Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages 20725-20729

  Osawa, Tsuyoshi ^a,b   Muramatsu, Masashi ^c   Wang, Feng ^a   Tsuchida, Rika ^a   Kodama, Tatsuhiko ^b   Minami, Takashi ^b   Shibuya, Masabumi ^a,d  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d JOBU UNIVERSITY   (Japan)

Author keywords

Antiangiogenesis; Epigenetics; Nutrient deprivation; Tumor microenvironment

Indexed keywords

ANGIOPOIETIN; CD11B ANTIGEN; CD31 ANTIGEN; COMPLEMENTARY DNA; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE JHDM1D; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MELANOMA B16; MOUSE; NONHUMAN; NUTRIENT LIMITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

ANIMALS; CELL PROLIFERATION; CULTURE MEDIA; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862966741     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108462109     Document Type: Article

References (33)

1. Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438:967-974. (Pubitemid 43093963)
2. Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653-660.
3. Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 312:549-560. (Pubitemid 43290332)
4. Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47.
5. Klose RJ, Kallin EM, Zhang Y (2006) JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7:715-727. (Pubitemid 44260007)
6. Wen H, et al. (2010) Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem 285:9322-9326.
7. Qi HH, et al. (2010) Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature 466:503-507.
8. Hasenpusch-Theil K, et al. (1999) PHF2, a novel PHD finger gene located on human chromosome 9q22. Mamm Genome 10:294-298. (Pubitemid 29390519)
9. Laumonnier F, et al. (2005) Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. J Med Genet 42:780-786. (Pubitemid 41475255)
10. Horton JR, et al. (2010) Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol 17:38-43.
11. Huang C, et al. (2010) Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res 20:154-165.
12. Tsukada Y, Ishitani T, Nakayama KI (2010) KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev 24:432-437.
13. Hurwitz H, et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342. (Pubitemid 38702844)
14. Sandler A, et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542-2550. (Pubitemid 44917502)
15. Escudier B, et al.; TARGET Study Group (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125-134. (Pubitemid 46089673)
16. Osawa T, Muramatsu M, Watanabe M, Shibuya M (2009) Hypoxia and low-nutrition double stress induces aggressiveness in a murine model of melanoma. Cancer Sci 100:844-851.
17. Osawa T, Tsuchida R, Muramatsu M, Yuasa Y, Shibuya M (2011) Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T-cell leukemia in mice. Blood Cancer J. 1:e6, 1-4.
18. Liu W, et al. (2010) PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 466:508-512.
19. Warburg O (1956) On the origin of cancer cells. Science 123:309-314.
20. Takasu M, Tada Y, Wang JO, Tagawa M, Takenaga K (1999) Resistance to apoptosis induced by microenvironmental stresses is correlated with metastatic potential in Lewis lung carcinoma. Clin Exp Metastasis 17:409-416. (Pubitemid 30019998)
21. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-1033.
22. Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891-899. (Pubitemid 39472955)
23. Sokawa Y, Sokawa J, Kaziro Y (1974) Role of rel gene in translation during amino acid starvation in Escherichia coli. Nature 249:59-62.
24. Shibuya M, Kaziro Y (1979) Studies on stringent control in a cell-free system. Regulation by guanosine-5′-diphosphate-3′-diphosphate of the synthesis of elongation factor Tu. J Biochem 86:403-411.
25. McLaughlin-Drubin ME, Crum CP, Münger K (2011) Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 108:2130-2135.
26. Hsia DA, et al. (2010) KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci USA 107:9671-9676.
27. Ikeda E, Achen MG, Breier G, Risau W (1995) Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270:19761-19766.
28. Pouysségur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441:437-443. (Pubitemid 44050138)
29. Das B, et al. (2005) A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Res 65:7267-7275. (Pubitemid 41161258)
30. Butler JM, Kobayashi H, Rafii S (2010) Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer 10:138-146.
31. Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS (2002) Effect of p53 status on tumor response to antiangiogenic therapy. Science 295:1526-1528. (Pubitemid 34174008)
32. Ricci-Vitiani L, et al. (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468:824-828.
33. Morita S, Kojima T, Kitamura T (2000) Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 7:1063-1066. (Pubitemid 30398356)