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Volumn 49, Issue 7, 2007, Pages 961-974

Terpenoid indole alkaloids biosynthesis and metabolic engineering in Catharanthus roseus

Author keywords

Biosynthesis pathway; Catharanthus roseus; Metabolic engineering; Terpenoid indole alkaloids

Indexed keywords

ALKALOID; BIOENGINEERING; CLONE; ENZYME; GENE; METABOLITE; MOLECULAR ANALYSIS; PLANT; PROTEIN;

EID: 34347405302     PISSN: 16729072     EISSN: 17447909     Source Type: Journal    
DOI: 10.1111/j.1672-9072.2007.00457.x     Document Type: Review
Times cited : (43)

References (101)
  • 1
    • 0033198833 scopus 로고    scopus 로고
    • Incorporation of 1-[1-13C]-Deoxy-D-xylulose in chamomile sesquiterpenes
    • Adam KP, Thiel R, Zapp J (1999). Incorporation of 1-[1-13C]-Deoxy-D-xylulose in chamomile sesquiterpenes. Arch. Biochem. Biophys. 369, 127-132.
    • (1999) Arch. Biochem. Biophys. , vol.369 , pp. 127-132
    • Adam, K.P.1    Thiel, R.2    Zapp, J.3
  • 2
    • 0028092392 scopus 로고
    • Methyl jasmonate vapor increases the developmentally controlled synthesis of alkaloids in Catharanthus and Cinchona seedlings
    • Aerts RJ, Gisi D, De Carolis E, De Luca V, Baumann TW (1994). Methyl jasmonate vapor increases the developmentally controlled synthesis of alkaloids in Catharanthus and Cinchona seedlings. Plant J. 5, 635-643.
    • (1994) Plant J. , vol.5 , pp. 635-643
    • Aerts, R.J.1    Gisi, D.2    De Carolis, E.3    De Luca, V.4    Baumann, T.W.5
  • 3
    • 0036210001 scopus 로고    scopus 로고
    • Overexpression in Catharanthus roseus hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-CoA reductase gene
    • Ayora-Talavera T, Chappell J, Lozoya-Gloria E, Loyola-Vargas VM (2002). Overexpression in Catharanthus roseus hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-CoA reductase gene. Appl. Biochem. Biotechnol. 97, 135-146.
    • (2002) Appl. Biochem. Biotechnol. , vol.97 , pp. 135-146
    • Ayora-Talavera, T.1    Chappell, J.2    Lozoya-Gloria, E.3    Loyola-Vargas, V.M.4
  • 4
    • 33746512285 scopus 로고
    • The intermediacy of geissoschizine in indole alkaloid biosynthesis: Rearrangement to the Strychnos skeleton
    • Battersby AR, Hall ES (1969). The intermediacy of geissoschizine in indole alkaloid biosynthesis: Rearrangement to the Strychnos skeleton. Chem. Commun. (Camb) 14, 793-794.
    • (1969) Chem. Commun. (Camb) , vol.14 , pp. 793-794
    • Battersby, A.R.1    Hall, E.S.2
  • 5
    • 0000091266 scopus 로고
    • Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cells of Catharanthus roseus (L.) G. Don. and its conversion into serpentine
    • Blom TJM, Sierra M, van Vliet TB, Franke-van Dijk MEI, de Koning P et al. (1991). Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cells of Catharanthus roseus (L.) G. Don. and its conversion into serpentine. Planta 183, 170-177.
    • (1991) Planta , vol.183 , pp. 170-177
    • Blom, T.J.M.1    Sierra, M.2    van Vliet, T.B.3    Franke-van Dijk, M.E.I.4    deKoning, P.5
  • 6
    • 0033763533 scopus 로고    scopus 로고
    • Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells
    • Bouvier F, Suire C, d'Harlingue A, Backhaus RA, Camara B (2000). Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells. Plant J. 24, 241-252.
    • (2000) Plant J. , vol.24 , pp. 241-252
    • Bouvier, F.1    Suire, C.2    d'Harlingue, A.3    Backhaus, R.A.4    Camara, B.5
  • 7
    • 1542351251 scopus 로고    scopus 로고
    • Transcription factors as tools for metabolic engineering in plants
    • Broun P (2004). Transcription factors as tools for metabolic engineering in plants. Curr. Opin. Plant Biol. 7, 202-209.
    • (2004) Curr. Opin. Plant Biol. , vol.7 , pp. 202-209
    • Broun, P.1
  • 8
    • 0033539554 scopus 로고    scopus 로고
    • Geranyl diphosphate synthase: Cloning, expression, and haracterization of this prenyltransferase as a heterodimer
    • Burke CC, Wildung MR, Croteau R (1999). Geranyl diphosphate synthase: Cloning, expression, and haracterization of this prenyltransferase as a heterodimer. Proc. Natl. Acad. Sci. USA 96, 13062-13067.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13062-13067
    • Burke, C.C.1    Wildung, M.R.2    Croteau, R.3
  • 9
    • 0032127941 scopus 로고    scopus 로고
    • Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
    • Canel C, Lopes-Cardoso MI, Whitmer S, Van Der Fits L, Pasquali G, Van Der Heijden R et al. (1998). Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 205, 414-419.
    • (1998) Planta , vol.205 , pp. 414-419
    • Canel, C.1    Lopes-Cardoso, M.I.2    Whitmer, S.3    Van Der Fits, L.4    Pasquali, G.5    Van Der Heijden, R.6
  • 10
    • 0030698684 scopus 로고    scopus 로고
    • A promoter region that controls basal and elicitor-inducible expression levels of the NADPH: Cytochrome P450 reductase gene (Cpr) from Catharanthus roseus binds nuclear factor GT-1
    • Cardoso MI, Meijer AH, Rueb JA, Memelink J, Hoge JH (1997). A promoter region that controls basal and elicitor-inducible expression levels of the NADPH: Cytochrome P450 reductase gene (Cpr) from Catharanthus roseus binds nuclear factor GT-1. Mol. Gen. Genet. 256, 674-681.
    • (1997) Mol. Gen. Genet , vol.256 , pp. 674-681
    • Cardoso, M.I.1    Meijer, A.H.2    Rueb, J.A.3    Memelink, J.4    Hoge, J.H.5
  • 11
    • 0033843763 scopus 로고    scopus 로고
    • 1-Deoxy-D-xylulose 5-phosphate synthase from periwinkle: cDNA identification and induced gene expression in terpenoid indole alkaloid-producing cells
    • Chahed K, Oudin A, Guivarch N, Hamdi S, Chenieux JC, Rideau M et al. (2000). 1-Deoxy-D-xylulose 5-phosphate synthase from periwinkle: CDNA identification and induced gene expression in terpenoid indole alkaloid-producing cells. Plant Physiol. Biochem. 38, 559-566.
    • (2000) Plant Physiol. Biochem. , vol.38 , pp. 559-566
    • Chahed, K.1    Oudin, A.2    Guivarch, N.3    Hamdi, S.4    Chenieux, J.C.5    Rideau, M.6
  • 12
    • 0036008773 scopus 로고    scopus 로고
    • The genetics and molecular genetics of terpene and sterol origami
    • Chappell J (2002). The genetics and molecular genetics of terpene and sterol origami. Curr. Opin. Plant Biol. 5, 151-157.
    • (2002) Curr. Opin. Plant Biol. , vol.5 , pp. 151-157
    • Chappell, J.1
  • 13
    • 0242628016 scopus 로고    scopus 로고
    • CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter
    • Chatel G, Montiel G, PréM, Memelink J, Thiersault M, Saint-Pierre B et al. (2003). CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter. J. Exp. Bot. 54, 2587-2588.
    • (2003) J. Exp. Bot. , vol.54 , pp. 2587-2588
    • Chatel, G.1    Montiel, G.2    Pré, M.3    Memelink, J.4    Thiersault, M.5    Saint-Pierre, B.6
  • 14
    • 0033924907 scopus 로고    scopus 로고
    • Increasing tryptophan synthesis in a forage legume Astragalus sinicus by expressing the tobacco feedback-insensitive anthranilate synthase (ASA2) gene
    • Cho HJ, Brotherton JE, Song HS, Widholm JM (2000). Increasing tryptophan synthesis in a forage legume Astragalus sinicus by expressing the tobacco feedback-insensitive anthranilate synthase (ASA2) gene. Plant Physiol. 123, 1069-1076.
    • (2000) Plant Physiol. , vol.123 , pp. 1069-1076
    • Cho, H.J.1    Brotherton, J.E.2    Song, H.S.3    Widholm, J.M.4
  • 16
    • 0032423802 scopus 로고    scopus 로고
    • The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture
    • Contin A, Van Der Heijden R, Lefeber WM, Verpoorte R (1998). The iridoid glucoside secologanin is derived from the novel triose phosphate/ pyruvate pathway in a Catharanthus roseus cell culture. FEBS Lett. 434, 413-416.
    • (1998) FEBS Lett. , vol.434 , pp. 413-416
    • Contin, A.1    Van Der Heijden, R.2    Lefeber, W.M.3    Verpoorte, R.4
  • 17
    • 0000456472 scopus 로고
    • Isolation and characterization of a 2-oxoglutarate dependent dioxygenase involved in the second-to-last step in vindoline biosynthesis
    • De Carolis E, Chan F, Balsevich J, De Luca V (1990). Isolation and characterization of a 2-oxoglutarate dependent dioxygenase involved in the second-to-last step in vindoline biosynthesis. Plant Physiol. 94, 1323-1329.
    • (1990) Plant Physiol. , vol.94 , pp. 1323-1329
    • De Carolis, E.1    Chan, F.2    Balsevich, J.3    De Luca, V.4
  • 18
    • 0011623122 scopus 로고
    • Acetyl coenzyme A: Deacetylvindoline O-acetyltransferase, a novel enzyme from Catharanthus roseus
    • De Luca V, Balsevivh J, Kurz WGW (1985). Acetyl coenzyme A: Deacetylvindoline O-acetyltransferase, a novel enzyme from Catharanthus roseus. J. Plant Physiol. 121, 417-428.
    • (1985) J. Plant Physiol. , vol.121 , pp. 417-428
    • De Luca, V.1    Balsevivh, J.2    Kurz, W.G.W.3
  • 19
    • 0011621325 scopus 로고
    • Characterization of a novel N-methyltransferase (NMT) from Catharanthus roseus plants
    • De Luca V, Balsevivh J, Tyler RT, Kurz WGW (1987a). Characterization of a novel N-methyltransferase (NMT) from Catharanthus roseus plants. Plant Cell Rep. 6, 458-461.
    • (1987) Plant Cell Rep. , vol.6 , pp. 458-461
    • De Luca, V.1    Balsevivh, J.2    Tyler, R.T.3    Kurz, W.G.W.4
  • 20
    • 0000331036 scopus 로고
    • Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus
    • De Luca V, Cutler AJ (1987b). Subcellular localization of enzymes involved in indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol. 85, 1099-1102.
    • (1987) Plant Physiol. , vol.85 , pp. 1099-1102
    • De Luca, V.1    Cutler, A.J.2
  • 21
    • 0001177661 scopus 로고
    • Developmental regulation of enzymes of indole alkaloid biosynthesis in Catharanthus roseus
    • De Luca V, Fernandez JA, Campbell D, Kurz WGW (1988). Developmental regulation of enzymes of indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol. 86, 447-450.
    • (1988) Plant Physiol. , vol.86 , pp. 447-450
    • De Luca, V.1    Fernandez, J.A.2    Campbell, D.3    Kurz, W.G.W.4
  • 22
    • 0024653312 scopus 로고
    • Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: Comparison with animal dopa decarboxylases
    • De Luca V, Marineau C, Brission N (1989). Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: Comparison with animal dopa decarboxylases. Proc. Natl. Acad. Sci. USA 86, 2582-2586.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2582-2586
    • De Luca, V.1    Marineau, C.2    Brission, N.3
  • 23
    • 0035023464 scopus 로고    scopus 로고
    • The expanding universe of alkaloid biosynthesis
    • De Luca V, Laflamme P (2001). The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Biol. 4, 225-233.
    • (2001) Curr. Opin. Plant Biol. , vol.4 , pp. 225-233
    • De Luca, V.1    Laflamme, P.2
  • 24
    • 0141590584 scopus 로고    scopus 로고
    • An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants
    • Dubey VS, Bhalla R, Luthra R (2003). An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. J. Biosci. 28, 637-646.
    • (2003) J. Biosci. , vol.28 , pp. 637-646
    • Dubey, V.S.1    Bhalla, R.2    Luthra, R.3
  • 25
    • 14944343800 scopus 로고    scopus 로고
    • Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don
    • Dutta A, Batra J, Pandey-Rai S, Singh D, Kumar S, Sen J (2005). Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don. Planta 220, 376-383.
    • (2005) Planta , vol.220 , pp. 376-383
    • Dutta, A.1    Batra, J.2    Pandey-Rai, S.3    Singh, D.4    Kumar, S.5    Sen, J.6
  • 26
    • 0023340310 scopus 로고
    • Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus
    • Eilert U, De Luca V, Constabel F, Kuez WG (1987). Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus. Arch. Biochem. Biophys. 254, 491-497.
    • (1987) Arch. Biochem. Biophys. , vol.254 , pp. 491-497
    • Eilert, U.1    De Luca, V.2    Constabel, F.3    Kuez, W.G.4
  • 27
    • 0030995585 scopus 로고    scopus 로고
    • Monoterpenoid essential oils are not of mevalonoid origin
    • Eisenreich W, Sagner S, Zenk NH, Bacher A (1997). Monoterpenoid essential oils are not of mevalonoid origin. Tetrahedron Lett. 38, 3889-3892.
    • (1997) Tetrahedron Lett. , vol.38 , pp. 3889-3892
    • Eisenreich, W.1    Sagner, S.2    Zenk, N.H.3    Bacher, A.4
  • 29
    • 3342941008 scopus 로고    scopus 로고
    • Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine
    • El-Sayed M, Choi YH, Frédérich M, Roytrakul S, Verpoorte R (2004). Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine. Biotechnol. Lett. 26, 793-798.
    • (2004) Biotechnol. Lett. , vol.26 , pp. 793-798
    • El-Sayed, M.1    Choi, Y.H.2    Frédérich, M.3    Roytrakul, S.4    Verpoorte, R.5
  • 30
    • 0035780976 scopus 로고    scopus 로고
    • Alkaloid Biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications
    • Facchini PJ (2001). Alkaloid Biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 29-66.
    • (2001) Annu. Rev. Plant Physiol. Plant Mol. Biol. , vol.52 , pp. 29-66
    • Facchini, P.J.1
  • 31
    • 26844465113 scopus 로고    scopus 로고
    • Synthesis and trafficking of alkaloid biosynthetic enzymes
    • Facchini PJ, St-Pierre (2005). Synthesis and trafficking of alkaloid biosynthetic enzymes. Curr. Opin. Plant Biol. 8, 657-666.
    • (2005) Curr. Opin. Plant Biol. , vol.8 , pp. 657-666
    • Facchini, P.J.1    St-Pierre2
  • 33
    • 0019881731 scopus 로고
    • Enzyme activities of the primary and secondary metabolism of simultaneously permeabilized and immobilized plant cells
    • Felix H, Brodelius P, Mosbach K (1981). Enzyme activities of the primary and secondary metabolism of simultaneously permeabilized and immobilized plant cells. Anal. Biochem. 116, 462-470.
    • (1981) Anal. Biochem. , vol.116 , pp. 462-470
    • Felix, H.1    Brodelius, P.2    Mosbach, K.3
  • 34
    • 0036890833 scopus 로고    scopus 로고
    • Transcription factors: Tools to engineer the production of pharmacologically active plant metabolites
    • Gantet P, Memelink J (2002). Transcription factors: Tools to engineer the production of pharmacologically active plant metabolites. Trends Pharmacol. Sci. 23, 563-569.
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 563-569
    • Gantet, P.1    Memelink, J.2
  • 35
    • 0039596881 scopus 로고    scopus 로고
    • Molecular cloning and analysis of strictosidine b-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus
    • Geerlings A, Ibañez MML, Memelink J, Van Der Heijden R, Verpoorte R (2000). Molecular cloning and analysis of strictosidine b-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J. Biol. Chem. 275, 3051-3056.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3051-3056
    • Geerlings, A.1    Ibañez, M.M.L.2    Memelink, J.3    Van Der Heijden, R.4    Verpoorte, R.5
  • 36
    • 0026842775 scopus 로고
    • Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus
    • Goddijn OJM, de Kam RJ, Zanetti A, Schilperoort RA, Hoge JHC (1992). Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 18, 1113-1120.
    • (1992) Plant Mol. Biol. , vol.18 , pp. 1113-1120
    • Goddijn, O.J.M.1    de Kam, R.J.2    Zanetti, A.3    Schilperoort, R.A.4    Hoge, J.H.C.5
  • 37
    • 0029360669 scopus 로고
    • Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production
    • Goddijn OJ, Pennings EJ, Van Der Helm P, Schilperoort RA, Verpoorte R, Hoge JH (1995). Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production. Transgenic Res. 4, 315-323.
    • (1995) Transgenic Res. , vol.4 , pp. 315-323
    • Goddijn, O.J.1    Pennings, E.J.2    Van Der Helm, P.3    Schilperoort, R.A.4    Verpoorte, R.5    Hoge, J.H.6
  • 38
    • 33645034954 scopus 로고    scopus 로고
    • Engineering terpenoid indole alkaloids biosynthesis pathway in Catharanthus roseus hairy root cultures by overexpressing the geraniol-10-hydroxylase gene
    • Gong YH, Liao ZH, Pi Y, Guo BH, Miao ZQ, Sun XF et al. (2005). Engineering terpenoid indole alkaloids biosynthesis pathway in Catharanthus roseus hairy root cultures by overexpressing the geraniol-10-hydroxylase gene. J. Shanghai Jiaotong Univ. (Sci.) S1, 8-13.
    • (2005) J. Shanghai Jiaotong Univ. (Sci.) , vol.1 S , pp. 8-13
    • Gong, Y.H.1    Liao, Z.H.2    Pi, Y.3    Guo, B.H.4    Miao, Z.Q.5    Sun, X.F.6
  • 39
    • 3342937338 scopus 로고
    • Involvement of cathenamine in the formation of N-analogues of indole alkaloids
    • Heinstein P, Hófle G, Stóckigt J (1979). Involvement of cathenamine in the formation of N-analogues of indole alkaloids. Planta Med. 37, 349-357.
    • (1979) Planta Med. , vol.37 , pp. 349-357
    • Heinstein, P.1    Hófle, G.2    Stóckigt, J.3
  • 41
    • 0038796531 scopus 로고    scopus 로고
    • Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots
    • Hong SB, Hughes EH, Shanks JV, San KY, Gibson SI (2003). Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. Biotechnol. Prog. 19, 1105-1108.
    • (2003) Biotechnol. Prog. , vol.19 , pp. 1105-1108
    • Hong, S.B.1    Hughes, E.H.2    Shanks, J.V.3    San, K.Y.4    Gibson, S.I.5
  • 42
    • 32644476854 scopus 로고    scopus 로고
    • Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots
    • Hong SB, Peebles CAM, Shanks JV, San KY, Gibson SI (2006). Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots. J. Biotechnol. 122, 28-38.
    • (2006) J. Biotechnol. , vol.122 , pp. 28-38
    • Hong, S.B.1    Peebles, C.A.M.2    Shanks, J.V.3    San, K.Y.4    Gibson, S.I.5
  • 43
    • 0036332024 scopus 로고    scopus 로고
    • Metabolic engineering of plants for alkaloid production
    • Hughes EH, Shanks JV (2002). Metabolic engineering of plants for alkaloid production. Metab. Eng. 4, 41-48.
    • (2002) Metab. Eng. , vol.4 , pp. 41-48
    • Hughes, E.H.1    Shanks, J.V.2
  • 44
    • 2542488359 scopus 로고    scopus 로고
    • Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels
    • Hughes EH, Hong SB, Gilson SI, Shanks JV, San KY (2004a). Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Biotechnol. Bioeng. 86, 718-727.
    • (2004) Biotechnol. Bioeng. , vol.86 , pp. 718-727
    • Hughes, E.H.1    Hong, S.B.2    Gilson, S.I.3    Shanks, J.V.4    San, K.Y.5
  • 45
    • 6044269447 scopus 로고    scopus 로고
    • Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine
    • Hughes EH, Hong SB, Gilson SI, Shanks JV, San KY (2004b). Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine. Metab. Eng. 6, 268-276.
    • (2004) Metab. Eng. , vol.6 , pp. 268-276
    • Hughes, E.H.1    Hong, S.B.2    Gilson, S.I.3    Shanks, J.V.4    San, K.Y.5
  • 46
    • 0034490132 scopus 로고    scopus 로고
    • Indole alkaloid biosynthesis in Catharanthus roseus: New enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase
    • Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J et al. (2000). Indole alkaloid biosynthesis in Catharanthus roseus: New enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24, 797-804.
    • (2000) Plant J. , vol.24 , pp. 797-804
    • Irmler, S.1    Schroder, G.2    St-Pierre, B.3    Crouch, N.P.4    Hotze, M.5    Schmidt, J.6
  • 47
    • 0025824979 scopus 로고
    • Mechanism of inhibition of cell proliferation by Vinca alkaloids
    • Jordan MA, Thrower D, Wilsen L (1991). Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 51, 2212-2222.
    • (1991) Cancer Res. , vol.51 , pp. 2212-2222
    • Jordan, M.A.1    Thrower, D.2    Wilsen, L.3
  • 48
    • 0002317514 scopus 로고    scopus 로고
    • Natural products (secondary metabolites)
    • In: Buchanan BB, Gruissem W, Jones RL, eds. American Society of Plant Physiologists, Rochville
    • Kutchan T (2000). Natural products (secondary metabolites). In: Buchanan BB, Gruissem W, Jones RL, eds. Biochemistry & Molecular Biology of Plants. American Society of Plant Physiologists, Rochville. pp. 1268-1286.
    • (2000) Biochemistry & Molecular Biology of Plants , pp. 1268-1286
    • Kutchan, T.1
  • 49
    • 33646877044 scopus 로고    scopus 로고
    • Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures
    • Lee-Parsons CWT, Royce AJ (2006). Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures. Plant Cell Rep. 25, 607-612.
    • (2006) Plant Cell Rep. , vol.25 , pp. 607-612
    • Lee-Parsons, C.W.T.1    Royce, A.J.2
  • 50
    • 0030024965 scopus 로고    scopus 로고
    • The Arabidopsis trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan
    • Li JY, Last RL (1996). The Arabidopsis trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan. Plant Physiol. 110, 51-59.
    • (1996) Plant Physiol. , vol.110 , pp. 51-59
    • Li, J.Y.1    Last, R.L.2
  • 51
    • 0031015862 scopus 로고    scopus 로고
    • Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via mevalonate independent pathway
    • Lichtenthaler HK, Schwender J, Disch A, Rohmer M (1997). Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via mevalonate independent pathway. FEBS Lett. 400, 271-274.
    • (1997) FEBS Lett. , vol.400 , pp. 271-274
    • Lichtenthaler, H.K.1    Schwender, J.2    Disch, A.3    Rohmer, M.4
  • 52
    • 0028118349 scopus 로고
    • Nucleotide sequence of the tryptophan decarboxylase gene of ssion of tdc-gusA gene fusions in Nicotiana tabacum
    • Lohmann FPM Lohman FP, de Kam RJ, Schilperoort RA, Hoge HJC (1994). Nucleotide sequence of the tryptophan decarboxylase gene of ssion of tdc-gusA gene fusions in Nicotiana tabacum. Mol. Gen. Genet. 245, 217-225.
    • (1994) Mol. Gen. Genet. , vol.245 , pp. 217-225
    • Lohmann, F.P.M.1    Lohman, F.P.2    de Kam, R.J.3    Schilperoort, R.A.4    Hoge, H.J.C.5
  • 53
    • 0029795353 scopus 로고    scopus 로고
    • Involvement of strictisidine as a defensive chemical in Catharanthus roseus
    • Luijendijk TJC, Vandermeijden E, Verpoorte R (1996a). Involvement of strictisidine as a defensive chemical in Catharanthus roseus. J. Chem. Ecol. 22, 1355-1366.
    • (1996) J. Chem. Ecol. , vol.22 , pp. 1355-1366
    • Luijendijk, T.J.C.1    Vandermeijden, E.2    Verpoorte, R.3
  • 54
    • 0030045088 scopus 로고    scopus 로고
    • Strictosidine glucosidase from suspension cultures cells of Tabernaemontana divaricata
    • Luijendijk TJC, Nowak A, Verpoorte R (1996b). Strictosidine glucosidase from suspension cultures cells of Tabernaemontana divaricata. Phytochemistry 41, 1451-1456.
    • (1996) Phytochemistry , vol.41 , pp. 1451-1456
    • Luijendijk, T.J.C.1    Nowak, A.2    Verpoorte, R.3
  • 55
    • 0032104144 scopus 로고    scopus 로고
    • Purification and characterization of strictosidine β-D-glucosidase from Catharanthus roseus cell suspension cultures
    • Luijendijk TJC, Stevens LH, Verpoorte R (1998). Purification and characterization of strictosidine β-D-glucosidase from Catharanthus roseus cell suspension cultures. Plant Physiol. Biochem. 36, 419-425.
    • (1998) Plant Physiol. Biochem. , vol.36 , pp. 419-425
    • Luijendijk, T.J.C.1    Stevens, L.H.2    Verpoorte, R.3
  • 56
    • 33646414497 scopus 로고    scopus 로고
    • Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs
    • Mahroug S, Courdavault V, Thiersault M, St-Pierre B, Burlat V (2006). Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs. Planta 223, 1191-1200.
    • (2006) Planta , vol.223 , pp. 1191-1200
    • Mahroug, S.1    Courdavault, V.2    Thiersault, M.3    St-Pierre, B.4    Burlat, V.5
  • 57
  • 58
    • 0025044913 scopus 로고
    • Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus
    • McKnight TD, Roessner CA, Devagupta R, Scott AI, Nessler CL (1990). Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus. Nucleic Acids Res. 18, 4939.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 4939
    • McKnight, T.D.1    Roessner, C.A.2    Devagupta, R.3    Scott, A.I.4    Nessler, C.L.5
  • 59
    • 0027630948 scopus 로고
    • Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH:Cytochrome P450 reductase, an enzyme essential for reactions catalyzed by cytichrome P450 mono-oxygenases in plants
    • Meijer AH, Cardoso MIL, Voskuilen JT, de Waal A, Verpoorte R, Hoge HC (1993). Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH:CYtochrome P450 reductase, an enzyme essential for reactions catalyzed by cytichrome P450 mono-oxygenases in plants. Plant J. 4, 47-60.
    • (1993) Plant J. , vol.4 , pp. 47-60
    • Meijer, A.H.1    Cardoso, M.I.L.2    Voskuilen, J.T.3    de Waal, A.4    Verpoorte, R.5    Hoge, H.C.6
  • 60
    • 0035213471 scopus 로고    scopus 로고
    • ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism
    • Memelink J, Verpoorte R, Kijne JW (2001a). ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism. Trends Plant Sci. 6, 212-219.
    • (2001) Trends Plant Sci. , vol.6 , pp. 212-219
    • Memelink, J.1    Verpoorte, R.2    Kijne, J.W.3
  • 61
    • 0035238593 scopus 로고    scopus 로고
    • Genetic modification of plant secondary metabolite pathways using transcriptional regulators
    • Memelink J, Kijne J, Van Der Heijden R, Verpoorte R (2001b). Genetic modification of plant secondary metabolite pathways using transcriptional regulators. Adv. Biochem. Eng./Biotechnol. 72, 103-126.
    • (2001) Adv. Biochem. Eng./Biotechnol. , vol.72 , pp. 103-126
    • Memelink, J.1    Kijne, J.2    Van Der Heijden, R.3    Verpoorte, R.4
  • 62
    • 0033575710 scopus 로고    scopus 로고
    • A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2
    • Menke FLH, Champion A, Kijne JW, Memelink J (1999). A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J. 18, 4455-4463.
    • (1999) EMBO J. , vol.18 , pp. 4455-4463
    • Menke, F.L.H.1    Champion, A.2    Kijne, J.W.3    Memelink, J.4
  • 63
    • 0038404731 scopus 로고    scopus 로고
    • Plant cytochrommes 450: Tools for pharmacology, plant protection and phytoremediation
    • Morant M, Bak S, Moller BL, Werck-Reichhart D (2003). Plant cytochrommes 450: Tools for pharmacology, plant protection and phytoremediation. Curr. Opin. Biotechnol. 14, 151-162.
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 151-162
    • Morant, M.1    Bak, S.2    Moller, B.L.3    Werck-Reichhart, D.4
  • 64
    • 0034725086 scopus 로고    scopus 로고
    • Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures
    • Morgan JA, Shanks JV (2000). Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures. J. Biotechnol. 79, 137-145.
    • (2000) J. Biotechnol. , vol.79 , pp. 137-145
    • Morgan, J.A.1    Shanks, J.V.2
  • 65
    • 33644674347 scopus 로고    scopus 로고
    • Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus
    • Murata J, De Luca V (2005). Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. Plant J. 44, 581-594.
    • (2005) Plant J. , vol.44 , pp. 581-594
    • Murata, J.1    De Luca, V.2
  • 66
    • 0036008008 scopus 로고    scopus 로고
    • Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus
    • Namdeo A, Patil S, Fulzele DP (2002). Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus. Biotechnol. Prog. 18, 159-162.
    • (2002) Biotechnol. Prog. , vol.18 , pp. 159-162
    • Namdeo, A.1    Patil, S.2    Fulzele, D.P.3
  • 67
    • 0033231621 scopus 로고    scopus 로고
    • Identification of UV-B light-responsive regions in the promoter of the tryptophan decarboxylase gene from Catharanthus roseus
    • Ouwerkerk PBF, Hallard D, Verpoorte R, Memelink J (1999a). Identification of UV-B light-responsive regions in the promoter of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 41, 491-503.
    • (1999) Plant Mol. Biol. , vol.41 , pp. 491-503
    • Ouwerkerk, P.B.F.1    Hallard, D.2    Verpoorte, R.3    Memelink, J.4
  • 68
    • 0032991530 scopus 로고    scopus 로고
    • A G-box element from the Catharanthus roseus strictosidine synthase (Str) gene promoter confers seed-specific expression in transgenic tobacco plants
    • Ouwerkerk PBF, Memelink J (1999b). A G-box element from the Catharanthus roseus strictosidine synthase (Str) gene promoter confers seed-specific expression in transgenic tobacco plants. Mol. Gen. Genet. 261, 635-643.
    • (1999) Mol. Gen. Genet. , vol.261 , pp. 635-643
    • Ouwerkerk, P.B.F.1    Memelink, J.2
  • 69
    • 0026841089 scopus 로고
    • Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors
    • Pasquali G, Goddijn OJ, de Waal A, Verpoorte R, Schilperoort RA, Hoge JH et al. (1992). Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors. Plant Mol. Biol. 18, 1121-1131.
    • (1992) Plant Mol. Biol. , vol.18 , pp. 1121-1131
    • Pasquali, G.1    Goddijn, O.J.2    de Waal, A.3    Verpoorte, R.4    Schilperoort, R.A.5    Hoge, J.H.6
  • 70
    • 19944424420 scopus 로고    scopus 로고
    • Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus
    • Pauw B, Hilliou FA, Martin VS, Chatel G, de Wolf CJ, Champion A et al. (2004a). Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus. J. Biol. Chem. 279, 52940-52948.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52940-52948
    • Pauw, B.1    Hilliou, F.A.2    Martin, V.S.3    Chatel, G.4    de Wolf, C.J.5    Champion, A.6
  • 71
    • 16644383297 scopus 로고    scopus 로고
    • Activation of the oxidative burst by elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis
    • Pauw B, van Duijn B, Kijne JW, Memelink J (2004b). Activation of the oxidative burst by elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis. Plant Mol. Biol. 55, 797-805.
    • (2004) Plant Mol. Biol. , vol.55 , pp. 797-805
    • Pauw, B.1    van Duijn, B.2    Kijne, J.W.3    Memelink, J.4
  • 72
    • 32544444288 scopus 로고    scopus 로고
    • Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase
    • Peebles CAM, Hong SB, Gibson SI, Shanks JV, San KY (2006). Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase. Biotechnol. Bioeng. 93, 534-540.
    • (2006) Biotechnol. Bioeng , vol.93 , pp. 534-540
    • Peebles, C.A.M.1    Hong, S.B.2    Gibson, S.I.3    Shanks, J.V.4    San, K.Y.5
  • 73
    • 0027459522 scopus 로고
    • Purification and characterization of anthranilate synthase from Catharanthus roseus
    • Poulsen C, Bongaerts RJ, Verpoorte R (1993). Purification and characterization of anthranilate synthase from Catharanthus roseus. Eur. J. Biochem. 212, 431-440.
    • (1993) Eur. J. Biochem. , vol.212 , pp. 431-440
    • Poulsen, C.1    Bongaerts, R.J.2    Verpoorte, R.3
  • 74
    • 0025333983 scopus 로고
    • Purification and characterization of acetylcoenzyme A: Deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus
    • Power R, Kurz WGW, De Luca V (1990). Purification and characterization of acetylcoenzyme A: Deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus. Arch. Biochem. Biophys. 279, 370-376.
    • (1990) Arch. Biochem. Biophys. , vol.279 , pp. 370-376
    • Power, R.1    Kurz, W.G.W.2    De Luca, V.3
  • 75
    • 0037070556 scopus 로고    scopus 로고
    • Functional analysis of the Arabodopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis
    • Querol J, Campos N, Imperial S, Boronat A, Rodríguez-Concepción M (2002). Functional analysis of the Arabodopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis. FEBS Lett. 514, 343-346.
    • (2002) FEBS Lett. , vol.514 , pp. 343-346
    • Querol, J.1    Campos, N.2    Imperial, S.3    Boronat, A.4    Rodríguez-Concepción, M.5
  • 76
    • 0032077393 scopus 로고    scopus 로고
    • Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures
    • Rijhwani SK, Shanks JV (1998). Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures. Biotechnol. Prog. 14, 442-449.
    • (1998) Biotechnol. Prog. , vol.14 , pp. 442-449
    • Rijhwani, S.K.1    Shanks, J.V.2
  • 78
    • 0036851226 scopus 로고    scopus 로고
    • Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids
    • Rodríguez-Concepción M, Boronat A (2002). Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol. 130, 1079-1089.
    • (2002) Plant Physiol. , vol.130 , pp. 1079-1089
    • Rodríguez-Concepción, M.1    Boronat, A.2
  • 81
    • 0142036457 scopus 로고    scopus 로고
    • Light-induced cytochrome P450- dependent enzyme in indole alkaloid biosynthesis: Tabersonine 16-hydroxylase1
    • Schröder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V et al. (1999). Light-induced cytochrome P450- dependent enzyme in indole alkaloid biosynthesis: Tabersonine 16-hydroxylase1. FEBS Lett. 458, 97-102.
    • (1999) FEBS Lett. , vol.458 , pp. 97-102
    • Schröder, G.1    Unterbusch, E.2    Kaltenbach, M.3    Schmidt, J.4    Strack, D.5    De Luca, V.6
  • 82
    • 0035039494 scopus 로고    scopus 로고
    • Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures
    • Sibéril Y, Benhamron S, Memelink J, Giglioli-Guivarch N, Thiersault M, Boisson B et al. (2001). Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures. Plant Mol. Biol. 45, 477-488.
    • (2001) Plant Mol. Biol. , vol.45 , pp. 477-488
    • Sibéril, Y.1    Benhamron, S.2    Memelink, J.3    Giglioli-Guivarch, N.4    Thiersault, M.5    Boisson, B.6
  • 83
    • 0344972955 scopus 로고    scopus 로고
    • Purification and characterization of α-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don
    • Sottomayor M, López-Serrano M, DiCosmo F, Ros-Barcelo A (1998). Purification and characterization of α-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don. FEBS Lett. 428, 299-303.
    • (1998) FEBS Lett. , vol.428 , pp. 299-303
    • Sottomayor, M.1    López-Serrano, M.2    DiCosmo, F.3    Ros-Barcelo, A.4
  • 84
    • 0020545226 scopus 로고
    • Steric course of hydrogen transfer during enzymatic formation of 3α-heteroyohimbine alkaloids
    • Stóckigt J, Hemscheidt T, Hófle G, Heinstein P, Formacek V (1983). Steric course of hydrogen transfer during enzymatic formation of 3α-heteroyohimbine alkaloids. Biochemistry 22, 3448-3452.
    • (1983) Biochemistry , vol.22 , pp. 3448-3452
    • Stóckigt, J.1    Hemscheidt, T.2    Hófle, G.3    Heinstein, P.4    Formacek, V.5
  • 85
    • 0028855024 scopus 로고
    • A cytochrome P-450 monooxygenase catalyzes the first step in the conversion of tabersonine to vindoline in Catharanthus roseus
    • St-Pierre B, De Luca V (1995). A cytochrome P-450 monooxygenase catalyzes the first step in the conversion of tabersonine to vindoline in Catharanthus roseus. Plant Physiol. 109, 131-139.
    • (1995) Plant Physiol. , vol.109 , pp. 131-139
    • St-Pierre, B.1    De Luca, V.2
  • 86
    • 0032104554 scopus 로고    scopus 로고
    • The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer
    • St-Pierre B, Laflamme P, Alarco AM, De Luca V (1998). The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer. Plant J. 14, 703-713.
    • (1998) Plant J. , vol.14 , pp. 703-713
    • St-Pierre, B.1    Laflamme, P.2    Alarco, A.M.3    De Luca, V.4
  • 87
    • 0032720893 scopus 로고    scopus 로고
    • Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate
    • St-Pierre B, Vazquez-Flota FA, De Luca V (1999). Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11, 887-900.
    • (1999) Plant Cell , vol.11 , pp. 887-900
    • St-Pierre, B.1    Vazquez-Flota, F.A.2    De Luca, V.3
  • 88
    • 0034647914 scopus 로고    scopus 로고
    • ORCA3, a jasmonate-responsive transcription regulator of plant primary and secondary metabolism
    • van der Fits L, Memelink J (2000a). ORCA3, a jasmonate-responsive transcription regulator of plant primary and secondary metabolism. Science 289, 295-297.
    • (2000) Science , vol.289 , pp. 295-297
    • van der Fits, L.1    Memelink, J.2
  • 89
    • 0034486601 scopus 로고    scopus 로고
    • A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway
    • van der Fits L, Zhang H, Menke FLH, Deneka M, Memelink J (2000b). A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway. Plant Mol. Biol. 44, 675-685.
    • (2000) Plant Mol. Biol. , vol.44 , pp. 675-685
    • van der Fits, L.1    Zhang, H.2    Menke, F.L.H.3    Deneka, M.4    Memelink, J.5
  • 90
    • 0035121285 scopus 로고    scopus 로고
    • The jasmonate-inducible AP2/ERf-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element
    • van der Fits L, Memelink J (2001). The jasmonate-inducible AP2/ ERf-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. Plant J. 25, 43-53.
    • (2001) Plant J. , vol.25 , pp. 43-53
    • van der Fits, L.1    Memelink, J.2
  • 91
    • 0031214493 scopus 로고    scopus 로고
    • Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don
    • Vazquez-Flota F, Carolis ED, Alarco AM, De Luca V (1997). Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don. Plant Mol. Biol. 34, 935-948.
    • (1997) Plant Mol. Biol. , vol.34 , pp. 935-948
    • Vazquez-Flota, F.1    Carolis, E.D.2    Alarco, A.M.3    De Luca, V.4
  • 92
    • 0001136463 scopus 로고    scopus 로고
    • Developmental and light regulation of desacetoxyvindoline 4-hydroxylase in Catharanthus roseus (L.) G. Don
    • Vazquez-Flota F, De Luca V (1998a). Developmental and light regulation of desacetoxyvindoline 4-hydroxylase in Catharanthus roseus (L.) G. Don. Plant Physiol. 117, 1351-1361.
    • (1998) Plant Physiol. , vol.117 , pp. 1351-1361
    • Vazquez-Flota, F.1    De Luca, V.2
  • 93
    • 0032575918 scopus 로고    scopus 로고
    • Jasmonate modulates development- and light-regulated alkaloid biosynthesis in Catharanthus roseus
    • Vazquez-Flota F, De Luca V (1998b). Jasmonate modulates development- and light-regulated alkaloid biosynthesis in Catharanthus roseus. Phytochemistry 49, 395-402.
    • (1998) Phytochemistry , vol.49 , pp. 395-402
    • Vazquez-Flota, F.1    De Luca, V.2
  • 95
    • 0034672597 scopus 로고    scopus 로고
    • Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus
    • Veau B, Courtois M, Oudin A, Chenieux JC, Rideau M, Clastre M (2000). Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus. Biochim. Biophys. Acta 1517, 159-163.
    • (2000) Biochim. Biophys. Acta , vol.1517 , pp. 159-163
    • Veau, B.1    Courtois, M.2    Oudin, A.3    Chenieux, J.C.4    Rideau, M.5    Clastre, M.6
  • 96
    • 0036536289 scopus 로고    scopus 로고
    • Engineering secondary metabolite production in plants
    • Verpoorte R, Memelink J (2002). Engineering secondary metabolite production in plants. Curr. Opin. Biotechnol. 13, 181-187.
    • (2002) Curr. Opin. Biotechnol. , vol.13 , pp. 181-187
    • Verpoorte, R.1    Memelink, J.2
  • 97
    • 0000278185 scopus 로고
    • Molecular analysis and heterologous expression of an inducible cytochrome P-450 protein from periwinkle (Catharanthus roseus L.)
    • Vetter HP, Mangold U, Schroeder G, Marner FJ, Werck-Reichhart D, Schroeder J (1992). Molecular analysis and heterologous expression of an inducible cytochrome P-450 protein from periwinkle (Catharanthus roseus L.). Plant Physiol. 100, 998-1007.
    • (1992) Plant Physiol. , vol.100 , pp. 998-1007
    • Vetter, H.P.1    Mangold, U.2    Schroeder, G.3    Marner, F.J.4    Werck-Reichhart, D.5    Schroeder, J.6
  • 98
    • 0037072486 scopus 로고    scopus 로고
    • Transcription factors controlling plant secondary metabolism: What regulates the regulators?
    • Vom Endt D, Kijne JW, Memelink J (2002). Transcription factors controlling plant secondary metabolism: What regulates the regulators?Phytochemistry 61, 107-114.
    • (2002) Phytochemistry , vol.61 , pp. 107-114
    • Vom Endt, D.1    Kijne, J.W.2    Memelink, J.3
  • 99
    • 0000326239 scopus 로고    scopus 로고
    • Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus
    • Whitmer S, Canel C, Hallard D, Goncalves C, Verpoorte R (1998). Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus. Plant Physiol. 116, 853-857.
    • (1998) Plant Physiol. , vol.116 , pp. 853-857
    • Whitmer, S.1    Canel, C.2    Hallard, D.3    Goncalves, C.4    Verpoorte, R.5
  • 100
    • 14244257703 scopus 로고    scopus 로고
    • Effect of nitric oxide on catharanthine production and growth of Catharanthus roseus suspension cells
    • Xu MJ, Dong JF, Zhu MY (2005). Effect of nitric oxide on catharanthine production and growth of Catharanthus roseus suspension cells. Biotechnol. Bioeng. 89, 367-371.
    • (2005) Biotechnol. Bioeng , vol.89 , pp. 367-371
    • Xu, M.J.1    Dong, J.F.2    Zhu, M.Y.3
  • 101
    • 0033977809 scopus 로고    scopus 로고
    • Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450
    • Yamamoto H, Katano N, Ooi A, Inoue K (2000). Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450. Phytochemistry 53, 7-12.
    • (2000) Phytochemistry , vol.53 , pp. 7-12
    • Yamamoto, H.1    Katano, N.2    Ooi, A.3    Inoue, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.