On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements

Biotechnology and Bioengineering

Volumn 63, Issue 1, 1999, Pages 122-126

  Zeiser, A ^a   Bedard C ^a   Voyer, R ^a   Jardin, B ^a   Tom, R ^a   Kamen, Amine A ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Baculovirus; Capacitance; Insect cells; On line monitoring; Permittivity

Indexed keywords

BATCH CELL CULTURE; CAPACITANCE MEASUREMENT; ENZYMES; PERMITTIVITY MEASUREMENT; VIRUSES;

BACULOVIRUS; GALACTOSIDASE; INFECTION;

ANIMAL CELL CULTURE;

ANIMAL CELL; ARTICLE; BACULOVIRUS; BIOREACTOR; CELL CULTURE; CELL DENSITY; CELL SUSPENSION; CELL VIABILITY; CONTROLLED STUDY; INSECT; MEASUREMENT; MONITORING; NONHUMAN; ONLINE SYSTEM; VIRUS INFECTION;

ANIMALS; BACULOVIRIDAE; BETA-GALACTOSIDASE; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL SURVIVAL; KINETICS; MODELS, BIOLOGICAL; ONLINE SYSTEMS; RECOMBINANT PROTEINS; SPODOPTERA; TIME FACTORS; TRANSFECTION;

ANIMALIA; DNA VIRUSES; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0039136064     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19990405)63:1<122::AID-BIT13>3.0.CO;2-I     Document Type: Article

References (22)

1. Aknoukh R, Kretzmer G, Schügerl K. 1996. On-line monitoring and control of the cultivation of Spodoptera frugiperda Sf-9 insect cells and β-galactosidase production by Autographa californica virus vector. Enzyme Microb Technol 18:220-228.
2. Bédard C, Jolicoeur M, Jardin B, Tom R, Perret S, Kamen A. 1994. Insect cell density in bioreactor cultures can be estimated from on-line measurements of optical density. Biotechnol Tech 8:605-610.
3. Davey CL. 1993. The Biomass Monitor Source Book. Aberystwyth, Wales: Aber Instruments Ltd.
4. Harris CM, Todd RW, Bungard SJ, Lovitt RW, Morris JG, Kell DB. 1987. Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass. Enzyme Microb Technol 9:181-186.
5. Hensler WT, Agathos SN. 1994. Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells. Cytotechnology 15:177-186.
6. Junker BH, Reddy J, Gbewonyo K, Greasham R. 1994. On-line and in-situ monitoring technology for cell density measurement in microbial and animal cell cultures. Bioprocess Eng 10:195-207.
7. Kamen AA, Bédard C, Tom R, Perret S, Jardin B. 1996. On-line monitoring of respiration in recombinant-baculovirus-infected and uninfected insect cell bioreactor cultures. Biotechnol Bioeng 50:36-48.
8. Kamen AA, Chavarie C, André G, Archambault J. 1992. Design parameters and performance of a surface baffled helical ribbon impeller bioreactor for the culture of shear sensitive cells. Chem Eng Sci 47: 2375-2380.
9. Kamen AA, Tom R. 1994. Mass spectroscopy determination of insect cell respiration rates in culture and production processes. In: Spier RE, Griffiths JB, Berthold W, editors. Animal cell technology. Products of today, prospects for tomorrow (12th Meeting of the European Society for Animal Cell Technology). Oxford: Butterworth-Heinemann Ltd. p 345-350.
10. Kamen AA, Tom RL, Caron AW, Chavarie C, Massie B, Archambault J. 1991. Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnol Bioeng 38:619-628.
11. Kell DB, Markx GH, Davey CL, Todd RW. 1990. Real-time monitoring of cellular biomass: Methods and applications. Trends Anal Chem 9: 190-194.
12. Konstantinov K, Chuppa S, Sajan E, Tsai Y, Yoon S, Golini F. 1994. Real-time biomass-concentration monitoring in animal-cell cultures. Trends Biotechnol 12:324-333.
13. Licari P, Bailey JE. 1992. Modeling the population dynamics of baculovirus-infected insect cells: Optimizing infection strategies for enhanced recombinant protein yields. Biotechnol Bioeng 39:432-441.
14. Matanguihan RM, Konstantinov KB, Yoshida T. 1994. Dielectric measurement to monitor the growth and the physiological states of biological cells. Bioprocess Eng 11:213-222.
15. Nielsen LK, Wong TKK, Power J, Reid S, Greenfield PF. 1994. Using oxygen uptake rates to time infections in the baculovirus expression vector system. In: Okumura, editor. Animal Cell Technology. Basic and Applied Aspects. Dordrecht: Kluwer Academic Publishers.
16. Olsson L, Nielsen J. 1997. On-line and in situ monitoring of biomass in submerged cultivations. Trends Biotechnol 15:517-522.
17. Palomares LA, Ramirez OT. 1996. The effect of dissolved oxygen tension and the utility of oxygen uptake rate in insect cell culture. Cytotechnology 22:225-237.
18. Power JF, Reid S, Radford KM, Greenfield PF, Nielsen LK. 1994. Modeling and optimization of the baculovirus expression vector system in batch suspension culture. Biotechnol Bioeng 44:710-719.
19. Schopf B, Howaldt MW, Bailey JE. 1990. DNA distribution and respiratory activity of Spodoptera frugiperda populations infected with wild-type and recombinant Autographa californica nuclear polyhedrosis virus. J Biotechnol 15:169-186.
20. Siano SA. 1997. Biomass measurement by inductive permittivity. Biotechnol Bioeng 55:289-304.
21. Taticek RA, Shuler ML. 1997. Effect of elevated oxygen and glutamine levels on foreign protein production at high cell densities using the insect cell - baculovirus expression system. Biotechnol Bioeng 54: 142-152.
22. Wong TKK, Nielsen LK, Greenfield PF, Reid S. 1994. Relationship between oxygen uptake rate and time of infection of Sf-9 insect cells infected with a recombinant baculovirus. Cytotechnology 15:157-167.