메뉴 건너뛰기




Volumn 136, Issue , 2013, Pages 65-100

Optimization of insect cell based protein production processes - online monitoring, expression systems, scale up

Author keywords

BEVS; Drosophila S2; FBRM; Gloverin; In situ monitoring; Scale up

Indexed keywords

GLOVERIN; PROTEIN; RECOMBINANT PROTEIN;

EID: 84902674930     PISSN: 07246145     EISSN: None     Source Type: Book Series    
DOI: 10.1007/10_2013_205     Document Type: Chapter
Times cited : (17)

References (129)
  • 2
    • 0000968374 scopus 로고
    • Establishment of four strains of cells from insect tissues grown in vitro
    • Grace TDC (1962) Establishment of four strains of cells from insect tissues grown in vitro. Nature 195(4843): 788-789
    • (1962) Nature , vol.195 , Issue.4843 , pp. 788-789
    • Grace, T.D.C.1
  • 3
    • 67549088805 scopus 로고    scopus 로고
    • Insect cell culture and applications to research and pest management
    • Smagghe G, Goodman C, Stanley D (2009) Insect cell culture and applications to research and pest management. In Vitro Cell Dev Biol Animal 45(3): 93-105. doi: 10.1007/ s11626-009-9181-x
    • (2009) In Vitro Cell Dev Biol Animal , vol.45 , Issue.3 , pp. 93-105
    • Smagghe, G.1    Goodman, C.2    Stanley, D.3
  • 5
    • 0017475358 scopus 로고
    • The establishment of two cell lines from the insect spodoptera frugiperda (lepidoptera; noctuidae)
    • Vaughn J, Goodwin R, Tompkins G, McCawley P (1977) The establishment of two cell lines from the insect spodoptera frugiperda (lepidoptera; noctuidae). In Vitro Cell Dev Biol Plant 13(4): 213-217. doi: 10.1007/bf02615077
    • (1977) In Vitro Cell Dev Biol Plant , vol.13 , Issue.4 , pp. 213-217
    • Vaughn, J.1    Goodwin, R.2    Tompkins, G.3    McCawley, P.4
  • 6
    • 0003022406 scopus 로고
    • Studies on serum-free culture of insect cells for virus propagation and recombinant protein production
    • Wang P, Granados RR, Shuler ML (1992) Studies on serum-free culture of insect cells for virus propagation and recombinant protein production. J Invertebr Pathol 59(1): 46-53. doi: 10.1016/0022-2011(92)90110-p
    • (1992) J Invertebr Pathol , vol.59 , Issue.1 , pp. 46-53
    • Wang, P.1    Granados, R.R.2    Shuler, M.L.3
  • 7
    • 0025920325 scopus 로고
    • Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines
    • Hink WF, Thomsen DR, Davidson DJ, Meyer AL, Castellino FJ (1991) Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines. Biotechnol Prog 7(1): 9-14. doi: 10.1021/bp00007a002
    • (1991) Biotechnol Prog , vol.7 , Issue.1 , pp. 9-14
    • Hink, W.F.1    Thomsen, D.R.2    Davidson, D.J.3    Meyer, A.L.4    Castellino, F.J.5
  • 8
    • 0032848027 scopus 로고    scopus 로고
    • Insect cells as hosts for the expression of recombinant glycoproteins
    • Altmann F, Staudacher E, Wilson IH, März L (1999) Insect cells as hosts for the expression of recombinant glycoproteins. Glycoconj J 16(2): 109-123. doi: 10.1023/a: 1026488408951
    • (1999) Glycoconj J , vol.16 , Issue.2 , pp. 109-123
    • Altmann, F.1    Staudacher, E.2    Wilson, I.H.3    März, L.4
  • 9
    • 0032190659 scopus 로고    scopus 로고
    • Engineering N-glycosylation pathways in the baculovirus-insect cell system
    • Jarvis DL, Kawar ZS, Hollister JR (1998) Engineering N-glycosylation pathways in the baculovirus-insect cell system. Curr Opin Biotechnol 9(5): 528-533. doi: 10.1016/ s0958-1669(98)80041-4
    • (1998) Curr Opin Biotechnol , vol.9 , Issue.5 , pp. 528-533
    • Jarvis, D.L.1    Kawar, Z.S.2    Hollister, J.R.3
  • 10
    • 0015328565 scopus 로고
    • Cell lines derived from late embryonic stages of Drosophila melanogaster
    • Schneider I (1972) Cell lines derived from late embryonic stages of Drosophila melanogaster. J Embryol Exp Morphol 27(2): 353-365
    • (1972) J Embryol Exp Morphol , vol.27 , Issue.2 , pp. 353-365
    • Schneider, I.1
  • 12
    • 65249105786 scopus 로고    scopus 로고
    • A new cell clone derived from trichoplusia ni Tn5B1-4 cells
    • Tian JX, Li CY, Zheng GL, Li GX, Wang P, Granados RR (2004) A new cell clone derived from trichoplusia ni Tn5B1-4 cells. Insect Sci 11(3): 165-171. doi: 10.1111/ j.1744-7917.2004.tb00236.x
    • (2004) Insect Sci , vol.11 , Issue.3 , pp. 165-171
    • Tian, J.X.1    Li, C.Y.2    Zheng, G.L.3    Li, G.X.4    Wang, P.5    Granados, R.R.6
  • 13
    • 0026918457 scopus 로고
    • Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system
    • Wickham TJ, Davis T, Granados RR, Shuler ML, Wood HA (1992) Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnol Prog 8(5): 391-396. doi: 10.1021/bp00017a003
    • (1992) Biotechnol Prog , vol.8 , Issue.5 , pp. 391-396
    • Wickham, T.J.1    Davis, T.2    Granados, R.R.3    Shuler, M.L.4    Wood, H.A.5
  • 14
    • 0023881356 scopus 로고
    • Trends in the development of baculovirus expression vectors
    • Luckow VA, Summers MD (1988) Trends in the development of baculovirus expression vectors. Nat Biotech 6(1): 47-55
    • (1988) Nat Biotech , vol.6 , Issue.1 , pp. 47-55
    • Luckow, V.A.1    Summers, M.D.2
  • 15
    • 0024997847 scopus 로고
    • Expression of cauliflower mosaic virus gene I using a baculovirus vector based upon the p10 gene and a novel selection method
    • Vlak JM, Schouten A, Usmany M, Belsham GJ, Klinge-Roode EC, Maule AJ, Van Lent JWM, Zuidema D (1990) Expression of cauliflower mosaic virus gene I using a baculovirus vector based upon the p10 gene and a novel selection method. Virology 179(1): 312-320. doi: 10.1016/0042-6822(90)90299-7
    • (1990) Virology , vol.179 , Issue.1 , pp. 312-320
    • Vlak, J.M.1    Schouten, A.2    Usmany, M.3    Belsham, G.J.4    Klinge-Roode, E.C.5    Maule, A.J.6    Van Lent, J.W.M.7    Zuidema, D.8
  • 16
    • 0030250433 scopus 로고    scopus 로고
    • Immediate-early baculovirus vectors for foreign gene expression in transformed or infected insect cells
    • Jarvis DL, Weinkauf C, Guarino LA (1996) Immediate-early baculovirus vectors for foreign gene expression in transformed or infected insect cells. Protein Expr Purif 8(2): 191-203. doi: 10.1006/prep.1996.0092
    • (1996) Protein Expr Purif , vol.8 , Issue.2 , pp. 191-203
    • Jarvis, D.L.1    Weinkauf, C.2    Guarino, L.A.3
  • 17
    • 0027209690 scopus 로고
    • Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in E. coli
    • Luckow VA, Lee SC, Barry GF, Olins PO (1993) Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in E. coli. J virol 67(8): 4566-4579
    • (1993) J virol , vol.67 , Issue.8 , pp. 4566-4579
    • Luckow, V.A.1    Lee, S.C.2    Barry, G.F.3    Olins, P.O.4
  • 18
    • 84891775537 scopus 로고    scopus 로고
    • Optimising the drosophila S2 expression system for production of therapeutic vaccines
    • Dyring C (2011) Optimising the drosophila S2 expression system for production of therapeutic vaccines. Bioprocess J 10(2): 28-35
    • (2011) Bioprocess J , vol.10 , Issue.2 , pp. 28-35
    • Dyring, C.1
  • 19
    • 0024284041 scopus 로고
    • Characterization and use of the drosophila metallothionein promoter in cultured drosophila melanogaster cells
    • Bunch TA, Grinblat Y, Goldstein LSB (1988) Characterization and use of the drosophila metallothionein promoter in cultured drosophila melanogaster cells. Nucleic acids res 16(3): 1043-1061. doi: 10.1093/nar/16.3.1043
    • (1988) Nucleic acids res , vol.16 , Issue.3 , pp. 1043-1061
    • Bunch, T.A.1    Grinblat, Y.2    Goldstein, L.S.B.3
  • 20
    • 0025221434 scopus 로고
    • Positive and negative regulatory elements mediating transcription from the drosophila melanogaster actin 5C distal promoter
    • Chung YT, Keller EB (1990) Positive and negative regulatory elements mediating transcription from the drosophila melanogaster actin 5C distal promoter. Mol Cell Bio 10(12): 6172-6180. doi: 10.1128/mcb.10.12.6172
    • (1990) Mol Cell Bio , vol.10 , Issue.12 , pp. 6172-6180
    • Chung, Y.T.1    Keller, E.B.2
  • 21
    • 0030892183 scopus 로고    scopus 로고
    • Baculovirus immediateearly promoter-mediated expression of the Zeocin TM resistance gene for use as a dominant selectable marker in dipteran and lepidopteran insect cell lines
    • Pfeifer TA, Hegedus DD, Grigliatti TA, Theilmann DA (1997) Baculovirus immediateearly promoter-mediated expression of the Zeocin TM resistance gene for use as a dominant selectable marker in dipteran and lepidopteran insect cell lines. Gene 188(2): 183-190. doi: 10.1016/s0378-1119(96)00756-1
    • (1997) Gene , vol.188 , Issue.2 , pp. 183-190
    • Pfeifer, T.A.1    Hegedus, D.D.2    Grigliatti, T.A.3    Theilmann, D.A.4
  • 23
    • 0032122306 scopus 로고    scopus 로고
    • Antibody engineering: Comparison of bacterial, yeast, insect and mammalian expression systems
    • Verma R, Boleti E, George AJT (1998) Antibody engineering: comparison of bacterial, yeast, insect and mammalian expression systems. J Immunol Methods 216(1-2): 165-181. doi: 10.1016/s0022-1759(98)00077-5
    • (1998) J Immunol Methods , vol.216 , Issue.1-2 , pp. 165-181
    • Verma, R.1    Boleti, E.2    George, A.J.T.3
  • 24
    • 58149199027 scopus 로고    scopus 로고
    • Nonviral production of human interleukin-7 in spodoptera frugiperda insect cells as a soluble recombinant protein
    • Mirzaei M, Xu Y, Elias CB, Prakash S (2009) Nonviral production of human interleukin-7 in spodoptera frugiperda insect cells as a soluble recombinant protein. J Biomed Biot 2009: 527. doi: 10.1155/2009/637942
    • (2009) J Biomed Biot , vol.2009 , pp. 527
    • Mirzaei, M.1    Xu, Y.2    Elias, C.B.3    Prakash, S.4
  • 25
    • 79958146342 scopus 로고    scopus 로고
    • ANTI-infective therapeutics from the lepidopteran model host galleria mellonella
    • Vilcinskas A (2011) ANTI-infective therapeutics from the lepidopteran model host galleria mellonella. Curr Phar Des 17(13): 1240-1245. doi: 10.2174/138161211795703799
    • (2011) Curr Phar Des , vol.17 , Issue.13 , pp. 1240-1245
    • Vilcinskas, A.1
  • 26
    • 0030752238 scopus 로고    scopus 로고
    • Gloverin, an antibacterial protein from the immune hemolymph of hyalophora pupae
    • Axen A, Carlsson A, Engstrom A, Bennich H (1997) Gloverin, an antibacterial protein from the immune hemolymph of hyalophora pupae. Eur J Biochem 247(2): 614-619. doi: 10.1111/j.1432-1033.1997.00614.x
    • (1997) Eur J Biochem , vol.247 , Issue.2 , pp. 614-619
    • Axen, A.1    Carlsson, A.2    Engstrom, A.3    Bennich, H.4
  • 27
    • 0036015622 scopus 로고    scopus 로고
    • Trichoplusia ni gloverin, an inducible immune gene encoding an antibacterial insect protein
    • Lundstrom A, Liu G, Kang DW, Berzins K, Steiner H (2002) Trichoplusia ni gloverin, an inducible immune gene encoding an antibacterial insect protein. Insect Biochem Mol Biol 32(7): 795-801. doi: 10.1016/s0965-1748(01)00162-x
    • (2002) Insect Biochem Mol Biol , vol.32 , Issue.7 , pp. 795-801
    • Lundstrom, A.1    Liu, G.2    Kang, D.W.3    Berzins, K.4    Steiner, H.5
  • 28
    • 0031846514 scopus 로고    scopus 로고
    • A gloverin-like antibacterial protein is synthesized in helicoverpa armigera following bacterial challenge
    • Mackintosh JA, Gooley AA, Karuso PH, Beattie AJ, Jardine DR, Veal DA (1998) A gloverin-like antibacterial protein is synthesized in helicoverpa armigera following bacterial challenge. Dev Comp Immunol 22(4): 387-399. doi: 10.1016/s0145-305x(98)00025-1
    • (1998) Dev Comp Immunol , vol.22 , Issue.4 , pp. 387-399
    • Mackintosh, J.A.1    Gooley, A.A.2    Karuso, P.H.3    Beattie, A.J.4    Jardine, D.R.5    Veal, D.A.6
  • 30
    • 80054112855 scopus 로고    scopus 로고
    • RNA interference of an antimicrobial peptide, gloverin, of the beet armyworm, spodoptera exigua, enhances susceptibility to b
    • Hwang J, Kim Y (2011) RNA interference of an antimicrobial peptide, gloverin, of the beet armyworm, spodoptera exigua, enhances susceptibility to b. thuringiensis. J Invertebr Patho 108(3): 194-200. doi: 10.1016/j.jip.2011.09.003
    • (2011) thuringiensis. J Invertebr Patho , vol.108 , Issue.3 , pp. 194-200
    • Hwang, J.1    Kim, Y.2
  • 31
    • 84866183312 scopus 로고    scopus 로고
    • Manduca sexta gloverin binds microbial components and is active against bacteria and fungi
    • Xu X-X, Zhong X, Yi H-Y, Yu X-Q (2012) Manduca sexta gloverin binds microbial components and is active against bacteria and fungi. Dev Comp Immunol 38(2): 275-284. doi: 10.1016/j.dci.2012.06.012
    • (2012) Dev Comp Immunol , vol.38 , Issue.2 , pp. 275-284
    • Xu, X.-X.1    Zhong, X.2    Yi, H.-Y.3    Yu, X.-Q.4
  • 34
    • 33645217831 scopus 로고    scopus 로고
    • Real-time bioprocess monitoring part I: In situ sensors
    • Vojinovic V, Cabral JMS, Fonseca LP (2006) Real-time bioprocess monitoring part I: In situ sensors. Sens Actuators B-Chem 114(2): 1083-1091. doi: 10.1016/j.snb.2005.07.059
    • (2006) Sens Actuators B-Chem , vol.114 , Issue.2 , pp. 1083-1091
    • Vojinovic, V.1    Cabral, J.M.S.2    Fonseca, L.P.3
  • 35
    • 25644438314 scopus 로고    scopus 로고
    • Challenges in biotechnology production—generic processes and process optimization for monoclonal antibodies
    • Sommerfeld S, Strube J (2005) Challenges in biotechnology production—generic processes and process optimization for monoclonal antibodies. Chem Eng Process 44(10): 1123-1137. doi: 10.1016/j.cep.2005.03.006
    • (2005) Chem Eng Process , vol.44 , Issue.10 , pp. 1123-1137
    • Sommerfeld, S.1    Strube, J.2
  • 36
    • 70349949073 scopus 로고    scopus 로고
    • Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative
    • Teixeira AP, Oliveira R, Alves PM, Carrondo MJT (2009) Advances in on-line monitoring and control of mammalian cell cultures: supporting the PAT initiative. Biotechnol Adv 27(6): 726-732. doi: 10.1016/j.biotechadv.2009.05.003
    • (2009) Biotechnol Adv , vol.27 , Issue.6 , pp. 726-732
    • Teixeira, A.P.1    Oliveira, R.2    Alves, P.M.3    Carrondo, M.J.T.4
  • 38
    • 80052610035 scopus 로고    scopus 로고
    • In situ sensor techniques in modern bioprocess monitoring
    • Beutel S, Henkel S (2011) In situ sensor techniques in modern bioprocess monitoring. Appl Microbiol Biotechnol 91(6): 1493-1505. doi: 10.1007/s00253-011-3470-5
    • (2011) Appl Microbiol Biotechnol , vol.91 , Issue.6 , pp. 1493-1505
    • Beutel, S.1    Henkel, S.2
  • 40
    • 0141616435 scopus 로고    scopus 로고
    • Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system
    • Maranga L, Brazao TF, Carrondo MJT (2003) Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system. Biotechnol Bioeng 84(2): 245-253. doi: 10.1002/bit.10773
    • (2003) Biotechnol Bioeng , vol.84 , Issue.2 , pp. 245-253
    • Maranga, L.1    Brazao, T.F.2    Carrondo, M.J.T.3
  • 44
    • 70349087374 scopus 로고    scopus 로고
    • Online-infrarotspektroskopie in der bioprozessanalytik
    • Haake C, Landgrebe D, Scheper T, Rhiel M, Rhiel M (2009) Online-infrarotspektroskopie in der bioprozessanalytik. Chem Ing Tech 81(9): 1385-1396. doi: 10.1002/cite.200900042
    • (2009) Chem Ing Tech , vol.81 , Issue.9 , pp. 1385-1396
    • Haake, C.1    Landgrebe, D.2    Scheper, T.3    Rhiel, M.4    Rhiel, M.5
  • 45
    • 34047124391 scopus 로고    scopus 로고
    • Multiplexing fibre optic near infrared (NIR) spectroscopy as an emerging technology to monitor industrial bioprocesses
    • Roychoudhury P, O'Kennedy R, McNeil B, Harvey LM (2007) Multiplexing fibre optic near infrared (NIR) spectroscopy as an emerging technology to monitor industrial bioprocesses. Anal Chim Acta 590(1): 110-117. doi: 10.1016/j.aca.2007.03.011
    • (2007) Anal Chim Acta , vol.590 , Issue.1 , pp. 110-117
    • Roychoudhury, P.1    O'Kennedy, R.2    McNeil, B.3    Harvey, L.M.4
  • 46
    • 0043195339 scopus 로고    scopus 로고
    • In-situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation
    • Arnold SA, Crowley J, Woods N, Harvey LM, McNeill B (2003) In-situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation. Biotechnol Bioeng 84(1): 13-19. doi: 10.1002/bit.10738
    • (2003) Biotechnol Bioeng , vol.84 , Issue.1 , pp. 13-19
    • Arnold, S.A.1    Crowley, J.2    Woods, N.3    Harvey, L.M.4    McNeill, B.5
  • 47
    • 0037137921 scopus 로고    scopus 로고
    • Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements
    • Rhiel M, Ducommun P, Bolzonella I, Marison I, von Stockar U (2002) Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements. Biotechnol Bioeng 77(2): 174-185. doi: 10.1002/bit.10134
    • (2002) Biotechnol Bioeng , vol.77 , Issue.2 , pp. 174-185
    • Rhiel, M.1    Ducommun, P.2    Bolzonella, I.3    Marison, I.4    von Stockar, U.5
  • 48
    • 77955547388 scopus 로고    scopus 로고
    • Monitoring mammalian cell cultivations for monoclonal antibody production using near-infrared spectroscopy
    • Henriques JG, Buziol S, Stocker E, Voogd A, Menezes JC (2009) Monitoring mammalian cell cultivations for monoclonal antibody production using near-infrared spectroscopy. Optical Sens Syst Biotechnol 116: 73-97. doi: 10.1007/10_2009_11
    • (2009) Optical Sens Syst Biotechnol , vol.116 , pp. 73-97
    • Henriques, J.G.1    Buziol, S.2    Stocker, E.3    Voogd, A.4    Menezes, J.C.5
  • 49
    • 77953598931 scopus 로고    scopus 로고
    • Rapid monitoring of recombinant antibody production by mammalian cell cultures using Fourier transform infrared spectroscopy and chemometrics
    • Sellick CA, Hansen R, Jarvis RM, Maqsood AR, Stephens GM, Dickson AJ, Goodacre R (2010) Rapid monitoring of recombinant antibody production by mammalian cell cultures using Fourier transform infrared spectroscopy and chemometrics. Biotechnol Bioeng 106(3): 432-442. doi: 10.1002/bit.22707
    • (2010) Biotechnol Bioeng , vol.106 , Issue.3 , pp. 432-442
    • Sellick, C.A.1    Hansen, R.2    Jarvis, R.M.3    Maqsood, A.R.4    Stephens, G.M.5    Dickson, A.J.6    Goodacre, R.7
  • 50
    • 77957305369 scopus 로고    scopus 로고
    • In situ quantification of microcarrier animal cell cultures using near-infrared spectroscopy
    • Petiot E, Bernard-Moulin P, Magadoux T, Geny C, Pinton H, Marc A (2010) In situ quantification of microcarrier animal cell cultures using near-infrared spectroscopy. Process Biochem 45(11): 1832-1836. doi: 10.1016/j.procbio.2010.08.010
    • (2010) Process Biochem , vol.45 , Issue.11 , pp. 1832-1836
    • Petiot, E.1    Bernard-Moulin, P.2    Magadoux, T.3    Geny, C.4    Pinton, H.5    Marc, A.6
  • 51
    • 0031554631 scopus 로고    scopus 로고
    • Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy
    • Riley MR, Rhiel M, Zhou XJ, Arnold MA, Murhammer DW (1997) Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy. Biotechnol Bioeng 55(1): 11-15. doi: 10.1002/(sici)1097-0290 (19970705)55: 1(11: aid-bit2)3.0.co; 2-#
    • (1997) Biotechnol Bioeng , vol.55 , Issue.1 , pp. 11-15
    • Riley, M.R.1    Rhiel, M.2    Zhou, X.J.3    Arnold, M.A.4    Murhammer, D.W.5
  • 52
    • 0017805603 scopus 로고
    • Estimation of fermentation biomass concentration by measuring culture fluorescence
    • Zabriskie DW, Humphrey AE (1978) Estimation of fermentation biomass concentration by measuring culture fluorescence. Appl Environ Microbiol 35(2): 337-343
    • (1978) Appl Environ Microbiol , vol.35 , Issue.2 , pp. 337-343
    • Zabriskie, D.W.1    Humphrey, A.E.2
  • 53
    • 0026153234 scopus 로고
    • Use of fluorometry for monitoring and control of a bioreactor
    • Li JK, Humphrey AE (1991) Use of fluorometry for monitoring and control of a bioreactor. Biotechnol Bioeng 37(11): 1043-1049. doi: 10.1002/bit.260371109
    • (1991) Biotechnol Bioeng , vol.37 , Issue.11 , pp. 1043-1049
    • Li, J.K.1    Humphrey, A.E.2
  • 54
    • 0027703777 scopus 로고
    • Real-time compensation of the inner filter effect in high-density bioluminescent cultures
    • Konstantinov KB, Dhurjati P, Van Dyk T, Majarian W, Larossa R (1993) Real-time compensation of the inner filter effect in high-density bioluminescent cultures. Biotechnol Bioeng 42(10): 1190-1198. doi: 10.1002/bit.260421009
    • (1993) Biotechnol Bioeng , vol.42 , Issue.10 , pp. 1190-1198
    • Konstantinov, K.B.1    Dhurjati, P.2    Van Dyk, T.3    Majarian, W.4    Larossa, R.5
  • 55
    • 0023438099 scopus 로고
    • Inner filter effects and their interferences in the interpretation of culture fluorescence
    • Srinivas SP, Mutharasan R (1987) Inner filter effects and their interferences in the interpretation of culture fluorescence. Biotechnol Bioeng 30(6): 769-774. doi: 10.1002/ bit.260300609
    • (1987) Biotechnol Bioeng , vol.30 , Issue.6 , pp. 769-774
    • Srinivas, S.P.1    Mutharasan, R.2
  • 57
    • 0035028745 scopus 로고    scopus 로고
    • Mechanisms of tryptophan fluorescence shifts in proteins
    • Vivian JT, Callis PR (2001) Mechanisms of tryptophan fluorescence shifts in proteins. Biophys J 80(5): 2093-2109
    • (2001) Biophys J , vol.80 , Issue.5 , pp. 2093-2109
    • Vivian, J.T.1    Callis, P.R.2
  • 58
    • 84984348431 scopus 로고
    • Messung der Kulturfluoreszenz zur Überwachung und Charakterisierung von Insektenzellkultivierungen in Bioreaktoren
    • Anders K-D, Akhnoukh R, Scheper T, Kretzmer G (1992) Messung der Kulturfluoreszenz zur Überwachung und Charakterisierung von Insektenzellkultivierungen in Bioreaktoren. Chem Ing Tech 64(6): 572-573. doi: 10.1002/cite.330640625
    • (1992) Chem Ing Tech , vol.64 , Issue.6 , pp. 572-573
    • Anders, K.-D.1    Akhnoukh, R.2    Scheper, T.3    Kretzmer, G.4
  • 59
    • 19744366576 scopus 로고    scopus 로고
    • A multiwavelength fluorescence probe: Is one probe capable for on-line monitoring of recombinant protein production and biomass activity?
    • Hisiger S, Jolicoeur M (2005) A multiwavelength fluorescence probe: Is one probe capable for on-line monitoring of recombinant protein production and biomass activity? J Biotechnol 117(4): 325-336. doi: 10.1016/j.jbiotec.2005.03.004
    • (2005) J Biotechnol , vol.117 , Issue.4 , pp. 325-336
    • Hisiger, S.1    Jolicoeur, M.2
  • 60
    • 79959238152 scopus 로고    scopus 로고
    • Synchronous fluorescence spectroscopy as a novel tool to enable pat applications in bioprocesses
    • Teixeira AP, Duarte TM, Carrondo MJT, Alves PM (2011) Synchronous fluorescence spectroscopy as a novel tool to enable pat applications in bioprocesses. Biotechnol Bioeng 108(8): 1852-1861. doi: 10.1002/bit.23131
    • (2011) Biotechnol Bioeng , vol.108 , Issue.8 , pp. 1852-1861
    • Teixeira, A.P.1    Duarte, T.M.2    Carrondo, M.J.T.3    Alves, P.M.4
  • 62
    • 79953152705 scopus 로고    scopus 로고
    • Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe
    • Abu-Absi NR, Kenty BM, Cuellar ME, Borys MC, Sakhamuri S, Strachan DJ, Hausladen MC, Li ZJ (2011) Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe. Biotechnol Bioeng 108(5): 1215-1221. doi: 10.1002/bit.23023
    • (2011) Biotechnol Bioeng , vol.108 , Issue.5 , pp. 1215-1221
    • Abu-Absi, N.R.1    Kenty, B.M.2    Cuellar, M.E.3    Borys, M.C.4    Sakhamuri, S.5    Strachan, D.J.6    Hausladen, M.C.7    Li, Z.J.8
  • 63
    • 0042922828 scopus 로고    scopus 로고
    • Optical sensor systems for bioprocess monitoring
    • Ulber R, Frerichs JG, Beutel S (2003) Optical sensor systems for bioprocess monitoring. Anal Bioanal Chem 376(3): 342-348. doi: 10.1007/s00216-003-1930-1
    • (2003) Anal Bioanal Chem , vol.376 , Issue.3 , pp. 342-348
    • Ulber, R.1    Frerichs, J.G.2    Beutel, S.3
  • 64
    • 85056049630 scopus 로고    scopus 로고
    • Cultivation and differentiation of encapsulated hMSC-TERT in a disposable small-scale syringe-like fixed bed reactor
    • Weber C, Pohl S, Portner R, Wallrapp C, Kassem M, Geigle P, Czermak P (2007) Cultivation and differentiation of encapsulated hMSC-TERT in a disposable small-scale syringe-like fixed bed reactor. Open Biomed Eng J 1: 64-70. doi: 10.2174/ 187412070701016407
    • (2007) Open Biomed Eng J , vol.1 , pp. 64-70
    • Weber, C.1    Pohl, S.2    Portner, R.3    Wallrapp, C.4    Kassem, M.5    Geigle, P.6    Czermak, P.7
  • 65
    • 77955408026 scopus 로고    scopus 로고
    • Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier-part A: Inoculation, cultivation, and cell harvest procedures
    • Weber C, Freimark D, Portner R, Pino-Grace P, Pohl S, Wallrapp C, Geigle P, Czermak P (2010) Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier-part A: inoculation, cultivation, and cell harvest procedures. Int J Artif Organs 33(8): 512-525
    • (2010) Int J Artif Organs , vol.33 , Issue.8 , pp. 512-525
    • Weber, C.1    Freimark, D.2    Portner, R.3    Pino-Grace, P.4    Pohl, S.5    Wallrapp, C.6    Geigle, P.7    Czermak, P.8
  • 66
    • 78650801253 scopus 로고    scopus 로고
    • Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier—Part B: Modeling and scale up of the system
    • Weber C, Freimark D, Portner R, Pino-Grace P, Pohl S, Wallrapp C, Geigle P, Czermak P (2010) Expansion of human mesenchymal stem cells in a fixed-bed bioreactor system based on non-porous glass carrier—Part B: modeling and scale up of the system. Int J Artif Organs 33(11): 782-795
    • (2010) Int J Artif Organs , vol.33 , Issue.11 , pp. 782-795
    • Weber, C.1    Freimark, D.2    Portner, R.3    Pino-Grace, P.4    Pohl, S.5    Wallrapp, C.6    Geigle, P.7    Czermak, P.8
  • 68
    • 78650803399 scopus 로고    scopus 로고
    • Production process for stem cell based therapeutic implants: Expansion of the production cell line and cultivation of encapsulated cells
    • Weber C, Pohl S, Poertner R, Pino-Grace P, Freimark D, Wallrapp C, Geigle P, Czermak P (2010) Production process for stem cell based therapeutic implants: expansion of the production cell line and cultivation of encapsulated cells. Adv Biochem Eng Biotechnol 123: 143-162. doi: 10.1007/10_2009_25
    • (2010) Adv Biochem Eng Biotechnol , vol.123 , pp. 143-162
    • Weber, C.1    Pohl, S.2    Poertner, R.3    Pino-Grace, P.4    Freimark, D.5    Wallrapp, C.6    Geigle, P.7    Czermak, P.8
  • 70
    • 0542371854 scopus 로고    scopus 로고
    • Faseroptische Sauerstoffsensoren für Biotechnologie Umwelt- und Lebensmitteltechnik
    • Köneke R, Comte A, Jurgens H, Kohls O, Lam H, Scheper T (1998) Faseroptische Sauerstoffsensoren für Biotechnologie Umwelt- und Lebensmitteltechnik. Chem Ing Tech 70(12): 1611-1617. doi: 10.1002/cite.330701224
    • (1998) Chem Ing Tech , vol.70 , Issue.12 , pp. 1611-1617
    • Köneke, R.1    Comte, A.2    Jurgens, H.3    Kohls, O.4    Lam, H.5    Scheper, T.6
  • 71
    • 0034320861 scopus 로고    scopus 로고
    • Setup of a fiber optical oxygen multisensor-system and its applications in biotechnology
    • Kohls O, Scheper T (2000) Setup of a fiber optical oxygen multisensor-system and its applications in biotechnology. Sens Actuators B 70(1-3): 121-130. doi: 10.1016/ s0925-4005(00)00581-5
    • (2000) Sens Actuators B , vol.70 , Issue.1-3 , pp. 121-130
    • Kohls, O.1    Scheper, T.2
  • 72
    • 0001532670 scopus 로고
    • Electrodes for blood pO2 and pCO2 determination
    • Severinghaus JW, Bradley AF (1958) Electrodes for blood pO2 and pCO2 determination. J Appl Physiol 13(3): 515-520
    • (1958) J Appl Physiol , vol.13 , Issue.3 , pp. 515-520
    • Severinghaus, J.W.1    Bradley, A.F.2
  • 73
    • 33746190879 scopus 로고    scopus 로고
    • Luminescence lifetime-based carbon dioxide optical sensor for clinical applications
    • Cajlakovic M, Bizzarri A, Ribitsch V (2006) Luminescence lifetime-based carbon dioxide optical sensor for clinical applications. Anal Chim Acta 573: 57-64. doi: 10.1016/ j.aca.2006.05.085
    • (2006) Anal Chim Acta , vol.573 , pp. 57-64
    • Cajlakovic, M.1    Bizzarri, A.2    Ribitsch, V.3
  • 74
    • 0029350635 scopus 로고
    • Sensitivity studies on optical carbon dioxide sensors based on ion pairing
    • Weigl BH, Wolfbeis OS (1995) Sensitivity studies on optical carbon dioxide sensors based on ion pairing. Sens Actuators, B 28(2): 151-156. doi: 10.1016/0925-4005(95)80041-7
    • (1995) Sens Actuators, B , vol.28 , Issue.2 , pp. 151-156
    • Weigl, B.H.1    Wolfbeis, O.S.2
  • 75
    • 0001426915 scopus 로고
    • Determination of pH with acid-base indicators: Implications for optical fibre probes
    • Edmonds TE, Flatters NJ, Jones CF, Miller JN (1988) Determination of pH with acid-base indicators: implications for optical fibre probes. Talanta 35(2): 103-107. doi: 10.1016/ 0039-9140(88)80046-8
    • (1988) Talanta , vol.35 , Issue.2 , pp. 103-107
    • Edmonds, T.E.1    Flatters, N.J.2    Jones, C.F.3    Miller, J.N.4
  • 76
    • 33644633833 scopus 로고    scopus 로고
    • A wide pH range optical sensing system based on a sol-gel encapsulated amino-functionalised corrole
    • Li CY, Zhang XB, Han ZX, Akermark B, Sun LC, Shen GL, Yu RQ (2006) A wide pH range optical sensing system based on a sol-gel encapsulated amino-functionalised corrole. Analyst 131(3): 388-393. doi: 10.1039/b514510d
    • (2006) Analyst , vol.131 , Issue.3 , pp. 388-393
    • Li, C.Y.1    Zhang, X.B.2    Han, Z.X.3    Akermark, B.4    Sun, L.C.5    Shen, G.L.6    Yu, R.Q.7
  • 77
    • 0026873901 scopus 로고
    • Optische Sensoren für die Bioprozeß-Kontrolle
    • Dremel BAA, Schmid RD (1992) Optische Sensoren für die Bioprozeß-Kontrolle. Chem Ing Tech 64(6): 510-517. doi: 10.1002/cite.330640607
    • (1992) Chem Ing Tech , vol.64 , Issue.6 , pp. 510-517
    • Dremel, B.A.A.1    Schmid, R.D.2
  • 78
    • 0001006613 scopus 로고
    • Development of submicron chemical fiber optic sensors
    • Tan W, Shi Z-R, Kopelman R (1992) Development of submicron chemical fiber optic sensors. Anal Chem 64: 2985-2990
    • (1992) Anal Chem , vol.64 , pp. 2985-2990
    • Tan, W.1    Shi, Z.-R.2    Kopelman, R.3
  • 79
    • 0141650712 scopus 로고    scopus 로고
    • Rapid method for the preparation of a robust optical pH sensor
    • Kermis HR, Kostov Y, Rao G (2003) Rapid method for the preparation of a robust optical pH sensor. Analyst 128(9): 1181-1186. doi: 10.1039/b304902g
    • (2003) Analyst , vol.128 , Issue.9 , pp. 1181-1186
    • Kermis, H.R.1    Kostov, Y.2    Rao, G.3
  • 81
    • 77649234358 scopus 로고    scopus 로고
    • A review of non-invasive optical-based image analysis systems for continuous bioprocess monitoring
    • Hoepfner T, Bluma A, Rudolph G, Lindner P, Scheper T (2010) A review of non-invasive optical-based image analysis systems for continuous bioprocess monitoring. Bioprocess Biosyst Eng 33(2): 247-256. doi: 10.1007/s00449-009-0319-8
    • (2010) Bioprocess Biosyst Eng , vol.33 , Issue.2 , pp. 247-256
    • Hoepfner, T.1    Bluma, A.2    Rudolph, G.3    Lindner, P.4    Scheper, T.5
  • 83
    • 33847038002 scopus 로고    scopus 로고
    • Use of an in situ microscope for on-line observation of animal cell cultures
    • Frerichs JG, Joeris K, Konstantinov K, Scheper T (2002) Use of an in situ microscope for on-line observation of animal cell cultures. Chem Ing Tech 74(11): 1629-1633. doi: 10.1002/1522-2640(20021115)74: 11\1629: aid-cite1629[3.0.co; 2-7
    • (2002) Chem Ing Tech , vol.74 , Issue.11 , pp. 1629-1633
    • Frerichs, J.G.1    Joeris, K.2    Konstantinov, K.3    Scheper, T.4
  • 84
    • 0036425993 scopus 로고    scopus 로고
    • In-situ microscopy: Online process monitoring of mammalian cell cultures
    • Joeris K, Frerichs JG, Konstantinov K, Scheper T (2002) In-situ microscopy: Online process monitoring of mammalian cell cultures. Cytotechnology 38(1-2): 129-134. doi: 10.1023/ a: 1021170502775
    • (2002) Cytotechnology , vol.38 , Issue.1-2 , pp. 129-134
    • Joeris, K.1    Frerichs, J.G.2    Konstantinov, K.3    Scheper, T.4
  • 85
    • 33847159854 scopus 로고    scopus 로고
    • Preliminary study towards the use of in situ microscopy for the online analysis of microcarrier cultivations
    • Anton F, Burzlaff A, Kasper C, Brueckerhoff T, Scheper T (2007) Preliminary study towards the use of in situ microscopy for the online analysis of microcarrier cultivations. Eng Life Sci 7(1): 91-96. doi: 10.1002/elsc.200620172
    • (2007) Eng Life Sci , vol.7 , Issue.1 , pp. 91-96
    • Anton, F.1    Burzlaff, A.2    Kasper, C.3    Brueckerhoff, T.4    Scheper, T.5
  • 86
    • 37549064018 scopus 로고    scopus 로고
    • Online monitoring of microcarrier based fibroblast cultivations with in situ microscopy
    • Rudolph G, Lindner P, Gierse A, Bluma A, Martinez G, Hitzmann B, Scheper T (2008) Online monitoring of microcarrier based fibroblast cultivations with in situ microscopy. Biotechnol Bioeng 99(1): 136-145. doi: 10.1002/bit.21523
    • (2008) Biotechnol Bioeng , vol.99 , Issue.1 , pp. 136-145
    • Rudolph, G.1    Lindner, P.2    Gierse, A.3    Bluma, A.4    Martinez, G.5    Hitzmann, B.6    Scheper, T.7
  • 87
    • 3042837382 scopus 로고    scopus 로고
    • Real time in situ microscopy for animal cell-concentration monitoring during high density culture in bioreactor
    • Guez JS, Cassar JP, Wartelle F, Dhulster P, Suhr H (2004) Real time in situ microscopy for animal cell-concentration monitoring during high density culture in bioreactor. J Biotechnol 111(3): 335-343. doi: 10.1016/j.jbiotec.2004.04.028
    • (2004) J Biotechnol , vol.111 , Issue.3 , pp. 335-343
    • Guez, J.S.1    Cassar, J.P.2    Wartelle, F.3    Dhulster, P.4    Suhr, H.5
  • 88
    • 0029636675 scopus 로고
    • In situ Microscopy for online characterisation of cell-populations in bioreactors, including cell-concentration measurements by depth from focus
    • Suhr H, Wehnert G, Schneider K, Bittner C, Scholz T, Geissler P, Jahne B, Scheper T (1995) In situ Microscopy for online characterisation of cell-populations in bioreactors, including cell-concentration measurements by depth from focus. Biotechnol Bioeng 47(1): 106-116. doi: 10.1002/bit.260470113
    • (1995) Biotechnol Bioeng , vol.47 , Issue.1 , pp. 106-116
    • Suhr, H.1    Wehnert, G.2    Schneider, K.3    Bittner, C.4    Scholz, T.5    Geissler, P.6    Jahne, B.7    Scheper, T.8
  • 89
    • 34547646206 scopus 로고    scopus 로고
    • An in situ probe for on-line monitoring of cell density and viability on the basis of dark field microscopy in conjunction with image processing and supervised machine learning
    • Wei N, You J, Friehs K, Flaschel E, Nattkemper TW (2007) An in situ probe for on-line monitoring of cell density and viability on the basis of dark field microscopy in conjunction with image processing and supervised machine learning. Biotechnol Bioeng 97(6): 1489-1500. doi: 10.1002/bit.21368
    • (2007) Biotechnol Bioeng , vol.97 , Issue.6 , pp. 1489-1500
    • Wei, N.1    You, J.2    Friehs, K.3    Flaschel, E.4    Nattkemper, T.W.5
  • 90
    • 33847280608 scopus 로고    scopus 로고
    • In situ dark field microscopy for on-line monitoring of yeast cultures
    • Wei N, You J, Friehs K, Flaschel E, Nattkemper TW (2007) In situ dark field microscopy for on-line monitoring of yeast cultures. Biotechnol Lett 29(3): 373-378. doi: 10.1007/ s10529-006-9245-x
    • (2007) Biotechnol Lett , vol.29 , Issue.3 , pp. 373-378
    • Wei, N.1    You, J.2    Friehs, K.3    Flaschel, E.4    Nattkemper, T.W.5
  • 91
    • 0027698083 scopus 로고
    • The use of laser backscatter instumentation for the online measurement of the particle-size distribution of emulsions
    • Sparks RG, Dobbs CL (1993) The use of laser backscatter instumentation for the online measurement of the particle-size distribution of emulsions. Part Part Syst Charact 10: 279-289
    • (1993) Part Part Syst Charact , vol.10 , pp. 279-289
    • Sparks, R.G.1    Dobbs, C.L.2
  • 92
    • 0033207774 scopus 로고    scopus 로고
    • In-line FBRM monitoring of particle size in dilute agitated suspensions
    • Barrett P, Glennon B (1999) In-line FBRM monitoring of particle size in dilute agitated suspensions. Part Part Syst Charact 16(5): 207-211. doi: 10.1002/(sici)1521-4117(199910)1 6: 5\207: aid-ppsc207[3.0.co; 2-u
    • (1999) Part Part Syst Charact , vol.16 , Issue.5 , pp. 207-211
    • Barrett, P.1    Glennon, B.2
  • 93
    • 0032094046 scopus 로고    scopus 로고
    • Determination of particle size distribution by par-tec (R) 100: Modeling and experimental results
    • Tadayyon A, Rohani S (1998) Determination of particle size distribution by par-tec (R) 100: modeling and experimental results. Part Part Syst Charact 15(3): 127-135. doi: 10.1002/(sici)1521-4117(199817)15: 3\127: aid-ppsc127[3.0.co; 2-b
    • (1998) Part Part Syst Charact , vol.15 , Issue.3 , pp. 127-135
    • Tadayyon, A.1    Rohani, S.2
  • 94
    • 0036576017 scopus 로고    scopus 로고
    • Estimating average particle size by focused beam reflectance measurement (FBRM)
    • Heath AR, Fawell PD, Bahri PA, Swift JD (2002) Estimating average particle size by focused beam reflectance measurement (FBRM). Part Part Syst Charact 19(2): 84-95. doi: 10.1002/1521-4117(200205)19: 2\84: aid-ppsc84[3.0.co; 2-1
    • (2002) Part Part Syst Charact , vol.19 , Issue.2 , pp. 84-95
    • Heath, A.R.1    Fawell, P.D.2    Bahri, P.A.3    Swift, J.D.4
  • 95
    • 0042009574 scopus 로고    scopus 로고
    • Comparison of morphological characteristics of Streptomyces natalensis by image analysis and focused beam reflectance measurement
    • Pearson AP, Glennon B, Kieran PM (2003) Comparison of morphological characteristics of Streptomyces natalensis by image analysis and focused beam reflectance measurement. Biotechnol Prog 19(4): 1342-1347. doi: 10.1021/bp025734p
    • (2003) Biotechnol Prog , vol.19 , Issue.4 , pp. 1342-1347
    • Pearson, A.P.1    Glennon, B.2    Kieran, P.M.3
  • 96
    • 5044226511 scopus 로고    scopus 로고
    • Monitoring of cell growth using the focused beam reflectance method
    • Pearson AP, Glennon B, Kieran PM (2004) Monitoring of cell growth using the focused beam reflectance method. J Chem Technol Biotechnol 79(10): 1142-1147. doi: 10.1002/jctb.1105
    • (2004) J Chem Technol Biotechnol , vol.79 , Issue.10 , pp. 1142-1147
    • Pearson, A.P.1    Glennon, B.2    Kieran, P.M.3
  • 97
    • 19544376842 scopus 로고    scopus 로고
    • Online monitoring and characterization of flocculating yeast cell flocs during continuous ethanol fermentation
    • Ge XM, Zhao XQ, Bai FW (2005) Online monitoring and characterization of flocculating yeast cell flocs during continuous ethanol fermentation. Biotechnol Bioeng 90(5): 523-531. doi: 10.1002/bit.20391
    • (2005) Biotechnol Bioeng , vol.90 , Issue.5 , pp. 523-531
    • Ge, X.M.1    Zhao, X.Q.2    Bai, F.W.3
  • 99
    • 0035108280 scopus 로고    scopus 로고
    • Characterization of plant suspension cultures using the focused beam reflectance technique
    • McDonald KA, Jackman AP, Hurst S (2001) Characterization of plant suspension cultures using the focused beam reflectance technique. Biotechnol Lett 23(4): 317-324. doi: 10.1023/a: 1005646826204
    • (2001) Biotechnol Lett , vol.23 , Issue.4 , pp. 317-324
    • McDonald, K.A.1    Jackman, A.P.2    Hurst, S.3
  • 100
    • 0344232763 scopus 로고    scopus 로고
    • Focussed beam reflectance measurement (FBRM) monitoring of particle size and morphology in suspension cultures of morinda citrifolia and centaurea calcitrapa
    • Jeffers P, Raposo S, Lima-Costa ME, Connolly P, Glennon B, Kieran PM (2003) Focussed beam reflectance measurement (FBRM) monitoring of particle size and morphology in suspension cultures of morinda citrifolia and centaurea calcitrapa. Biotechnol Lett 25(23): 2023-2028. doi: 10.1023/B: BILE.0000004396.97796.0c
    • (2003) Biotechnol Lett , vol.25 , Issue.23 , pp. 2023-2028
    • Jeffers, P.1    Raposo, S.2    Lima-Costa, M.E.3    Connolly, P.4    Glennon, B.5    Kieran, P.M.6
  • 101
    • 77955927554 scopus 로고    scopus 로고
    • Marine microalgae flocculation and focused beam reflectance measurement
    • Uduman N, Qi Y, Danquah MK, Hoadley AFA (2010) Marine microalgae flocculation and focused beam reflectance measurement. Chem Eng J 162(3): 935-940. doi: 10.1016/ j.cej.2010.06.046
    • (2010) Chem Eng J , vol.162 , Issue.3 , pp. 935-940
    • Uduman, N.1    Qi, Y.2    Danquah, M.K.3    Hoadley, A.F.A.4
  • 102
    • 0027281110 scopus 로고
    • Introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions
    • Davey CL, Davey HM, Kell DB, Todd RW (1993) Introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions. Anal Chim Acta 279(1): 155-161. doi: 10.1016/0003-2670(93)85078-X
    • (1993) Anal Chim Acta , vol.279 , Issue.1 , pp. 155-161
    • Davey, C.L.1    Davey, H.M.2    Kell, D.B.3    Todd, R.W.4
  • 103
    • 33747362088 scopus 로고
    • Dielectric spectroscopy: A rapid method for the determination of solvent biocompatibility during biotransformations
    • Stoicheva NG, Davey CL, Markx GH, Kell DB (1989) Dielectric spectroscopy: a rapid method for the determination of solvent biocompatibility during biotransformations. Biocatal Biotransform 2(4): 245-255. doi: 8992034
    • (1989) Biocatal Biotransform , vol.2 , Issue.4 , pp. 245-255
    • Stoicheva, N.G.1    Davey, C.L.2    Markx, G.H.3    Kell, D.B.4
  • 105
    • 80052442508 scopus 로고    scopus 로고
    • Online- and offline- monitoring of stem cell expansion on microcarrier
    • Justice C, Leber J, Freimark D, Pino Grace P, Kraume M, Czermak P (2011) Online- and offline- monitoring of stem cell expansion on microcarrier. Cytotechnology 63 (4): 325-335. doi: 10.1007/s10616-011-9359-4
    • (2011) Cytotechnology , vol.63 , Issue.4 , pp. 325-335
    • Justice, C.1    Leber, J.2    Freimark, D.3    Pino Grace, P.4    Kraume, M.5    Czermak, P.6
  • 106
    • 0038731394 scopus 로고    scopus 로고
    • On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy
    • Cannizzaro C, Gugerli R, Marison I, von Stockar U (2003) On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy. Biotechnol Bioeng 84(5): 597-610. doi: 10.1002/bit.10809
    • (2003) Biotechnol Bioeng , vol.84 , Issue.5 , pp. 597-610
    • Cannizzaro, C.1    Gugerli, R.2    Marison, I.3    von Stockar, U.4
  • 108
    • 0039136064 scopus 로고    scopus 로고
    • On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements
    • Zeiser A, Bedard C, Voyer R, Jardin B, Tom R, Kamen AA (1999) On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements. Biotechnol Bioeng 63(1): 122-126. doi: 10.1002/(sici)1097-0290(19990405) 63: 1\122: aid-bit13[3.0.co; 2-i
    • (1999) Biotechnol Bioeng , vol.63 , Issue.1 , pp. 122-126
    • Zeiser, A.1    Bedard, C.2    Voyer, R.3    Jardin, B.4    Tom, R.5    Kamen, A.A.6
  • 109
    • 0034281764 scopus 로고    scopus 로고
    • On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process
    • Zeiser A, Elias CB, Voyer R, Jardin B, Kamen AA (2000) On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process. Biotechnol Prog 16(5): 803-808. doi: 10.1021/bp000092w
    • (2000) Biotechnol Prog , vol.16 , Issue.5 , pp. 803-808
    • Zeiser, A.1    Elias, C.B.2    Voyer, R.3    Jardin, B.4    Kamen, A.A.5
  • 110
    • 0034690746 scopus 로고    scopus 로고
    • Enhanced growth of Sf-9 cells to a maximum density of 5.2 9 10(7) cells per mL and production of beta-galactosidase at high cell density by fed batch culture
    • Elias CB, Zeiser A, Bedard C, Kamen AA (2000) Enhanced growth of Sf-9 cells to a maximum density of 5.2 9 10(7) cells per mL and production of beta-galactosidase at high cell density by fed batch culture. Biotechnol Bioeng 68(4): 381-388. doi: 10.1002/(sici) 1097-0290(20000520)68: 4\381:: aid-bit3[3.0.co; 2-d
    • (2000) Biotechnol Bioeng , vol.68 , Issue.4 , pp. 381-388
    • Elias, C.B.1    Zeiser, A.2    Bedard, C.3    Kamen, A.A.4
  • 111
    • 34548314442 scopus 로고    scopus 로고
    • Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy
    • Negrete A, Esteban G, Kotin RM (2007) Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Appl Microbiol Biotechnol 76(4): 761-772. doi: 10.1007/s00253-007-1030-9
    • (2007) Appl Microbiol Biotechnol , vol.76 , Issue.4 , pp. 761-772
    • Negrete, A.1    Esteban, G.2    Kotin, R.M.3
  • 112
    • 36749020097 scopus 로고    scopus 로고
    • On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements
    • Ansorge S, Esteban G, Schmid G (2007) On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements. Cytotechnology 55(2-3): 115-124. doi: 10.1007/s10616-007-9093-0
    • (2007) Cytotechnology , vol.55 , Issue.2-3 , pp. 115-124
    • Ansorge, S.1    Esteban, G.2    Schmid, G.3
  • 113
    • 33747337529 scopus 로고    scopus 로고
    • On-line measurements and control of viable cell density in cell culture manufacturing processes using radio-frequency impedance
    • Carvell JP, Dowd JE (2006) On-line measurements and control of viable cell density in cell culture manufacturing processes using radio-frequency impedance. Cytotechnology 50(1-3): 35-48. doi: 10.1007/s10616-005-3974-x
    • (2006) Cytotechnology , vol.50 , Issue.1-3 , pp. 35-48
    • Carvell, J.P.1    Dowd, J.E.2
  • 114
    • 84857455818 scopus 로고    scopus 로고
    • Recombinant protein vaccines produced in insect cells
    • Cox MMJ (2012) Recombinant protein vaccines produced in insect cells. Vaccine 30(10): 1759. doi: 10.1016/j.vaccine.2012.01.016
    • (2012) Vaccine , vol.30 , Issue.10 , pp. 1759
    • Cox, M.M.J.1
  • 116
    • 27644509570 scopus 로고    scopus 로고
    • Optimization and scale up of industrial fermentation processes
    • Schmidt FR (2005) Optimization and scale up of industrial fermentation processes. Appl Microbiol Biotechnol 68(4): 425. doi: 10.1007/s00253-005-0003-0
    • (2005) Appl Microbiol Biotechnol , vol.68 , Issue.4 , pp. 425
    • Schmidt, F.R.1
  • 117
    • 84355161981 scopus 로고    scopus 로고
    • Process optimization and scale up for production of rabies vaccine live adenovirus vector (AdRG1.3)
    • Shen CF, Lanthier S, Jacob D, Montes J, Beath A, Beresford A, Kamen A (2012) Process optimization and scale up for production of rabies vaccine live adenovirus vector (AdRG1.3). Vaccine 30(2), doi: 10.1016/j.vaccine.2011.10.095
    • (2012) Vaccine , vol.30 , Issue.2
    • Shen, C.F.1    Lanthier, S.2    Jacob, D.3    Montes, J.4    Beath, A.5    Beresford, A.6    Kamen, A.7
  • 118
    • 0035313635 scopus 로고    scopus 로고
    • Industrial choices for protein production by large-scale cell culture
    • Chu L, Robinson DK (2001) Industrial choices for protein production by large-scale cell culture. Curr Opin Biotechnol 12(2): 180. doi: 10.1016/s0958-1669(00)00197-x
    • (2001) Curr Opin Biotechnol , vol.12 , Issue.2 , pp. 180
    • Chu, L.1    Robinson, D.K.2
  • 119
    • 79952532845 scopus 로고    scopus 로고
    • Development and strategies of cellculture technology for influenza vaccine
    • Feng S-Z, Jiao P-R, Qi W-B, Fan H-Y, Liao M (2011) Development and strategies of cellculture technology for influenza vaccine. Appl Microbiol Biotechnol 89(4): 893. doi: 10.1007/s00253-010-2973-9
    • (2011) Appl Microbiol Biotechnol , vol.89 , Issue.4 , pp. 893
    • Feng, S.-Z.1    Jiao, P.-R.2    Qi, W.-B.3    Fan, H.-Y.4    Liao, M.5
  • 122
    • 79956006654 scopus 로고    scopus 로고
    • Large-scale recombinant adeno-associated virus production
    • Kotin RM (2011) Large-scale recombinant adeno-associated virus production. Hum Mol Genet 20(R1): R2. doi: 10.1093/hmg/ddr141
    • (2011) Hum Mol Genet , vol.20 , Issue.R1
    • Kotin, R.M.1
  • 123
    • 22844450442 scopus 로고    scopus 로고
    • Baculovirus as versatile vectors for protein expression in insect and mammalian cells
    • Kost TA, Condreay JP, Jarvis DL (2005) Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat Biotechnol 23(5): 567. doi: 10.1038/nbt1095
    • (2005) Nat Biotechnol , vol.23 , Issue.5 , pp. 567
    • Kost, T.A.1    Condreay, J.P.2    Jarvis, D.L.3
  • 124
    • 33747343749 scopus 로고    scopus 로고
    • Reactor engineering in large scale animal cell culture
    • Nienow AW (2006) Reactor engineering in large scale animal cell culture. Cytotechnology 50(1-3): 9. doi: 10.1007/s10616-006-9005-8
    • (2006) Cytotechnology , vol.50 , Issue.1-3 , pp. 9
    • Nienow, A.W.1
  • 125
    • 0242642141 scopus 로고    scopus 로고
    • Equipment design considerations for large scale cell culture
    • Marks DM (2003) Equipment design considerations for large scale cell culture. Cytotechnology 42(1): 21. doi: 10.1023/a: 1026103405618
    • (2003) Cytotechnology , vol.42 , Issue.1 , pp. 21
    • Marks, D.M.1
  • 126
    • 0037560084 scopus 로고    scopus 로고
    • Insect cell culture for industrial production of recombinant proteins
    • Ikonomou L, Schneider YJ, Agathos SN (2003) Insect cell culture for industrial production of recombinant proteins. Appl Microbiol Biotechnol 62(1): 1. doi: 10.1007/s00253- 003-1223-9
    • (2003) Appl Microbiol Biotechnol , vol.62 , Issue.1 , pp. 1
    • Ikonomou, L.1    Schneider, Y.J.2    Agathos, S.N.3
  • 127
    • 0036417632 scopus 로고    scopus 로고
    • Optimisation of protein expression and establishment of the wave bioreactor for baculovirus/insect cell culture
    • Weber W, Weber E, Geisse S, Memmert K (2002) Optimisation of protein expression and establishment of the wave bioreactor for baculovirus/insect cell culture. Cytotechnology 38(1-2): 77. doi: 10.1023/a: 1021102015070
    • (2002) Cytotechnology , vol.38 , Issue.1-2 , pp. 77
    • Weber, W.1    Weber, E.2    Geisse, S.3    Memmert, K.4
  • 128
    • 0032924570 scopus 로고    scopus 로고
    • Disposable bioreactor for cell culture using wave-induced agitation
    • Singh V (1999) Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology 30(1-3): 149. doi: 10.1023/a: 1008025016272
    • (1999) Cytotechnology , vol.30 , Issue.1-3 , pp. 149
    • Singh, V.1
  • 129
    • 77149175420 scopus 로고    scopus 로고
    • Disposable bioreactors: The current state-ofthe- art and recommended applications in biotechnology
    • Eibl R, Kaiser S, Lombriser R, Eibl D (2010) Disposable bioreactors: the current state-ofthe- art and recommended applications in biotechnology. Appl Microbiol Biotechnol 86(1): 41. doi: 10.1007/s00253-009-2422-9
    • (2010) Appl Microbiol Biotechnol , vol.86 , Issue.1 , pp. 41
    • Eibl, R.1    Kaiser, S.2    Lombriser, R.3    Eibl, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.