Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas

Pancreas

Volumn 23, Issue 3, 2001, Pages 302-308

  Brunicardi, F C ^a   Kleinman, R ^a   Moldovan, S ^a   Nguyen, T H L ^a   Watt, P C ^a   Walsh, J ^a   Gingerich, R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Glucagon; Insulin; Islets; Perfused human pancreas; Somatostatin

Indexed keywords

GLUCAGON; GLUCAGON ANTIBODY; GLUCOSE; INSULIN; INSULIN ANTIBODY; SOMATOSTATIN; SOMATOSTATIN ANTIBODY;

ARTICLE; CELL INTERACTION; CELL SECRETION; CLINICAL ARTICLE; FEMALE; GLUCAGON RELEASE; HORMONE RESPONSE; HUMAN; HUMAN TISSUE; IMMUNE SYSTEM; INSULIN RELEASE; MALE; PANCREAS; PANCREAS ISLET CELL; PRIORITY JOURNAL; SOMATOSTATIN RELEASE;

ADOLESCENT; ADULT; ANTIBODIES; ANTIBODIES, MONOCLONAL; CADAVER; CHILD; FEMALE; GLUCAGON; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PERFUSION; SOMATOSTATIN;

EID: 0034801880     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200110000-00012     Document Type: Article

References (34)

1. Pancreatic polypeptide, glucagon, and insulin secretion from the isolated perfused canine pancreas
2. The order of microvascular cellular perfusion is B-A-D in the perfused rat pancreas
3. Intra-islet regulation
4. B to A to D pancreatic islet cellular perfusion in dogs
5. Anterograde and retrograde infusion of glucagon antibodies suggests that the A cells are vascularly perfused before D cells within the rat islet
6. Perfusion with anti-insulin gamma globulin indicates a B to A to D cellular perfusion sequence in the pancreas of the rhesus monkey, Macaca Mulatta
7. The vascular order of islet cellular perfusion in the human pancreas
8. Selective neurohormonal interactions in islet cell secretion in the isolated perfused human pancreas
9. The regulatory role of intraislet somatostatin on insulin secretion in the isolated perfused human pancreas
10. Use of the Fab fragment for immunoneutralization of somatostatin in the isolated perfused human pancreas
11. The influence of somatostatin on glucagon and pancreatic polypeptide secretion in the isolated perfused human pancreas
12. Somatostatin inhibits B-cell secretion by a subtype-2 receptor in the isolated perfused human pancreas
13. Solid phase insulin radioimmunoassay with human serum based calibrators: Clinical data and comparison with four other methodologies
14. Human pancreatic islet cell clones secreting insulin, glucagon, and somatostatin: Immunocytochemical and functional studies
15. Isolated pancreatic islets of the rat: An immunohistochemical and morphometric study
16. New perspectives on the micovasculature of the islets of Langerhans in the rat
17. The insulo-acinar portal and insulo-venule drainage systems in the pancreas of the mouse, dog, monkey, and certain other animals: A scanning electron microscopic study of corrosion casts
18. Dynamic in vivo observation of rat islet microcirculation
19. Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreas
20. Neural and hormonal regulation of insulin release in the isolated perfused human pancreas
21. GIP induces insulin release by calcium transport: Further evidence of a common mechanism with arginine
22. Nitric oxide regulates insulin secretion in the isolated perfused human pancreas via a cholinergic mechanism
23. Passive immunoneutralization: A method for studying the regulation of basal and pulsatile hormone secretion
24. Antibodies in passive immunization studies: Characteristics and consequences
25. A monoclonal antibody to somatostatin with potent in vivo immunoneutralizing activity
26. Intraislet and islet-acinar portal systems and their significance
27. Role of insulin secretagogues in the regulation of somatostatin binding by isolated rat islets
28. Characterization of functional receptors for somatostatin in rat pituitary cells in culture
29. Somatostatin receptors: Identification in rat brain membranes
30. Three-dimensional imaging of intact isolated islets of Langerhans with confocal microscopy
31. Physiologic role of somatostatin: Insulin release from rat islets treated by somatostatin antiserum
32. Glucose stimulation of somatostatin and insulin release from the isolated perfused rat pancreas
33. Sensitivity of rat pancreatic A and B cells to somatostatin
34. Molecular biology of somatostatin receptor subtypes