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Volumn 61, Issue 6, 2014, Pages 577-588

Analysis of the expression of candidate genes for type 1 diabetes susceptibility in T cells

Author keywords

Genetic susceptibility genes; Nonobese diabetic (NOD) mice; Transforming growth factor ; Type 1 diabetes

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903596084     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ14-0002     Document Type: Article
Times cited : (6)

References (57)
  • 1
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch R, McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85: 291-297.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 2
    • 0025234628 scopus 로고
    • Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat
    • Castano L, Eisenbarth GS (1990) Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 8: 647-679.
    • (1990) Annu Rev Immunol , vol.8 , pp. 647-679
    • Castano, L.1    Eisenbarth, G.S.2
  • 3
    • 82955247941 scopus 로고    scopus 로고
    • Diabetogenic T lymphocytes in human type 1 diabetes
    • Roep BO, Peakman M (2011) Diabetogenic T lymphocytes in human type 1 diabetes. Curr Opin Immunol 23: 746-753.
    • (2011) Curr Opin Immunol , vol.23 , pp. 746-753
    • Roep, B.O.1    Peakman, M.2
  • 4
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Kikutani H, Makino S (1992) The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51: 285-322.
    • (1992) Adv Immunol , vol.51 , pp. 285-322
    • Kikutani, H.1    Makino, S.2
  • 5
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23: 447-485.
    • (2005) Annu Rev Immunol , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 7
    • 0034777837 scopus 로고    scopus 로고
    • A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    • Cucca F, Lampis R, Congia M, Angius E, Nutland S, et al. (2001) A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet 10: 2025-2037.
    • (2001) Hum Mol Genet , vol.10 , pp. 2025-2037
    • Cucca, F.1    Lampis, R.2    Congia, M.3    Angius, E.4    Nutland, S.5
  • 8
    • 77951905379 scopus 로고    scopus 로고
    • Molecular targeting of islet autoantigens
    • Stadinski B, Kappler J, Eisenbarth GS (2010) Molecular targeting of islet autoantigens. Immunity 32: 446-456.
    • (2010) Immunity , vol.32 , pp. 446-456
    • Stadinski, B.1    Kappler, J.2    Eisenbarth, G.S.3
  • 9
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas J, Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172: 2731-2738.
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 10
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifes KIAA0350 as a type 1 diabetes gene
    • Hakonarson H, Grant SF, Bradfeld JP, Marchand L, Kim CE, et al. (2007) A genome-wide association study identifes KIAA0350 as a type 1 diabetes gene. Nature 448: 591-594.
    • (2007) Nature , vol.448 , pp. 591-594
    • Hakonarson, H.1    Grant, S.F.2    Bradfeld, J.P.3    Marchand, L.4    Kim, C.E.5
  • 11
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, et al. (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39: 857-864.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5
  • 12
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis fnd that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, et al. (2009) Genome-wide association study and meta-analysis fnd that over 40 loci affect risk of type 1 diabetes. Nat Genet 41: 703-707.
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3    Akolkar, B.4    Cooper, J.D.5
  • 14
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 15
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 17
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-5153.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5
  • 18
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5
  • 19
    • 33947644716 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson TS, DiPaolo RJ, Andersson J, Shevach EM (2007) Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 178: 4022-4026.
    • (2007) J Immunol , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    Dipaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 20
    • 84862621461 scopus 로고    scopus 로고
    • TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
    • Zhang N, Bevan MJ (2012) TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol 13: 667-673.
    • (2012) Nat Immunol , vol.13 , pp. 667-673
    • Zhang, N.1    Bevan, M.J.2
  • 21
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcrip-tional signature
    • Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, et al. (2007) Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcrip-tional signature. Immunity 27: 786-800.
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5
  • 22
    • 84866533054 scopus 로고    scopus 로고
    • A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
    • Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, et al. (2012) A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol 13: 972-980.
    • (2012) Nat Immunol , vol.13 , pp. 972-980
    • Fu, W.1    Ergun, A.2    Lu, T.3    Hill, J.A.4    Haxhinasto, S.5
  • 23
    • 0034108118 scopus 로고    scopus 로고
    • Paternal-maternal effects on pheno-typic characteristics in spontaneously diabetic Nagoya-Shibata-Yasuda mice
    • Ueda H, Ikegami H, Kawaguchi, Fujisawa T, Nojima K, et al. (2000) Paternal-maternal effects on pheno-typic characteristics in spontaneously diabetic Nagoya-Shibata-Yasuda mice. Metabolism 49: 651-656.
    • (2000) Metabolism , vol.49 , pp. 651-656
    • Ueda, H.1    Ikegami, H.2    Kawaguchi Fujisawa, T.3    Nojima, K.4
  • 24
    • 84884915819 scopus 로고    scopus 로고
    • Hyperglycemia induces differential change in oxida-tive stress at gene expression and functional levels in HUVEC and HMVEC
    • Patel H, Chen J, Das KC, Kavdia M (2013) Hyperglycemia induces differential change in oxida-tive stress at gene expression and functional levels in HUVEC and HMVEC. Cardiovasc Diabetol 12: 142-155.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 142-155
    • Patel, H.1    Chen, J.2    Das, K.C.3    Kavdia, M.4
  • 26
    • 0022646067 scopus 로고
    • The NOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
    • Hattori M, Buse JB, Jackson RA, Glimcher L, Dorf ME, et al. (1986) The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231: 733-735.
    • (1986) Science , vol.231 , pp. 733-735
    • Hattori, M.1    Buse, J.B.2    Jackson, R.A.3    Glimcher, L.4    Dorf, M.E.5
  • 27
    • 0027331410 scopus 로고
    • P21ras and calcineurin synergize to regulate the nuclear factor of activated T cells
    • Woodrow M, Clipstone NA, Cantrell D (1993) P21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J Exp Med 178: 1517-1522.
    • (1993) J Exp Med , vol.178 , pp. 1517-1522
    • Woodrow, M.1    Clipstone, N.A.2    Cantrell, D.3
  • 28
    • 38349095578 scopus 로고    scopus 로고
    • Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    • Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, et al. (2008) Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol 9: 194-202.
    • (2008) Nat Immunol , vol.9 , pp. 194-202
    • Tone, Y.1    Furuuchi, K.2    Kojima, Y.3    Tykocinski, M.L.4    Greene, M.I.5
  • 29
    • 0021245601 scopus 로고
    • The role of T3 surface molecules in the activation of human T cells: A two-stimulus requirement for IL 2 production refects events occurring at a pre-translational level
    • Weiss A, Wiskocil RL, Stobo JD (1984) The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production refects events occurring at a pre-translational level. J Immunol 133: 123-128.
    • (1984) J Immunol , vol.133 , pp. 123-128
    • Weiss, A.1    Wiskocil, R.L.2    Stobo, J.D.3
  • 31
    • 0033955282 scopus 로고    scopus 로고
    • Mouse Zac1, a tran-scriptional coactivator and repressor for nuclear receptors
    • Huang SM, Stallcup MR (2000) Mouse Zac1, a tran-scriptional coactivator and repressor for nuclear receptors. Mol Cell Biol 20: 1855-1867.
    • (2000) Mol Cell Biol , vol.20 , pp. 1855-1867
    • Huang, S.M.1    Stallcup, M.R.2
  • 33
    • 0030955765 scopus 로고    scopus 로고
    • Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc fnger protein expressed in the pituitary gland and the brain
    • Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, et al. (1997) Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc fnger protein expressed in the pituitary gland and the brain. EMBO J 16: 2814-2825.
    • (1997) EMBO J , vol.16 , pp. 2814-2825
    • Spengler, D.1    Villalba, M.2    Hoffmann, A.3    Pantaloni, C.4    Houssami, S.5
  • 34
    • 0034639657 scopus 로고    scopus 로고
    • The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes
    • Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, et al. (2000) The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes. Hum Mol Genet 9: 453-460.
    • (2000) Hum Mol Genet , vol.9 , pp. 453-460
    • Kamiya, M.1    Judson, H.2    Okazaki, Y.3    Kusakabe, M.4    Muramatsu, M.5
  • 35
    • 33750470266 scopus 로고    scopus 로고
    • Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    • Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, et al. (2006) Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell 11: 711-722.
    • (2006) Dev Cell , vol.11 , pp. 711-722
    • Varrault, A.1    Gueydan, C.2    Delalbre, A.3    Bellmann, A.4    Houssami, S.5
  • 36
    • 33846214379 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation
    • Barz T, Hoffmann A, Panhuysen M, Spengler D (2006) Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation. Cancer Res 66: 11975-11982.
    • (2006) Cancer Res , vol.66 , pp. 11975-11982
    • Barz, T.1    Hoffmann, A.2    Panhuysen, M.3    Spengler, D.4
  • 37
    • 1842480959 scopus 로고    scopus 로고
    • TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
    • Peng Y, Laouar Y, Li MO, Green EA, Flavell RA (2004) TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A 101: 4572-4577.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4572-4577
    • Peng, Y.1    Laouar, Y.2    Li, M.O.3    Green, E.A.4    Flavell, R.A.5
  • 38
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, et al. (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39: 329-337.
    • (2007) Nat Genet , vol.39 , pp. 329-337
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3    Howlett, S.4    Hunter, K.5
  • 39
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, et al. (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28: 687-697.
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5
  • 40
    • 84867741377 scopus 로고    scopus 로고
    • A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
    • Winkler C, Krumsiek J, Lempainen J, Achenbach P, Grallert H, et al. (2012) A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes. Genes Immun 13: 549-555.
    • (2012) Genes Immun , vol.13 , pp. 549-555
    • Winkler, C.1    Krumsiek, J.2    Lempainen, J.3    Achenbach, P.4    Grallert, H.5
  • 41
    • 84868036600 scopus 로고    scopus 로고
    • Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes
    • Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, et al. (2012) Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes 61: 3012-3017.
    • (2012) Diabetes , vol.61 , pp. 3012-3017
    • Howson, J.M.1    Cooper, J.D.2    Smyth, D.J.3    Walker, N.M.4    Stevens, H.5
  • 42
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
    • Herold KC, Vignali DA, Cooke A, Bluestone JA (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13: 243-256.
    • (2013) Nat Rev Immunol , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.2    Cooke, A.3    Bluestone, J.A.4
  • 43
    • 84871431712 scopus 로고    scopus 로고
    • How the immune system talks to itself: The varied role of synapses
    • Xie J, Tato CM, Davis MM (2013) How the immune system talks to itself: the varied role of synapses. Immunol Rev 251: 65-79.
    • (2013) Immunol Rev , vol.251 , pp. 65-79
    • Xie, J.1    Tato, C.M.2    Davis, M.M.3
  • 44
    • 56749183605 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association study data identifes additional type 1 diabetes risk loci
    • Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, et al. (2008) Meta-analysis of genome-wide association study data identifes additional type 1 diabetes risk loci. Nat Genet 40: 1399-1401.
    • (2008) Nat Genet , vol.40 , pp. 1399-1401
    • Cooper, J.D.1    Smyth, D.J.2    Smiles, A.M.3    Plagnol, V.4    Walker, N.M.5
  • 45
    • 0036699521 scopus 로고    scopus 로고
    • Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
    • Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, et al. (2002) Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 31: 391-394.
    • (2002) Nat Genet , vol.31 , pp. 391-394
    • Yokoi, N.1    Komeda, K.2    Wang, H.Y.3    Yano, H.4    Kitada, K.5
  • 46
    • 79960431415 scopus 로고    scopus 로고
    • Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice
    • Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, et al. (2011) Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol 187: 325-336.
    • (2011) J Immunol , vol.187 , pp. 325-336
    • Rainbow, D.B.1    Moule, C.2    Fraser, H.I.3    Clark, J.4    Howlett, S.K.5
  • 47
    • 80855138424 scopus 로고    scopus 로고
    • Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes
    • Yamashita H, Awata T, Kawasaki E, Ikegami H, Tanaka S, et al. (2011) Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes. Diabetes Metab Res Rev 27: 844-848.
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 844-848
    • Yamashita, H.1    Awata, T.2    Kawasaki, E.3    Ikegami, H.4    Tanaka, S.5
  • 48
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito L, Heward J, Snook H, et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5
  • 49
    • 73349115848 scopus 로고    scopus 로고
    • The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
    • Wallace C, Smyth DJ, Maisuria-Armer M, Walker NM, Todd JA, et al. (2009) The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet 42: 68-71.
    • (2009) Nat Genet , vol.42 , pp. 68-71
    • Wallace, C.1    Smyth, D.J.2    Maisuria-Armer, M.3    Walker, N.M.4    Todd, J.A.5
  • 50
    • 42449094966 scopus 로고    scopus 로고
    • A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    • Hakonarson H, Qu HQ, Bradfeld JP, Marchand L, Kim CE, et al. (2008) A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes 57: 1143-1146.
    • (2008) Diabetes , vol.57 , pp. 1143-1146
    • Hakonarson, H.1    Qu, H.Q.2    Bradfeld, J.P.3    Marchand, L.4    Kim, C.E.5
  • 51
    • 79952417604 scopus 로고    scopus 로고
    • An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes
    • Swafford AD, Howson JM, Davison LJ, Wallace C, Smyth DJ, et al. (2011) An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes 60: 1041-1044.
    • (2011) Diabetes , vol.60 , pp. 1041-1044
    • Swafford, A.D.1    Howson, J.M.2    Davison, L.J.3    Wallace, C.4    Smyth, D.J.5
  • 52
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, et al. (2005) Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet 76: 773-779.
    • (2005) Am J Hum Genet , vol.76 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3    Walker, N.4    Nutland, S.5
  • 53
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fne mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, et al. (2007) Large-scale genetic fne mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 39: 1074-1082.
    • (2007) Nat Genet , vol.39 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3    Walker, N.M.4    Smyth, D.J.5
  • 54
    • 69949171150 scopus 로고    scopus 로고
    • No association of multiple type 2 diabetes loci with type 1 diabetes
    • Raj SM, Howson JM, Walker NM, Cooper JD, Smyth DJ, et al. (2009) No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia 52: 2109-2116.
    • (2009) Diabetologia , vol.52 , pp. 2109-2116
    • Raj, S.M.1    Howson, J.M.2    Walker, N.M.3    Cooper, J.D.4    Smyth, D.J.5
  • 55
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, et al. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36: 337-338.
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5
  • 56
    • 58149090841 scopus 로고    scopus 로고
    • A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    • Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, et al. (2008) A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes 57: 2858-2861.
    • (2008) Diabetes , vol.57 , pp. 2858-2861
    • Concannon, P.1    Onengut-Gumuscu, S.2    Todd, J.A.3    Smyth, D.J.4    Pociot, F.5
  • 57
    • 77954504241 scopus 로고    scopus 로고
    • Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene
    • Fraser HI, Dendrou CA, Healy B, Rainbow DB, Howlett S, et al. (2010) Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol 184: 5075-5084.
    • (2010) J Immunol , vol.184 , pp. 5075-5084
    • Fraser, H.I.1    Dendrou, C.A.2    Healy, B.3    Rainbow, D.B.4    Howlett, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.