-
1
-
-
0029004775
-
Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation
-
Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T. Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211-22.
-
(1995)
Genes Dev
, vol.9
, pp. 1211-1222
-
-
Takeuchi, T.1
Yamazaki, Y.2
Katoh-Fukui, Y.3
Tsuchiya, R.4
Kondo, S.5
Motoyama, J.6
Higashinakagawa, T.7
-
2
-
-
36849074774
-
Dynamics and interplay of nuclear architecture, genome organization, and gene expression
-
Schneider R, Grosschedl R. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes Dev 2007; 21: 3027-43.
-
(2007)
Genes Dev
, vol.21
, pp. 3027-3043
-
-
Schneider, R.1
Grosschedl, R.2
-
3
-
-
84979581717
-
The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells
-
Franci G, Casalino L, Petraglia F, Miceli M, Menafra R, Radic B, Tarallo V, Vitale M, Scarfò M, Pocsfalvi G, Baldi A, Ambrosino C, Zambrano N, Patriarca E, De Falco S, Minchiotti G, Stunnenberg HG, Altucci L. The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells. Biol Open 2013; 2: 1070-7.
-
(2013)
Biol Open
, vol.2
, pp. 1070-1077
-
-
Franci, G.1
Casalino, L.2
Petraglia, F.3
Miceli, M.4
Menafra, R.5
Radic, B.6
Tarallo, V.7
Vitale, M.8
Scarfò, M.9
Pocsfalvi, G.10
Baldi, A.11
Ambrosino, C.12
Zambrano, N.13
Patriarca, E.14
De Falco, S.15
Minchiotti, G.16
Stunnenberg, H.G.17
Altucci, L.18
-
4
-
-
84880425891
-
Mechanisms of epigenetic deregulation in lymphoid neoplasms
-
Jiang Y, Hatzi K, Shaknovich R. Mechanisms of epigenetic deregulation in lymphoid neoplasms. Blood 2013; 121: 4271-9.
-
(2013)
Blood
, vol.121
, pp. 4271-4279
-
-
Jiang, Y.1
Hatzi, K.2
Shaknovich, R.3
-
5
-
-
84897309171
-
Functions, aberrations, and advances for chromatin modulation in cancer
-
Conte M, Altucci L. Functions, aberrations, and advances for chromatin modulation in cancer. Cancer Treat Res 2014; 159: 227-39.
-
(2014)
Cancer Treat Res
, vol.159
, pp. 227-239
-
-
Conte, M.1
Altucci, L.2
-
6
-
-
84888787152
-
Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis
-
Connelly JJ, Cherepanova OA, Doss JF, Karaoli T, Lillard TS, Markunas CA, Nelson S, Wang T, Ellis PD, Langford CF, Haynes C, Seo DM, Goldschmidt-Clermont PJ, Shah SH, Kraus WE, Hauser ER, Gregory SG. Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. Hum Mol Genet 2013; 22: 5107-20.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 5107-5120
-
-
Connelly, J.J.1
Cherepanova, O.A.2
Doss, J.F.3
Karaoli, T.4
Lillard, T.S.5
Markunas, C.A.6
Nelson, S.7
Wang, T.8
Ellis, P.D.9
Langford, C.F.10
Haynes, C.11
Seo, D.M.12
Goldschmidt-Clermont, P.J.13
Shah, S.H.14
Kraus, W.E.15
Hauser, E.R.16
Gregory, S.G.17
-
7
-
-
84890644637
-
Status of large-scale analysis of post-translational modifications by mass spectrometry
-
Olsen JV, Mann M. Status of large-scale analysis of post-translational modifications by mass spectrometry. Mol Cell Proteomics 2013; 12: 3444-52.
-
(2013)
Mol Cell Proteomics
, vol.12
, pp. 3444-3452
-
-
Olsen, J.V.1
Mann, M.2
-
8
-
-
34249900454
-
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
-
Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 2007; 447: 601-5.
-
(2007)
Nature
, vol.447
, pp. 601-605
-
-
Tahiliani, M.1
Mei, P.2
Fang, R.3
Leonor, T.4
Rutenberg, M.5
Shimizu, F.6
Li, J.7
Rao, A.8
Shi, Y.9
-
9
-
-
78650582970
-
Histone lysine methylation and demethylation pathways in cancer
-
Varier RA, Timmers HT. Histone lysine methylation and demethylation pathways in cancer. Biochim Biophys Acta 2011; 1815: 75-89.
-
(2011)
Biochim Biophys Acta
, vol.1815
, pp. 75-89
-
-
Varier, R.A.1
Timmers, H.T.2
-
10
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-92.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
11
-
-
77954103911
-
Arginine/lysinemethyl/methyl switches: Biochemical role of histone arginine methylation in transcriptional regulation
-
Migliori V, Phalke S, Bezzi M, Guccione E. Arginine/lysinemethyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation. Epigenomics 2010; 2: 119-37.
-
(2010)
Epigenomics
, vol.2
, pp. 119-137
-
-
Migliori, V.1
Phalke, S.2
Bezzi, M.3
Guccione, E.4
-
12
-
-
84860371870
-
Combinatorial complexity in chromatin structure and function: Revisiting the histone code
-
Rando OJ. Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr Opin Genet Dev 2012; 22: 148-55.
-
(2012)
Curr Opin Genet Dev
, vol.22
, pp. 148-155
-
-
Rando, O.J.1
-
13
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012; 150: 12-27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
14
-
-
79959484677
-
Signals and combinatorial functions of histone modifications
-
Suganuma T, Workman JL. Signals and combinatorial functions of histone modifications. Annu Rev Biochem 2011; 80: 473-99.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 473-499
-
-
Suganuma, T.1
Workman, J.L.2
-
15
-
-
4143140016
-
Histone deacetylase inhibitors open new doors in cancer therapy
-
McLaughlin F, La Thangue NB. Histone deacetylase inhibitors open new doors in cancer therapy. Biochem Pharmacol 2004; 68: 1139-44.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1139-1144
-
-
McLaughlin, F.1
La Thangue, N.B.2
-
17
-
-
34548644772
-
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
-
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007; 130: 1083-94.
-
(2007)
Cell
, vol.130
, pp. 1083-1094
-
-
De Santa, F.1
Totaro, M.G.2
Prosperini, E.3
Notarbartolo, S.4
Testa, G.5
Natoli, G.6
-
18
-
-
84859725611
-
Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D
-
Kim TD, Oh S, Shin S, Janknecht R. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One 2012; 7: e34618.
-
(2012)
PLoS One
, vol.7
-
-
Kim, T.D.1
Oh, S.2
Shin, S.3
Janknecht, R.4
-
19
-
-
35148898348
-
A histone H3 lysine 27 demethylase regulates animal posterior development
-
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 2007; 449: 689-94.
-
(2007)
Nature
, vol.449
, pp. 689-694
-
-
Lan, F.1
Bayliss, P.E.2
Rinn, J.L.3
Whetstine, J.R.4
Wang, J.K.5
Chen, S.6
Iwase, S.7
Alpatov, R.8
Issaeva, I.9
Canaani, E.10
Roberts, T.M.11
Chang, H.Y.12
Shi, Y.13
-
20
-
-
35148867907
-
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
-
Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449: 731-4.
-
(2007)
Nature
, vol.449
, pp. 731-734
-
-
Agger, K.1
Cloos, P.A.2
Christensen, J.3
Pasini, D.4
Rose, S.5
Rappsilber, J.6
Issaeva, I.7
Canaani, E.8
Salcini, A.E.9
Helin, K.10
-
21
-
-
33947245128
-
RBP2 belongs to a family of demethylases, specific for tri- and dimethylated lysine 4 on histone 3
-
Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K. RBP2 belongs to a family of demethylases, specific for tri- and dimethylated lysine 4 on histone 3. Cell 2007; 128: 1063-76.
-
(2007)
Cell
, vol.128
, pp. 1063-1076
-
-
Christensen, J.1
Agger, K.2
Cloos, P.A.3
Pasini, D.4
Rose, S.5
Sennels, L.6
Rappsilber, J.7
Hansen, K.H.8
Salcini, A.E.9
Helin, K.10
-
22
-
-
33746332412
-
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
-
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006; 442: 307-11.
-
(2006)
Nature
, vol.442
, pp. 307-311
-
-
Cloos, P.A.1
Christensen, J.2
Agger, K.3
Maiolica, A.4
Rappsilber, J.5
Antal, T.6
Hansen, K.H.7
Helin, K.8
-
23
-
-
33745146571
-
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
-
Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, Opravil S, Mechtler K, Schotta G, Jenuwein T. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev 2006; 20: 1557-62.
-
(2006)
Genes Dev
, vol.20
, pp. 1557-1562
-
-
Fodor, B.D.1
Kubicek, S.2
Yonezawa, M.3
O'Sullivan, R.J.4
Sengupta, R.5
Perez-Burgos, L.6
Opravil, S.7
Mechtler, K.8
Schotta, G.9
Jenuwein, T.10
-
24
-
-
33745847680
-
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
-
Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 2006; 442: 312-6.
-
(2006)
Nature
, vol.442
, pp. 312-316
-
-
Klose, R.J.1
Yamane, K.2
Bae, Y.3
Zhang, D.4
Erdjument-Bromage, H.5
Tempst, P.6
Wong, J.7
Zhang, Y.8
-
25
-
-
33646124469
-
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
-
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 2006; 125: 467-81.
-
(2006)
Cell
, vol.125
, pp. 467-481
-
-
Whetstine, J.R.1
Nottke, A.2
Lan, F.3
Huarte, M.4
Smolikov, S.5
Chen, Z.6
Spooner, E.7
Li, E.8
Zhang, G.9
Colaiacovo, M.10
Shi, Y.11
-
26
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y. Histone demethylation by a family of JmjC domain-containing proteins. Nature 2006; 439: 811-6.
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
Zhang, Y.7
-
27
-
-
36049022778
-
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
-
Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 2007; 450: 309-13.
-
(2007)
Nature
, vol.450
, pp. 309-313
-
-
Frescas, D.1
Guardavaccaro, D.2
Bassermann, F.3
Koyama-Nasu, R.4
Pagano, M.5
-
28
-
-
33947244845
-
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
-
Yamane K, Tateishi K, Klose RJ, Fang J, Fabrizio LA, Erdjument-Bromage H, Taylor-Papadimitriou J, Tempst P, Zhang Y. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell 2007; 25: 801-12.
-
(2007)
Mol Cell
, vol.25
, pp. 801-812
-
-
Yamane, K.1
Tateishi, K.2
Klose, R.J.3
Fang, J.4
Fabrizio, L.A.5
Erdjument-Bromage, H.6
Taylor-Papadimitriou, J.7
Tempst, P.8
Zhang, Y.9
-
29
-
-
33847401344
-
The retinoblastoma binding protein RBP2 is an H3K4 demethylase
-
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 2007; 128: 889-900.
-
(2007)
Cell
, vol.128
, pp. 889-900
-
-
Klose, R.J.1
Yan, Q.2
Tothova, Z.3
Yamane, K.4
Erdjument-Bromage, H.5
Tempst, P.6
Gilliland, D.G.7
Zhang, Y.8
Kaelin Jr., W.G.9
-
30
-
-
35348993743
-
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
-
Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 2007; 318: 447-50.
-
(2007)
Science
, vol.318
, pp. 447-450
-
-
Lee, M.G.1
Villa, R.2
Trojer, P.3
Norman, J.4
Yan, K.P.5
Reinberg, D.6
Di Croce, L.7
Shiekhattar, R.8
-
31
-
-
77954954200
-
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
-
Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 2010; 466: 508-12.
-
(2010)
Nature
, vol.466
, pp. 508-512
-
-
Liu, W.1
Tanasa, B.2
Tyurina, O.V.3
Zhou, T.Y.4
Gassmann, R.5
Liu, W.T.6
Ohgi, K.A.7
Benner, C.8
Garcia-Bassets, I.9
Aggarwal, A.K.10
Desai, A.11
Dorrestein, P.C.12
Glass, C.K.13
Rosenfeld, M.G.14
-
32
-
-
0034640295
-
Jumonji, a nuclear protein that is necessary for normal heart development
-
Lee Y, Song AJ, Baker R, Micales B, Conway SJ, Lyons GE. Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res 2000; 86: 932-8.
-
(2000)
Circ Res
, vol.86
, pp. 932-938
-
-
Lee, Y.1
Song, A.J.2
Baker, R.3
Micales, B.4
Conway, S.J.5
Lyons, G.E.6
-
33
-
-
35948993829
-
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
-
Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 2007; 450: 119-23.
-
(2007)
Nature
, vol.450
, pp. 119-123
-
-
Okada, Y.1
Scott, G.2
Ray, M.K.3
Mishina, Y.4
Zhang, Y.5
-
34
-
-
68049095260
-
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice
-
Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells 2009; 14: 991-1001.
-
(2009)
Genes Cells
, vol.14
, pp. 991-1001
-
-
Inagaki, T.1
Tachibana, M.2
Magoori, K.3
Kudo, H.4
Tanaka, T.5
Okamura, M.6
Naito, M.7
Kodama, T.8
Shinkai, Y.9
Sakai, J.10
-
35
-
-
77449121100
-
Jmjd1a demethylase-regulated histone modification is essential for cAMPresponse element modulator-regulated gene expression and spermatogenesis
-
Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J. Jmjd1a demethylase-regulated histone modification is essential for cAMPresponse element modulator-regulated gene expression and spermatogenesis. J Biol Chem 2010; 285: 2758-70.
-
(2010)
J Biol Chem
, vol.285
, pp. 2758-2770
-
-
Liu, Z.1
Zhou, S.2
Liao, L.3
Chen, X.4
Meistrich, M.5
Xu, J.6
-
36
-
-
79957892087
-
The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice
-
Zhang QJ, Chen HZ, Wang L, Liu DP, Hill JA, Liu ZP. The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest 2011; 121: 2447-56.
-
(2011)
J Clin Invest
, vol.121
, pp. 2447-2456
-
-
Zhang, Q.J.1
Chen, H.Z.2
Wang, L.3
Liu, D.P.4
Hill, J.A.5
Liu, Z.P.6
-
37
-
-
79958217709
-
The testisenriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility
-
Iwamori N, Zhao M, Meistrich ML, Matzuk MM. The testisenriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod 2011; 84: 1225-34.
-
(2011)
Biol Reprod
, vol.84
, pp. 1225-1234
-
-
Iwamori, N.1
Zhao, M.2
Meistrich, M.L.3
Matzuk, M.M.4
-
38
-
-
79955019522
-
PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells
-
Catchpole S, Spencer-Dene B, Hall D, Santangelo S, Rosewell I, Guenatri M, Beatson R, Scibetta AG, Burchell JM, Taylor-Papadimitriou J. PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. Int J Oncol 2011; 38: 1267-77.
-
(2011)
Int J Oncol
, vol.38
, pp. 1267-1277
-
-
Catchpole, S.1
Spencer-Dene, B.2
Hall, D.3
Santangelo, S.4
Rosewell, I.5
Guenatri, M.6
Beatson, R.7
Scibetta, A.G.8
Burchell, J.M.9
Taylor-Papadimitriou, J.10
-
39
-
-
81255160602
-
Jarid1b targets genes regulating development and is involved in neural differentiation
-
Schmitz SU, Albert M, Malatesta M, Morey L, Johansen JV, Bak M, Tommerup N, Abarrategui I, Helin K. Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J 2011; 30: 4586-600.
-
(2011)
EMBO J
, vol.30
, pp. 4586-4600
-
-
Schmitz, S.U.1
Albert, M.2
Malatesta, M.3
Morey, L.4
Johansen, J.V.5
Bak, M.6
Tommerup, N.7
Abarrategui, I.8
Helin, K.9
-
40
-
-
84860215207
-
Molecular mechanisms and potential functions of histone demethylases
-
Kooistra SM, Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012; 13: 297-311.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 297-311
-
-
Kooistra, S.M.1
Helin, K.2
-
41
-
-
77955085896
-
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
-
May 31. [Epub ahead of print]
-
Mantri M, Krojer T, Bagg EA, Webby CA, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. J Mol Biol. 2010 May 31. [Epub ahead of print].
-
(2010)
J Mol Biol.
-
-
Mantri, M.1
Krojer, T.2
Bagg, E.A.3
Webby, C.A.4
Butler, D.S.5
Kochan, G.6
Kavanagh, K.L.7
Oppermann, U.8
McDonough, M.A.9
Schofield, C.J.10
-
42
-
-
23044433837
-
The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal
-
Bose J, Gruber AD, Helming L, Schiebe S, Wegener I, Hafner M, Beales M, Köntgen F, Lengeling A. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. J Biol 2004; 3: 15.
-
(2004)
J Biol
, vol.3
, pp. 15
-
-
Bose, J.1
Gruber, A.D.2
Helming, L.3
Schiebe, S.4
Wegener, I.5
Hafner, M.6
Beales, M.7
Köntgen, F.8
Lengeling, A.9
-
43
-
-
0345374586
-
Phosphatidylserine receptor is required for clearance of apoptotic cells
-
Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 2003; 302: 1560-3.
-
(2003)
Science
, vol.302
, pp. 1560-1563
-
-
Li, M.O.1
Sarkisian, M.R.2
Mehal, W.Z.3
Rakic, P.4
Flavell, R.A.5
-
44
-
-
79951855952
-
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly
-
Fukuda T, Tokunaga A, Sakamoto R, Yoshida N. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci 2011; 46: 614-24.
-
(2011)
Mol Cell Neurosci
, vol.46
, pp. 614-624
-
-
Fukuda, T.1
Tokunaga, A.2
Sakamoto, R.3
Yoshida, N.4
-
45
-
-
55549147132
-
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15 (Ink4b)
-
He J, Kallin EM, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15 (Ink4b). Nat Struct Mol Biol 2008; 15: 1169-75.
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 1169-1175
-
-
He, J.1
Kallin, E.M.2
Tsukada, Y.3
Zhang, Y.4
-
46
-
-
33746569501
-
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
-
Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J 2006; 25: 3422-31.
-
(2006)
EMBO J
, vol.25
, pp. 3422-3431
-
-
Suzuki, T.1
Minehata, K.2
Akagi, K.3
Jenkins, N.A.4
Copeland, N.G.5
-
47
-
-
84873343056
-
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs
-
Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N. KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest 2013; 123: 727-39.
-
(2013)
J Clin Invest
, vol.123
, pp. 727-739
-
-
Tzatsos, A.1
Paskaleva, P.2
Ferrari, F.3
Deshpande, V.4
Stoykova, S.5
Contino, G.6
Wong, K.K.7
Lan, F.8
Trojer, P.9
Park, P.J.10
Bardeesy, N.11
-
48
-
-
84890060286
-
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling
-
Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest 2013; 123: 5231-46.
-
(2013)
J Clin Invest
, vol.123
, pp. 5231-5246
-
-
Wagner, K.W.1
Alam, H.2
Dhar, S.S.3
Giri, U.4
Li, N.5
Wei, Y.6
Giri, D.7
Cascone, T.8
Kim, J.H.9
Ye, Y.10
Multani, A.S.11
Chan, C.H.12
Erez, B.13
Saigal, B.14
Chung, J.15
Lin, H.K.16
Wu, X.17
Hung, M.C.18
Heymach, J.V.19
Lee, M.G.20
more..
-
49
-
-
84896291131
-
Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells
-
Dhar SS, Alam H, Li N, Wagner KW, Chung J, Ahn YW, Lee MG. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem 2014; 289: 7483-96.
-
(2014)
J Biol Chem
, vol.289
, pp. 7483-7496
-
-
Dhar, S.S.1
Alam, H.2
Li, N.3
Wagner, K.W.4
Chung, J.5
Ahn, Y.W.6
Lee, M.G.7
-
50
-
-
82355171922
-
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
-
Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem 2011; 286: 41616-25.
-
(2011)
J Biol Chem
, vol.286
, pp. 41616-41625
-
-
Hillringhaus, L.1
Yue, W.W.2
Rose, N.R.3
Ng, S.S.4
Gileadi, C.5
Loenarz, C.6
Bello, S.H.7
Bray, J.E.8
Schofield, C.J.9
Oppermann, U.10
-
51
-
-
84877861510
-
KDM4/JMJD2 histone demethylases: Epigenetic regulators in cancer cells
-
Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res 2013; 73: 2936-42.
-
(2013)
Cancer Res
, vol.73
, pp. 2936-2942
-
-
Berry, W.L.1
Janknecht, R.2
-
52
-
-
22544465244
-
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)
-
Zhang D, Yoon HG, Wong J. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol Cell Biol 2005; 25: 6404-14.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6404-6414
-
-
Zhang, D.1
Yoon, H.G.2
Wong, J.3
-
53
-
-
23344436787
-
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein
-
Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem 2005; 280: 28507-18.
-
(2005)
J Biol Chem
, vol.280
, pp. 28507-28518
-
-
Gray, S.G.1
Iglesias, A.H.2
Lizcano, F.3
Villanueva, R.4
Camelo, S.5
Jingu, H.6
Teh, B.T.7
Koibuchi, N.8
Chin, W.W.9
Kokkotou, E.10
Dangond, F.11
-
55
-
-
79956291600
-
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
-
Shi L, Sun L, Li Q, Liang J, Yu W, Yi X, Yang X, Li Y, Han X, Zhang Y, Xuan C, Yao Z, Shang Y. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci USA 2011; 108: 7541-6.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 7541-7546
-
-
Shi, L.1
Sun, L.2
Li, Q.3
Liang, J.4
Yu, W.5
Yi, X.6
Yang, X.7
Li, Y.8
Han, X.9
Zhang, Y.10
Xuan, C.11
Yao, Z.12
Shang, Y.13
-
56
-
-
84877616497
-
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis
-
ra28 1-13
-
Ding X, Pan H, Li J, Zhong Q, Chen X, Dry SM, Wang C-Y. Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis. Science Signal 2013; 6: ra28 1-13, S0-5.
-
(2013)
Science Signal
, vol.6
-
-
Ding, X.1
Pan, H.2
Li, J.3
Zhong, Q.4
Chen, X.5
Dry, S.M.6
Wang, C.-Y.7
-
57
-
-
84870463217
-
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5
-
Mallette FA, Richard S. JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. Cell Rep 2012; 2: 1233-43.
-
(2012)
Cell Rep
, vol.2
, pp. 1233-1243
-
-
Mallette, F.A.1
Richard, S.2
-
58
-
-
72449186524
-
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
-
Liu G, Bollig-Fischer A, Kreike B, van de Vijver MJ, Abrams J, Ethier SP, Yang Z-Q. Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene 2009; 28: 4491-500.
-
(2009)
Oncogene
, vol.28
, pp. 4491-4500
-
-
Liu, G.1
Bollig-Fischer, A.2
Kreike, B.3
Van De-Vijver, M.J.4
Abrams, J.5
Ethier, S.P.6
Yang, Z.-Q.7
-
59
-
-
33646826162
-
Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C
-
Italiano A, Attias R, Aurias A, Perot G, Burel-Vandenbos F, Otto J, Venissac N, Pedeutour F. Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C. Cancer Genet Cytogenet 2006; 167: 122-30.
-
(2006)
Cancer Genet Cytogenet
, vol.167
, pp. 122-130
-
-
Italiano, A.1
Attias, R.2
Aurias, A.3
Perot, G.4
Burel-Vandenbos, F.5
Otto, J.6
Venissac, N.7
Pedeutour, F.8
-
60
-
-
58149198591
-
Mucosa-associated lymphoid tissue lymphoma: Novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3
-
Vinatzer U, Gollinger M, Mullauer L, Raderer M, Chott A, Streubel B. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. Clin Cancer Res 2008; 14: 6426-31.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6426-6431
-
-
Vinatzer, U.1
Gollinger, M.2
Mullauer, L.3
Raderer, M.4
Chott, A.5
Streubel, B.6
-
61
-
-
0034282790
-
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines
-
Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res 2000; 60: 4735-9.
-
(2000)
Cancer Res
, vol.60
, pp. 4735-4739
-
-
Yang, Z.Q.1
Imoto, I.2
Fukuda, Y.3
Pimkhaokham, A.4
Shimada, Y.5
Imamura, M.6
Sugano, S.7
Nakamura, Y.8
Inazawa, J.9
-
62
-
-
84890283718
-
JMJD2B promotes epithelial-mesenchymal transition by cooperating with beta-catenin and enhances gastric cancer metastasis
-
Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J. JMJD2B promotes epithelial-mesenchymal transition by cooperating with beta-catenin and enhances gastric cancer metastasis. Clin Cancer Res 2013; 19: 6419-29.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6419-6429
-
-
Zhao, L.1
Li, W.2
Zang, W.3
Liu, Z.4
Xu, X.5
Yu, H.6
Yang, Q.7
Jia, J.8
-
63
-
-
84894358412
-
Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
-
Chen L, Fu L, Kong X, Xu J, Wang Z, Ma X, Akiyama Y, Chen Y, Fang J. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer. Br J Cancer 2014; 110: 1014-26.
-
(2014)
Br J Cancer
, vol.110
, pp. 1014-1026
-
-
Chen, L.1
Fu, L.2
Kong, X.3
Xu, J.4
Wang, Z.5
Ma, X.6
Akiyama, Y.7
Chen, Y.8
Fang, J.9
-
64
-
-
78650012116
-
Cooperative epigenetic modulation by cancer amplicon genes
-
Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, Powell J, Maloney D, Thomas CJ, Möller P, Rosenwald A, Ott G, Muller-Hermelink HK, Savage K, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Weisenburger DD, Chan WC, Gascoyne RD, Levens D, Staudt LM. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell 2010; 18: 590-605.
-
(2010)
Cancer Cell
, vol.18
, pp. 590-605
-
-
Rui, L.1
Emre, N.C.2
Kruhlak, M.J.3
Chung, H.J.4
Steidl, C.5
Slack, G.6
Wright, G.W.7
Lenz, G.8
Ngo, V.N.9
Shaffer, A.L.10
Xu, W.11
Zhao, H.12
Yang, Y.13
Lamy, L.14
Davis, R.E.15
Xiao, W.16
Powell, J.17
Maloney, D.18
Thomas, C.J.19
Möller, P.20
Rosenwald, A.21
Ott, G.22
Muller-Hermelink, H.K.23
Savage, K.24
Connors, J.M.25
Rimsza, L.M.26
Campo, E.27
Jaffe, E.S.28
Delabie, J.29
Smeland, E.B.30
Weisenburger, D.D.31
Chan, W.C.32
Gascoyne, R.D.33
Levens, D.34
Staudt, L.M.35
more..
-
65
-
-
34547688895
-
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase
-
Couture JF, Collazo E, Ortiz-Tello PA, Brunzelle JS, Trievel RC. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol 2007; 14: 689-95.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 689-695
-
-
Couture, J.F.1
Collazo, E.2
Ortiz-Tello, P.A.3
Brunzelle, J.S.4
Trievel, R.C.5
-
66
-
-
16544389546
-
Identification and characterization of JMJD2 family genes in silico
-
Katoh M, Katoh M. Identification and characterization of JMJD2 family genes in silico. Int J Oncol 2004; 24: 1623-8.
-
(2004)
Int J Oncol
, vol.24
, pp. 1623-1628
-
-
Katoh, M.1
Katoh, M.2
-
67
-
-
84861429489
-
Cell-type-specific control of enhancer activity by H3K9 trimethylation
-
Zhu Y, van Essen D, Saccani S. Cell-type-specific control of enhancer activity by H3K9 trimethylation. Mol Cell 2012; 46: 408-23.
-
(2012)
Mol Cell
, vol.46
, pp. 408-423
-
-
Zhu, Y.1
Van Essen, D.2
Saccani, S.3
-
68
-
-
77449088946
-
The histone demethylase RBP2 is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells
-
Zeng J, Ge Z, Wang L, Li Q, Wang N, Bjorkholm M, Jia J, Xu D. The histone demethylase RBP2 is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 2010; 138: 981-92.
-
(2010)
Gastroenterology
, vol.138
, pp. 981-992
-
-
Zeng, J.1
Ge, Z.2
Wang, L.3
Li, Q.4
Wang, N.5
Bjorkholm, M.6
Jia, J.7
Xu, D.8
-
69
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010; 141: 69-80.
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
Quinlan, M.P.4
Takahashi, F.5
Maheswaran, S.6
McDermott, U.7
Azizian, N.8
Zou, L.9
Fischbach, M.A.10
Wong, K.K.11
Brandstetter, K.12
Wittner, B.13
Ramaswamy, S.14
Classon, M.15
Settleman, J.16
-
70
-
-
37649023563
-
JARID1B is a histone H3 lysine 4 demethylase upregulated in prostate cancer
-
Xiang Y, Zhu Z, Han G, Ye X, Xu B, Peng Z, Ma Y, Yu Y, Lin H, Chen AP, Chen CD. JARID1B is a histone H3 lysine 4 demethylase upregulated in prostate cancer. Proc Natl Acad Sci USA 2007; 104: 19226-31.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19226-19231
-
-
Xiang, Y.1
Zhu, Z.2
Han, G.3
Ye, X.4
Xu, B.5
Peng, Z.6
Ma, Y.7
Yu, Y.8
Lin, H.9
Chen, A.P.10
Chen, C.D.11
-
71
-
-
84893591021
-
Deregulated expression of selected histone methylases and demethylases in prostate carcinoma
-
Vieira FQ, Costa-Pinheiro P, Ramalho-Carvalho J, Pereira A, Menezes FD, Antunes L, Carneiro I, Oliveira J, Henrique R, Jerónimo C. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Endocr Relat Cancer 2014; 21: 51-61.
-
(2014)
Endocr Relat Cancer
, vol.21
, pp. 51-61
-
-
Vieira, F.Q.1
Costa-Pinheiro, P.2
Ramalho-Carvalho, J.3
Pereira, A.4
Menezes, F.D.5
Antunes, L.6
Carneiro, I.7
Oliveira, J.8
Henrique, R.9
Jerónimo, C.10
-
72
-
-
84888273443
-
Deletion of an X-inactivation boundary disrupts adjacent gene silencing
-
Horvath LM, Li N, Carrel L. Deletion of an X-inactivation boundary disrupts adjacent gene silencing. PLoS Genet 2013; 9: e1003952.
-
(2013)
PLoS Genet
, vol.9
-
-
Horvath, L.M.1
Li, N.2
Carrel, L.3
-
73
-
-
77649248469
-
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression
-
Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci USA 2010; 107: 3752-7.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3752-3757
-
-
Smith, J.A.1
White, E.A.2
Sowa, M.E.3
Powell, M.L.4
Ottinger, M.5
Harper, J.W.6
Howley, P.M.7
-
74
-
-
57349176997
-
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia
-
Abidi FE, Holloway L, Moore CA, Weaver DD, Simensen RJ, Stevenson RE, Rogers RC, Schwartz CE. Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. J Med Genet 2008; 45: 787-93.
-
(2008)
J Med Genet
, vol.45
, pp. 787-793
-
-
Abidi, F.E.1
Holloway, L.2
Moore, C.A.3
Weaver, D.D.4
Simensen, R.J.5
Stevenson, R.E.6
Rogers, R.C.7
Schwartz, C.E.8
-
75
-
-
77149178699
-
Identification and characterization of two novel JARID1C mutations: Suggestion of an emerging genotypephenotype correlation
-
Rujirabanjerd S, Nelson J, Tarpey PS, Hackett A, Edkins S, Raymond FL, Schwartz CE, Turner G, Iwase S, Shi Y, Futreal PA, Stratton MR, Gecz J. Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotypephenotype correlation. Eur J Hum Genet 2010; 18: 330-5.
-
(2010)
Eur J Hum Genet
, vol.18
, pp. 330-335
-
-
Rujirabanjerd, S.1
Nelson, J.2
Tarpey, P.S.3
Hackett, A.4
Edkins, S.5
Raymond, F.L.6
Schwartz, C.E.7
Turner, G.8
Iwase, S.9
Shi, Y.10
Futreal, P.A.11
Stratton, M.R.12
Gecz, J.13
-
76
-
-
33646045352
-
A novel mutation in JARID1C gene associated with mental retardation
-
Santos C, Rodriguez-Revenga L, Madrigal I, Badenas C, Pineda M, Mila M. A novel mutation in JARID1C gene associated with mental retardation. Eur J Hum Genet 2006; 14: 583-6.
-
(2006)
Eur J Hum Genet
, vol.14
, pp. 583-586
-
-
Santos, C.1
Rodriguez-Revenga, L.2
Madrigal, I.3
Badenas, C.4
Pineda, M.5
Mila, M.6
-
77
-
-
77953383178
-
A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C
-
Jensen LR, Bartenschlager H, Rujirabanjerd S, Tzschach A, Numann A, Janecke AR, Spörle R, Stricker S, Raynaud M, Nelson J, Hackett A, Fryns JP, Chelly J, de Brouwer AP, Hamel B, Gecz J, Ropers HH, Kuss AW. A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C. Pathogenetics 2010; 3: 2.
-
(2010)
Pathogenetics
, vol.3
, pp. 2
-
-
Jensen, L.R.1
Bartenschlager, H.2
Rujirabanjerd, S.3
Tzschach, A.4
Numann, A.5
Janecke, A.R.6
Spörle, R.7
Stricker, S.8
Raynaud, M.9
Nelson, J.10
Hackett, A.11
Fryns, J.P.12
Chelly, J.13
De Brouwer, A.P.14
Hamel, B.15
Gecz, J.16
Ropers, H.H.17
Kuss, A.W.18
-
78
-
-
33847219608
-
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
-
Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol 2007; 27: 1889-903.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1889-1903
-
-
Issaeva, I.1
Zonis, Y.2
Rozovskaia, T.3
Orlovsky, K.4
Croce, C.M.5
Nakamura, T.6
Mazo, A.7
Eisenbach, L.8
Canaani, E.9
-
79
-
-
84896536423
-
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
-
Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res 2014; 74: 1705-17.
-
(2014)
Cancer Res
, vol.74
, pp. 1705-1717
-
-
Kim, J.H.1
Sharma, A.2
Dhar, S.S.3
Lee, S.H.4
Gu, B.5
Chan, C.H.6
Lin, H.K.7
Lee, M.G.8
-
80
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009; 41: 521-3.
-
(2009)
Nat Genet
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
Edkins, S.7
Hardy, C.8
O'Meara, S.9
Teague, J.10
Butler, A.11
Hinton, J.12
Latimer, C.13
Andrews, J.14
Barthorpe, S.15
Beare, D.16
Buck, G.17
Campbell, P.J.18
Cole, J.19
Forbes, S.20
Jia, M.21
Jones, D.22
Kok, C.Y.23
Leroy, C.24
Lin, M.L.25
McBride, D.J.26
Maddison, M.27
Maquire, S.28
McLay, K.29
Menzies, A.30
Mironenko, T.31
Mulderrig, L.32
Mudie, L.33
Pleasance, E.34
Shepherd, R.35
Smith, R.36
Stebbings, L.37
Stephens, P.38
Tang, G.39
Tarpey, P.S.40
Turner, R.41
Turrell, K.42
Varian, J.43
West, S.44
Widaa, S.45
Wray, P.46
Collins, V.P.47
Ichimura, K.48
Law, S.49
Wong, J.50
Yuen, S.T.51
Leung, S.Y.52
Tonon, G.53
Depinho, R.A.54
Tai, Y.T.55
Anderson, K.C.56
Kahnoski, R.J.57
Massie, A.58
Khoo, S.K.59
Teh, B.T.60
Stratton, M.R.61
Futreal, P.A.62
more..
-
81
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Butler A, Davies H, Edkins S, Hardy C, Latimer C, Teague J, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Forbes S, Jia M, Jones D, Knott H, Kok CY, Lau KW, Leroy C, Lin ML, McBride DJ, Maddison M, Maguire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, O'Meara S, Pleasance E, Rajasingham A, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turrell K, Dykema KJ, Khoo SK, Petillo D, Wondergem B, Anema J, Kahnoski RJ, Teh BT, Stratton MR, Futreal PA. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010; 463: 360-3.
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
Butler, A.7
Davies, H.8
Edkins, S.9
Hardy, C.10
Latimer, C.11
Teague, J.12
Andrews, J.13
Barthorpe, S.14
Beare, D.15
Buck, G.16
Campbell, P.J.17
Forbes, S.18
Jia, M.19
Jones, D.20
Knott, H.21
Kok, C.Y.22
Lau, K.W.23
Leroy, C.24
Lin, M.L.25
McBride, D.J.26
Maddison, M.27
Maguire, S.28
McLay, K.29
Menzies, A.30
Mironenko, T.31
Mulderrig, L.32
Mudie, L.33
O'Meara, S.34
Pleasance, E.35
Rajasingham, A.36
Shepherd, R.37
Smith, R.38
Stebbings, L.39
Stephens, P.40
Tang, G.41
Tarpey, P.S.42
Turrell, K.43
Dykema, K.J.44
Khoo, S.K.45
Petillo, D.46
Wondergem, B.47
Anema, J.48
Kahnoski, R.J.49
Teh, B.T.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
82
-
-
80054787805
-
Targeting histone demethylases: A new avenue for the fight against cancer
-
Rotili D, Mai A. Targeting histone demethylases: a new avenue for the fight against cancer. Genes Cancer 2011; 2: 663-79.
-
(2011)
Genes Cancer
, vol.2
, pp. 663-679
-
-
Rotili, D.1
Mai, A.2
-
83
-
-
74949142886
-
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
-
Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res 2010; 20: 36-44.
-
(2010)
Genome Res
, vol.20
, pp. 36-44
-
-
Fei, T.1
Xia, K.2
Li, Z.3
Zhou, B.4
Zhu, S.5
Chen, H.6
Zhang, J.7
Chen, Z.8
Xiao, H.9
Han, J.D.10
Chen, Y.G.11
-
84
-
-
35348826654
-
JMJD3 is a histone H3K27 demethylase
-
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD. JMJD3 is a histone H3K27 demethylase. Cell Res 2007; 17: 850-7.
-
(2007)
Cell Res
, vol.17
, pp. 850-857
-
-
Xiang, Y.1
Zhu, Z.2
Han, G.3
Lin, H.4
Xu, L.5
Chen, C.D.6
-
85
-
-
84862966741
-
Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis
-
Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, Shibuya M. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci USA 2011; 108: 20725-9.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 20725-20729
-
-
Osawa, T.1
Muramatsu, M.2
Wang, F.3
Tsuchida, R.4
Kodama, T.5
Minami, T.6
Shibuya, M.7
-
86
-
-
84864014101
-
KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia
-
Kim JY, Kim KB, Eom GH, Choe N, Kee HJ, Son HJ, Oh ST, Kim DW, Pak JH, Baek HJ, Kook H, Hahn Y, Kook H, Chakravarti D, Seo SB. KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia. Mol Cell Biol 2012; 32: 2917-33.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2917-2933
-
-
Kim, J.Y.1
Kim, K.B.2
Eom, G.H.3
Choe, N.4
Kee, H.J.5
Son, H.J.6
Oh, S.T.7
Kim, D.W.8
Pak, J.H.9
Baek, H.J.10
Kook, H.11
Hahn, Y.12
Kook, H.13
Chakravarti, D.14
Seo, S.B.15
-
87
-
-
84876142888
-
Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation
-
Brauchle M, Yao Z, Arora R, Thigale S, Clay I, Inverardi B, Fletcher J, Taslimi P, Acker MG, Gerrits B, Voshol J, Bauer A, Schübeler D, Bouwmeester T, Ruffner H. Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One 2013; 8: e60549.
-
(2013)
PLoS One
, vol.8
-
-
Brauchle, M.1
Yao, Z.2
Arora, R.3
Thigale, S.4
Clay, I.5
Inverardi, B.6
Fletcher, J.7
Taslimi, P.8
Acker, M.G.9
Gerrits, B.10
Voshol, J.11
Bauer, A.12
Schübeler, D.13
Bouwmeester, T.14
Ruffner, H.15
-
88
-
-
33947608608
-
A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR
-
Wolf SS, Patchev VK, Obendorf M. A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. Arch Biochem Biophys 2007; 460: 56-66.
-
(2007)
Arch Biochem Biophys
, vol.460
, pp. 56-66
-
-
Wolf, S.S.1
Patchev, V.K.2
Obendorf, M.3
-
89
-
-
84897550318
-
ShRNA screening identifies JMJD1C as being required for leukemia maintenance
-
Sroczynska P, Cruickshank VA, Bukowski JP, Miyagi S, Bagger FO, Walfridsson J, Schuster MB, Porse B, Helin K. shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood 2014; 123: 1870-82.
-
(2014)
Blood
, vol.123
, pp. 1870-1882
-
-
Sroczynska, P.1
Cruickshank, V.A.2
Bukowski, J.P.3
Miyagi, S.4
Bagger, F.O.5
Walfridsson, J.6
Schuster, M.B.7
Porse, B.8
Helin, K.9
-
91
-
-
67650072604
-
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
-
Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR 3rd, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science 2009; 325: 90-3.
-
(2009)
Science
, vol.325
, pp. 90-93
-
-
Webby, C.J.1
Wolf, A.2
Gromak, N.3
Dreger, M.4
Kramer, H.5
Kessler, B.6
Nielsen, M.L.7
Schmitz, C.8
Butler, D.S.9
Yates III, J.R.10
Delahunty, C.M.11
Hahn, P.12
Lengeling, A.13
Mann, M.14
Proudfoot, N.J.15
Schofield, C.J.16
Böttger, A.17
-
92
-
-
84861330841
-
JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer
-
Lee YF, Miller LD, Chan XB, Black MA, Pang B, Ong CW, Salto-Tellez M, Liu ET, Desai KV. JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer. Breast Cancer Res 2012; 14: R85.
-
(2012)
Breast Cancer Res
, vol.14
-
-
Lee, Y.F.1
Miller, L.D.2
Chan, X.B.3
Black, M.A.4
Pang, B.5
Ong, C.W.6
Salto-Tellez, M.7
Liu, E.T.8
Desai, K.V.9
-
93
-
-
84859099457
-
Histone demethylase JMJD5 is essential for embryonic development
-
Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun 2012; 420: 61-5.
-
(2012)
Biochem Biophys Res Commun
, vol.420
, pp. 61-65
-
-
Oh, S.1
Janknecht, R.2
-
94
-
-
84885459160
-
Structure of the JmjC-domain-containing protein JMJD5
-
Wang H, Zhou X, Wu M, Wang C, Zhang X, Tao Y, Chen N, Zang J. Structure of the JmjC-domain-containing protein JMJD5. Acta Crystallogr D Biol Crystallogr 2013; 69: 1911-20.
-
(2013)
Acta Crystallogr D Biol Crystallogr
, vol.69
, pp. 1911-1920
-
-
Wang, H.1
Zhou, X.2
Wu, M.3
Wang, C.4
Zhang, X.5
Tao, Y.6
Chen, N.7
Zang, J.8
-
95
-
-
84866912634
-
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
-
Shpargel KB, Sengoku T, Yokoyama S, Magnuson T. UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet 2012; 8: e1002964.
-
(2012)
PLoS Genet
, vol.8
-
-
Shpargel, K.B.1
Sengoku, T.2
Yokoyama, S.3
Magnuson, T.4
-
96
-
-
84865640904
-
Establishment of mouse teratocarcinomas stem cells line and screening genes responsible for malignancy
-
Liu T, Wang Y, Peng X, Zhang L, Cheng J, Jin H, Wu M, Qian Q. Establishment of mouse teratocarcinomas stem cells line and screening genes responsible for malignancy. PLoS One 2012; 7: e43955.
-
(2012)
PLoS One
, vol.7
-
-
Liu, T.1
Wang, Y.2
Peng, X.3
Zhang, L.4
Cheng, J.5
Jin, H.6
Wu, M.7
Qian, Q.8
-
97
-
-
84891860126
-
Transcriptional activation of mina by sp1/3 factors
-
Lian S, Potula HH, Pillai MR, Van Stry M, Koyanagi M, Chung L, Watanabe M, Bix M. Transcriptional activation of mina by sp1/3 factors. PLoS One 2013; 8: e80638.
-
(2013)
PLoS One
, vol.8
-
-
Lian, S.1
Potula, H.H.2
Pillai, M.R.3
Van Stry, M.4
Koyanagi, M.5
Chung, L.6
Watanabe, M.7
Bix, M.8
-
98
-
-
75649143350
-
Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase
-
Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J 2010; 29: 68-79.
-
(2010)
EMBO J
, vol.29
, pp. 68-79
-
-
Sinha, K.M.1
Yasuda, H.2
Coombes, M.M.3
Dent, S.Y.4
De Crombrugghe, B.5
-
99
-
-
0042334606
-
Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t (2; 3) (q35; Q21)
-
Bodmer D, Schepens M, Eleveld MJ, Schoenmakers EF, Geurts van Kessel A. Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t (2; 3) (q35; q21). Genes Chromosomes Cancer 2003; 38: 107-16.
-
(2003)
Genes Chromosomes Cancer
, vol.38
, pp. 107-116
-
-
Bodmer, D.1
Schepens, M.2
Eleveld, M.J.3
Schoenmakers, E.F.4
Geurts Van-Kessel, A.5
-
100
-
-
84896691188
-
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells
-
Walters ZS, Villarejo-Balcells B, Olmos D, Buist TW, Missiaglia E, Allen R, Al-Lazikani B, Garrett MD, Blagg J, Shipley J. JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells. Oncogene 2014; 33: 1148-57.
-
(2014)
Oncogene
, vol.33
, pp. 1148-1157
-
-
Walters, Z.S.1
Villarejo-Balcells, B.2
Olmos, D.3
Buist, T.W.4
Missiaglia, E.5
Allen, R.6
Al-Lazikani, B.7
Garrett, M.D.8
Blagg, J.9
Shipley, J.10
-
101
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep 2011; 12: 463-9.
-
(2011)
EMBO Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
Leung, I.K.7
Li, X.S.8
Woon, E.C.9
Yang, M.10
McDonough, M.A.11
King, O.N.12
Clifton, I.J.13
Klose, R.J.14
Claridge, T.D.15
Ratcliffe, P.J.16
Schofield, C.J.17
Kawamura, A.18
-
102
-
-
84859906199
-
Identification of catechols as histone-lysine demethylase inhibitors
-
Nielsen AL, Kristensen LH, Stephansen KB, Kristensen JB, Helgstrand C, Lees M, Cloos P, Helin K, Gajhede M, Olsen L. Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett 2012; 586: 1190-4.
-
(2012)
FEBS Lett
, vol.586
, pp. 1190-1194
-
-
Nielsen, A.L.1
Kristensen, L.H.2
Stephansen, K.B.3
Kristensen, J.B.4
Helgstrand, C.5
Lees, M.6
Cloos, P.7
Helin, K.8
Gajhede, M.9
Olsen, L.10
-
103
-
-
77649224314
-
Selective inhibitors of the JMJD2 histone demethylases: Combined nondenaturing mass spectrometric screening and crystallographic approaches
-
Rose NR, Woon EC, Kingham GL, King ON, Mecinovic J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem 2010; 53: 1810-8.
-
(2010)
J Med Chem
, vol.53
, pp. 1810-1818
-
-
Rose, N.R.1
Woon, E.C.2
Kingham, G.L.3
King, O.N.4
Mecinovic, J.5
Clifton, I.J.6
Ng, S.S.7
Talib-Hardy, J.8
Oppermann, U.9
McDonough, M.A.10
Schofield, C.J.11
-
104
-
-
77955345001
-
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors
-
Hamada S, Suzuki T, Mino K, Koseki K, Oehme F, Flamme I, Ozasa H, Itoh Y, Ogasawara D, Komaarashi H, Kato A, Tsumoto H, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem 2010; 53: 5629-38.
-
(2010)
J Med Chem
, vol.53
, pp. 5629-5638
-
-
Hamada, S.1
Suzuki, T.2
Mino, K.3
Koseki, K.4
Oehme, F.5
Flamme, I.6
Ozasa, H.7
Itoh, Y.8
Ogasawara, D.9
Komaarashi, H.10
Kato, A.11
Tsumoto, H.12
Nakagawa, H.13
Hasegawa, M.14
Sasaki, R.15
Mizukami, T.16
Miyata, N.17
-
105
-
-
70350315800
-
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn (II)
-
Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinovic J, Schofield CJ. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn (II). Chem Commun (Camb). 2009: 6376-8.
-
(2009)
Chem Commun (Camb)
, pp. 6376-6378
-
-
Sekirnik, R.1
Rose, N.R.2
Thalhammer, A.3
Seden, P.T.4
Mecinovic, J.5
Schofield, C.J.6
-
106
-
-
84857008823
-
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases
-
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed 2012; 51: 1631-4.
-
(2012)
Angew Chem Int Ed
, vol.51
, pp. 1631-1634
-
-
Woon, E.C.1
Tumber, A.2
Kawamura, A.3
Hillringhaus, L.4
Ge, W.5
Rose, N.R.6
Ma, J.H.7
Chan, M.C.8
Walport, L.J.9
Che, K.H.10
Ng, S.S.11
Marsden, B.D.12
Oppermann, U.13
McDonough, M.A.14
Schofield, C.J.15
-
107
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012; 488: 404-8.
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
Bantscheff, M.7
Bountra, C.8
Bridges, A.9
Diallo, H.10
Eberhard, D.11
Hutchinson, S.12
Jones, E.13
Katso, R.14
Leveridge, M.15
Mander, P.K.16
Mosley, J.17
Ramirez-Molina, C.18
Rowland, P.19
Schofield, C.J.20
Sheppard, R.J.21
Smith, J.E.22
Swales, C.23
Tanner, R.24
Thomas, P.25
more..
-
108
-
-
80455140217
-
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
-
Sengoku T, Yokoyama S. Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev 2011; 25: 2266-77.
-
(2011)
Genes Dev
, vol.25
, pp. 2266-2277
-
-
Sengoku, T.1
Yokoyama, S.2
-
109
-
-
84879215757
-
Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy
-
Giri NC, Passantino L, Sun H, Zoroddu MA, Costa M, Maroney MJ. Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy. Biochemistry 2013; 52: 4168-83.
-
(2013)
Biochemistry
, vol.52
, pp. 4168-4183
-
-
Giri, N.C.1
Passantino, L.2
Sun, H.3
Zoroddu, M.A.4
Costa, M.5
Maroney, M.J.6
-
110
-
-
84872130436
-
Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases
-
Krishnan S, Trievel RC. Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases. Structure 2013; 21: 98-108.
-
(2013)
Structure
, vol.21
, pp. 98-108
-
-
Krishnan, S.1
Trievel, R.C.2
-
111
-
-
84862777760
-
An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases
-
Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol 2012; 416: 319-27.
-
(2012)
J Mol Biol
, vol.416
, pp. 319-327
-
-
Upadhyay, A.K.1
Rotili, D.2
Han, J.W.3
Hu, R.4
Chang, Y.5
Labella, D.6
Zhang, X.7
Yoon, Y.S.8
Mai, A.9
Cheng, X.10
-
112
-
-
84889573275
-
Histone lysine demethylases as targets for anticancer therapy
-
Hojfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov 2013; 12: 917-30.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 917-930
-
-
Hojfeldt, J.W.1
Agger, K.2
Helin, K.3
-
113
-
-
84884997299
-
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity
-
Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem 2013; 56: 7222-31.
-
(2013)
J Med Chem
, vol.56
, pp. 7222-7231
-
-
Suzuki, T.1
Ozasa, H.2
Itoh, Y.3
Zhan, P.4
Sawada, H.5
Mino, K.6
Walport, L.7
Ohkubo, R.8
Kawamura, A.9
Yonezawa, M.10
Tsukada, Y.11
Tumber, A.12
Nakagawa, H.13
Hasegawa, M.14
Sasaki, R.15
Mizukami, T.16
Schofield, C.J.17
Miyata, N.18
-
114
-
-
84889595831
-
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
-
Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun 2013; 4: 2035.
-
(2013)
Nat Commun
, vol.4
, pp. 2035
-
-
Wang, L.1
Chang, J.2
Varghese, D.3
Dellinger, M.4
Kumar, S.5
Best, A.M.6
Ruiz, J.7
Bruick, R.8
Peña-Llopis, S.9
Xu, J.10
Babinski, D.J.11
Frantz, D.E.12
Brekken, R.A.13
Quinn, A.M.14
Simeonov, A.15
Easmon, J.16
Martinez, E.D.17
-
116
-
-
42149117769
-
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
-
Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci USA 2008; 105: 3368-73.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3368-3373
-
-
Zheng, X.1
Linke, S.2
Dias, J.M.3
Zheng, X.4
Gradin, K.5
Wallis, T.P.6
Hamilton, B.R.7
Gustafsson, M.8
Ruas, J.L.9
Wilkins, S.10
Bilton, R.L.11
Brismar, K.12
Whitelaw, M.L.13
Pereira, T.14
Gorman, J.J.15
Ericson, J.16
Peet, D.J.17
Lendahl, U.18
Poellinger, L.19
-
117
-
-
1642556829
-
Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer
-
Datta K, Li J, Bhattacharya R, Gasparian L, Wang E, Mukhopadhyay D. Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res 2004; 64: 456-62.
-
(2004)
Cancer Res
, vol.64
, pp. 456-462
-
-
Datta, K.1
Li, J.2
Bhattacharya, R.3
Gasparian, L.4
Wang, E.5
Mukhopadhyay, D.6
-
118
-
-
0001491660
-
UV-B irradiated cell lines execute programmed cell death in various forms
-
Hagenhofer M, Germaier H, Hohenadl C, Rohwer P, Kalden JR, Herrmann M. UV-B irradiated cell lines execute programmed cell death in various forms. Apoptosis 1998; 3: 123-32.
-
(1998)
Apoptosis
, vol.3
, pp. 123-132
-
-
Hagenhofer, M.1
Germaier, H.2
Hohenadl, C.3
Rohwer, P.4
Kalden, J.R.5
Herrmann, M.6
-
119
-
-
33646829674
-
The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells
-
Mitchell JE, Cvetanovic M, Tibrewal N, Patel V, Colamonici OR, Li MO, Flavell RA, Levine JS, Birge RB, Ucker DS. The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. J Biol Chem 2006; 281: 5718-25.
-
(2006)
J Biol Chem
, vol.281
, pp. 5718-5725
-
-
Mitchell, J.E.1
Cvetanovic, M.2
Tibrewal, N.3
Patel, V.4
Colamonici, O.R.5
Li, M.O.6
Flavell, R.A.7
Levine, J.S.8
Birge, R.B.9
Ucker, D.S.10
-
120
-
-
0031037455
-
Expression of transferrin receptors in endothelial cells transfected by electroporation
-
Heltianu C, Serban G, Alexandru V, Gafencu A, Simionescu N, Simionescu M. Expression of transferrin receptors in endothelial cells transfected by electroporation. Eur J Cell Biol 1997; 72: 79-89.
-
(1997)
Eur J Cell Biol
, vol.72
, pp. 79-89
-
-
Heltianu, C.1
Serban, G.2
Alexandru, V.3
Gafencu, A.4
Simionescu, N.5
Simionescu, M.6
-
121
-
-
79958797383
-
F-box protein 10, an NF-kappaB-dependent anti-apoptotic protein, regulates TRAILinduced apoptosis through modulating c-Fos/c-FLIP pathway
-
Ge R, Wang Z, Zeng Q, Xu X, Olumi AF. F-box protein 10, an NF-kappaB-dependent anti-apoptotic protein, regulates TRAILinduced apoptosis through modulating c-Fos/c-FLIP pathway. Cell Death Differ 2011; 18: 1184-95.
-
(2011)
Cell Death Differ
, vol.18
, pp. 1184-1195
-
-
Ge, R.1
Wang, Z.2
Zeng, Q.3
Xu, X.4
Olumi, A.F.5
-
122
-
-
76249100563
-
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65
-
Lu T, Jackson MW, Wang B, Yang M, Chance MR, Miyagi M, Gudkov AV, Stark GR. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci USA 2010; 107: 46-51.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 46-51
-
-
Lu, T.1
Jackson, M.W.2
Wang, B.3
Yang, M.4
Chance, M.R.5
Miyagi, M.6
Gudkov, A.V.7
Stark, G.R.8
-
123
-
-
66149135288
-
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
-
Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev 2009; 23: 1177-82.
-
(2009)
Genes Dev
, vol.23
, pp. 1177-1182
-
-
Barradas, M.1
Anderton, E.2
Acosta, J.C.3
Li, S.4
Banito, A.5
Rodriguez-Niedenfuhr, M.6
Maertens, G.7
Banck, M.8
Zhou, M.M.9
Walsh, M.J.10
Peters, G.11
Gil, J.12
-
124
-
-
79952114947
-
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells
-
Das ND, Jung KH, Chai YG. The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells. PLoS One 2010; 5: e9913.
-
(2010)
PLoS One
, vol.5
-
-
Das, N.D.1
Jung, K.H.2
Chai, Y.G.3
-
125
-
-
70350435962
-
Epigenetic regulation of the alternatively activated macrophage phenotype
-
Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF 4th, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 2009; 114: 3244-54.
-
(2009)
Blood
, vol.114
, pp. 3244-3254
-
-
Ishii, M.1
Wen, H.2
Corsa, C.A.3
Liu, T.4
Coelho, A.L.5
Allen, R.M.6
Carson, I.V.W.F.7
Cavassani, K.A.8
Li, X.9
Lukacs, N.W.10
Hogaboam, C.M.11
Dou, Y.12
Kunkel, S.L.13
-
126
-
-
33947375476
-
An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells
-
Hu LY, Tepper CG, Lo SH, Lin WC. An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells. Gene Exp 2006; 13: 179-89.
-
(2006)
Gene Exp
, vol.13
, pp. 179-189
-
-
Hu, L.Y.1
Tepper, C.G.2
Lo, S.H.3
Lin, W.C.4
-
127
-
-
77956634439
-
Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes
-
Dahle O, Kumar A, Kuehn MR. Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. Sci Signal 2010; 3: ra48.
-
(2010)
Sci Signal
, vol.3
-
-
Dahle, O.1
Kumar, A.2
Kuehn, M.R.3
-
128
-
-
79953666919
-
P53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation
-
Sola S, Xavier JM, Santos DM, Aranha MM, Morgado AL, Jepsen K, Rodrigues CM. p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One 2011; 6: e18421.
-
(2011)
PLoS One
, vol.6
-
-
Sola, S.1
Xavier, J.M.2
Santos, D.M.3
Aranha, M.M.4
Morgado, A.L.5
Jepsen, K.6
Rodrigues, C.M.7
-
129
-
-
33847381108
-
Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer
-
Suzuki C, Takahashi K, Hayama S, Ishikawa N, Kato T, Ito T, Tsuchiya E, Nakamura Y, Daigo Y. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. Mol Cancer Ther 2007; 6: 542-51.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 542-551
-
-
Suzuki, C.1
Takahashi, K.2
Hayama, S.3
Ishikawa, N.4
Kato, T.5
Ito, T.6
Tsuchiya, E.7
Nakamura, Y.8
Daigo, Y.9
-
130
-
-
0034596260
-
Jumonji is a nuclear protein that participates in the negative regulation of cell growth
-
Toyoda M, Kojima M, Takeuchi T. Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Biochem Biophys Res Commun 2000; 274: 332-6.
-
(2000)
Biochem Biophys Res Commun
, vol.274
, pp. 332-336
-
-
Toyoda, M.1
Kojima, M.2
Takeuchi, T.3
-
131
-
-
79955379525
-
Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
-
Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, Kubota M, Noda M, Ogawa S, Shirato H, Sato M, Suzuki-Migishima R, Hino T, Satoh Y, Kitagawa M, Takeuchi T. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development 2011; 138: 1771-82.
-
(2011)
Development
, vol.138
, pp. 1771-1782
-
-
Nakajima, K.1
Inagawa, M.2
Uchida, C.3
Okada, K.4
Tane, S.5
Kojima, M.6
Kubota, M.7
Noda, M.8
Ogawa, S.9
Shirato, H.10
Sato, M.11
Suzuki-Migishima, R.12
Hino, T.13
Satoh, Y.14
Kitagawa, M.15
Takeuchi, T.16
-
132
-
-
79955754376
-
Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
-
Mysliwiec MR, Bresnick EH, Lee Y. Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem 2011; 286: 17193-204.
-
(2011)
J Biol Chem
, vol.286
, pp. 17193-17204
-
-
Mysliwiec, M.R.1
Bresnick, E.H.2
Lee, Y.3
-
133
-
-
77949468885
-
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway
-
Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto R. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 2010; 9: 59.
-
(2010)
Mol Cancer
, vol.9
, pp. 59
-
-
Hayami, S.1
Yoshimatsu, M.2
Veerakumarasivam, A.3
Unoki, M.4
Iwai, Y.5
Tsunoda, T.6
Field, H.I.7
Kelly, J.D.8
Neal, D.E.9
Yamaue, H.10
Ponder, B.A.11
Nakamura, Y.12
Hamamoto, R.13
-
134
-
-
37449019096
-
Repression of Smad3 activity by histone demethylase SMCX/JARID1C
-
Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun 2008; 366: 563-7.
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 563-567
-
-
Kim, T.D.1
Shin, S.2
Janknecht, R.3
-
135
-
-
77954957901
-
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
-
Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature 2010; 466: 503-7.
-
(2010)
Nature
, vol.466
, pp. 503-507
-
-
Qi, H.H.1
Sarkissian, M.2
Hu, G.Q.3
Wang, Z.4
Bhattacharjee, A.5
Gordon, D.B.6
Gonzales, M.7
Lan, F.8
Ongusaha, P.P.9
Huarte, M.10
Yaghi, N.K.11
Lim, H.12
Garcia, B.A.13
Brizuela, L.14
Zhao, K.15
Roberts, T.M.16
Shi, Y.17
-
136
-
-
26844523484
-
Hairless triggers reactivation of hair growth by promoting Wnt signaling
-
Beaudoin GM, 3rd, Sisk JM, Coulombe PA, Thompson CC. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci USA 2005; 102: 14653-8.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14653-14658
-
-
Beaudoin III, G.M.1
Sisk, J.M.2
Coulombe, P.A.3
Thompson, C.C.4
-
137
-
-
45449110185
-
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
-
Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, Bührer C. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun 2008; 372: 892-7.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 892-897
-
-
Wellmann, S.1
Bettkober, M.2
Zelmer, A.3
Seeger, K.4
Faigle, M.5
Eltzschig, H.K.6
Bührer, C.7
-
138
-
-
78649787015
-
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells
-
Chen H, Kluz T, Zhang R, Costa M. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis 2010; 31: 2136-44.
-
(2010)
Carcinogenesis
, vol.31
, pp. 2136-2144
-
-
Chen, H.1
Kluz, T.2
Zhang, R.3
Costa, M.4
|