A et al. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension 1999; 33: 232-237.
    • (1999) Hypertension , vol.33 , pp. 232-237
    • Rocha, R.1    Chander, P.N.2    Zuckerman, A.3
  • 14
    • 0033745021 scopus 로고    scopus 로고
    • Aldosterone: A mediator of myocardial necrosis and renal arteriopathy
    • Rocha R, Stier CT, Jr, Kifor I et al. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 2000; 141: 3871-3878.
    • (2000) Endocrinology , vol.141 , pp. 3871-3878
    • Rocha, R.1    Stier Jr., C.T.2    Kifor, I.3
  • 15
    • 3042845741 scopus 로고    scopus 로고
    • Aldosterone in the development and progression of renal injury
    • Hollenberg NK. Aldosterone in the development and progression of renal injury. Kidney Int 2004; 66: 1-9.
    • (2004) Kidney Int , vol.66 , pp. 1-9
    • Hollenberg, N.K.1
  • 16
    • 31544448314 scopus 로고    scopus 로고
    • Regression of existing glomerulosclerosis by inhibition of aldosterone
    • Aldigier JC, Kanjanbuch T, Ma LJ et al. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol 2005; 16: 3306-3314.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3306-3314
    • Aldigier, J.C.1    Kanjanbuch, T.2    Ma, L.J.3
  • 17
    • 20544465842 scopus 로고    scopus 로고
    • Antagonists of aldosterone and proteinuria in patients with CKD: An uncontrolled pilot study
    • Bianchi S, Bigazzi R, Campese VM. Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis 2005; 46: 45-51.
    • (2005) Am J Kidney Dis , vol.46 , pp. 45-51
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 18
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • Sato A, Hayashi K, Naruse M et al. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 2003; 41: 64-68.
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3
  • 19
    • 0041883742 scopus 로고    scopus 로고
    • Non-genomic actions of aldosterone: Mechanisms and consequences in kidney cells
    • Boldyreff B, Wehling M. Non-genomic actions of aldosterone: mechanisms and consequences in kidney cells. Nephrol Dial Transplant 2003; 18: 1693-1695.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1693-1695
    • Boldyreff, B.1    Wehling, M.2
  • 20
    • 0041318968 scopus 로고    scopus 로고
    • Nongenomic vascular action of aldosterone in the glomerular microcirculation
    • Arima S, Kohagura K, Xu HL et al. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol 2003; 14: 2255-2263.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2255-2263
    • Arima, S.1    Kohagura, K.2    Xu, H.L.3
  • 21
    • 33847023036 scopus 로고    scopus 로고
    • Rapid effects of aldosterone on clonal human vascular smooth muscle cells
    • Gros R, Ding Q, Armstrong S et al. Rapid effects of aldosterone on clonal human vascular smooth muscle cells. Am J Physiol Cell Physiol 2007; 292: C788-C794.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Gros, R.1    Ding, Q.2    Armstrong, S.3
  • 22
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
    • Leopold JA, Dam A, Maron BA et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 2007; 13: 189-197.
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 23
    • 6444245944 scopus 로고    scopus 로고
    • Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity
    • Feria I, Pichardo I, Juarez P et al. Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity. Kidney Int 2003; 63: 43-52.
    • (2003) Kidney Int , vol.63 , pp. 43-52
    • Feria, I.1    Pichardo, I.2    Juarez, P.3
  • 24
    • 26844546641 scopus 로고    scopus 로고
    • Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity
    • Perez-Rojas JM, Derive S, Blanco JA et al. Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 2005; 289: F1020-F1030.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Perez-Rojas, J.M.1    Derive, S.2    Blanco, J.A.3
  • 25
    • 33846210660 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
    • Perez-Rojas J, Blanco JA, Cruz C et al. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 2007; 292: F131-F139.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Perez-Rojas, J.1    Blanco, J.A.2    Cruz, C.3
  • 26
    • 34548012161 scopus 로고    scopus 로고
    • Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone
    • Mejia-Vilet JM, Ramirez V, Cruz C et al. Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol 2007; 293: F78-F86.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Mejia-Vilet, J.M.1    Ramirez, V.2    Cruz, C.3
  • 28
    • 0037530588 scopus 로고    scopus 로고
    • Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats
    • Matsumoto M, Makino Y, Tanaka T et al. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 2003; 14: 1825-1832.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1825-1832
    • Matsumoto, M.1    Makino, Y.2    Tanaka, T.3
  • 29
    • 0026472514 scopus 로고
    • Ischemia-reperfusion induced acute renal failure in the rat is ameliorated by the spin-trapping agent alpha-phenyl-N-tert-butyl nitrone (PBN)
    • Pedraza-Chaverri J, Tapia E, Bobadilla N. Ischemia-reperfusion induced acute renal failure in the rat is ameliorated by the spin-trapping agent alpha-phenyl-N-tert-butyl nitrone (PBN). Ren Fail 1992; 14: 467-471.
    • (1992) Ren Fail , vol.14 , pp. 467-471
    • Pedraza-Chaverri, J.1    Tapia, E.2    Bobadilla, N.3
  • 30
    • 35348835394 scopus 로고    scopus 로고
    • Selective antagonism of the postsynaptic alpha(1)-adrenoceptor is protective against ischemic acute renal failure in rats
    • Fujii T, Sugiura T, Ohkita M et al. Selective antagonism of the postsynaptic alpha(1)-adrenoceptor is protective against ischemic acute renal failure in rats. Eur J Pharmacol 2007; 574: 185-191.
    • (2007) Eur J Pharmacol , vol.574 , pp. 185-191
    • Fujii, T.1    Sugiura, T.2    Ohkita, M.3
  • 31
    • 36448958155 scopus 로고    scopus 로고
    • Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic antiinflammatory pathway
    • Sadis C, Teske G, Stokman G et al. Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic antiinflammatory pathway. PLoS ONE 2007; 2: e469..
    • (2007) PLoS ONE , vol.2
    • Sadis, C.1    Teske, G.2    Stokman, G.3
  • 32
    • 0037337260 scopus 로고    scopus 로고
    • GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury
    • Chatterjee PK, Patel NS, Sivarajah A et al. GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int 2003; 63: 853-865.
    • (2003) Kidney Int , vol.63 , pp. 853-865
    • Chatterjee, P.K.1    Patel, N.S.2    Sivarajah, A.3
  • 33
    • 23044436363 scopus 로고    scopus 로고
    • Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70
    • Suzuki S, Maruyama S, Sato W et al. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Kidney Int 2005; 67: 2210-2220.
    • (2005) Kidney Int , vol.67 , pp. 2210-2220
    • Suzuki, S.1    Maruyama, S.2    Sato, W.3
  • 34
    • 31644440707 scopus 로고    scopus 로고
    • Low calorie commercial sugar is a sensitive marker of glomerular filtration rate
    • Perez-Rojas JM, Blanco JA, Gamba G et al. Low calorie commercial sugar is a sensitive marker of glomerular filtration rate. Kidney Int 2005; 68: 1888-1893.
    • (2005) Kidney Int , vol.68 , pp. 1888-1893
    • Perez-Rojas, J.M.1    Blanco, J.A.2    Gamba, G.3
  • 35
    • 50549208964 scopus 로고
    • Simplification of the anthrone method for the determination of inulin in clearance studies
    • Davidson DW, Sackner MA. Simplification of the anthrone method for the determination of inulin in clearance studies. J Lab Clin Med 1963; 62: 351-356.
    • (1963) J Lab Clin Med , vol.62 , pp. 351-356
    • Davidson, D.W.1    Sackner, M.A.2
  • 36
    • 77049290688 scopus 로고
    • Turbidimetric determination of proteins with sulfosalicylic and tricholoroacetic acids
    • Henry RJ, Sobel C, Segalove M. Turbidimetric determination of proteins with sulfosalicylic and tricholoroacetic acids. Proc Soc Exp Biol Med 1956; 92: 748-751.
    • (1956) Proc Soc Exp Biol Med , vol.92 , pp. 748-751
    • Henry, R.J.1    Sobel, C.2    Segalove, M.3
  • 37
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 78650824849 scopus 로고    scopus 로고
    • Hsp72 is an early and sensitive biomarker to detect acute kidney injury
    • Barrera-Chimal J, Perez-Villalva R, Cortes-Gonzalez C et al. Hsp72 is an early and sensitive biomarker to detect acute kidney injury. EMBO Mol Med 2011; 3: 5-20.
    • (2011) EMBO Mol Med , vol.3 , pp. 5-20
    • Barrera-Chimal, J.1    Perez-Villalva, R.2    Cortes-Gonzalez, C.3
  • 39
    • 24144498411 scopus 로고    scopus 로고
    • Rho-kinase is an important therapeutic target in cardiovascular medicine
    • Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 2005; 25: 1767-1775.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1767-1775
    • Shimokawa, H.1    Takeshita, A.2
  • 40
    • 33744944269 scopus 로고    scopus 로고
    • Update on mechanisms of ischemic acute kidney injury
    • Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 2006; 17: 1503-1520.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1503-1520
    • Devarajan, P.1
  • 41
    • 57049090585 scopus 로고    scopus 로고
    • Radicicol, a heat shock protein 90 inhibitor, reduces glomerular filtration rate
    • Ramirez V, Mejia-Vilet JM, Hernandez D et al. Radicicol, a heat shock protein 90 inhibitor, reduces glomerular filtration rate. Am J Physiol Renal Physiol 2008; 295: F1044-F1051.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Ramirez, V.1    Mejia-Vilet, J.M.2    Hernandez, D.3
  • 42
    • 77952160766 scopus 로고    scopus 로고
    • Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    • Vaidya VS, Ozer JS, Dieterle F et al. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol 2010; 28: 478-485.
    • (2010) Nat Biotechnol , vol.28 , pp. 478-485
    • Vaidya, V.S.1    Ozer, J.S.2    Dieterle, F.3
  • 43
    • 67449143211 scopus 로고    scopus 로고
    • A rapid urine test for early detection of kidney injury
    • Vaidya VS, Ford GM, Waikar SS et al. A rapid urine test for early detection of kidney injury. Kidney Int 2009; 76: 108-114.
    • (2009) Kidney Int , vol.76 , pp. 108-114
    • Vaidya, V.S.1    Ford, G.M.2    Waikar, S.S.3
  • 44
    • 33644870877 scopus 로고    scopus 로고
    • Urinary kidney injury molecule- 1: A sensitive quantitative biomarker for early detection of kidney tubular injury
    • Vaidya VS, Ramirez V, Ichimura T et al. Urinary kidney injury molecule- 1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol 2006; 290: F517-F529.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Vaidya, V.S.1    Ramirez, V.2    Ichimura, T.3
  • 45
    • 68049144273 scopus 로고    scopus 로고
    • Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery
    • Han WK, Wagener G, Zhu Y et al. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 2009; 4: 873-882.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 873-882
    • Han, W.K.1    Wagener, G.2    Zhu, Y.3
  • 46
    • 3242793421 scopus 로고    scopus 로고
    • The role of mitochondria in ischemia/reperfusion injury in organ transplantation
    • Jassem W, Heaton ND. The role of mitochondria in ischemia/reperfusion injury in organ transplantation. Kidney Int 2004; 66: 514-517.
    • (2004) Kidney Int , vol.66 , pp. 514-517
    • Jassem, W.1    Heaton, N.D.2
  • 47
    • 21244497660 scopus 로고    scopus 로고
    • The mineralocorticoid receptor and oxidative stress
    • Fiebeler A, Luft FC. The mineralocorticoid receptor and oxidative stress. Heart Fail Rev 2005; 10: 47-52.
    • (2005) Heart Fail Rev , vol.10 , pp. 47-52
    • Fiebeler, A.1    Luft, F.C.2
  • 48
    • 31544473558 scopus 로고    scopus 로고
    • Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells
    • Miyata K, Rahman M, Shokoji T et al. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol 2005; 16: 2906-2912.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2906-2912
    • Miyata, K.1    Rahman, M.2    Shokoji, T.3
  • 49
    • 5344242464 scopus 로고    scopus 로고
    • Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules
    • Caron A, Desrosiers RR, Beliveau R. Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules. Arch Biochem Biophys 2004; 431: 31-46.
    • (2004) Arch Biochem Biophys , vol.431 , pp. 31-46
    • Caron, A.1    Desrosiers, R.R.2    Beliveau, R.3
  • 50
    • 33746539611 scopus 로고    scopus 로고
    • Involvements of rho-kinase and tgf- Beta pathways in aldosterone-induced renal injury
    • Sun GP, Kohno M, Guo P et al. Involvements of rho-kinase and tgf- Beta pathways in aldosterone-induced renal injury. J Am Soc Nephrol 2006; 17: 2193-2201.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2193-2201
    • Sun, G.P.1    Kohno, M.2    Guo, P.3
  • 51
    • 79952937372 scopus 로고    scopus 로고
    • The role of RhoA/Rho kinase pathway in endothelial dysfunction
    • Yao L, Romero MJ, Toque HA et al. The role of RhoA/Rho kinase pathway in endothelial dysfunction. J Cardiovasc Dis Res 2010; 1: 165-170.
    • (2010) J Cardiovasc Dis Res , vol.1 , pp. 165-170
    • Yao, L.1    Romero, M.J.2    Toque, H.A.3
  • 52
    • 80052333245 scopus 로고    scopus 로고
    • Activation of RhoA in podocytes induces focal segmental glomerulosclerosis
    • Zhu L, Jiang R, Aoudjit L et al. Activation of RhoA in podocytes induces focal segmental glomerulosclerosis. J Am Soc Nephrol 2011; 22: 1621-1630.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1621-1630
    • Zhu, L.1    Jiang, R.2    Aoudjit, L.3
  • 53
    • 20144365615 scopus 로고    scopus 로고
    • Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon- MAPK-p90RSK, and Rho-kinase pathway
    • Kobayashi N, Hara K, Tojo A et al. Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon- MAPK-p90RSK, and Rho-kinase pathway. Hypertension 2005; 45: 538-544.
    • (2005) Hypertension , vol.45 , pp. 538-544
    • Kobayashi, N.1    Hara, K.2    Tojo, A.3
  • 54
    • 55749097408 scopus 로고    scopus 로고
    • Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury
    • Prakash J, de Borst MH, Lacombe M et al. Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury. J Am Soc Nephrol 2008; 19: 2086-2097.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2086-2097
    • Prakash, J.1    De Borst, M.H.2    Lacombe, M.3
  • 55
    • 48849094089 scopus 로고    scopus 로고
    • Endothelin: 20 years from discovery to therapy
    • Barton M, Yanagisawa M. Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol 2008; 86: 485-498.
    • (2008) Can J Physiol Pharmacol , vol.86 , pp. 485-498
    • Barton, M.1    Yanagisawa, M.2
  • 56
    • 33947418892 scopus 로고    scopus 로고
    • A direct effect of aldosterone on endothelin-1 gene expression in vivo
    • Wong S, Brennan FE, Young MJ et al. A direct effect of aldosterone on endothelin-1 gene expression in vivo. Endocrinology 2007; 148: 1511-1517.
    • (2007) Endocrinology , vol.148 , pp. 1511-1517
    • Wong, S.1    Brennan, F.E.2    Young, M.J.3
  • 57
    • 33644829277 scopus 로고    scopus 로고
    • Stimulation of serum- and glucocorticoid- regulated kinase-1 gene expression by endothelin-1
    • Wolf SC, Schultze M, Risler T et al. Stimulation of serum- and glucocorticoid- regulated kinase-1 gene expression by endothelin-1. Biochem Pharmacol 2006; 71: 1175-1183.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1175-1183
    • Wolf, S.C.1    Schultze, M.2    Risler, T.3
  • 58
    • 54049126622 scopus 로고    scopus 로고
    • Aldosterone induces interleukin- 18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes
    • Doi T, Sakoda T, Akagami T et al. Aldosterone induces interleukin- 18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. Am J Physiol Heart Circ Physiol 2008; 295: H1279-H1287.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Doi, T.1    Sakoda, T.2    Akagami, T.3
  • 59
    • 0141702086 scopus 로고    scopus 로고
    • Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line
    • Gumz ML, Popp MP, Wingo CS et al. Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line. Am J Physiol Renal Physiol 2003; 285: F664-F673.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Gumz, M.L.1    Popp, M.P.2    Wingo, C.S.3
  • 60
    • 71049194257 scopus 로고    scopus 로고
    • Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1)
    • Stow LR, Gumz ML, Lynch IJ et al. Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1). J Biol Chem 2009; 284: 30087-30096.
    • (2009) J Biol Chem , vol.284 , pp. 30087-30096
    • Stow, L.R.1    Gumz, M.L.2    Lynch, I.J.3
  • 61
    • 63349112142 scopus 로고    scopus 로고
    • Effects of losartan pretreatment in an experimental model of ischemic acute kidneyinjury
    • Molinas SM, Cortes-Gonzalez C, Gonzalez-Bobadilla Y et al. Effects of losartan pretreatment in an experimental model of ischemic acute kidneyinjury. Nephron Exp Nephrol 2009; 112: e10-e19
    • (2009) Nephron Exp Nephrol , vol.112
    • Molinas, S.M.1    Cortes-Gonzalez, C.2    Gonzalez-Bobadilla, Y.3


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