Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy

Biochemistry

Volumn 52, Issue 24, 2013, Pages 4168-4183

  Giri, Nitai Charan ^a   Passantino, Lisa ^b   Sun, Hong ^b   Zoroddu, Maria Antonietta ^c   Costa, Max ^b   Maroney, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINARY AND TERNARY COMPLEXES; DEMETHYLATION; DIOXYGENASES; ENVIRONMENTAL EXPOSURE; EPIGENETIC MECHANISMS; STERIC FACTOR; STRUCTURAL INVESTIGATION;

AMINO ACIDS; ENZYME INHIBITION; GENE EXPRESSION; IONS; IRON COMPOUNDS; ONCOGENIC VIRUSES; X RAY ABSORPTION SPECTROSCOPY; ZINC;

NICKEL;

HISTONE DEMETHYLASE; NICKEL; PROTEIN JMJD2A; PROTEIN JMJD2C; PROTEIN JMJD2D; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; BINDING SITE; CARCINOGENESIS; CATALYSIS; CRYSTAL STRUCTURE; DEMETHYLATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; EPIGENETICS; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION; X RAY ABSORPTION SPECTROSCOPY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HISTONE DEMETHYLASES; HISTONES; HUMANS; INHIBITORY CONCENTRATION 50; IONS; IRON; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MODELS, CHEMICAL; MODELS, STATISTICAL; MOLECULAR CONFORMATION; NICKEL; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; X-RAY ABSORPTION SPECTROSCOPY; ZINC;

EID: 84879215757     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400274v     Document Type: Article

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