Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective

Pharmacognosy Reviews

Volumn 5, Issue 10, 2011, Pages 189-194

  Wen, Wei ^a   Yu, Rongmin ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Artemisinin; biosynthesis pathway; progress and perspective; regulatory enzymes

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE SYNTHASE; 3 HYDROXYL 3 METHYGLUTARYL COA REDUCTASE; ALDEHYDE DEHYDROGENASE; ARTEMISINIC ALDEHYDE DELTA 11 (13) REDUCTASE; ARTEMISININ; CYTOCHROME P450; DEOXYXYLULOSE PHOSPHATE; DIMETHYLALLYL DIPHOSPHATE; DIMETHYLALLYLTRANSFERASE; ENZYME; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; ISOPENTENYL DIPHOSPHATE; METHYLERYTHRITOL PHOSPHATE; PHOSPHORUS ACID DERIVATIVE; SESQUITERPENE SYNTHASE; SQUALENE SYNTHASE; UNCLASSIFIED DRUG;

ARTEMISIA ANNUA; CATALYSIS; CYCLIZATION; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME METABOLISM; NONHUMAN; PHYLOGENY; PROTEIN EXPRESSION; REVIEW; UPREGULATION;

AMORPHA; ARTEMISIA ANNUA;

EID: 84856611060     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: 10.4103/0973-7847.91118     Document Type: Review

References (39)

1. 2 study. Phytochemistry 2010;71:179-87.
2. Zeng Q, Qiu F, Yuan L. Production of artemisinin by genetically- modifiedmicrobes. Biotechonol Lett 2008;30:581-92.
3. White NJ. Qinghaosu (Artemisinin) The price of success. Science 2008;320:331-4.
4. Covello PS, Teoh KH, Polichuk DR, Reed DW, Nowak G. Functional genomics and the biosynthesis of artemisinin. Phytochemistry 2007;68:1864-71. (Pubitemid 47039172)
5. Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 2004;430:900-4. (Pubitemid 39119218)
6. Eckstein-Ludwig U, Webb RJ, Goethem IDA, East JM, Lee AG, Kimura M, et al. Artemisinins target the SERCA of Plasemodium falciparum. Nature 2003;424:957-61. (Pubitemid 37051688)
7. Xiao SH. Development of antischistosomal drugs in China, with particular consideration to Praziquantel and the Artemisinins. Acta Trop 2005;96:153-67.
8. Romero MR, Serrano MA, Vallejo M, Efferth T, Alvarez M, Marin JJ. Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhea virus (BVDV). Planta Med 2006;72:1169-74. (Pubitemid 44759224)
9. Efferth T. Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr Drug Targets 2006;7:407-21. (Pubitemid 43744832)
10. Mutabingwa TK. Artemisinin-based combination therapies (ACTs): Best hope for malaria treatment but inaccessible to the needy. Acta Trop 2005;95:305-15. (Pubitemid 41207297)
11. Abdin MZ, Israr M, Rehman RU, Jain SK. Artemisinin, a novel antimalarial drug: Biochemical and molecular approaches for enhanced production. Planta Med 2003;69:289-99. (Pubitemid 36577992)
12. Towler MJ, Weathers PJ. Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. Plant Cell Rep 2007;26:2129-36. (Pubitemid 350165569)
13. Tang KX, Jing FY, Zhang L, Wang GF. Method for increasing artemisinin content by co-transferring genes HMGR and FPS into Artemisia annua [P]. Faming Zhuanli Shenqing 2008;CN 101182545A.
14. Ram M, Khan MA, Jha P, Khan S, Kiran U, Ahmad MM, et al. HMG-CoA reductase limits artemisinin biosynthesis and accumulation in Artemisia annua L. Plants. Acta Physiol Plant 2010;32:859-66.
15. Souret FF, Kim Y, Wyslouzil BE, Wobbe KK, Weathers PJ. Scale-up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression. Biotechnol Bioeng 2003;83:653-67. (Pubitemid 36998965)
16. Han JL, Liu BY, Ye HC, Wang H, Li ZQ, Li GF. Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in Artemisia annua L. J Integrat Plant Biol 2006;48:482-7.
17. Banyai W, Kirdmanee C, Mii M, Supaibulwatana K. Overexpression of farnesyl pyrophosphate synthase gene affected artemisinin content and growth of Artemisia annua L. Plant Cell Tiss Organ 2010;103:255-65.
18. Mercke P, Bengtsson M, Bouwmeester HJ, Posthumus MA, Brodelius PE. Molecular cloning, expression and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. Arch Biochem Biophys 2000;381:173-80. (Pubitemid 32260303)
19. Cai Y, Jia JW, Crock J, Lin ZX, Chen XY, Croteau R. A cDNA clone for -caryophyllene synthase from Artemisia annua. Phytochemistry 2002;61:523-9. (Pubitemid 35345859)
20. Picaud S, Brodelius M, Brodelius PE. Expression, purification and characterization of recombinant (E) - farnesene synthase from Artemisia annua. Phytochemistry 2005;66:961-7. (Pubitemid 40717486)
21. Bertea CM, Voster A, Verstappen FW, Maffei M, Beekwilder J, Bouwmeester HJ. Isoprenoid biosynthesis in Artemisia annua: Cloning and heterologous expression of a germacrene a synthase from a glandular trichome cDNA library. Arch Biochem Biophys 2006;448:3-12.
22. Tang KX, Jing FY, Zhang L, Wang GF. Transformation of gene ADS into Artemisia annua to increase arteannuin content [P]. Faming Zhuanli Gongkai Shuomingshu 2008;CN 101182544A.
23. Li ZQ, Liu Y, Liu BY, Wang H, Ye HC, Li GF. Cloning, E. coli expression and molecular analysis of amorpha-4,11-diene synthase from a high-yield strain of Artemisia annua L. J Integrat Plant Biol 2006;48:1466-92.
24. Alam P, Kiran U, Ahmad MM, Kamaluddin, Khan MA, Jhanwar S, et al. Isolation, characterization and structural studies of amorpha-4,11-diene synthase (ADS(3963)) from Artemisia annua L. Bioinformation 2010;4:421-9.
25. Zeng QP, Zeng XM, Yin LL, Yang RY, Feng LL, Yang XQ. Quantification of three key enzymes involved in artemisinin biogenesis in Artemisia annua by polyclonal antisera-based ELISA. Plant Mol Biol Rep 2009;27:50-7.
26. Yin L, Zhao C, Huang Y, Yang RY, Zeng QP. Abiotic stress-induced expression of artemisinin biosynthesis genes in Artemisia annua L. Chin J Appl Environ Biol 2008;14:1-5. (Pubitemid 351397338)
27. Feng LL, Yang RY, Yang XQ, Zeng XM, Lu WJ, Zeng QP. Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgentic Artemisia annua. Plant Sci 2009;177:57-67.
28. Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS. Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett 2006;580:1411-6. (Pubitemid 43222008)
29. Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, et al. Producation of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006;440:940-3.
30. Zhang YS, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, et al. The molecular cloning of artemisinic aldehyde 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem 2008;283:21501-8.
31. Wallaart TE, Pras N, Beekman AC, Quax WJ. Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: Proof for the existence of chemotypes. Planta Med 2000;66:57-62. (Pubitemid 30097282)
32. Covello PS. Making artemisinin. Phytochemistry 2008;69:2881-5.
33. Teoh KH, Polichuk DR, Reed DW, Covello PS. Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany 2009;87:635-42.
34. Dhingra V, Narasu ML. Purification and characterization of an enzyme involved in biochenmical transformation of arteannuin B to artemisinin from Artemisia annua. Biochem Bioph Res Co 2001;281:558-61. (Pubitemid 32928190)
35. Zhang YS, Liu BY, Li ZQ, Ye HC, Wang H, Li GF, et al. Molecular cloning of a classical plant peroxidase from Artemisia annua and its effect on the biosynthesis of artemisinin in vitro. Acta Bot Sin 2004;46:1338-46. (Pubitemid 40599407)
36. Zhang YS, Ye HC, Li GF. Effect of horseradish peroxidase on the biosynthesis of artemisinin in Artemisia annua in vitro. Chin J Appl Envirom Biol 2003;9:616-8.
37. Brown GD, Sy LK. In vivo transformations of artemisinic acid in Artemisia annua plants. Tetrahedron 2007;63:9548-66. (Pubitemid 47208563)
38. Brown GD, Sy LK. In vivo transformations of diartemisinic acid in Artemisia annua plants. Tetrahedron 2004;60:1139-59. (Pubitemid 38071822)
39. Bertea CM, Freije JR, Van der Woude H, Verstappen FW, Perk L, Marquez V, et al. Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med 2005;71:40-7. (Pubitemid 40223350)