-
1
-
-
79956054956
-
Comparing photosynthetic and photovoltaic efficiencies and recognizing the potential for improvement
-
Blankenship, R. E., Tiede, D. M., Barber, J., Brudvig, G. W., Fleming, G., Ghirardi, M., Gunner, M. R., Junge, W., Kramer, D. M., Melis, A., Moore, T. A., Moser, C. C., Nocera, D. G., Nozik, A. J., Ort, D. R., Parson, W. W., Prince, R. C., and Sayre, R. T. (2011) Comparing photosynthetic and photovoltaic efficiencies and recognizing the potential for improvement. Science 332, 805-809.
-
(2011)
Science
, vol.332
, pp. 805-809
-
-
Blankenship, R.E.1
Tiede, D.M.2
Barber, J.3
Brudvig, G.W.4
Fleming, G.5
Ghirardi, M.6
Gunner, M.R.7
Junge, W.8
Kramer, D.M.9
Melis, A.10
Moore, T.A.11
Moser, C.C.12
Nocera, D.G.13
Nozik, A.J.14
Ort, D.R.15
Parson, W.W.16
Prince, R.C.17
Sayre, R.T.18
-
2
-
-
42249085227
-
What is the maximum efficiency with which photosynthesis can convert solar energy into biomass?
-
Zhu, X.-G., Long, S. P., and Ort, D. R. (2008) What is the maximum efficiency with which photosynthesis can convert solar energy into biomass? Curr. Opin. Biotechnol. 19, 153-159.
-
(2008)
Curr. Opin. Biotechnol.
, vol.19
, pp. 153-159
-
-
Zhu, X.-G.1
Long, S.P.2
Ort, D.R.3
-
3
-
-
72949109936
-
Solar fuels via artificial photosynthesis
-
Gust, D., Moore, T. A., and Moore, A. L. (2009) Solar fuels via artificial photosynthesis. Acc. Chem. Res. 42, 1890-1898.
-
(2009)
Acc. Chem. Res.
, vol.42
, pp. 1890-1898
-
-
Gust, D.1
Moore, T.A.2
Moore, A.L.3
-
4
-
-
84856746106
-
Light-driven chemical synthesis
-
Jensen, K., Jensen, P. E., and Moller, B. L. (2012) Light-driven chemical synthesis. Trends Plant Sci. 17, 533-539.
-
(2012)
Trends Plant Sci.
, vol.17
, pp. 533-539
-
-
Jensen, K.1
Jensen, P.E.2
Moller, B.L.3
-
5
-
-
0035927420
-
Three-dimensional structure of cyanobacterial photosystem i at 2.5 angstrom resolution
-
Jordan, P., Fromme, P., Witt, H. T., Klukas, O., Saenger, W., and Krauss, N. (2001) Three-dimensional structure of cyanobacterial photosystem I at 2.5 angstrom resolution. Nature 411, 909-917.
-
(2001)
Nature
, vol.411
, pp. 909-917
-
-
Jordan, P.1
Fromme, P.2
Witt, H.T.3
Klukas, O.4
Saenger, W.5
Krauss, N.6
-
6
-
-
10044254637
-
The complex architecture of oxygenic photosynthesis
-
Nelson, N., and Ben-Shem, A. (2004) The complex architecture of oxygenic photosynthesis. Nat. Rev. Mol. Cell Biol. 5, 971-982.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 971-982
-
-
Nelson, N.1
Ben-Shem, A.2
-
7
-
-
60749136076
-
Redox regulation in photosynthetic organisms: Signaling, acclimation, and practical implications
-
Foyer, C. H., and Noctor, G. (2009) Redox regulation in photosynthetic organisms: signaling, acclimation, and practical implications. Antioxid. Redox. Signal 11, 861-905.
-
(2009)
Antioxid. Redox. Signal
, vol.11
, pp. 861-905
-
-
Foyer, C.H.1
Noctor, G.2
-
8
-
-
0022420493
-
Natural plant chemicals: Sources of industrial and medicinal materials
-
Balandrin, M. F., Klocke, J. A., Wurtele, E. S., and Bollinger, W. H. (1985) Natural plant chemicals: Sources of industrial and medicinal materials. Science 228, 1154-1160.
-
(1985)
Science
, vol.228
, pp. 1154-1160
-
-
Balandrin, M.F.1
Klocke, J.A.2
Wurtele, E.S.3
Bollinger, W.H.4
-
9
-
-
84872172091
-
Metabolic engineering of microorganisms for the synthesis of plant natural products
-
Marienhagen, J., and Bott, M. (2012) Metabolic engineering of microorganisms for the synthesis of plant natural products. J. Biotechnol. 163, 166-178.
-
(2012)
J. Biotechnol.
, vol.163
, pp. 166-178
-
-
Marienhagen, J.1
Bott, M.2
-
10
-
-
0038404731
-
Plant cytochromes P450: Tools for pharmacology, plant protection, and phytoremediation
-
Morant, M., Bak, S., Moller, B. L., and Werck-Reichhart, D. (2003) Plant cytochromes P450: Tools for pharmacology, plant protection, and phytoremediation. Curr. Opin. Biotechnol. 14, 151-162.
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 151-162
-
-
Morant, M.1
Bak, S.2
Moller, B.L.3
Werck-Reichhart, D.4
-
12
-
-
84865515585
-
Synthetic biological approaches to natural product biosynthesis
-
Winter, J. M., and Tang, Y. (2012) Synthetic biological approaches to natural product biosynthesis. Curr. Opin. Biotechnol. 23, 736-743.
-
(2012)
Curr. Opin. Biotechnol.
, vol.23
, pp. 736-743
-
-
Winter, J.M.1
Tang, Y.2
-
13
-
-
0142151125
-
Electron transfer between membrane complexes and soluble proteins in photosynthesis
-
Hervas, M., Navarro, J. A., and De La Rosa, M. A. (2003) Electron transfer between membrane complexes and soluble proteins in photosynthesis. Acc. Chem. Res. 36, 798-805.
-
(2003)
Acc. Chem. Res.
, vol.36
, pp. 798-805
-
-
Hervas, M.1
Navarro, J.A.2
De La Rosa, M.A.3
-
14
-
-
78650856943
-
Wiring an FeFe-hydrogenase with photosystem i for light-induced hydrogen production
-
Lubner, C. E., Knorzer, P., Silva, P. J. N., Vincent, K. A., Happe, T., Bryant, D. A., and Golbeck, J. H. (2010) Wiring an FeFe-hydrogenase with photosystem I for light-induced hydrogen production. Biochemistry 49, 10264-10266.
-
(2010)
Biochemistry
, vol.49
, pp. 10264-10266
-
-
Lubner, C.E.1
Knorzer, P.2
Silva, P.J.N.3
Vincent, K.A.4
Happe, T.5
Bryant, D.A.6
Golbeck, J.H.7
-
15
-
-
33745936562
-
Structure and function of photosystems i and II
-
Nelson, N., and Yocum, C. F. (2006) Structure and function of photosystems I and II. Annu. Rev. Plant Biol. 57, 521-565.
-
(2006)
Annu. Rev. Plant Biol.
, vol.57
, pp. 521-565
-
-
Nelson, N.1
Yocum, C.F.2
-
16
-
-
34247479035
-
Structure, function, and regulation of plant photosystem i
-
Jensen, P. E., Bassi, R., Boekema, E. J., Dekker, J. P., Jansson, S., Leister, D., Robinson, C., and Scheller, H. V. (2007) Structure, function, and regulation of plant photosystem I. Biochim. Biophys. Acta, Bioenerg. 1767, 335-352.
-
(2007)
Biochim. Biophys. Acta, Bioenerg.
, vol.1767
, pp. 335-352
-
-
Jensen, P.E.1
Bassi, R.2
Boekema, E.J.3
Dekker, J.P.4
Jansson, S.5
Leister, D.6
Robinson, C.7
Scheller, H.V.8
-
17
-
-
80051683768
-
Light driven hydrogen production in protein based semi-artificial systems
-
Winkler, M., Kawelke, S., and Happe, T. (2011) Light driven hydrogen production in protein based semi-artificial systems. Bioresour. Technol. 102, 8493-8500.
-
(2011)
Bioresour. Technol.
, vol.102
, pp. 8493-8500
-
-
Winkler, M.1
Kawelke, S.2
Happe, T.3
-
18
-
-
33745844815
-
Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacterial photosystem i
-
Ihara, M., Nishihara, H., Yoon, K. S., Lenz, O., Friedrich, B., Nakamoto, H., Kojima, K., Honma, D., Kamachi, T., and Okura, I. (2006) Light-driven hydrogen production by a hybrid complex of a [NiFe]-hydrogenase and the cyanobacterial photosystem I. Photochem. Photobiol. 82, 676-682.
-
(2006)
Photochem. Photobiol.
, vol.82
, pp. 676-682
-
-
Ihara, M.1
Nishihara, H.2
Yoon, K.S.3
Lenz, O.4
Friedrich, B.5
Nakamoto, H.6
Kojima, K.7
Honma, D.8
Kamachi, T.9
Okura, I.10
-
19
-
-
33846469977
-
Photoinduced hydrogen production by direct electron transfer from photosystem i cross-linked with cytochrome c(3) to [NiFe]- hydrogenase
-
Ihara, M., Nakamoto, H., Kamachi, T., Okura, I., and Maeda, M. (2006) Photoinduced hydrogen production by direct electron transfer from photosystem I cross-linked with cytochrome c(3) to [NiFe]- hydrogenase. Photochem. Photobiol. 82, 1677-1685.
-
(2006)
Photochem. Photobiol.
, vol.82
, pp. 1677-1685
-
-
Ihara, M.1
Nakamoto, H.2
Kamachi, T.3
Okura, I.4
Maeda, M.5
-
20
-
-
84855497373
-
Solar hydrogen-producing bionanodevice outperforms natural photosynthesis
-
Lubner, C. E., Applegate, A. M., Knorzer, P., Ganago, A., Bryant, D. A., Happe, T., and Golbeck, J. H. (2011) Solar hydrogen-producing bionanodevice outperforms natural photosynthesis. Proc. Natl. Acad. Sci. U.S.A. 108, 20988-20991.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 20988-20991
-
-
Lubner, C.E.1
Applegate, A.M.2
Knorzer, P.3
Ganago, A.4
Bryant, D.A.5
Happe, T.6
Golbeck, J.H.7
-
21
-
-
74949093472
-
Wiring photosystem i for direct solar hydrogen production
-
Lubner, C. E., Grimme, R., Bryant, D. A., and Golbeck, J. H. (2010) Wiring photosystem I for direct solar hydrogen production. Biochemistry 49, 404-414.
-
(2010)
Biochemistry
, vol.49
, pp. 404-414
-
-
Lubner, C.E.1
Grimme, R.2
Bryant, D.A.3
Golbeck, J.H.4
-
22
-
-
79959329033
-
Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP(+)-oxidoreductase (FNR) enzymes in vitro
-
Yacoby, I., Pochekailov, S., Toporik, H., Ghirardi, M. L., King, P. W., and Zhang, S. G. (2011) Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP(+)-oxidoreductase (FNR) enzymes in vitro. Proc. Natl. Acad. Sci. U.S.A. 108, 9396-9401.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 9396-9401
-
-
Yacoby, I.1
Pochekailov, S.2
Toporik, H.3
Ghirardi, M.L.4
King, P.W.5
Zhang, S.G.6
-
23
-
-
43949105847
-
Photosystem I/molecular wire/metal nanoparticle bioconjugates for the photocatalytic production of H-2
-
Grimme, R. A., Lubner, C. E., Bryant, D. A., and Golbeck, J. H. (2008) Photosystem I/molecular wire/metal nanoparticle bioconjugates for the photocatalytic production of H-2. J. Am. Chem. Soc. 130, 6308-6309.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6308-6309
-
-
Grimme, R.A.1
Lubner, C.E.2
Bryant, D.A.3
Golbeck, J.H.4
-
24
-
-
72749103175
-
Maximizing H(2) production in photosystem I/dithiol molecular wire/platinum nanoparticle bioconjugates
-
Grimme, R. A., Lubner, C. E., and Golbeck, J. H. (2009) Maximizing H(2) production in photosystem I/dithiol molecular wire/platinum nanoparticle bioconjugates. Dalton Trans., 10106-10113.
-
(2009)
Dalton Trans.
, pp. 10106-10113
-
-
Grimme, R.A.1
Lubner, C.E.2
Golbeck, J.H.3
-
25
-
-
79952940108
-
Photocatalytic hydrogen production from noncovalent biohybrid photosystem I/Pt nanoparticle complexes
-
Utschig, L. M., Dimitrijevic, N. M., Poluektov, O. G., Chemerisov, S. D., Mulfort, K. L., and Tiede, D. M. (2011) Photocatalytic hydrogen production from noncovalent biohybrid photosystem I/Pt nanoparticle complexes. J. Phys. Chem. Lett. 2, 236-241.
-
(2011)
J. Phys. Chem. Lett.
, vol.2
, pp. 236-241
-
-
Utschig, L.M.1
Dimitrijevic, N.M.2
Poluektov, O.G.3
Chemerisov, S.D.4
Mulfort, K.L.5
Tiede, D.M.6
-
26
-
-
79251471610
-
Solar hydrogen evolution with hydrogenases: From natural to hybrid systems
-
Reisner, E. (2011) Solar hydrogen evolution with hydrogenases: From natural to hybrid systems. Eur. J. Inorg. Chem., 1005-1016.
-
(2011)
Eur. J. Inorg. Chem.
, pp. 1005-1016
-
-
Reisner, E.1
-
27
-
-
84856644400
-
Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function
-
Kennedy, D. O., and Wightman, E. L. (2011) Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function. Adv. Nutr. 2, 32-50.
-
(2011)
Adv. Nutr.
, vol.2
, pp. 32-50
-
-
Kennedy, D.O.1
Wightman, E.L.2
-
28
-
-
79955574643
-
Convergent evolution in plant specialized metabolism
-
Pichersky, E., and Lewinsohn, E. (2011) Convergent evolution in plant specialized metabolism. Annu. Rev. Plant Biol. 62, 549-566.
-
(2011)
Annu. Rev. Plant Biol.
, vol.62
, pp. 549-566
-
-
Pichersky, E.1
Lewinsohn, E.2
-
29
-
-
79955058143
-
Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects
-
DOI: 10.1038/ ncomms1271
-
Jensen, N. B., Zagrobelny, M., Hjerno, K., Olsen, C. E., Houghton-Larsen, J., Borch, J., Moller, B. L., and Bak, S. (2011) Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects. Nat. Commun. 2, DOI: 10.1038/ ncomms1271.
-
(2011)
Nat. Commun.
, pp. 2
-
-
Jensen, N.B.1
Zagrobelny, M.2
Hjerno, K.3
Olsen, C.E.4
Houghton-Larsen, J.5
Borch, J.6
Moller, B.L.7
Bak, S.8
-
30
-
-
33845422264
-
The cyanogenic glucoside composition of Zygaena f ilipendulae (Lepidoptera: Zygaenidae) as effected by feeding on wild-type and transgenic lotus populations with variable cyanogenic glucoside profiles
-
Zagrobelny, M., Bak, S., Ekstrom, C. T., Olsen, C. E., and Moller, B. L. (2007) The cyanogenic glucoside composition of Zygaena f ilipendulae (Lepidoptera: Zygaenidae) as effected by feeding on wild-type and transgenic lotus populations with variable cyanogenic glucoside profiles. Insect Biochem. Mol. Biol. 37, 10-18.
-
(2007)
Insect Biochem. Mol. Biol.
, vol.37
, pp. 10-18
-
-
Zagrobelny, M.1
Bak, S.2
Ekstrom, C.T.3
Olsen, C.E.4
Moller, B.L.5
-
31
-
-
0033779923
-
Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective
-
Pichersky, E., and Gang, D. R. (2000) Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective. Trends Plant Sci. 5, 439-445.
-
(2000)
Trends Plant Sci.
, vol.5
, pp. 439-445
-
-
Pichersky, E.1
Gang, D.R.2
-
32
-
-
77952834061
-
UV-B induced changes in the secondary metabolites of Morus alba L. Leaves
-
Gu, X.-D., Sun, M.-Y., Zhang, L., Fu, H.-W., Cui, L., Chen, R.-Z., Zhang, D.-W., and Tian, J.-K. (2010) UV-B induced changes in the secondary metabolites of Morus alba L. leaves. Molecules 15, 2980-2993.
-
(2010)
Molecules
, vol.15
, pp. 2980-2993
-
-
Gu, X.-D.1
Sun, M.-Y.2
Zhang, L.3
Fu, H.-W.4
Cui, L.5
Chen, R.-Z.6
Zhang, D.-W.7
Tian, J.-K.8
-
33
-
-
84877146738
-
Plant chemical defense: At what cost?
-
Neilson, E. H., Goodger, J. Q. D., Woodrow, I. E., and Moller, B. L. (2013) Plant chemical defense: At what cost? Trends Plant Sci. 18, 250-258.
-
(2013)
Trends Plant Sci.
, vol.18
, pp. 250-258
-
-
Neilson, E.H.1
Goodger, J.Q.D.2
Woodrow, I.E.3
Moller, B.L.4
-
34
-
-
77955879607
-
Functional diversifications of cyanogenic glucosides
-
Moller, B. L. (2010) Functional diversifications of cyanogenic glucosides. Curr. Opin. Plant Biol. 13, 338-347.
-
(2010)
Curr. Opin. Plant Biol.
, vol.13
, pp. 338-347
-
-
Moller, B.L.1
-
35
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., and Keasling, J. D. (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol. 21, 796-802.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 796-802
-
-
Martin, V.J.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
36
-
-
77954568426
-
Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism
-
DOI: 10.1155/2010/483958
-
Goto, T., Takahashi, N., Hirai, S., and Kawada, T. (2010) Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism. PPAR Res., DOI: 10.1155/2010/483958.
-
(2010)
PPAR Res
-
-
Goto, T.1
Takahashi, N.2
Hirai, S.3
Kawada, T.4
-
37
-
-
33646157726
-
Terpene synthases and the regulation, diversity, and biological roles of terpene metabolism
-
Tholl, D. (2006) Terpene synthases and the regulation, diversity, and biological roles of terpene metabolism. Curr Opin Plant Biol 9, 297-304.
-
(2006)
Curr Opin Plant Biol
, vol.9
, pp. 297-304
-
-
Tholl, D.1
-
38
-
-
84859126293
-
Structure and dynamics of the isoprenoid pathway network
-
Vranova, E., Coman, D., and Gruissem, W. (2012) Structure and Dynamics of the Isoprenoid Pathway Network. Molecular Plant 5, 318-333.
-
(2012)
Molecular Plant
, vol.5
, pp. 318-333
-
-
Vranova, E.1
Coman, D.2
Gruissem, W.3
-
39
-
-
57649100762
-
Metabolic engineering for plant natural product biosynthesis in microbes
-
Chemler, J. A., and Koffas, M. A. (2008) Metabolic engineering for plant natural product biosynthesis in microbes. Curr Opin Biotechnol 19, 597-605.
-
(2008)
Curr Opin Biotechnol
, vol.19
, pp. 597-605
-
-
Chemler, J.A.1
Koffas, M.A.2
-
40
-
-
0003737298
-
-
Rockville MD
-
Buchanan, B. B., Gruissem, W., and Jones, R. L. (2000) Biochemistry & Molecular Biology of Plants, American Society of Plant Physiologists, Rockville, MD.
-
(2000)
Biochemistry & Molecular Biology of Plants, American Society of Plant Physiologists
-
-
Buchanan, B.B.1
Gruissem, W.2
Jones, R.L.3
-
41
-
-
76549093442
-
Phenylpropanoid biosynthesis
-
Vogt, T. (2010) Phenylpropanoid biosynthesis. Mol. Plant 3, 2-20.
-
(2010)
Mol. Plant
, vol.3
, pp. 2-20
-
-
Vogt, T.1
-
42
-
-
73849152200
-
Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis
-
Schafer, H., and Wink, M. (2009) Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis. Biotechnol. J. 4, 1684-1703.
-
(2009)
Biotechnol. J.
, vol.4
, pp. 1684-1703
-
-
Schafer, H.1
Wink, M.2
-
43
-
-
16644372517
-
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species
-
Aharoni, A., Giri, A. P., Verstappen, F. W. A., Bertea, C. M., Sevenier, R., Sun, Z. K., Jongsma, M. A., Schwab, W., and Bouwmeester, H. J. (2004) Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species. Plant Cell 16, 3110-3131.
-
(2004)
Plant Cell
, vol.16
, pp. 3110-3131
-
-
Aharoni, A.1
Giri, A.P.2
Verstappen, F.W.A.3
Bertea, C.M.4
Sevenier, R.5
Sun, Z.K.6
Jongsma, M.A.7
Schwab, W.8
Bouwmeester, H.J.9
-
44
-
-
20444385145
-
Evolution of flavors and scents
-
Gang, D. R. (2005) Evolution of flavors and scents. Annu. Rev. Plant Biol., 301-325.
-
(2005)
Annu. Rev. Plant Biol.
, pp. 301-325
-
-
Gang, D.R.1
-
45
-
-
43549124628
-
Biosynthesis of plant-derived flavor compounds
-
Schwab, W., Davidovich-Rikanati, R., and Lewinsohn, E. (2008) Biosynthesis of plant-derived flavor compounds. Plant J. 54, 712-732.
-
(2008)
Plant J.
, vol.54
, pp. 712-732
-
-
Schwab, W.1
Davidovich-Rikanati, R.2
Lewinsohn, E.3
-
46
-
-
28344449080
-
Menthol biosynthesis and molecular genetics
-
Croteau, R. B., Davis, E. M., Ringer, K. L., and Wildung, M. R. (2005) (-)-Menthol biosynthesis and molecular genetics. Naturwissenschaften 92, 562-577.
-
(2005)
Naturwissenschaften
, vol.92
, pp. 562-577
-
-
Croteau, R.B.1
Davis, E.M.2
Ringer, K.L.3
Wildung, M.R.4
-
47
-
-
22544442768
-
Gingerol content of diploid and tetraploid clones of ginger (Zingiber of f icinale Roscoe)
-
Wohlmuth, H., Leach, D. N., Smith, M. K., and Myers, S. P. (2005) Gingerol content of diploid and tetraploid clones of ginger (Zingiber of f icinale Roscoe). J. Agric. Food Chem. 53, 5772-5778.
-
(2005)
J. Agric. Food Chem.
, vol.53
, pp. 5772-5778
-
-
Wohlmuth, H.1
Leach, D.N.2
Smith, M.K.3
Myers, S.P.4
-
48
-
-
65549118633
-
De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae)
-
Hansen, E. H., Moller, B. L., Kock, G. R., Bunner, C. M., Kristensen, C., Jensen, O. R., Okkels, F. T., Olsen, C. E., Motawia, M. S., and Hansen, J. (2009) De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae). Appl. Environ. Microbiol. 75, 2765-2774.
-
(2009)
Appl. Environ. Microbiol.
, vol.75
, pp. 2765-2774
-
-
Hansen, E.H.1
Moller, B.L.2
Kock, G.R.3
Bunner, C.M.4
Kristensen, C.5
Jensen, O.R.6
Okkels, F.T.7
Olsen, C.E.8
Motawia, M.S.9
Hansen, J.10
-
49
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
Cragg, G. M., and Newman, D. J. (2005) Plants as a source of anti-cancer agents. J. Ethnopharmacol. 100, 72-79.
-
(2005)
J. Ethnopharmacol.
, vol.100
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
50
-
-
84861722221
-
Ingenol mebutate: An introduction
-
Fallen, R. S., and Gooderham, M. (2012) Ingenol mebutate: an introduction. Skin Therapy Lett. 17 (2), 1-3.
-
(2012)
Skin Therapy Lett.
, vol.17
, Issue.2
, pp. 1-3
-
-
Fallen, R.S.1
Gooderham, M.2
-
51
-
-
0025281884
-
Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestive cardiomyopathy-A comparative study with dobutamine and sodium nitroprusside
-
Baumann, G., Felix, S., Sattelberger, U., and Klein, G. (1990) Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestive cardiomyopathy-A comparative study with dobutamine and sodium nitroprusside. J. Cardiovasc. Pharmacol. 16, 93-100.
-
(1990)
J. Cardiovasc. Pharmacol.
, vol.16
, pp. 93-100
-
-
Baumann, G.1
Felix, S.2
Sattelberger, U.3
Klein, G.4
-
52
-
-
0021246766
-
Pharmacology and inotropic potential of forskolin in the human heart
-
Bristow, M. R., Ginsburg, R., Strosberg, A., Montgomery, W., and Minobe, W. (1984) Pharmacology and inotropic potential of forskolin in the human heart. J. Clin. Invest. 74, 212-223.
-
(1984)
J. Clin. Invest.
, vol.74
, pp. 212-223
-
-
Bristow, M.R.1
Ginsburg, R.2
Strosberg, A.3
Montgomery, W.4
Minobe, W.5
-
53
-
-
34347405302
-
Terpenoid indole alkaloids biosynthesis and metabolic engineering in Catharanthus roseus
-
Liu, D. H., Jin, H. B., Chen, Y. H., Cui, L. J., Ren, W. W., Gong, Y. F., and Tang, K. X. (2007) Terpenoid indole alkaloids biosynthesis and metabolic engineering in Catharanthus roseus. J. Integr. Plant Biol. 49, 961-974.
-
(2007)
J. Integr. Plant Biol.
, vol.49
, pp. 961-974
-
-
Liu, D.H.1
Jin, H.B.2
Chen, Y.H.3
Cui, L.J.4
Ren, W.W.5
Gong, Y.F.6
Tang, K.X.7
-
54
-
-
84870208120
-
Medicinal plants: A source of anti-parasitic secondary metabolites
-
Wink, M. (2012) Medicinal plants: A source of anti-parasitic secondary metabolites. Molecules 17, 12771-12791.
-
(2012)
Molecules
, vol.17
, pp. 12771-12791
-
-
Wink, M.1
-
55
-
-
4644289320
-
The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum
-
Weid, M., Ziegler, J., and Kutchan, T. M. (2004) The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. Proc. Natl. Acad. Sci. U.S.A. 101, 13957-13962.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 13957-13962
-
-
Weid, M.1
Ziegler, J.2
Kutchan, T.M.3
-
56
-
-
2342501400
-
Galanthamine from snowdrop-The development of a modern drug against Alzheimer's disease from local Caucasian knowledge
-
Heinrich, M., and Lee Teoh, H. (2004) Galanthamine from snowdrop-The development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J. Ethnopharmacol. 92, 147-162.
-
(2004)
J. Ethnopharmacol.
, vol.92
, pp. 147-162
-
-
Heinrich, M.1
Lee Teoh, H.2
-
57
-
-
34447287328
-
Functional genomics and the biosynthesis of artemisinin
-
Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., and Nowak, G. (2007) Functional genomics and the biosynthesis of artemisinin. Phytochemistry 68, 1864-1871.
-
(2007)
Phytochemistry
, vol.68
, pp. 1864-1871
-
-
Covello, P.S.1
Teoh, K.H.2
Polichuk, D.R.3
Reed, D.W.4
Nowak, G.5
-
58
-
-
0036198801
-
Essential oil composition of Damask rose (Rosa damascena Mill.) distilled under different pressures and temperatures
-
Babu, K. G. D., Singh, B., Joshi, V. P., and Singh, V. (2002) Essential oil composition of Damask rose (Rosa damascena Mill.) distilled under different pressures and temperatures. Flavour Fragrance J. 17, 136-140.
-
(2002)
Flavour Fragrance J.
, vol.17
, pp. 136-140
-
-
Babu, K.G.D.1
Singh, B.2
Joshi, V.P.3
Singh, V.4
-
59
-
-
55549116661
-
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
-
Anthony, J. R., Anthony, L. C., Nowroozi, F., Kwon, G., Newman, J. D., and Keasling, J. D. (2009) Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metab. Eng. 11, 13-19.
-
(2009)
Metab. Eng.
, vol.11
, pp. 13-19
-
-
Anthony, J.R.1
Anthony, L.C.2
Nowroozi, F.3
Kwon, G.4
Newman, J.D.5
Keasling, J.D.6
-
60
-
-
0028012837
-
Total synthesis of taxol
-
Nicolaou, K. C., Yang, Z., Liu, J. J., Ueno, H., Nantermet, P. G., Guy, R. K., Claiborne, C. F., Renaud, J., Couladouros, E. A., Paulvannan, K., and Sorensen, E. J. (1994) Total synthesis of taxol. Nature 367, 630-634.
-
(1994)
Nature
, vol.367
, pp. 630-634
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Ueno, H.4
Nantermet, P.G.5
Guy, R.K.6
Claiborne, C.F.7
Renaud, J.8
Couladouros, E.A.9
Paulvannan, K.10
Sorensen, E.J.11
-
61
-
-
84882907547
-
14-step synthesis of (+)-ingenol from (+)-3-carene
-
Jorgensen, L., McKerrall, S. J., Kuttruff, C. A., Ungeheuer, F., Felding, J., and Baran, P. S. (2013) 14-step synthesis of (+)-ingenol from (+)-3-carene. Science 341, 878-882.
-
(2013)
Science
, vol.341
, pp. 878-882
-
-
Jorgensen, L.1
McKerrall, S.J.2
Kuttruff, C.A.3
Ungeheuer, F.4
Felding, J.5
Baran, P.S.6
-
62
-
-
0036275284
-
Plant cell cultures: Chemical factories of secondary metabolites
-
Rao, S. R., and Ravishankar, G. A. (2002) Plant cell cultures: Chemical factories of secondary metabolites. Biotechnol. Adv. 20, 101-153.
-
(2002)
Biotechnol. Adv.
, vol.20
, pp. 101-153
-
-
Rao, S.R.1
Ravishankar, G.A.2
-
63
-
-
84859155070
-
Plant production systems for bioactive small molecules
-
Lim, E. K., and Bowles, D. (2012) Plant production systems for bioactive small molecules. Curr. Opin. Biotechnol. 23, 271-277.
-
(2012)
Curr. Opin. Biotechnol.
, vol.23
, pp. 271-277
-
-
Lim, E.K.1
Bowles, D.2
-
64
-
-
77957329119
-
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
-
Ajikumar, P. K., Xiao, W. H., Tyo, K. E., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T. H., Pfeifer, B., and Stephanopoulos, G. (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 330, 70-74.
-
(2010)
Science
, vol.330
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.H.2
Tyo, K.E.3
Wang, Y.4
Simeon, F.5
Leonard, E.6
Mucha, O.7
Phon, T.H.8
Pfeifer, B.9
Stephanopoulos, G.10
-
65
-
-
0020577131
-
Total synthesis of qinghaosu
-
Schmid, G., and Hofheinz, W. (1983) Total synthesis of qinghaosu. J. Am. Chem. Soc. 105, 624-625.
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 624-625
-
-
Schmid, G.1
Hofheinz, W.2
-
66
-
-
44749083814
-
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (paclitaxel) production
-
Engels, B., Dahm, P., and Jennewein, S. (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (paclitaxel) production. Metab. Eng. 10, 201-206.
-
(2008)
Metab. Eng.
, vol.10
, pp. 201-206
-
-
Engels, B.1
Dahm, P.2
Jennewein, S.3
-
67
-
-
84862873972
-
Downstream reactions and engineering in the microbially reconstituted pathway for Taxol
-
Jiang, M., Stephanopoulos, G., and Pfeifer, B. A. (2012) Downstream reactions and engineering in the microbially reconstituted pathway for Taxol. Appl. Microbiol. Biotechnol. 94, 841-849.
-
(2012)
Appl. Microbiol. Biotechnol.
, vol.94
, pp. 841-849
-
-
Jiang, M.1
Stephanopoulos, G.2
Pfeifer, B.A.3
-
68
-
-
84859772410
-
Synthetic biology and the development of tools for metabolic engineering
-
Keasling, J. D. (2012) Synthetic biology and the development of tools for metabolic engineering. Metab. Eng. 14, 189-195.
-
(2012)
Metab. Eng.
, vol.14
, pp. 189-195
-
-
Keasling, J.D.1
-
69
-
-
84856611060
-
Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective
-
Wen, W., and Yu, R. (2011) Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. Pharmacogn. Rev. 5, 189-194.
-
(2011)
Pharmacogn. Rev.
, vol.5
, pp. 189-194
-
-
Wen, W.1
Yu, R.2
-
70
-
-
84856389651
-
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
-
Westfall, P. J., Pitera, D. J., Lenihan, J. R., Eng, D., Woolard, F. X., Regentin, R., Horning, T., Tsuruta, H., Melis, D. J., Owens, A., Fickes, S., Diola, D., Benjamin, K. R., Keasling, J. D., Leavell, M. D., McPhee, D. J., Renninger, N. S., Newman, J. D., and Paddon, C. J. (2012) Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc. Natl. Acad. Sci. U.S.A. 109, E111-118.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
-
-
Westfall, P.J.1
Pitera, D.J.2
Lenihan, J.R.3
Eng, D.4
Woolard, F.X.5
Regentin, R.6
Horning, T.7
Tsuruta, H.8
Melis, D.J.9
Owens, A.10
Fickes, S.11
Diola, D.12
Benjamin, K.R.13
Keasling, J.D.14
Leavell, M.D.15
McPhee, D.J.16
Renninger, N.S.17
Newman, J.D.18
Paddon, C.J.19
-
71
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro, D. K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., Chang, M. C. Y., Withers, S. T., Shiba, Y., Sarpong, R., and Keasling, J. D. (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440, 940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
Ho, K.A.7
Eachus, R.A.8
Ham, T.S.9
Kirby, J.10
Chang, M.C.Y.11
Withers, S.T.12
Shiba, Y.13
Sarpong, R.14
Keasling, J.D.15
-
72
-
-
34247182988
-
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
-
Chang, M. C. Y., Eachus, R. A., Trieu, W., Ro, D. K., and Keasling, J. D. (2007) Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat. Chem. Biol. 3, 274-277.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 274-277
-
-
Chang, M.C.Y.1
Eachus, R.A.2
Trieu, W.3
Ro, D.K.4
Keasling, J.D.5
-
73
-
-
84876784070
-
Highlevel semi-synthetic production of the potent antimalarial artemisinin
-
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., Polichuk, D. R., Teoh, K. H., Reed, D. W., Treynor, T., Lenihan, J., Fleck, M., Bajad, S., Dang, G., Dengrove, D., Diola, D., Dorin, G., Ellens, K. W., Fickes, S., Galazzo, J., Gaucher, S. P., Geistlinger, T., Henry, R., Hepp, M., Horning, T., Iqbal, T., Jiang, H., Kizer, L., Lieu, B., Melis, D., Moss, N., Regentin, R., Secrest, S., Tsuruta, H., Vazquez, R., Westblade, L. F., Xu, L., Yu, M., Zhang, Y., Zhao, L., Lievense, J., Covello, P. S., Keasling, J. D., Reiling, K. K., Renninger, N. S., and Newman, J. D. (2013) Highlevel semi-synthetic production of the potent antimalarial artemisinin. Nature 496, 528-536.
-
(2013)
Nature
, vol.496
, pp. 528-536
-
-
Paddon, C.J.1
Westfall, P.J.2
Pitera, D.J.3
Benjamin, K.4
Fisher, K.5
McPhee, D.6
Leavell, M.D.7
Tai, A.8
Main, A.9
Eng, D.10
Polichuk, D.R.11
Teoh, K.H.12
Reed, D.W.13
Treynor, T.14
Lenihan, J.15
Fleck, M.16
Bajad, S.17
Dang, G.18
Dengrove, D.19
Diola, D.20
Dorin, G.21
Ellens, K.W.22
Fickes, S.23
Galazzo, J.24
Gaucher, S.P.25
Geistlinger, T.26
Henry, R.27
Hepp, M.28
Horning, T.29
Iqbal, T.30
Jiang, H.31
Kizer, L.32
Lieu, B.33
Melis, D.34
Moss, N.35
Regentin, R.36
Secrest, S.37
Tsuruta, H.38
Vazquez, R.39
Westblade, L.F.40
Xu, L.41
Yu, M.42
Zhang, Y.43
Zhao, L.44
Lievense, J.45
Covello, P.S.46
Keasling, J.D.47
Reiling, K.K.48
Renninger, N.S.49
Newman, J.D.50
more..
-
74
-
-
79953234390
-
A P450-centric view of plant evolution
-
Nelson, D., and Werck-Reichhart, D. (2011) A P450-centric view of plant evolution. Plant J. 66, 194-211.
-
(2011)
Plant J.
, vol.66
, pp. 194-211
-
-
Nelson, D.1
Werck-Reichhart, D.2
-
75
-
-
77952824272
-
Exploiting cyanobacterial P450 pathways
-
Robert, F., Pandhal, J., and Wright, P. C. (2010) Exploiting cyanobacterial P450 pathways. Curr. Opin. Microbiol. 13, 301-306.
-
(2010)
Curr. Opin. Microbiol.
, vol.13
, pp. 301-306
-
-
Robert, F.1
Pandhal, J.2
Wright, P.C.3
-
76
-
-
33746378650
-
Taxol biosynthesis and molecular genetics
-
Croteau, R., Ketchum, R. E., Long, R. M., Kaspera, R., and Wildung, M. R. (2006) Taxol biosynthesis and molecular genetics. Phytochem. Rev. 5, 75-97.
-
(2006)
Phytochem. Rev.
, vol.5
, pp. 75-97
-
-
Croteau, R.1
Ketchum, R.E.2
Long, R.M.3
Kaspera, R.4
Wildung, M.R.5
-
77
-
-
33845402189
-
Cytochrome P450 oxygenases of Taxol biosynthesis
-
Kaspera, R., and Croteau, R. (2006) Cytochrome P450 oxygenases of Taxol biosynthesis. Phytochem. Rev. 5, 433-444.
-
(2006)
Phytochem. Rev.
, vol.5
, pp. 433-444
-
-
Kaspera, R.1
Croteau, R.2
-
78
-
-
33846473252
-
Cytochrome P450 systems-Biological variations of electron transport chains
-
Hannemann, F., Bichet, A., Ewen, K. M., and Bernhardt, R. (2007) Cytochrome P450 systems-Biological variations of electron transport chains. Biochim. Biophys. Acta, Gen. Subj. 1770, 330-344.
-
(2007)
Biochim. Biophys. Acta Gen. Subj.
, vol.1770
, pp. 330-344
-
-
Hannemann, F.1
Bichet, A.2
Ewen, K.M.3
Bernhardt, R.4
-
79
-
-
37549012937
-
Cytochromes P450 and drug discovery
-
Lamb, D. C., Waterman, M. R., Kelly, S. L., and Guengerich, F. P. (2007) Cytochromes P450 and drug discovery. Curr. Opin. Biotechnol. 18, 504-512.
-
(2007)
Curr. Opin. Biotechnol.
, vol.18
, pp. 504-512
-
-
Lamb, D.C.1
Waterman, M.R.2
Kelly, S.L.3
Guengerich, F.P.4
-
80
-
-
0034572736
-
Cytochromes P450: A success story
-
Werck-Reichhart, D., and Feyereisen, R. (2000) Cytochromes P450: A success story. Genome Biol. 1, 3003.3001-3003.3009.
-
(2000)
Genome Biol.
, vol.1
, pp. 30033001-30033009
-
-
Werck-Reichhart, D.1
Feyereisen, R.2
-
81
-
-
57849111310
-
Oxygen activation by cytochrome P450 monooxygenase
-
Hamdane, D., Zhang, H., and Hollenberg, P. (2008) Oxygen activation by cytochrome P450 monooxygenase. Photosynth. Res. 98, 657-666.
-
(2008)
Photosynth. Res.
, vol.98
, pp. 657-666
-
-
Hamdane, D.1
Zhang, H.2
Hollenberg, P.3
-
82
-
-
80053634615
-
Homology modeling of the three membrane proteins of the dhurrin metabolon: Catalytic sites, membrane surface association, and protein-protein interactions
-
Jensen, K., Osmani, S. A., Hamann, T., Naur, P., and Moller, B. L. (2011) Homology modeling of the three membrane proteins of the dhurrin metabolon: Catalytic sites, membrane surface association, and protein-protein interactions. Phytochemistry 72, 2113-2123.
-
(2011)
Phytochemistry
, vol.72
, pp. 2113-2123
-
-
Jensen, K.1
Osmani, S.A.2
Hamann, T.3
Naur, P.4
Moller, B.L.5
-
83
-
-
78649710230
-
Dynamic metabolons
-
Moller, B. L. (2010) Dynamic metabolons. Science 330, 1328-1329.
-
(2010)
Science
, vol.330
, pp. 1328-1329
-
-
Moller, B.L.1
-
84
-
-
84862965798
-
-
Royal Society of Chemistry, Cambridge, U.K
-
Lewis, D. F. V., and Ito, Y. (2008) Cytochrome P450 Structure and Function: An Evolutionary Perspective, Royal Society of Chemistry, Cambridge, U.K.
-
(2008)
Cytochrome P450 Structure and Function: An Evolutionary Perspective
-
-
Lewis, D.F.V.1
Ito, Y.2
-
85
-
-
84879051428
-
Unusual cytochrome P450 enzymes and reactions
-
Guengerich, F. P., and Munro, A. W. (2013) Unusual cytochrome P450 enzymes and reactions. J. Biol. Chem. 288, 17065-17073.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 17065-17073
-
-
Guengerich, F.P.1
Munro, A.W.2
-
86
-
-
70349648642
-
CYP704B1 is a longchain fatty acid υ-hydroxylase essential for sporopollenin synthesis in pollen of arabidopsis
-
Dobritsa, A. A., Shrestha, J., Morant, M., Pinot, F., Matsuno, M., Swanson, R., Moller, B. L., and Preuss, D. (2009) CYP704B1 is a longchain fatty acid υ-hydroxylase essential for sporopollenin synthesis in pollen of arabidopsis. Plant Physiol. 151, 574-589.
-
(2009)
Plant Physiol.
, vol.151
, pp. 574-589
-
-
Dobritsa, A.A.1
Shrestha, J.2
Morant, M.3
Pinot, F.4
Matsuno, M.5
Swanson, R.6
Moller, B.L.7
Preuss, D.8
-
87
-
-
33846356640
-
Cytochrome P450-Redox partner fusion enzymes
-
Munro, A. W., Girvan, H. M., and McLean, K. J. (2007) Cytochrome P450-Redox partner fusion enzymes. Biochim. Biophys. Acta, Gen. Subj. 1770, 345-359.
-
(2007)
Biochim. Biophys. Acta Gen. Subj.
, vol.1770
, pp. 345-359
-
-
Munro, A.W.1
Girvan, H.M.2
McLean, K.J.3
-
88
-
-
73649131594
-
Plant NADPH-cytochrome P450 oxidoreductases
-
Jensen, K., and Moller, B. L. (2010) Plant NADPH-cytochrome P450 oxidoreductases. Phytochemistry 71, 132-141.
-
(2010)
Phytochemistry
, vol.71
, pp. 132-141
-
-
Jensen, K.1
Moller, B.L.2
-
89
-
-
70249094589
-
Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368
-
Goni, G., Zollner, A., Lisurek, M., Velazquez-Campoy, A., Pinto, S., Gomez-Moreno, C., Hannemann, F., Bernhardt, R., and Medina, M. (2009) Cyanobacterial electron carrier proteins as electron donors to CYP106A2 from Bacillus megaterium ATCC 13368. Biochim. Biophys. Acta 1794, 1635-1642.
-
(2009)
Biochim. Biophys. Acta
, vol.1794
, pp. 1635-1642
-
-
Goni, G.1
Zollner, A.2
Lisurek, M.3
Velazquez-Campoy, A.4
Pinto, S.5
Gomez-Moreno, C.6
Hannemann, F.7
Bernhardt, R.8
Medina, M.9
-
90
-
-
79952268861
-
Cytochromes P450 as useful biocatalysts: Addressing the limitations
-
O'Reilly, E., Kohler, V., Flitsch, S. L., and Turner, N. J. (2011) Cytochromes P450 as useful biocatalysts: Addressing the limitations. Chem. Commun. 47, 2490-2501.
-
(2011)
Chem. Commun.
, vol.47
, pp. 2490-2501
-
-
O'reilly, E.1
Kohler, V.2
Flitsch, S.L.3
Turner, N.J.4
-
91
-
-
84880144950
-
Human cytochromes P450 in health and disease
-
Nebert, D. W., Wikvall, K., and Miller, W. L. (2013) Human cytochromes P450 in health and disease. Philos. Trans. R. Soc. B: Biol. Sci. 368, 20120431.
-
(2013)
Philos. Trans. R. Soc. B: Biol. Sci.
, vol.368
, pp. 20120431
-
-
Nebert, D.W.1
Wikvall, K.2
Miller, W.L.3
-
92
-
-
47649089787
-
Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis
-
McLean, K. J., and Munro, A. W. (2008) Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis. Drug Metab. Rev. 40, 427-446.
-
(2008)
Drug Metab. Rev.
, vol.40
, pp. 427-446
-
-
McLean, K.J.1
Munro, A.W.2
-
93
-
-
33947286723
-
The evolutionary history of cytochrome P450 genes in four filamentous ascomycetes
-
Deng, J., Carbone, I., and Dean, R. A. (2007) The evolutionary history of cytochrome P450 genes in four filamentous ascomycetes. BMC Evol. Biol. 7, 30.
-
(2007)
BMC Evol. Biol.
, vol.7
, pp. 30
-
-
Deng, J.1
Carbone, I.2
Dean, R.A.3
-
94
-
-
33845427915
-
Arabidopsis cytochrome P450s through the looking glass: A window on plant biochemistry
-
Schuler, M. A., Duan, H., Bilgin, M., and Ali, S. (2006) Arabidopsis cytochrome P450s through the looking glass: A window on plant biochemistry. Phytochem. Rev. 5, 205-237.
-
(2006)
Phytochem. Rev.
, vol.5
, pp. 205-237
-
-
Schuler, M.A.1
Duan, H.2
Bilgin, M.3
Ali, S.4
-
95
-
-
34250750268
-
Production and engineering of terpenoids in plant cell culture
-
Roberts, S. C. (2007) Production and engineering of terpenoids in plant cell culture. Nat. Chem. Biol. 3, 387-395.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 387-395
-
-
Roberts, S.C.1
-
96
-
-
33845461058
-
Heterologous expression and strategies for encapsulation of membrane-localized plant P450s
-
Duan, H., and Schuler, M. A. (2006) Heterologous expression and strategies for encapsulation of membrane-localized plant P450s. Phytochem. Rev. 5, 507-523.
-
(2006)
Phytochem. Rev.
, vol.5
, pp. 507-523
-
-
Duan, H.1
Schuler, M.A.2
-
97
-
-
0346328227
-
Metabolic engineering for drug discovery and development
-
Khosla, C., and Keasling, J. D. (2003) Metabolic engineering for drug discovery and development. Nat. Rev. Drug Discovery 2, 1019-1025.
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, pp. 1019-1025
-
-
Khosla, C.1
Keasling, J.D.2
-
98
-
-
0034673581
-
Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450
-
Inoue, E., Takahashi, Y., Imai, Y., and Kamataki, T. (2000) Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450. Biochem. Biophys. Res. Commun. 269, 623-627.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.269
, pp. 623-627
-
-
Inoue, E.1
Takahashi, Y.2
Imai, Y.3
Kamataki, T.4
-
99
-
-
2542433007
-
Identification of a novel rat microsomal vitamin D-3 25-hydroxylase
-
Yamasaki, T., Izumi, S., Ide, H., and Ohyama, Y. (2004) Identification of a novel rat microsomal vitamin D-3 25-hydroxylase. J. Biol. Chem. 279, 22848-22856.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22848-22856
-
-
Yamasaki, T.1
Izumi, S.2
Ide, H.3
Ohyama, Y.4
-
100
-
-
84886632399
-
Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems
-
Zelasko, S., Palaria, A., and Das, A. (2013) Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems. Protein Expr. Purif. 92 (1), 77.
-
(2013)
Protein Expr. Purif.
, vol.92
, Issue.1
, pp. 77
-
-
Zelasko, S.1
Palaria, A.2
Das, A.3
-
101
-
-
36649037393
-
Engineering of artificial plant cytochrome p450 enzymes for synthesis of isoflavones by Escherichia coli
-
Leonard, E., and Koffas, M. A. G. (2007) Engineering of artificial plant cytochrome p450 enzymes for synthesis of isoflavones by Escherichia coli. Appl Environ Microb 73, 7246-7251.
-
(2007)
Appl Environ Microb
, vol.73
, pp. 7246-7251
-
-
Leonard, E.1
Koffas, M.A.G.2
-
102
-
-
0032005917
-
Cloning of three A-type cytochromes p450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome p450 in the biosynthesis of the cyanogenic glucoside dhurrin
-
Bak, S., Kahn, R. A., Nielsen, H. L., Moller, B. L., and Halkier, B. A. (1998) Cloning of three A-type cytochromes p450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome p450 in the biosynthesis of the cyanogenic glucoside dhurrin. Plant Mol. Biol. 36, 393-405.
-
(1998)
Plant Mol. Biol.
, vol.36
, pp. 393-405
-
-
Bak, S.1
Kahn, R.A.2
Nielsen, H.L.3
Moller, B.L.4
Halkier, B.A.5
-
103
-
-
0029153022
-
Purification and characterization of recombinant cytochrome P450(Tyr) expressed at high-levels in Escherichia coli
-
Halkier, B. A., Nielsen, H. L., Koch, B., and Moller, B. L. (1995) Purification and characterization of recombinant cytochrome P450(Tyr) expressed at high-levels in Escherichia coli. Arch. Biochem. Biophys. 322, 369-377.
-
(1995)
Arch. Biochem. Biophys.
, vol.322
, pp. 369-377
-
-
Halkier, B.A.1
Nielsen, H.L.2
Koch, B.3
Moller, B.L.4
-
104
-
-
78649391538
-
Methods and options for the heterologous production of complex natural products
-
Zhang, H., Boghigian, B. A., Armando, J., and Pfeifer, B. A. (2011) Methods and options for the heterologous production of complex natural products. Nat. Prod. Rep. 28, 125-151.
-
(2011)
Nat. Prod. Rep.
, vol.28
, pp. 125-151
-
-
Zhang, H.1
Boghigian, B.A.2
Armando, J.3
Pfeifer, B.A.4
-
105
-
-
0025994649
-
Expression and enzymatic activity of recombinant cytochrome P450 17 ?-hydroxylase in Escherichia coli
-
Barnes, H. J., Arlotto, M. P., and Waterman, M. R. (1991) Expression and enzymatic activity of recombinant cytochrome P450 17 ?-hydroxylase in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 88, 5597-5601.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 5597-5601
-
-
Barnes, H.J.1
Arlotto, M.P.2
Waterman, M.R.3
-
106
-
-
84857048835
-
Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools
-
Siddiqui, M. S., Thodey, K., Trenchard, I., and Smolke, C. D. (2012) Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools. FEMS Yeast Res 12, 144-170.
-
(2012)
FEMS Yeast Res
, vol.12
, pp. 144-170
-
-
Siddiqui, M.S.1
Thodey, K.2
Trenchard, I.3
Smolke, C.D.4
-
107
-
-
83255177147
-
Generation of the potent anti-malarial drug artemisinin in tobacco
-
Farhi, M., Marhevka, E., Ben-Ari, J., Algamas-Dimantov, A., Liang, Z., Zeevi, V., Edelbaum, O., Spitzer-Rimon, B., Abeliovich, H., Schwartz, B., Tzfira, T., and Vainstein, A. (2011) Generation of the potent anti-malarial drug artemisinin in tobacco. Nat. Biotechnol. 29, 1072-1074.
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 1072-1074
-
-
Farhi, M.1
Marhevka, E.2
Ben-Ari, J.3
Algamas-Dimantov, A.4
Liang, Z.5
Zeevi, V.6
Edelbaum, O.7
Spitzer-Rimon, B.8
Abeliovich, H.9
Schwartz, B.10
Tzfira, T.11
Vainstein, A.12
-
108
-
-
84879771275
-
Redirecting photosynthetic reducing power toward bioactive natural product synthesis
-
Nielsen, A. Z., Ziersen, B., Jensen, K., Lassen, L. M., Olsen, C. E., Moller, B. L., and Jensen, P. E. (2013) Redirecting photosynthetic reducing power toward bioactive natural product synthesis. ACS Synth. Biol. 2, 308-315.
-
(2013)
ACS Synth. Biol.
, vol.2
, pp. 308-315
-
-
Nielsen, A.Z.1
Ziersen, B.2
Jensen, K.3
Lassen, L.M.4
Olsen, C.E.5
Moller, B.L.6
Jensen, P.E.7
-
109
-
-
0034727799
-
P450 in biotechnology: Zinc driven υ-hydroxylation of pnitrophenoxydodecanoic acid using P450 BM-3 F87A as a catalyst
-
Schwaneberg, U., Appel, D., Schmitt, J., and Schmid, R. D. (2000) P450 in biotechnology: Zinc driven υ-hydroxylation of pnitrophenoxydodecanoic acid using P450 BM-3 F87A as a catalyst. J. Biotechnol. 84, 249-257.
-
(2000)
J. Biotechnol.
, vol.84
, pp. 249-257
-
-
Schwaneberg, U.1
Appel, D.2
Schmitt, J.3
Schmid, R.D.4
-
110
-
-
0030816684
-
Functional interactions in cytochrome P450BM3: Flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain
-
Murataliev, M. B., Klein, M., Fulco, A., and Feyereisen, R. (1997) Functional interactions in cytochrome P450BM3: Flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. Biochemistry 36, 8401-8412.
-
(1997)
Biochemistry
, vol.36
, pp. 8401-8412
-
-
Murataliev, M.B.1
Klein, M.2
Fulco, A.3
Feyereisen, R.4
-
111
-
-
84355163053
-
Cytochrome P450 monooxygenases: An update on perspectives for synthetic application
-
Urlacher, V. B., and Girhard, M. (2012) Cytochrome P450 monooxygenases: An update on perspectives for synthetic application. Trends Biotechnol. 30, 26-36.
-
(2012)
Trends Biotechnol.
, vol.30
, pp. 26-36
-
-
Urlacher, V.B.1
Girhard, M.2
-
112
-
-
10044271107
-
(Cp*Rh-(bpy)(H2O) 2+: A versatile tool for efficient and non-enzymatic regeneration of nicotinamide and flavin coenzymes
-
Hollmann, F., Witholt, B., and Schmid, A. (2002) (Cp*Rh- (bpy)(H2O))2+: A versatile tool for efficient and non-enzymatic regeneration of nicotinamide and flavin coenzymes. J. Mol. Catal., B, 167-176.
-
(2002)
J. Mol. Catal., B
, pp. 167-176
-
-
Hollmann, F.1
Witholt, B.2
Schmid, A.3
-
113
-
-
33745652737
-
Cytochrome P450 monooxygenases: Perspectives for synthetic application
-
Urlacher, V. B., and Eiben, S. (2006) Cytochrome P450 monooxygenases: Perspectives for synthetic application. Trends Biotechnol. 24, 324-330.
-
(2006)
Trends Biotechnol.
, vol.24
, pp. 324-330
-
-
Urlacher, V.B.1
Eiben, S.2
-
114
-
-
65249136381
-
Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically- driven biocatalysis
-
Holtmann, D., Mangold, K.-M., and Schrader, J. (2009) Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically- driven biocatalysis. Biotechnol. Lett. 31, 765-770.
-
(2009)
Biotechnol. Lett.
, vol.31
, pp. 765-770
-
-
Holtmann, D.1
Mangold, K.-M.2
Schrader, J.3
-
115
-
-
0043269709
-
A self-sufficient peroxide-driven hydroxylation biocatalyst
-
Cirino, P. C., and Arnold, F. H. (2003) A self-sufficient peroxide-driven hydroxylation biocatalyst. Angew. Chem., Int. Ed. Engl. 42, 3299-3301.
-
(2003)
Angew. Chem. Int. Ed. Engl.
, vol.42
, pp. 3299-3301
-
-
Cirino, P.C.1
Arnold, F.H.2
-
116
-
-
0242500462
-
Practical issues in the application of oxygenases
-
van Beilen, J. B., Duetz, W. A., Schmid, A., and Witholt, B. (2003) Practical issues in the application of oxygenases. Trends Biotechnol. 21, 170-177.
-
(2003)
Trends Biotechnol.
, vol.21
, pp. 170-177
-
-
Van Beilen, J.B.1
Duetz, W.A.2
Schmid, A.3
Witholt, B.4
-
117
-
-
0030457025
-
Photo-induced activation of cytochrome P450/ reductase fusion enzyme coupled with spinach chloroplasts
-
Kim, Y. S., Hara, M., Ikebukuro, K., Miyake, J., Ohkawa, H., and Karube, I. (1996) Photo-induced activation of cytochrome P450/ reductase fusion enzyme coupled with spinach chloroplasts. Biotechnol. Tech. 10, 717-720.
-
(1996)
Biotechnol. Tech.
, vol.10
, pp. 717-720
-
-
Kim, Y.S.1
Hara, M.2
Ikebukuro, K.3
Miyake, J.4
Ohkawa, H.5
Karube, I.6
-
118
-
-
79961085133
-
Light-driven cytochrome P450 hydroxylations
-
Jensen, K., Jensen, P. E., and Moller, B. L. (2011) Light-driven cytochrome P450 hydroxylations. ACS Chem. Biol. 6, 533-539.
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 533-539
-
-
Jensen, K.1
Jensen, P.E.2
Moller, B.L.3
-
119
-
-
84856217991
-
Photosystem i from plants as a bacterial cytochrome P450 surrogate electron donor: Terminal hydroxylation of branched hydrocarbon chains
-
Jensen, K., Johnston, J. B., de Montellano, P. R. O., and Moller, B. L. (2012) Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: Terminal hydroxylation of branched hydrocarbon chains. Biotechnol. Lett. 34, 239-245.
-
(2012)
Biotechnol. Lett.
, vol.34
, pp. 239-245
-
-
Jensen, K.1
Johnston, J.B.2
De Montellano, P.R.O.3
Moller, B.L.4
-
120
-
-
0028057047
-
Plant expression of a bacterial cytochrome P450 that catalyzes activation of a sulfonylurea proherbicide
-
O'Keefe, D. P., Tepperman, J. M., Dean, C., Leto, K. J., Erbes, D. L., and Odell, J. T. (1994) Plant expression of a bacterial cytochrome P450 that catalyzes activation of a sulfonylurea proherbicide. Plant Physiol. 105, 473-482.
-
(1994)
Plant Physiol.
, vol.105
, pp. 473-482
-
-
O'keefe, D.P.1
Tepperman, J.M.2
Dean, C.3
Leto, K.J.4
Erbes, D.L.5
Odell, J.T.6
-
121
-
-
0032813363
-
Engineering and biochemical characterization of the rat microsomal cytochrome P4501A1 fused to ferredoxin and ferredoxin-NADP(+) reductase from plant chloroplasts
-
Lacour, T., and Ohkawa, H. (1999) Engineering and biochemical characterization of the rat microsomal cytochrome P4501A1 fused to ferredoxin and ferredoxin-NADP(+) reductase from plant chloroplasts. Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1433, 87-102.
-
(1999)
Biochim. Biophys. Acta Protein Struct. Mol. Enzymol.
, vol.1433
, pp. 87-102
-
-
Lacour, T.1
Ohkawa, H.2
-
122
-
-
0033544872
-
The UDPglucose: P-hydroxymandelonitrile-O-glucosyltransferase that catalyzes the last step in synthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor-Isolation, cloning, heterologous expression, and substrate specificity
-
Jones, P. R., Moller, B. L., and Hoj, P. B. (1999) The UDPglucose: p-hydroxymandelonitrile-O-glucosyltransferase that catalyzes the last step in synthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor-Isolation, cloning, heterologous expression, and substrate specificity. J. Biol. Chem. 274, 35483-35491.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35483-35491
-
-
Jones, P.R.1
Moller, B.L.2
Hoj, P.B.3
-
123
-
-
0031397803
-
Isolation and reconstitution of cytochrome P450ox and in vitro reconstitution of the entire biosynthetic pathway of the cyanogenic glucoside dhurrin from sorghum
-
Kahn, R. A., Bak, S., Svendsen, I., Halkier, B. A., and Moller, B. L. (1997) Isolation and reconstitution of cytochrome P450ox and in vitro reconstitution of the entire biosynthetic pathway of the cyanogenic glucoside dhurrin from sorghum. Plant Physiol. 115, 1661-1670.
-
(1997)
Plant Physiol.
, vol.115
, pp. 1661-1670
-
-
Kahn, R.A.1
Bak, S.2
Svendsen, I.3
Halkier, B.A.4
Moller, B.L.5
-
124
-
-
0028834385
-
The primary sequence of cytochrome P450tyr, the multifunctional N-hydroxylase catalyzing the conversion of Ltyrosine to p- hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) moench
-
Koch, B. M., Sibbesen, O., Halkier, B. A., Svendsen, I., and Moller, B. L. (1995) The primary sequence of cytochrome P450tyr, the multifunctional N-hydroxylase catalyzing the conversion of Ltyrosine to p- hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. Arch. Biochem. Biophys. 323, 177-186.
-
(1995)
Arch. Biochem. Biophys.
, vol.323
, pp. 177-186
-
-
Koch, B.M.1
Sibbesen, O.2
Halkier, B.A.3
Svendsen, I.4
Moller, B.L.5
-
125
-
-
84883256774
-
Strategies for metabolic pathway engineering with multiple transgenes
-
Bock, R. (2013) Strategies for metabolic pathway engineering with multiple transgenes. Plant Mol. Biol. 83, 21-31.
-
(2013)
Plant Mol. Biol.
, vol.83
, pp. 21-31
-
-
Bock, R.1
-
126
-
-
84874228036
-
Efficient metabolic pathway engineering in transgenic tobacco and tomato plastids with synthetic multigene operons
-
Lu, Y., Rijzaani, H., Karcher, D., Ruf, S., and Bock, R. (2013) Efficient metabolic pathway engineering in transgenic tobacco and tomato plastids with synthetic multigene operons. Proc. Natl. Acad. Sci. U.S.A. 110, E623-E632.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
-
-
Lu, Y.1
Rijzaani, H.2
Karcher, D.3
Ruf, S.4
Bock, R.5
-
127
-
-
78049460575
-
A new concept for ferredoxin-NADP(H) oxidoreductase binding to plant thylakoids
-
Benz, J. P., Lintala, M., Soll, J., Mulo, P., and Bolter, B. (2010) A new concept for ferredoxin-NADP(H) oxidoreductase binding to plant thylakoids. Trends Plant Sci. 15, 608-613.
-
(2010)
Trends Plant Sci.
, vol.15
, pp. 608-613
-
-
Benz, J.P.1
Lintala, M.2
Soll, J.3
Mulo, P.4
Bolter, B.5
-
128
-
-
0035781168
-
Photosystem I: Function and physiology
-
Chitnis, P. R. (2001) Photosystem I: Function and physiology. Annu. Rev. Plant Phys. 52, 593-626.
-
(2001)
Annu. Rev. Plant Phys.
, vol.52
, pp. 593-626
-
-
Chitnis, P.R.1
-
129
-
-
66649085738
-
Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms
-
Jacquot, J. P., Eklund, H., Rouhier, N., and Schurmann, P. (2009) Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms. Trends Plant Sci. 14, 336-343.
-
(2009)
Trends Plant Sci.
, vol.14
, pp. 336-343
-
-
Jacquot, J.P.1
Eklund, H.2
Rouhier, N.3
Schurmann, P.4
-
130
-
-
0026097297
-
Ferredoxin-dependent chloroplast enzymes
-
Knaff, D. B., and Hirasawa, M. (1991) Ferredoxin-dependent chloroplast enzymes. Biochim. Biophys. Acta 1056, 93-125.
-
(1991)
Biochim. Biophys. Acta
, vol.1056
, pp. 93-125
-
-
Knaff, D.B.1
Hirasawa, M.2
-
131
-
-
77954721067
-
The physiological importance of photosynthetic ferredoxin NADP(+) oxidoreductase (FNR) isoforms in wheat
-
Moolna, A., and Bowsher, C. G. (2010) The physiological importance of photosynthetic ferredoxin NADP(+) oxidoreductase (FNR) isoforms in wheat. J. Exp. Bot. 61, 2669-2681.
-
(2010)
J. Exp. Bot.
, vol.61
, pp. 2669-2681
-
-
Moolna, A.1
Bowsher, C.G.2
-
132
-
-
84867660750
-
Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network
-
Kim, J., and Copley, S. D. (2012) Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network. Proc. Natl. Acad. Sci. U.S.A. 109, E2856-2864.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
-
-
Kim, J.1
Copley, S.D.2
-
133
-
-
78651517511
-
Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
-
Medema, M. H., Breitling, R., Bovenberg, R., and Takano, E. (2011) Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms. Nat. Rev. Microbiol. 9, 131-137.
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 131-137
-
-
Medema, M.H.1
Breitling, R.2
Bovenberg, R.3
Takano, E.4
-
134
-
-
70450223309
-
Synthetic biology: Understanding biological design from synthetic circuits
-
Mukherji, S., and van Oudenaarden, A. (2009) Synthetic biology: Understanding biological design from synthetic circuits. Nat. Rev. Genet. 10, 859-871.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 859-871
-
-
Mukherji, S.1
Van Oudenaarden, A.2
|