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Volumn 102, Issue 2, 2014, Pages 126-138

Role of cilia in normal pancreas function and in diseased states

Author keywords

Beta cells; Cilia; Diabetes; Neurologic disorders; Pancreas

Indexed keywords

INSULIN; NOTCH RECEPTOR; SOMATOSTATIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SOX9; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL;

EID: 84903135002     PISSN: 1542975X     EISSN: 15429768     Source Type: Journal    
DOI: 10.1002/bdrc.21064     Document Type: Article
Times cited : (18)

References (142)
  • 1
    • 84875253441 scopus 로고    scopus 로고
    • Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects
    • Abdelhamed ZA, Wheway G, Szymanska K, et al. 2013. Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet 22:1358-1372.
    • (2013) Hum Mol Genet , vol.22 , pp. 1358-1372
    • Abdelhamed, Z.A.1    Wheway, G.2    Szymanska, K.3
  • 2
    • 0017162819 scopus 로고
    • A human syndrome caused by immotile cilia
    • Afzelius BA. 1976. A human syndrome caused by immotile cilia. Science 193:317-319.
    • (1976) Science , vol.193 , pp. 317-319
    • Afzelius, B.A.1
  • 3
    • 82855167167 scopus 로고    scopus 로고
    • Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism
    • Ahnfelt-Ronne J, Jorgensen MC, Klinck R, et al. 2012. Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development 139:33-45.
    • (2012) Development , vol.139 , pp. 33-45
    • Ahnfelt-Ronne, J.1    Jorgensen, M.C.2    Klinck, R.3
  • 4
    • 34047187934 scopus 로고    scopus 로고
    • Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas
    • Ait-Lounis A, Baas D, Barras E, et al. 2007. Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas. Diabetes 56:950-959.
    • (2007) Diabetes , vol.56 , pp. 950-959
    • Ait-Lounis, A.1    Baas, D.2    Barras, E.3
  • 6
    • 0142104970 scopus 로고    scopus 로고
    • Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
    • Ansley SJ, Badano JL, Blacque OE, et al. 2003. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425:628-633.
    • (2003) Nature , vol.425 , pp. 628-633
    • Ansley, S.J.1    Badano, J.L.2    Blacque, O.E.3
  • 7
    • 80052093967 scopus 로고    scopus 로고
    • Diabetes prevalence estimates in schizophrenia and risk factor assessment
    • Argo T, Carnahan R, Barnett M, et al. 2011. Diabetes prevalence estimates in schizophrenia and risk factor assessment. Ann Clin Psychiatry 23:117-124.
    • (2011) Ann Clin Psychiatry , vol.23 , pp. 117-124
    • Argo, T.1    Carnahan, R.2    Barnett, M.3
  • 8
    • 43049117188 scopus 로고    scopus 로고
    • Formation of a new receptor-operated channel by heteroeric assembly of TRPP2 and TRPC1 subunits
    • Bai CX, Giamarchi A, Rodat-Despoix L, et al. 2008. Formation of a new receptor-operated channel by heteroeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep 9:472-479.
    • (2008) EMBO Rep , vol.9 , pp. 472-479
    • Bai, C.X.1    Giamarchi, A.2    Rodat-Despoix, L.3
  • 9
    • 70449625440 scopus 로고    scopus 로고
    • Making sense of cilia in disease: the human ciliopathies
    • Baker K, Beales PL. 2009. Making sense of cilia in disease: the human ciliopathies. Am J Med Genet C Semin Med Genet 151C:281-295.
    • (2009) Am J Med Genet C Semin Med Genet , vol.151 C , pp. 281-295
    • Baker, K.1    Beales, P.L.2
  • 10
    • 33646152095 scopus 로고    scopus 로고
    • Recurrent pancreatitis in a patient with autosomal-dominant polycystic kidney disease
    • Basar O, Ibis M, Ucar E, et al. 2006. Recurrent pancreatitis in a patient with autosomal-dominant polycystic kidney disease. Pancreatology 6:160-162.
    • (2006) Pancreatology , vol.6 , pp. 160-162
    • Basar, O.1    Ibis, M.2    Ucar, E.3
  • 11
    • 0035859888 scopus 로고    scopus 로고
    • Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2
    • Benzing T, Gerke P, Hopker K, et al. 2001. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. Proc Natl Acad Sci USA 98:9784-9789.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9784-9789
    • Benzing, T.1    Gerke, P.2    Hopker, K.3
  • 12
    • 41949116864 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
    • Berbari NF, Lewis JS, Bishop GA, et al. 2008. Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc Natl Acad Sci USA 105:4242-4246.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4242-4246
    • Berbari, N.F.1    Lewis, J.S.2    Bishop, G.A.3
  • 13
    • 84877313950 scopus 로고    scopus 로고
    • Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice
    • Berbari NF, Pasek RC, Malarkey EB, et al. 2013. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci USA 110:7796-7801.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 7796-7801
    • Berbari, N.F.1    Pasek, R.C.2    Malarkey, E.B.3
  • 14
    • 84865957680 scopus 로고    scopus 로고
    • Educational paper: ciliopathies
    • Bergmann C. 2012. Educational paper: ciliopathies. Eur J Pediatr 171:1285-1300.
    • (2012) Eur J Pediatr , vol.171 , pp. 1285-1300
    • Bergmann, C.1
  • 15
    • 0020131661 scopus 로고
    • Ataxia telangiectasia and immotile cilia syndrome: what do these disorders have in common?
    • Berman BA, Ross RN. 1982. Ataxia telangiectasia and immotile cilia syndrome: what do these disorders have in common? Cutis 29:428-433.
    • (1982) Cutis , vol.29 , pp. 428-433
    • Berman, B.A.1    Ross, R.N.2
  • 16
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • Bonner-Weir S, Taneja M, Weir GC, et al. 2000. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 17
    • 0034725792 scopus 로고    scopus 로고
    • Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain
    • Brailov I, Bancila M, Brisorgueil MJ, et al. 2000. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res 872:271-275.
    • (2000) Brain Res , vol.872 , pp. 271-275
    • Brailov, I.1    Bancila, M.2    Brisorgueil, M.J.3
  • 18
    • 0034801880 scopus 로고    scopus 로고
    • Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas
    • Brunicardi FC, Kleinman R, Moldovan S, et al. 2001. Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas. Pancreas 23:302-308.
    • (2001) Pancreas , vol.23 , pp. 302-308
    • Brunicardi, F.C.1    Kleinman, R.2    Moldovan, S.3
  • 19
    • 2442605494 scopus 로고    scopus 로고
    • Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812
    • Cai Y, Anyatonwu G, Okuhara D, et al. 2004. Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J Biol Chem 279:19987-19995.
    • (2004) J Biol Chem , vol.279 , pp. 19987-19995
    • Cai, Y.1    Anyatonwu, G.2    Okuhara, D.3
  • 20
    • 0033214702 scopus 로고    scopus 로고
    • Identification and characterization of polycystin-2, the PKD2 gene product
    • Cai Y, Maeda Y, Cedzich A, et al. 1999. Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem 274:28557-28565.
    • (1999) J Biol Chem , vol.274 , pp. 28557-28565
    • Cai, Y.1    Maeda, Y.2    Cedzich, A.3
  • 21
    • 0035083551 scopus 로고    scopus 로고
    • The genetics and physiology of polycystic kidney disease
    • Calvet JP, Grantham JJ. 2001. The genetics and physiology of polycystic kidney disease. Semin Nephrol 21:107-123.
    • (2001) Semin Nephrol , vol.21 , pp. 107-123
    • Calvet, J.P.1    Grantham, J.J.2
  • 22
    • 9844222853 scopus 로고    scopus 로고
    • Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes
    • Campuzano V, Montermini L, Lutz Y, et al. 1997. Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes. Hum Mol Genet 6:1771-1780.
    • (1997) Hum Mol Genet , vol.6 , pp. 1771-1780
    • Campuzano, V.1    Montermini, L.2    Lutz, Y.3
  • 23
    • 4243144134 scopus 로고    scopus 로고
    • Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    • Cano DA, Murcia NS, Pazour GJ, et al. 2004. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131:3457-3467.
    • (2004) Development , vol.131 , pp. 3457-3467
    • Cano, D.A.1    Murcia, N.S.2    Pazour, G.J.3
  • 24
    • 33845661591 scopus 로고    scopus 로고
    • Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
    • Cano DA, Sekine S, Hebrok M. 2006. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131:1856-1869.
    • (2006) Gastroenterology , vol.131 , pp. 1856-1869
    • Cano, D.A.1    Sekine, S.2    Hebrok, M.3
  • 25
    • 70449627625 scopus 로고    scopus 로고
    • Ciliary biology: understanding the cellular and genetic basis of human ciliopathies
    • Cardenas-Rodriguez M, Badano JL. 2009. Ciliary biology: understanding the cellular and genetic basis of human ciliopathies. Am J Med Genet C Semin Med Genet 151C:263-280.
    • (2009) Am J Med Genet C Semin Med Genet , vol.151 C , pp. 263-280
    • Cardenas-Rodriguez, M.1    Badano, J.L.2
  • 26
    • 38949152272 scopus 로고    scopus 로고
    • The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation
    • Collet C, Schiltz C, Geoffroy V, et al. 2008. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. FASEB J 22:418-427.
    • (2008) FASEB J , vol.22 , pp. 418-427
    • Collet, C.1    Schiltz, C.2    Geoffroy, V.3
  • 27
    • 0036578890 scopus 로고    scopus 로고
    • Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome
    • Collin GB, Marshall JD, Ikeda A, et al. 2002. Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome. Nat Genet 31:74-78.
    • (2002) Nat Genet , vol.31 , pp. 74-78
    • Collin, G.B.1    Marshall, J.D.2    Ikeda, A.3
  • 28
    • 80455174174 scopus 로고    scopus 로고
    • Transient receptor potential cation channels in pancreatic beta cells
    • Colsoul B, Vennekens R, Nilius B. 2011. Transient receptor potential cation channels in pancreatic beta cells. Rev Physiol Biochem Pharmacol 161:87-110.
    • (2011) Rev Physiol Biochem Pharmacol , vol.161 , pp. 87-110
    • Colsoul, B.1    Vennekens, R.2    Nilius, B.3
  • 29
    • 26644460824 scopus 로고    scopus 로고
    • Vertebrate smoothened functions at the primary cilium
    • Corbit KC, Aanstad P, Singla V, et al. 2005. Vertebrate smoothened functions at the primary cilium. Nature 437:1018-1021.
    • (2005) Nature , vol.437 , pp. 1018-1021
    • Corbit, K.C.1    Aanstad, P.2    Singla, V.3
  • 30
    • 37749054886 scopus 로고    scopus 로고
    • Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
    • Corbit KC, Shyer AE, Dowdle WE, et al. 2008. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 10:70-76.
    • (2008) Nat Cell Biol , vol.10 , pp. 70-76
    • Corbit, K.C.1    Shyer, A.E.2    Dowdle, W.E.3
  • 31
    • 34548490748 scopus 로고    scopus 로고
    • Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease
    • Davenport JR, Watts AJ, Roper VC, et al. 2007. Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol 17:1586-1594.
    • (2007) Curr Biol , vol.17 , pp. 1586-1594
    • Davenport, J.R.1    Watts, A.J.2    Roper, V.C.3
  • 32
    • 19444371691 scopus 로고    scopus 로고
    • 5-HT2B-mediated serotonin signaling is required for eye morphogenesis in Xenopus
    • De Lucchini S, Ori M, Cremisi F, et al. 2005. 5-HT2B-mediated serotonin signaling is required for eye morphogenesis in Xenopus. Mol Cell Neurosci 29:299-312.
    • (2005) Mol Cell Neurosci , vol.29 , pp. 299-312
    • De Lucchini, S.1    Ori, M.2    Cremisi, F.3
  • 33
    • 84890352250 scopus 로고    scopus 로고
    • Direct recording and molecular identification of the calcium channel of primary cilia
    • DeCaen PG, Delling M, Vien TN, et al. 2013. Direct recording and molecular identification of the calcium channel of primary cilia. Nature 504:315-318.
    • (2013) Nature , vol.504 , pp. 315-318
    • DeCaen, P.G.1    Delling, M.2    Vien, T.N.3
  • 34
    • 84890746967 scopus 로고    scopus 로고
    • Identification and manipulation of biliary metaplasia in pancreatic tumors
    • Delgiorno KE, Hall JC, Takeuchi KK, et al. 2014. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology 146:233-244 e235.
    • (2014) Gastroenterology , vol.146
    • Delgiorno, K.E.1    Hall, J.C.2    Takeuchi, K.K.3
  • 35
    • 84890345523 scopus 로고    scopus 로고
    • Primary cilia are specialized calcium signalling organelles
    • Delling M, DeCaen PG, Doerner JF, et al. 2013. Primary cilia are specialized calcium signalling organelles. Nature 504:311-314.
    • (2013) Nature , vol.504 , pp. 311-314
    • Delling, M.1    DeCaen, P.G.2    Doerner, J.F.3
  • 36
    • 36749056212 scopus 로고    scopus 로고
    • Formation and regeneration of the endocrine pancreas
    • Dhawan S, Georgia S, Bhushan A. 2007. Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol 19:634-645.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 634-645
    • Dhawan, S.1    Georgia, S.2    Bhushan, A.3
  • 37
    • 0033756432 scopus 로고    scopus 로고
    • Prevalence and correlates of diabetes in national schizophrenia samples
    • Dixon L, Weiden P, Delahanty J, et al. 2000. Prevalence and correlates of diabetes in national schizophrenia samples. Schizophr Bull 26:903-912.
    • (2000) Schizophr Bull , vol.26 , pp. 903-912
    • Dixon, L.1    Weiden, P.2    Delahanty, J.3
  • 38
    • 79958027007 scopus 로고    scopus 로고
    • Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers
    • Dorrell C, Grompe MT, Pan FC, et al. 2011. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol 339:144-150.
    • (2011) Mol Cell Endocrinol , vol.339 , pp. 144-150
    • Dorrell, C.1    Grompe, M.T.2    Pan, F.C.3
  • 39
    • 0021927818 scopus 로고
    • Diabetes mellitus in Huntington disease
    • Farrer LA. 1985. Diabetes mellitus in Huntington disease. Clin Genet 27:62-67.
    • (1985) Clin Genet , vol.27 , pp. 62-67
    • Farrer, L.A.1
  • 41
    • 33646764178 scopus 로고    scopus 로고
    • Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif
    • Geng L, Okuhara D, Yu Z, et al. 2006. Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. J Cell Sci 119:1383-1395.
    • (2006) J Cell Sci , vol.119 , pp. 1383-1395
    • Geng, L.1    Okuhara, D.2    Yu, Z.3
  • 42
    • 12644290270 scopus 로고    scopus 로고
    • Identification and localization of polycystin, the PKD1 gene product
    • Geng L, Segal Y, Peissel B, et al. 1996. Identification and localization of polycystin, the PKD1 gene product. J Clin Invest 98:2674-2682.
    • (1996) J Clin Invest , vol.98 , pp. 2674-2682
    • Geng, L.1    Segal, Y.2    Peissel, B.3
  • 44
    • 4644362730 scopus 로고    scopus 로고
    • Melanin-concentrating hormone receptor mutations and human obesity: functional analysis
    • Gibson WT, Pissios P, Trombly DJ, et al. 2004. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. Obes Res 12:743-749.
    • (2004) Obes Res , vol.12 , pp. 743-749
    • Gibson, W.T.1    Pissios, P.2    Trombly, D.J.3
  • 45
    • 79451474853 scopus 로고    scopus 로고
    • Alstrom syndrome: insights into the pathogenesis of metabolic disorders
    • Girard D, Petrovsky N. 2011. Alstrom syndrome: insights into the pathogenesis of metabolic disorders. Nat Rev Endocrinol 7:77-88.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 77-88
    • Girard, D.1    Petrovsky, N.2
  • 46
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: a signalling centre during vertebrate development
    • Goetz SC, Anderson KV. 2010. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11:331-344.
    • (2010) Nat Rev Genet , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 47
    • 0035912767 scopus 로고    scopus 로고
    • Kinesin molecular motors: transport pathways, receptors, and human disease
    • Goldstein LS 2001. Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci USA 98:6999-7003.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6999-7003
    • Goldstein, L.S.1
  • 49
    • 70349503932 scopus 로고    scopus 로고
    • LKB1 regulates pancreatic beta cell size, polarity, and function
    • Granot Z, Swisa A, Magenheim J, et al. 2009. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab 10:296-308.
    • (2009) Cell Metab , vol.10 , pp. 296-308
    • Granot, Z.1    Swisa, A.2    Magenheim, J.3
  • 50
    • 0024472754 scopus 로고
    • The cardinal manifestations of Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome
    • Green JS, Parfrey PS, Harnett JD, et al. 1989. The cardinal manifestations of Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome. N Engl J Med 321:1002-1009.
    • (1989) N Engl J Med , vol.321 , pp. 1002-1009
    • Green, J.S.1    Parfrey, P.S.2    Harnett, J.D.3
  • 51
    • 0034700483 scopus 로고    scopus 로고
    • Co-assembly of polycystin-1 and -2 produces unique cation permeable currents
    • Hanaoka K, Qian F, Boletta A, et al. 2000. Co-assembly of polycystin-1 and -2 produces unique cation permeable currents. Nature 408:990-994.
    • (2000) Nature , vol.408 , pp. 990-994
    • Hanaoka, K.1    Qian, F.2    Boletta, A.3
  • 52
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, et al. 2005. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1:e53.
    • (2005) PLoS Genet , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3
  • 53
    • 17844367633 scopus 로고    scopus 로고
    • Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes
    • Hearn T, Spalluto C, Phillips VJ, et al. 2005. Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. Diabetes 54:1581-1587.
    • (2005) Diabetes , vol.54 , pp. 1581-1587
    • Hearn, T.1    Spalluto, C.2    Phillips, V.J.3
  • 54
    • 39749194712 scopus 로고    scopus 로고
    • Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    • Hezel AF, Gurumurthy S, Granot Z, et al. 2008. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 28:2414-2425.
    • (2008) Mol Cell Biol , vol.28 , pp. 2414-2425
    • Hezel, A.F.1    Gurumurthy, S.2    Granot, Z.3
  • 55
    • 34548515061 scopus 로고    scopus 로고
    • STAM and Hrs down-regulate ciliary TRP receptors
    • Hu J, Wittekind SG, Barr MM. 2007. STAM and Hrs down-regulate ciliary TRP receptors. Mol Biol Cell 18:3277-3289.
    • (2007) Mol Biol Cell , vol.18 , pp. 3277-3289
    • Hu, J.1    Wittekind, S.G.2    Barr, M.M.3
  • 56
    • 70349986352 scopus 로고    scopus 로고
    • Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    • Huang P, Schier AF. 2009. Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136:3089-3098.
    • (2009) Development , vol.136 , pp. 3089-3098
    • Huang, P.1    Schier, A.F.2
  • 57
    • 79952365931 scopus 로고    scopus 로고
    • Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes
    • Huang-Doran I, Bicknell LS, Finucane FM, et al. 2011. Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes. Diabetes 60:925-935.
    • (2011) Diabetes , vol.60 , pp. 925-935
    • Huang-Doran, I.1    Bicknell, L.S.2    Finucane, F.M.3
  • 58
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • Huangfu D, Liu A, Rakeman AS, et al. 2003. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426:83-87.
    • (2003) Nature , vol.426 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3
  • 59
    • 33846411850 scopus 로고    scopus 로고
    • Distribution of pancreatic endocrine cells including IAPP-expressing cells in non-diabetic and type 2 diabetic cases
    • Iki K, Pour PM. 2007. Distribution of pancreatic endocrine cells including IAPP-expressing cells in non-diabetic and type 2 diabetic cases. J Histochem Cytochem 55:111-118.
    • (2007) J Histochem Cytochem , vol.55 , pp. 111-118
    • Iki, K.1    Pour, P.M.2
  • 60
    • 79952806066 scopus 로고    scopus 로고
    • Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice
    • Iwanaga T, Miki T, Takahashi-Iwanaga H. 2011. Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice. Biomed Res 32:73-81.
    • (2011) Biomed Res , vol.32 , pp. 73-81
    • Iwanaga, T.1    Miki, T.2    Takahashi-Iwanaga, H.3
  • 61
    • 0038360823 scopus 로고    scopus 로고
    • The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    • Jacquemin P, Lemaigre FP, Rousseau GG. 2003. The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol 258:105-116.
    • (2003) Dev Biol , vol.258 , pp. 105-116
    • Jacquemin, P.1    Lemaigre, F.P.2    Rousseau, G.G.3
  • 62
    • 78651094693 scopus 로고    scopus 로고
    • Alstrom syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity
    • Jagger D, Collin G, Kelly J, et al. 2011. Alstrom syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity. Hum Mol Genet 20:466-481.
    • (2011) Hum Mol Genet , vol.20 , pp. 466-481
    • Jagger, D.1    Collin, G.2    Kelly, J.3
  • 63
    • 56149097603 scopus 로고    scopus 로고
    • Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease
    • Jonassen JA, San Agustin J, Follit JA, et al. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183:377-384.
    • (2008) J Cell Biol , vol.183 , pp. 377-384
    • Jonassen, J.A.1    San Agustin, J.2    Follit, J.A.3
  • 64
    • 4444320182 scopus 로고    scopus 로고
    • Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly
    • Jurczyk A, Gromley A, Redick S, et al. 2004. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol 166:637-643.
    • (2004) J Cell Biol , vol.166 , pp. 637-643
    • Jurczyk, A.1    Gromley, A.2    Redick, S.3
  • 65
    • 77955616568 scopus 로고    scopus 로고
    • A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells
    • Jurczyk A, Pino SC, O'Sullivan-Murphy B, et al. 2010. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One 5:e11812.
    • (2010) PLoS One , vol.5
    • Jurczyk, A.1    Pino, S.C.2    O'Sullivan-Murphy, B.3
  • 66
    • 80555136825 scopus 로고    scopus 로고
    • Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease
    • Keryer G, Pineda JR, Liot G, et al. 2011. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest 121:4372-4382.
    • (2011) J Clin Invest , vol.121 , pp. 4372-4382
    • Keryer, G.1    Pineda, J.R.2    Liot, G.3
  • 67
    • 20244381625 scopus 로고    scopus 로고
    • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
    • Kim JC, Badano JL, Sibold S, et al. 2004. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36:462-470.
    • (2004) Nat Genet , vol.36 , pp. 462-470
    • Kim, J.C.1    Badano, J.L.2    Sibold, S.3
  • 68
    • 77954480533 scopus 로고    scopus 로고
    • Serotonin regulates pancreatic beta cell mass during pregnancy
    • Kim H, Toyofuku Y, Lynn FC, et al. 2010. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 16:804-808.
    • (2010) Nat Med , vol.16 , pp. 804-808
    • Kim, H.1    Toyofuku, Y.2    Lynn, F.C.3
  • 69
    • 78149343518 scopus 로고    scopus 로고
    • Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731
    • Knorz VJ, Spalluto C, Lessard M, et al. 2010. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Mol Biol Cell 21:3617-3629.
    • (2010) Mol Biol Cell , vol.21 , pp. 3617-3629
    • Knorz, V.J.1    Spalluto, C.2    Lessard, M.3
  • 70
    • 72149113587 scopus 로고    scopus 로고
    • The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement
    • Kobori T, Smith GD, Sandford R, et al. 2009. The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J Biol Chem 284:35507-35513.
    • (2009) J Biol Chem , vol.284 , pp. 35507-35513
    • Kobori, T.1    Smith, G.D.2    Sandford, R.3
  • 71
    • 33751013309 scopus 로고    scopus 로고
    • Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
    • Koh HJ, Arnolds DE, Fujii N, et al. 2006. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26:8217-8227.
    • (2006) Mol Cell Biol , vol.26 , pp. 8217-8227
    • Koh, H.J.1    Arnolds, D.E.2    Fujii, N.3
  • 72
    • 9444235153 scopus 로고    scopus 로고
    • Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
    • Kokubu C, Heinzmann U, Kokubu T, et al. 2004. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131:5469-5480.
    • (2004) Development , vol.131 , pp. 5469-5480
    • Kokubu, C.1    Heinzmann, U.2    Kokubu, T.3
  • 73
    • 20144383835 scopus 로고    scopus 로고
    • Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
    • Kottgen M, Benzing T, Simmen T, et al. 2005. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J 24:705-716.
    • (2005) EMBO J , vol.24 , pp. 705-716
    • Kottgen, M.1    Benzing, T.2    Simmen, T.3
  • 74
    • 0036122434 scopus 로고    scopus 로고
    • Polycystin-2 is an intracellular calcium release channel
    • Koulen P, Cai Y, Geng L, et al. 2002. Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol 4:191-197.
    • (2002) Nat Cell Biol , vol.4 , pp. 191-197
    • Koulen, P.1    Cai, Y.2    Geng, L.3
  • 75
    • 36048929283 scopus 로고    scopus 로고
    • Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2
    • Kuehn EW, Hirt MN, John AK, et al. 2007. Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. Biochem Biophys Res Commun 364:861-866.
    • (2007) Biochem Biophys Res Commun , vol.364 , pp. 861-866
    • Kuehn, E.W.1    Hirt, M.N.2    John, A.K.3
  • 76
    • 4444254983 scopus 로고    scopus 로고
    • Loss of BBS proteins causes anosmia in humans and defects in olfactoy cilia structure and function in the mouse
    • Kulaga HM, Leitch CC, Eichers ER, et al. 2004. Loss of BBS proteins causes anosmia in humans and defects in olfactoy cilia structure and function in the mouse. Nat Genet 36:994-998.
    • (2004) Nat Genet , vol.36 , pp. 994-998
    • Kulaga, H.M.1    Leitch, C.C.2    Eichers, E.R.3
  • 77
    • 69949172478 scopus 로고    scopus 로고
    • Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
    • Lancaster MA, Louie CM, Silhavy JL, et al. 2009. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med 15:1046-1054.
    • (2009) Nat Med , vol.15 , pp. 1046-1054
    • Lancaster, M.A.1    Louie, C.M.2    Silhavy, J.L.3
  • 78
    • 80054743186 scopus 로고    scopus 로고
    • Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
    • Landsman L, Parent A, Hebrok M. 2011. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci USA 108:17010-17015.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17010-17015
    • Landsman, L.1    Parent, A.2    Hebrok, M.3
  • 79
    • 76149101303 scopus 로고    scopus 로고
    • The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
    • Lechtreck KF, Johnson EC, Sakai T, et al. 2009. The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol 187:1117-1132.
    • (2009) J Cell Biol , vol.187 , pp. 1117-1132
    • Lechtreck, K.F.1    Johnson, E.C.2    Sakai, T.3
  • 80
    • 33645666489 scopus 로고    scopus 로고
    • Platelet-derived serotonin mediates liver regeneration
    • Lesurtel M, Graf R, Aleil B, et al. 2006. Platelet-derived serotonin mediates liver regeneration. Science 312:104-107.
    • (2006) Science , vol.312 , pp. 104-107
    • Lesurtel, M.1    Graf, R.2    Aleil, B.3
  • 81
    • 33846507060 scopus 로고    scopus 로고
    • A role for Alstrom syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence
    • Li G, Vega R, Nelms K, et al. 2007. A role for Alstrom syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genet 3:e8.
    • (2007) PLoS Genet , vol.3
    • Li, G.1    Vega, R.2    Nelms, K.3
  • 82
    • 0037884961 scopus 로고    scopus 로고
    • Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
    • Lin F, Hiesberger T, Cordes K, et al. 2003. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 100:5286-5291.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5286-5291
    • Lin, F.1    Hiesberger, T.2    Cordes, K.3
  • 83
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 84
    • 0031252295 scopus 로고    scopus 로고
    • Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
    • Lu W, Peissel B, Babakhanlou H, et al. 1997. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet 17:179-181.
    • (1997) Nat Genet , vol.17 , pp. 179-181
    • Lu, W.1    Peissel, B.2    Babakhanlou, H.3
  • 85
    • 77956507253 scopus 로고    scopus 로고
    • DISC1 regulates primary cilia that display specific dopamine receptors
    • Marley A, von Zastrow M. 2010. DISC1 regulates primary cilia that display specific dopamine receptors. PLoS One 5:e10902.
    • (2010) PLoS One , vol.5
    • Marley, A.1    von Zastrow, M.2
  • 87
    • 79956271015 scopus 로고    scopus 로고
    • Alstrom syndrome: genetics and clinical overview
    • Marshall JD, Maffei P, Collin GB, et al. 2011. Alstrom syndrome: genetics and clinical overview. Curr Genomics 12:225-235.
    • (2011) Curr Genomics , vol.12 , pp. 225-235
    • Marshall, J.D.1    Maffei, P.2    Collin, G.B.3
  • 88
    • 0037766786 scopus 로고    scopus 로고
    • DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    • Morris JA, Kandpal G, Ma L, et al. 2003. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 12:1591-1608.
    • (2003) Hum Mol Genet , vol.12 , pp. 1591-1608
    • Morris, J.A.1    Kandpal, G.2    Ma, L.3
  • 89
    • 0034042763 scopus 로고    scopus 로고
    • The oak ridge polycystic kidney (orpk) disease gene is required for left-right axis determination
    • Murcia NS, Richards WG, Yoder BK, et al. 2000. The oak ridge polycystic kidney (orpk) disease gene is required for left-right axis determination. Development 127:2347-2355.
    • (2000) Development , vol.127 , pp. 2347-2355
    • Murcia, N.S.1    Richards, W.G.2    Yoder, B.K.3
  • 90
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    • Nachury MV, Loktev AV, Zhang Q, et al. 2007. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129:1201-1213.
    • (2007) Cell , vol.129 , pp. 1201-1213
    • Nachury, M.V.1    Loktev, A.V.2    Zhang, Q.3
  • 91
    • 0037317302 scopus 로고    scopus 로고
    • Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    • Nauli SM, Alenghat FJ, Luo Y, et al. 2003. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33:129-137.
    • (2003) Nat Genet , vol.33 , pp. 129-137
    • Nauli, S.M.1    Alenghat, F.J.2    Luo, Y.3
  • 92
    • 0034662967 scopus 로고    scopus 로고
    • Serotonin 2B receptor is required for heart development
    • Nebigil CG, Choi DS, Dierich A, et al. 2000. Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci USA 97:9508-9513.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9508-9513
    • Nebigil, C.G.1    Choi, D.S.2    Dierich, A.3
  • 93
    • 0032428685 scopus 로고    scopus 로고
    • Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
    • Nonaka S, Tanaka Y, Okada Y, et al. 1998. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95:829-837.
    • (1998) Cell , vol.95 , pp. 829-837
    • Nonaka, S.1    Tanaka, Y.2    Okada, Y.3
  • 94
    • 69949120070 scopus 로고    scopus 로고
    • Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo
    • Ocbina PJ, Tuson M, Anderson KV. 2009. Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One 4:e6839.
    • (2009) PLoS One , vol.4
    • Ocbina, P.J.1    Tuson, M.2    Anderson, K.V.3
  • 95
    • 0020069732 scopus 로고
    • Macro- and micro-domains in the endocrine pancreas
    • Orci L. 1982. Macro- and micro-domains in the endocrine pancreas. Diabetes 31:538-565.
    • (1982) Diabetes , vol.31 , pp. 538-565
    • Orci, L.1
  • 96
    • 0017065890 scopus 로고
    • Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes
    • Orci L, Baetens D, Rufener C, et al. 1976. Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Natl Acad Sci USA 73:1338-1342.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 1338-1342
    • Orci, L.1    Baetens, D.2    Rufener, C.3
  • 97
    • 79951648873 scopus 로고    scopus 로고
    • Pancreas organogenesis: from bud to plexus to gland
    • Pan FC, Wright C. 2011. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 240:530-565.
    • (2011) Dev Dyn , vol.240 , pp. 530-565
    • Pan, F.C.1    Wright, C.2
  • 98
    • 0034735526 scopus 로고    scopus 로고
    • Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    • Pazour GJ, Dickert BL, Vucica Y, et al. 2000. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151:709-718.
    • (2000) J Cell Biol , vol.151 , pp. 709-718
    • Pazour, G.J.1    Dickert, B.L.2    Vucica, Y.3
  • 99
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease
    • Pazour GJ, San Agustin JT, Follit JA, et al. 2002. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol 12:R378-380.
    • (2002) Curr Biol , vol.12
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3
  • 100
    • 32044438892 scopus 로고    scopus 로고
    • The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    • Pierreux CE, Poll AV, Kemp CR, et al. 2006. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology 130:532-541.
    • (2006) Gastroenterology , vol.130 , pp. 532-541
    • Pierreux, C.E.1    Poll, A.V.2    Kemp, C.R.3
  • 101
    • 0015521813 scopus 로고
    • Increased frequency of diabetes mellitus in patients with Huntington's chorea
    • Podolsky S, Leopold NA, Sax DS. 1972. Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet 1:1356-1358.
    • (1972) Lancet , vol.1 , pp. 1356-1358
    • Podolsky, S.1    Leopold, N.A.2    Sax, D.S.3
  • 102
    • 0035498717 scopus 로고    scopus 로고
    • Bending the MDCK cell primary cilium increases intracellular calcium
    • Praetorius HA, Spring KR. 2001. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184:71-79.
    • (2001) J Membr Biol , vol.184 , pp. 71-79
    • Praetorius, H.A.1    Spring, K.R.2
  • 103
    • 0030909957 scopus 로고    scopus 로고
    • PKD1 interacts with PKD2 through a probable coiled-coil domain
    • Qian F, Germino FJ, Cai Y, et al. 1997. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet 16:179-183.
    • (1997) Nat Genet , vol.16 , pp. 179-183
    • Qian, F.1    Germino, F.J.2    Cai, Y.3
  • 104
    • 41849134729 scopus 로고    scopus 로고
    • Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
    • Rahmouni K, Fath MA, Seo S, et al. 2008. Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest 118:1458-1467.
    • (2008) J Clin Invest , vol.118 , pp. 1458-1467
    • Rahmouni, K.1    Fath, M.A.2    Seo, S.3
  • 105
    • 38949087294 scopus 로고    scopus 로고
    • Mutations in the pericentrin (PCNT) gene cause primordial dwarfism
    • Rauch A, Thiel CT, Schindler D, et al. 2008. Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science 319:816-819.
    • (2008) Science , vol.319 , pp. 816-819
    • Rauch, A.1    Thiel, C.T.2    Schindler, D.3
  • 106
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    • Rohatgi R, Milenkovic L, Corcoran RB, et al. 2009. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci USA 106:3196-3201.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3
  • 107
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP. 2007. Patched1 regulates hedgehog signaling at the primary cilium. Science 317:372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 109
    • 0014954015 scopus 로고
    • An unusual form of diabetes mellitus in ataxia telangiectasia
    • Schalch DS, McFarlin DE, Barlow MH. 1970. An unusual form of diabetes mellitus in ataxia telangiectasia. N Engl J Med 282:1396-1402.
    • (1970) N Engl J Med , vol.282 , pp. 1396-1402
    • Schalch, D.S.1    McFarlin, D.E.2    Barlow, M.H.3
  • 110
    • 0018743098 scopus 로고
    • Effect of fasting on the release of insulin and somatostatin from perifused islets of Langerhans
    • Schauder P, McIntosh C, Arends J, et al. 1979. Effect of fasting on the release of insulin and somatostatin from perifused islets of Langerhans. Diabetes 28:204-207.
    • (1979) Diabetes , vol.28 , pp. 204-207
    • Schauder, P.1    McIntosh, C.2    Arends, J.3
  • 111
    • 78649329990 scopus 로고    scopus 로고
    • Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy
    • Schraenen A, Lemaire K, de Faudeur G, et al. 2010. Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy. Diabetologia 53:2589-2599.
    • (2010) Diabetologia , vol.53 , pp. 2589-2599
    • Schraenen, A.1    Lemaire, K.2    de Faudeur, G.3
  • 112
    • 63149175815 scopus 로고    scopus 로고
    • Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
    • Seo S, Guo DF, Bugge K, et al. 2009. Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet 18:1323-1331.
    • (2009) Hum Mol Genet , vol.18 , pp. 1323-1331
    • Seo, S.1    Guo, D.F.2    Bugge, K.3
  • 113
    • 33846910410 scopus 로고    scopus 로고
    • SOX9 is required for maintenance of the pancreatic progenitor cell pool
    • Seymour PA, Freude KK, Tran MN, et al. 2007. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci USA 104:1865-1870.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1865-1870
    • Seymour, P.A.1    Freude, K.K.2    Tran, M.N.3
  • 114
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw RJ, Lamia KA, Vasquez D, et al. 2005. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3
  • 115
    • 84863088235 scopus 로고    scopus 로고
    • A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
    • Shih HP, Kopp, JL. Sandhu M, et al. 2012. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139:2488-2499.
    • (2012) Development , vol.139 , pp. 2488-2499
    • Shih, H.P.1    Kopp, J.L.2    Sandhu, M.3
  • 116
    • 0035020865 scopus 로고    scopus 로고
    • Fine needle aspiration cytology of a pancreatic cyst in a patient with autosomal dominant polycystic kidney disease. A case report
    • Silverman JF, Prichard J, Regueiro MD. 2001. Fine needle aspiration cytology of a pancreatic cyst in a patient with autosomal dominant polycystic kidney disease. A case report. Acta Cytol 45:415-419.
    • (2001) Acta Cytol , vol.45 , pp. 415-419
    • Silverman, J.F.1    Prichard, J.2    Regueiro, M.D.3
  • 117
    • 0014291368 scopus 로고
    • Reconstructions of centriole formation and ciliogenesis in mammalian lungs
    • Sorokin SP. 1968. Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci 3:207-230.
    • (1968) J Cell Sci , vol.3 , pp. 207-230
    • Sorokin, S.P.1
  • 118
    • 33646408159 scopus 로고    scopus 로고
    • Non-specific detection of the centrosomes by antibodies recognizing phosphorylated ATM at serine 1981
    • Suzuki K, Morimoto M, Yamauchi M, et al. 2006. Non-specific detection of the centrosomes by antibodies recognizing phosphorylated ATM at serine 1981. Cell Cycle 5:1008-1009.
    • (2006) Cell Cycle , vol.5 , pp. 1008-1009
    • Suzuki, K.1    Morimoto, M.2    Yamauchi, M.3
  • 119
    • 84860879223 scopus 로고    scopus 로고
    • TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling
    • Tajeddine N, Gailly P. 2012. TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling. J Biol Chem 287:16146-16157.
    • (2012) J Biol Chem , vol.287 , pp. 16146-16157
    • Tajeddine, N.1    Gailly, P.2
  • 120
    • 0037162886 scopus 로고    scopus 로고
    • Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet
    • Takahashi N, Kishimoto T, Nemoto T. 2002. Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science 297:1349-1352.
    • (2002) Science , vol.297 , pp. 1349-1352
    • Takahashi, N.1    Kishimoto, T.2    Nemoto, T.3
  • 121
    • 2742559419 scopus 로고
    • Diabetes mellitus in Friedreich's ataxia
    • Thoren C. 1962. Diabetes mellitus in Friedreich's ataxia. Acta Paediatr Suppl 135:239-247.
    • (1962) Acta Paediatr Suppl , vol.135 , pp. 239-247
    • Thoren, C.1
  • 122
    • 0031020062 scopus 로고    scopus 로고
    • Ultrasonographic study of pancreatic cysts in autosomal dominant polycystic kidney disease
    • Torra R, Nicolau C, Badenas C, et al. 1997. Ultrasonographic study of pancreatic cysts in autosomal dominant polycystic kidney disease. Clin Nephrol 47:19-22.
    • (1997) Clin Nephrol , vol.47 , pp. 19-22
    • Torra, R.1    Nicolau, C.2    Badenas, C.3
  • 123
    • 84855178450 scopus 로고    scopus 로고
    • The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion
    • Uchida K, Tominaga M. 2011. The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion. Endocr J 58:1021-1028.
    • (2011) Endocr J , vol.58 , pp. 1021-1028
    • Uchida, K.1    Tominaga, M.2
  • 124
    • 0034810681 scopus 로고    scopus 로고
    • Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease
    • Vassilev PM, Guo L, Chen XZ, et al. 2001. Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. Biochem Biophys Res Commun 282:341-350.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 341-350
    • Vassilev, P.M.1    Guo, L.2    Chen, X.Z.3
  • 125
    • 34147215806 scopus 로고    scopus 로고
    • Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia
    • Wang S, Zhang J, Nauli SM, et al. 2007. Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol 27:3241-3252.
    • (2007) Mol Cell Biol , vol.27 , pp. 3241-3252
    • Wang, S.1    Zhang, J.2    Nauli, S.M.3
  • 126
    • 84865803552 scopus 로고    scopus 로고
    • The BBSome controls IFT assembly and turnaround in cilia
    • Wei Q, Zhang Y, Li Y, et al. 2012. The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol 14:950-957.
    • (2012) Nat Cell Biol , vol.14 , pp. 950-957
    • Wei, Q.1    Zhang, Y.2    Li, Y.3
  • 127
    • 0029586470 scopus 로고
    • Primary cilia in normal and pathological tissues
    • Wheatley DN. 1995. Primary cilia in normal and pathological tissues. Pathobiology 63:222-238.
    • (1995) Pathobiology , vol.63 , pp. 222-238
    • Wheatley, D.N.1
  • 129
    • 6344226513 scopus 로고    scopus 로고
    • Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii
    • Wilson NF, Lefebvre PA. 2004. Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii. Eukaryot Cell 3:1307-1319.
    • (2004) Eukaryot Cell , vol.3 , pp. 1307-1319
    • Wilson, N.F.1    Lefebvre, P.A.2
  • 130
    • 34548488655 scopus 로고    scopus 로고
    • Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors
    • Wouters MM, Gibbons SJ, Roeder JL, et al. 2007. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology 133:897-906.
    • (2007) Gastroenterology , vol.133 , pp. 897-906
    • Wouters, M.M.1    Gibbons, S.J.2    Roeder, J.L.3
  • 131
    • 33750391715 scopus 로고    scopus 로고
    • Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin
    • Wu Y, Dai XQ, Li Q, et al. 2006. Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. Hum Mol Genet 15:3280-3292.
    • (2006) Hum Mol Genet , vol.15 , pp. 3280-3292
    • Wu, Y.1    Dai, X.Q.2    Li, Q.3
  • 132
    • 0033972998 scopus 로고    scopus 로고
    • Molecular genetics and mechanism of autosomal dominant polycystic kidney disease
    • Wu G, Somlo S. 2000. Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. Mol Genet Metab 69:1-15.
    • (2000) Mol Genet Metab , vol.69 , pp. 1-15
    • Wu, G.1    Somlo, S.2
  • 133
    • 77956272001 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family
    • Wu LJ, Sweet TB, Clapham DE. 2010. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62:381-404.
    • (2010) Pharmacol Rev , vol.62 , pp. 381-404
    • Wu, L.J.1    Sweet, T.B.2    Clapham, D.E.3
  • 134
    • 33750067680 scopus 로고    scopus 로고
    • The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology
    • Yang SN, Berggren PO. 2006. The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Endocr Rev 27:621-676.
    • (2006) Endocr Rev , vol.27 , pp. 621-676
    • Yang, S.N.1    Berggren, P.O.2
  • 135
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder BK, Hou X, Guay-Woodford LM. 2002. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13:2508-2516.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3
  • 136
    • 79957524110 scopus 로고    scopus 로고
    • Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin
    • Yoshida N, Kobayashi K, Yu L, et al. 2011. Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin. Mol Pain 7:41.
    • (2011) Mol Pain , vol.7 , pp. 41
    • Yoshida, N.1    Kobayashi, K.2    Yu, L.3
  • 137
    • 65649147891 scopus 로고    scopus 로고
    • Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy
    • Zaghloul NA, Katsanis N. 2009. Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest 119:428-437.
    • (2009) J Clin Invest , vol.119 , pp. 428-437
    • Zaghloul, N.A.1    Katsanis, N.2
  • 138
    • 70350608140 scopus 로고    scopus 로고
    • Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation
    • Zhang H, Ables ET, Pope CF, et al. 2009. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev 126:958-973.
    • (2009) Mech Dev , vol.126 , pp. 958-973
    • Zhang, H.1    Ables, E.T.2    Pope, C.F.3
  • 139
    • 12344273107 scopus 로고    scopus 로고
    • Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice
    • Zhang Q, Davenport JR, Croyle MJ, et al. 2005. Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest 85:45-64.
    • (2005) Lab Invest , vol.85 , pp. 45-64
    • Zhang, Q.1    Davenport, J.R.2    Croyle, M.J.3
  • 140
    • 84859219770 scopus 로고    scopus 로고
    • BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes
    • Zhang Q, Seo S, Bugge K, et al. 2012. BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum Mol Genet 21:1945-1953.
    • (2012) Hum Mol Genet , vol.21 , pp. 1945-1953
    • Zhang, Q.1    Seo, S.2    Bugge, K.3
  • 141
    • 34247875990 scopus 로고    scopus 로고
    • Centrosomal localization of DNA damage checkpoint proteins
    • Zhang S, Hemmerich P, Grosse F. 2007. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem 101:451-465.
    • (2007) J Cell Biochem , vol.101 , pp. 451-465
    • Zhang, S.1    Hemmerich, P.2    Grosse, F.3
  • 142
    • 68549115658 scopus 로고    scopus 로고
    • Notch signaling controls liver development by regulating biliary differentiation
    • Zong Y, Panikkar A, Xu J, et al. 2009. Notch signaling controls liver development by regulating biliary differentiation. Development 136:1727-1739.
    • (2009) Development , vol.136 , pp. 1727-1739
    • Zong, Y.1    Panikkar, A.2    Xu, J.3


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