Expression of receptors for putative anabolic growth factors in human intervertebral disc: Implications for repair and regeneration of the disc

Journal of Pathology

Volumn 207, Issue 4, 2005, Pages 445-452

  Le Maitre, Christine L ^a   Richardson, Stephen M A ^a   Baird, Pauline ^a   Freemont, Anthony J ^a   Hoyland, Judith A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Expression; Growth factor receptors; Intervertebral disc degeneration; Therapies

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GROWTH FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CARTILAGE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TARGETING; FEMALE; HISTOPATHOLOGY; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; MALE; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; AGED; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; FEMALE; HUMANS; INTERVERTEBRAL DISK; LOW BACK PAIN; MALE; MIDDLE AGED; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECEPTOR, IGF TYPE 1; RECEPTORS, GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REGENERATION; SPINAL DISEASES; WOUND HEALING;

EID: 29744453149     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1862     Document Type: Article

References (49)

1. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine 2000;25:487-492.
2. Freemont AJ, Watkins A, Le Maitre C, Jeziorska M, Hoyland JA. Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J Pathol 2002;196:374-379.
3. Boos N, Nerlich AG, Wiest I, von der M, Aebi M. Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration. Histochem Cell Biol 1997;108:471-480.
4. Sive JI, Baird P, Jeziorsk M, Watkins A, Hoyland JA, Freemont AJ. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 2002;55:91-97.
5. Cs-Szabo G, Ragasa-San Juan D, Turumella V, Masuda K, Thonar EJ, An HS. Changes in mRNA and protein levels of proteoglycans of the annulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 2002;27:2212-2219.
6. Inkinen RI, Lammi MJ, Lehmonen S, Puustjarvi K, Kaapa E, Tammi MI. Relative increase of biglycan and decorin and altered chondroitin sulfate epitopes in the degenerating human intervertebral disc. J Rheumatol 1998;25:506-514.
7. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF III, Evans CH. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 1996;21:271-277.
8. Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC, Eisenstein SM. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine 2000;25:3005-3013.
9. Sztrolovics R, Alini M, Roughley PJ, Mort JS. Aggrecan degradation in human intervertebral disc and articular cartilage. Biochem J 1997;326(1):235-241.
10. Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004;204:47-54.
11. Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin (IL-1) in the pathogenesis of human Intervertebral disc (IVD) degeneration. Arthritis Res Ther 2005;7:R732-R745.
12. Osada R, Ohshima H, Ishihara H, Yudoh K, Sakai K, Matsui H, Tsuji H. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J Orthop Res 1996;14:690-699.
13. Wang H, Kroeber M, Hanke M, Ries R, Schmid C, Poller W, Richter W. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J Mol Med 2004;82:126-134.
14. Li X, Leo BM, Beck G, Balian G, Anderson GD. Collagen and proteoglycan abnormalities in the GDF-5-deficient mice and molecular changes when treating disk cells with recombinant growth factor. Spine 2004;29:2229-2234.
15. Thompson JP, Oegema TR Jr, Bradford DS. Stimulation of mature canine intervertebral disc by growth factors. Spine 1991;16:253-260.
16. Li J, Yoon ST, Hutton WC. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 2004;17:423-428.
17. Masuda K, An HS. Growth factors and the intervertebral disc. Spine J 2004;4:S330-S340.
18. Masuda K, Oegema TR Jr, An HS. Growth factors and treatment of intervertebral disc degeneration. Spine 2004;29:2757-2769.
19. Yoon ST, Park JS, Kim KS, Li J, Attallah-Wasif ES, et al. ISSLS Prize Winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine 2004;29:2603-2611.
20. Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002;118:211-215.
21. Yamashita H, ten Dijke P, Heldin CH, Miyazono K. Bone morphogenetic protein receptors. Bone 1996;19:569-574.
22. Leong LM, Brickell PM. Bone morphogenic protein-4. Int J Biochem Cell Biol 1996;28:1293-1296.
23. Attisano L, Wrana JL. Signal transduction by the TGF-β superfamily. Science 2002;296:1646-1647.
24. McIntosh I, Bellus GA, Jab EW. The pleiotropic effects of fibroblast growth factor receptors in mammalian development. Cell Struct Funct 2000;25:85-96.
25. Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996;84:911-921.
26. Adams TE, Epa VC, Garrett TP, Ward CW. Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 2000;57:1050-1093.
27. Konttinen YT, Kemppinen P, Li TF, Waris E, Pihlajamaki H, Sorsa T, et al. Transforming and epidermal growth factors in degenerated intervertebral discs. J Bone Joint Surg Br 1999;81:1058-1063.
28. Tolonen J, Gronblad M, Virri J, Seitsalo S, Rytomaa T, Karaharju E. Transforming growth factor beta receptor induction in herniated intervertebral disc tissue: an immunohistochemical study. Eur Spine J 2001;10:172-176.
29. Specchia N, Pagnotta A, Toesca A, Greco F. Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur Spine J 2002;11:145-151.
30. Tolonen J, Gronblad M, Virri J, Seitsalo S, Rytomaa T, Karaharju E. Basic fibroblast growth factor immunoreactivity in blood vessels and cells of disc herniations. Spine 1995;20:271-276.
31. Streiner DL. Maintaining standards: differences between the standard deviation and standard error, and when to use each. Can J Psychiat 1996;41:498-502.
32. Le Maitre CL, Freemont AJ, Hoyland JA. An in vitro feasibility study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2005;in press.
33. Gruber HE, Fisher EC Jr, Desai B, Stasky AA, Hoelscher G, Hanley EN Jr. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-β1. Exp Cell Res 1997;235:13-21.
34. Risbud MV, Izzo MW, Adams CS, Arnold WW, Hillibrand AS, Vresilovic EJ, et al. An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells. Spine 2003;28:2652-2658.
35. Walsh AJ, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs. Spine 2004;29:156-163.
36. Okuda S, Nakase T, Yonenobu, K, et al. Age-dependent expression of transforming growth factor beta 1 on proteoglycan synthesis in rat intervertebral discs. J Musc Res 2000;4:151-159.
37. Matsunaga S, Nagano S, Onishi T, Morimoto N, Suzuki S, Komiya S. Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs. J Neurosurg Spine 2003;98:63-67.
38. Takae R, Matsunaga S, Origuchi N, Yamamoto T, Morimoto N, Suzuki S, Sakou T. Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc. Spine 1999;24:1397-1401.
39. Nakase T, Ariga K, Miyamoto S, Okuda S, Tomita T, Iwasaki M, et al. Distribution of genes for bone morphogenetic protein-4, -6, growth differentiation factor-5, and bone morphogenetic protein receptors in the process of experimental spondylosis in mice. J Neurosurg Spine 2001;94:68-75.
40. Doita M, Kanatani T, Harada T, Mizuno K. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine. Spine 1996;21:235-241.
41. Okuda S, Myoui A, Ariga K, Nakase T, Yonenobu K, Yoshikawa H. Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine 2001;26:2421-2426.
42. Gruber HE, Norton HJ, Hanley EN. Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 2000;25:2153-2157.
43. Nerlich AG, Boos N, Wiest I, Aebi M. Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages. Virchows Arch 1998;432:67-76.
44. Hoyland JA, Freemont AJ, Jayson MI. Age-related changes in the structures within and bordering the intervertebral foramen: associations with low back pain. In The Ageing Spine, Hukins DW, Nelson MA (eds). Manchester University Press, 1987; 94-110.
45. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997;350:178-181.
46. Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, et al. Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 2002;197:286-292.
47. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986;83:4167-4171.
48. Auguste P, Javerzat S, Bikfalvi A. Regulation of vascular development by fibroblast growth factors. Cell Tissue Res 2003;314:157-166.
49. Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 2004;24:435-444.