Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella

Journal of Cell Biology

Volumn 151, Issue 3, 2000, Pages 709-718

  Pazour, Gregory J ^a   Dickert, Bethany L ^a   Vucica, Yvonne ^b,e   Seeley, E Scott ^b,d   Rosenbaum, Joel L ^b   Witman, George B ^a   Cole, Douglas G ^c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF IDAHO   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Cytoplasmic dynein; Intraflagellar transport; Kinesin II; Orpk; Primary cilia

Indexed keywords

KINESIN;

ARTICLE; CHLAMYDOMONAS; FLAGELLUM; KIDNEY COLLECTING TUBULE; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PSEUDOPODIUM;

AMINO ACID SEQUENCE; ANIMALS; CHLAMYDOMONAS; CILIA; CLONING, MOLECULAR; CONSERVED SEQUENCE; FLAGELLA; HUMANS; KIDNEY; MEIOSIS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; POLYCYSTIC KIDNEY, AUTOSOMAL RECESSIVE; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEINS; PROTOZOAN PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEINS;

ALGAE; CHLAMYDOMONAS; EUKARYOTA; MAMMALIA;

EID: 0034735526     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.3.709     Document Type: Article

References (63)

1. The immotile-cilia syndrome and other ciliary diseases
2. A scanning electron microscopic study of the nephron
3. Notulae seminologicae. 2. The 'short tail' and 'stump' defect in human spermatozoa
4. A polycistic kidney-disease gene homologue required for male mating behaviour in C. elegans
5. Localization of kinesin superfamily proteins to the connecting cilium of fish photoreceptors
6. The photoreceptor connecting cilium: A model for the transition zone
7. The tetratricopeptide repeat: A structural motif mediating protein-protein interactions
8. Polycystic disease of kidneys and liver presenting in childhood
9. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions
10. Polycystic kidney disease in the first year of life
11. Kinesin-II, coming and going
12. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons
13. Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans
14. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
15. Substructure of solitary cilia in mouse kidney
16. Vasoactive peptides and the kidney
17. Selective targeting of somatostatin receptor 3 to neuronal cilia
18. Snap helix with knob and hole: Essential repeats in S. pombe nuclear protein nuc2+
19. Outer doublet heterogeneity reveals structural polarity related to beat direction in Chlamydomonas flagella
20. The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
21. High-frequency nuclear transformation of Chlamydomonas reinhardtii
22. The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane
23. A motility in the eukaryotic flagellum unrelated to flagellar beating
24. Tetratrico peptide repeat interactions: To TPR or not to TPR?
25. The genetics and cytology of Chlamydomonas
26. Specific neuroanatomical changes in chemosensory mutants of the nematode Caenorhabditis elegans
27. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
28. Understanding the functions of kinesin-II
29. Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors
30. High-resolution scanning electron microscopy of milk products: A new sample preparation procedure
31. Scanning electron microscopy demonstration of cilia in rat intrahepatic bile ducts
32. Candidate gene associated with a mutation causing recessive polycistic kidney disease in mice
33. The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
34. The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors
35. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking kif3b motor protein
36. Movement of motor and cargo along cilia
37. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly
38. Mutational analysis of the phototransduction pathway of Chlamydomonas reinhardtii
39. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)
40. Forward and reverse genetic analysis of microtubule motors in Chlamydomonas
41. Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
42. Mutant sensory cilia in the nematode Caenorhabditis elegans
43. Monoclonal antibodies specific for an acetylated form of α-tubulin recognize the antigen in cilia and flagella from a variety of organisms
44. Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella
45. Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(Fla10) to reach the distal part of the flagella in Chlamydomonas
46. Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas
47. PKD1 interacts with PKD2 through a probable coiled-coil domain
48. Intraflagellar transport: The eyes have it
49. Flexible-substratum technique for viewing cells from the side: Some in vivo properties of primary (9+0) cilia in cultured kidney epithelia
50. Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans
51. Left-right asymmetry and kinesin superfamily protein KIF3A: New insights in determination of laterality and mesoderm induction by kif3A-/-mice analysis
52. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein
53. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice
54. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2
55. Primary cilia in normal and pathological tissues
56. Expression of primary cilia in mammalian cells
57. The structure of the ventral nerve cord of Caenorhabditis elegans
58. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina
59. CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans
60. The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein is a WD-repeat protein required for arm assembly
61. Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA
62. Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant