Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy

Applied Microbiology and Biotechnology

Volumn 76, Issue 4, 2007, Pages 761-772

  Negrete, Alejandro ^a   Esteban, Geoffrey ^b   Kotin, Robert M ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b FOGALE Nanotech   (France)

Author keywords

Adeno associated vectors; Bioprocessing; Dielectric spectroscopy; Gene therapy; Harvesting time; Large scale

Indexed keywords

BANDWIDTH; CELL CULTURE; DIELECTRIC SPECTROSCOPY; OPTIMIZATION; PROCESS CONTROL;

ADENO-ASSOCIATED VECTORS; BIOPROCESSING; GENE THERAPY; HARVESTING TIME; ONLINE MONITORING;

GENETIC ENGINEERING;

PARVOVIRUS VECTOR; RECOMBINANT DNA;

COMMERCIALIZATION; GENETIC ENGINEERING; OPTIMIZATION; RECOMBINATION; SPECTROSCOPY;

ANIMAL CELL; ARTICLE; BACULOVIRUS; BIOPROCESS; CONTROLLED STUDY; DNA DETERMINATION; HARVEST PERIOD; INFECTION; NONHUMAN; SCALE UP; SPECTROMETER; SPECTROSCOPY;

ANIMALS; BACULOVIRIDAE; BIOTECHNOLOGY; BLOTTING, WESTERN; CAPSID PROTEINS; DEPENDOVIRUS; GENETIC VECTORS; RECOMBINANT PROTEINS; SPECTRUM ANALYSIS; SPODOPTERA; TRANSDUCTION, GENETIC;

HEXAPODA;

EID: 34548314442     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-1030-9     Document Type: Article

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