Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 23, 2011, Pages 9484-9489

  Choi, Kyung Suk ^a   Harfe, Brian D ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Smoothened; Sonic Hedgehog

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; INTERVERTEBRAL DISK; MOUSE; NERVE SHEATH; NONHUMAN; NOTOCHORD; NUCLEUS PULPOSUS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VERTEBRA BODY;

ANIMALS; ANIMALS, NEWBORN; BODY PATTERNING; CELL MOVEMENT; CELL PROLIFERATION; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERVERTEBRAL DISK; MALE; MICE; MICE, KNOCKOUT; NOTOCHORD; SIGNAL TRANSDUCTION; TIME FACTORS;

ERINACEIDAE;

EID: 79959360699     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007566108     Document Type: Article

References (34)

1. Katz JN (2006) Lumbar disc disorders and low-back pain: Socioeconomic factors and consequences. J Bone Joint Surg Am 88(Suppl 2):21-24.
2. Hunter CJ, Matyas JR, Duncan NA (2003) The notochordal cell in the nucleus pulposus: A review in the context of tissue engineering. Tissue Eng 9:667-677. (Pubitemid 37048109)
3. Choi KS, Cohn MJ, Harfe BD (2008) Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation. Dev Dyn 237:3953-3958.
4. Adams MA, Roughley PJ (2006) What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976) 31:2151-2161.
5. Walmsley R (1953) The development and growth of the intervertebral disc. Edinburgh Med J 60:341-364.
6. Aszódi A, Chan D, Hunziker E, Bateman JF, Fässler R (1998) Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol 143:1399-1412.
7. Peters H, et al. (1999) Pax1 and Pax9 synergistically regulate vertebral column development. Development 126:5399-5408. (Pubitemid 30015932)
8. Wallin J, et al. (1994) The role of Pax-1 in axial skeleton development. Development 120:1109-1121. (Pubitemid 24150037)
9. Lettice LA, et al. (1999) The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc Natl Acad Sci USA 96:9695-9700. (Pubitemid 29398794)
10. Smits P, Lefebvre V (2003) Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development 130:1135-1148. (Pubitemid 36395695)
11. Rufai A, Benjamin M, Ralphs JR (1995) The development of fibrocartilage in the rat intervertebral disc. Anat Embryol (Berl) 192(1):53-62.
12. Theiler K (1988) Vertebral malformations. Adv Anat Embryol Cell Biol 112:1-99.
13. Duprez D, Fournier-Thibault C, Le Douarin N (1998) Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development 125:495-505. (Pubitemid 28102656)
14. Jensen AM, Wallace VA (1997) Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development 124:363-371. (Pubitemid 27101670)
15. Britto J, Tannahill D, Keynes R (2002) A critical role for Sonic hedgehog signaling in the early expansion of the developing brain. Nat Neurosci 5(2):103-110. (Pubitemid 34121576)
16. Dahia CL, Mahoney EJ, Durrani AA, Wylie C (2009) Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging. Spine (Phila Pa 1976) 34:456-462.
17. DiPaola CP, Farmer JC, Manova K, Niswander LA (2005) Molecular signaling in intervertebral disk development. J Orthop Res 23:1112-1119. (Pubitemid 41245436)
18. Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15:3059-3087. (Pubitemid 33115673)
19. Chiang C, et al. (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413. (Pubitemid 26330823)
20. Maeda Y, et al. (2007) Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci USA 104:6382-6387. (Pubitemid 47186103)
21. Zhang XM, Ramalho-Santos M, McMahon AP (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106:781-792. (Pubitemid 32635107)
22. Harfe BD, et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118:517-528. (Pubitemid 39485670)
23. Long F, Zhang XM, Karp S, Yang Y, McMahon AP (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128:5099-5108. (Pubitemid 34086893)
24. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21(1):70-71.
25. Paavola LG, Wilson DB, Center EM (1980) Histochemistry of the developing notochord, perichordal sheath and vertebrae in Danforth's short-tail (sd) and normal C57BL/6 mice. J Embryol Exp Morphol 55:227-245. (Pubitemid 10173802)
26. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127:4775-4785.
27. Zhu J, et al. (2008) Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell 14:624-632. (Pubitemid 351479933)
28. Parsons MJ, et al. (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development 129:3137-3146. (Pubitemid 34874288)
29. Camón J, Degollada E, Verdú J (1990) Ultrastructural aspects of the production of extracellular matrix components by the chick embryonic notochord in vitro. Acta Anat (Basel) 137(2):114-123.
30. Götz W, Osmers R, Herken R (1995) Localisation of extracellular matrix components in the embryonic human notochord and axial mesenchyme. J Anat 186:111-121.
31. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203:253-310.
32. Murtaugh LC, Chyung JH, Lassar AB (1999) Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev 13:225-237. (Pubitemid 29061952)
33. Wilkinson DG, Nieto MA (1993) Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225:361-373.
34. Karp SJ, et al. (2000) Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormonerelated-protein-dependent and -independent pathways. Development 127:543-548. (Pubitemid 30093402)