-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505): 425-432.
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
-
2
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normalweight and obese humans
-
Considine RV, et al. (1996) Serum immunoreactive-leptin concentrations in normalweight and obese humans. N Engl J Med 334(5): 292-295.
-
(1996)
N Engl J Med
, vol.334
, Issue.5
, pp. 292-295
-
-
Considine, R.V.1
-
3
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, et al. (1995) Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1(11): 1155-1161.
-
(1995)
Nat Med
, vol.1
, Issue.11
, pp. 1155-1161
-
-
Maffei, M.1
-
4
-
-
0036081096
-
Middle-aged C57BL/6 mice have impaired responses to leptin that are not improved by calorie restriction
-
Jacobson L (2002) Middle-aged C57BL/6 mice have impaired responses to leptin that are not improved by calorie restriction. Am J Physiol Endocrinol Metab 282(4): E786-E793.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
, Issue.4
-
-
Jacobson, L.1
-
5
-
-
0034006768
-
Impaired leptin responsiveness in aged rats
-
Scarpace PJ, Matheny M, Moore RL, Tümer N (2000) Impaired leptin responsiveness in aged rats. Diabetes 49(3): 431-435.
-
(2000)
Diabetes
, vol.49
, Issue.3
, pp. 431-435
-
-
Scarpace, P.J.1
Matheny, M.2
Moore, R.L.3
Tümer, N.4
-
6
-
-
33845882537
-
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
-
Morrison CD, et al. (2007) Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology 148(1): 433-440.
-
(2007)
Endocrinology
, vol.148
, Issue.1
, pp. 433-440
-
-
Morrison, C.D.1
-
7
-
-
0035851878
-
Peripheral and hypothalamic leptin resistance with agerelated obesity
-
Scarpace PJ, Tümer N (2001) Peripheral and hypothalamic leptin resistance with agerelated obesity. Physiol Behav 74(4-5): 721-727.
-
(2001)
Physiol Behav
, vol.74
, Issue.4-5
, pp. 721-727
-
-
Scarpace, P.J.1
Tümer, N.2
-
8
-
-
65649147891
-
Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy
-
Zaghloul NA, Katsanis N (2009) Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest 119(3): 428-437.
-
(2009)
J Clin Invest
, vol.119
, Issue.3
, pp. 428-437
-
-
Zaghloul, N.A.1
Katsanis, N.2
-
10
-
-
58149326846
-
Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling
-
Pedersen LB, Rosenbaum JL (2008) Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol 85: 23-61.
-
(2008)
Curr Top Dev Biol
, vol.85
, pp. 23-61
-
-
Pedersen, L.B.1
Rosenbaum, J.L.2
-
11
-
-
58149326842
-
Ciliary dysfunction in developmental abnormalities and diseases
-
Sharma N, Berbari NF, Yoder BK (2008) Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol 85: 371-427.
-
(2008)
Curr Top Dev Biol
, vol.85
, pp. 371-427
-
-
Sharma, N.1
Berbari, N.F.2
Yoder, B.K.3
-
12
-
-
41949116864
-
Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
-
Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K (2008) Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc Natl Acad Sci USA 105(11): 4242-4246.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.11
, pp. 4242-4246
-
-
Berbari, N.F.1
Lewis, J.S.2
Bishop, G.A.3
Askwith, C.C.4
Mykytyn, K.5
-
13
-
-
34250012834
-
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
-
Nachury MV, et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129(6): 1201-1213.
-
(2007)
Cell
, vol.129
, Issue.6
, pp. 1201-1213
-
-
Nachury, M.V.1
-
14
-
-
80051798889
-
Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
-
Domire JS, et al. (2011) Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins. Cell Mol Life Sci 68(17): 2951-2960.
-
(2011)
Cell Mol Life Sci
, vol.68
, Issue.17
, pp. 2951-2960
-
-
Domire, J.S.1
-
15
-
-
77953879123
-
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia
-
Jin H, et al. (2010) The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 141(7): 1208-1219.
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1208-1219
-
-
Jin, H.1
-
16
-
-
2942625562
-
Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
-
Mykytyn K, et al. (2004) Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly. Proc Natl Acad Sci USA 101(23): 8664-8669.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.23
, pp. 8664-8669
-
-
Mykytyn, K.1
-
17
-
-
9344261783
-
Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
-
Nishimura DY, et al. (2004) Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc Natl Acad Sci USA 101(47): 16588-16593.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.47
, pp. 16588-16593
-
-
Nishimura, D.Y.1
-
18
-
-
3042738924
-
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
-
Blacque OE, et al. (2004) Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev 18(13): 1630-1642.
-
(2004)
Genes Dev
, vol.18
, Issue.13
, pp. 1630-1642
-
-
Blacque, O.E.1
-
19
-
-
76149101303
-
The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins fromflagella
-
Lechtreck KF, et al. (2009) The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins fromflagella. J Cell Biol 187(7): 1117-1132.
-
(2009)
J Cell Biol
, vol.187
, Issue.7
, pp. 1117-1132
-
-
Lechtreck, K.F.1
-
20
-
-
63149175815
-
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
-
Seo S, et al. (2009) Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet 18(7): 1323-1331.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.7
, pp. 1323-1331
-
-
Seo, S.1
-
21
-
-
41849134729
-
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
-
Rahmouni K, et al. (2008) Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest 118(4): 1458-1467.
-
(2008)
J Clin Invest
, vol.118
, Issue.4
, pp. 1458-1467
-
-
Rahmouni, K.1
-
22
-
-
34548490748
-
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease
-
Davenport JR, et al. (2007) Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol 17(18): 1586-1594.
-
(2007)
Curr Biol
, vol.17
, Issue.18
, pp. 1586-1594
-
-
Davenport, J.R.1
-
23
-
-
0037090881
-
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/ inactivation in the mouse
-
Hayashi S, McMahon AP (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/ inactivation in the mouse. Dev Biol 244(2): 305-318.
-
(2002)
Dev Biol
, vol.244
, Issue.2
, pp. 305-318
-
-
Hayashi, S.1
McMahon, A.P.2
-
24
-
-
38049092146
-
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
-
Bishop GA, Berbari NF, Lewis J, Mykytyn K (2007) Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J Comp Neurol 505(5): 562-571.
-
(2007)
J Comp Neurol
, vol.505
, Issue.5
, pp. 562-571
-
-
Bishop, G.A.1
Berbari, N.F.2
Lewis, J.3
Mykytyn, K.4
-
25
-
-
0142062026
-
Meal pattern analysis of diet-induced obesity in susceptible and resistant rats
-
Farley C, Cook JA, Spar BD, Austin TM, Kowalski TJ (2003) Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Obes Res 11(7): 845-851.
-
(2003)
Obes Res
, vol.11
, Issue.7
, pp. 845-851
-
-
Farley, C.1
Cook, J.A.2
Spar, B.D.3
Austin, T.M.4
Kowalski, T.J.5
-
26
-
-
33845672095
-
Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1
-
Cui H, Cai F, Belsham DD (2006) Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. FASEB J 20(14): 2654-2656.
-
(2006)
FASEB J
, vol.20
, Issue.14
, pp. 2654-2656
-
-
Cui, H.1
Cai, F.2
Belsham, D.D.3
-
27
-
-
0034085453
-
Impaired leptin signal transduction with age-related obesity
-
Scarpace PJ, Matheny M, Shek EW (2000) Impaired leptin signal transduction with age-related obesity. Neuropharmacology 39(10): 1872-1879.
-
(2000)
Neuropharmacology
, vol.39
, Issue.10
, pp. 1872-1879
-
-
Scarpace, P.J.1
Matheny, M.2
Shek, E.W.3
-
28
-
-
0038376041
-
Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice
-
Pitts S, Perone E, Silver R (2003) Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice. Am J Physiol Regul Integr Comp Physiol 285(1): R57-R67.
-
(2003)
Am J Physiol Regul Integr Comp Physiol
, vol.285
, Issue.1
-
-
Pitts, S.1
Perone, E.2
Silver, R.3
-
29
-
-
2342507112
-
Dissociation between adipose tissue signals, behavior and the food-entrained oscillator
-
Martínez-Merlos MT, et al. (2004) Dissociation between adipose tissue signals, behavior and the food-entrained oscillator. J Endocrinol 181(1): 53-63.
-
(2004)
J Endocrinol
, vol.181
, Issue.1
, pp. 53-63
-
-
Martínez-Merlos, M.T.1
-
30
-
-
69849109042
-
Peripheral oscillators: The driving force for food-anticipatory activity
-
Escobar C, Cailotto C, Angeles-Castellanos M, Delgado RS, Buijs RM (2009) Peripheral oscillators: The driving force for food-anticipatory activity. Eur J Neurosci 30(9): 1665-1675.
-
(2009)
Eur J Neurosci
, vol.30
, Issue.9
, pp. 1665-1675
-
-
Escobar, C.1
Cailotto, C.2
Angeles-Castellanos, M.3
Delgado, R.S.4
Buijs, R.M.5
-
31
-
-
77249119177
-
Mild calorie restriction induces fat accumulation in female C57BL/6J mice
-
Li X, Cope MB, Johnson MS, Smith DL, Jr., Nagy TR (2010) Mild calorie restriction induces fat accumulation in female C57BL/6J mice. Obesity (Silver Spring) 18(3): 456-462.
-
(2010)
Obesity (Silver Spring)
, vol.18
, Issue.3
, pp. 456-462
-
-
Li, X.1
Cope, M.B.2
Johnson, M.S.3
Smith Jr., D.L.4
Nagy, T.R.5
-
32
-
-
84875058383
-
Sensitivity to cold in the hereditary obese-hyperglycemic syndrome of mice
-
Mayer J, Barrnett RJ (1953) Sensitivity to cold in the hereditary obese-hyperglycemic syndrome of mice. Yale J Biol Med 26(1): 38-45.
-
(1953)
Yale J Biol Med
, vol.26
, Issue.1
, pp. 38-45
-
-
Mayer, J.1
Barrnett, R.J.2
-
33
-
-
34247636362
-
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
Medina-Gomez G, et al. (2007) PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3(4):e64.
-
(2007)
PLoS Genet
, vol.3
, Issue.4
-
-
Medina-Gomez, G.1
-
34
-
-
0017364207
-
Thermogenic defect in pre-obese ob/ob mice
-
Trayhurn P, Thurlby PL, James WP (1977) Thermogenic defect in pre-obese ob/ob mice. Nature 266(5597): 60-62.
-
(1977)
Nature
, vol.266
, Issue.5597
, pp. 60-62
-
-
Trayhurn, P.1
Thurlby, P.L.2
James, W.P.3
-
35
-
-
33845867730
-
Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
-
Xu AW, Ste-Marie L, Kaelin CB, Barsh GS (2007) Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148(1): 72-80.
-
(2007)
Endocrinology
, vol.148
, Issue.1
, pp. 72-80
-
-
Xu, A.W.1
Ste-Marie, L.2
Kaelin, C.B.3
Barsh, G.S.4
-
36
-
-
33847319765
-
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
-
Enriori PJ, et al. (2007) Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab 5(3): 181-194.
-
(2007)
Cell Metab
, vol.5
, Issue.3
, pp. 181-194
-
-
Enriori, P.J.1
-
37
-
-
69749094930
-
Diet-induced obese mice are leptin insufficient after weight reduction
-
Shi H, et al. (2009) Diet-induced obese mice are leptin insufficient after weight reduction. Obesity (Silver Spring) 17(9): 1702-1709.
-
(2009)
Obesity (Silver Spring)
, vol.17
, Issue.9
, pp. 1702-1709
-
-
Shi, H.1
-
38
-
-
0029949063
-
Leptin activation in hypothalamus
-
Woods AJ, Stock MJ (1996) Leptin activation in hypothalamus. Nature 381(6585):745.
-
(1996)
Nature
, vol.381
, Issue.6585
, pp. 745
-
-
Woods, A.J.1
Stock, M.J.2
-
39
-
-
0036230922
-
Leptin resistance during aging is independent of fat mass
-
Gabriely I, Ma XH, Yang XM, Rossetti L, Barzilai N (2002) Leptin resistance during aging is independent of fat mass. Diabetes 51(4): 1016-1021.
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 1016-1021
-
-
Gabriely, I.1
Ma, X.H.2
Yang, X.M.3
Rossetti, L.4
Barzilai, N.5
-
40
-
-
0036265354
-
Aging is associated with resistance to effects of leptin on fat distribution and insulin action
-
Ma XH, et al. (2002) Aging is associated with resistance to effects of leptin on fat distribution and insulin action. J Gerontol A Biol Sci Med Sci 57(6):B225-B231.
-
(2002)
J Gerontol A Biol Sci Med Sci
, vol.57
, Issue.6
-
-
Ma, X.H.1
-
41
-
-
37649020306
-
A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity
-
Davis RE, et al. (2007) A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proc Natl Acad Sci USA 104(49): 19422-19427.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.49
, pp. 19422-19427
-
-
Davis, R.E.1
-
42
-
-
33746959616
-
Phenotypic characterization of Bbs4 null mice reveals agedependent penetrance and variable expressivity
-
Eichers ER, et al. (2006) Phenotypic characterization of Bbs4 null mice reveals agedependent penetrance and variable expressivity. Hum Genet 120(2): 211-226.
-
(2006)
Hum Genet
, vol.120
, Issue.2
, pp. 211-226
-
-
Eichers, E.R.1
-
43
-
-
69849094896
-
Food-anticipatory circadian rhythms: Concepts and methods
-
Mistlberger RE (2009) Food-anticipatory circadian rhythms: Concepts and methods. Eur J Neurosci 30(9): 1718-1729.
-
(2009)
Eur J Neurosci
, vol.30
, Issue.9
, pp. 1718-1729
-
-
Mistlberger, R.E.1
-
44
-
-
80755139624
-
Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation
-
Berbari NF, et al. (2011) Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360(1): 66-76.
-
(2011)
Dev Biol
, vol.360
, Issue.1
, pp. 66-76
-
-
Berbari, N.F.1
-
45
-
-
78149259013
-
Primary cilia regulate mTORC1 activity and cell size through Lkb1
-
Boehlke C, et al. (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol 12(11): 1115-1122.
-
(2010)
Nat Cell Biol
, vol.12
, Issue.11
, pp. 1115-1122
-
-
Boehlke, C.1
-
46
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312(5775): 927-930.
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
-
47
-
-
33645769011
-
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
-
Shillingford JM, et al. (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci USA 103(14): 5466-5471.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.14
, pp. 5466-5471
-
-
Shillingford, J.M.1
-
48
-
-
77951101203
-
The primary cilium: A signalling centre during vertebrate development
-
Goetz SC, Anderson KV (2010) The primary cilium: A signalling centre during vertebrate development. Nat Rev Genet 11(5): 331-344.
-
(2010)
Nat Rev Genet
, vol.11
, Issue.5
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
49
-
-
66149182895
-
Role of neuroepithelial Sonic hedgehog in hypothalamic patterning
-
Szabo NE, et al. (2009) Role of neuroepithelial Sonic hedgehog in hypothalamic patterning. J Neurosci 29(21): 6989-7002.
-
(2009)
J Neurosci
, vol.29
, Issue.21
, pp. 6989-7002
-
-
Szabo, N.E.1
-
50
-
-
51349167818
-
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
-
Breunig JJ, et al. (2008) Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci USA 105(35): 13127-13132.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.35
, pp. 13127-13132
-
-
Breunig, J.J.1
-
51
-
-
78650460050
-
Validation of quantitative magnetic resonance for the determination of body composition of mice
-
Jones AS, Johnson MS, Nagy TR (2009) Validation of quantitative magnetic resonance for the determination of body composition of mice. Int J Body Compos Res 7(2): 67-72.
-
(2009)
Int J Body Compos Res
, vol.7
, Issue.2
, pp. 67-72
-
-
Jones, A.S.1
Johnson, M.S.2
Nagy, T.R.3
|