Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: Implications for development of regenerative strategies

Arthritis Research and Therapy

Volumn 15, Issue 1, 2013, Pages

  Smolders, Lucas A ^a   Meij, Björn P ^a   Onis, David ^a   Riemers, Frank M ^a   Bergknut, Niklas ^a,b   Wubbolts, Richard ^c   Grinwis, Guy C M ^d   Houweling, Martin ^c   Groot Koerkamp, Marian J A ^e   van Leenen, Dik ^e   Holstege, Frank C P ^e   Hazewinkel, Herman A W ^a   Creemers, Laura B ^e   Penning, Louis C ^a   Tryfonidou, Marianna A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CAVEOLIN 1; CYTOKERATIN 19; CYTOKERATIN 8; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; WNT PROTEIN; WNT3A PROTEIN; WNT7B PROTEIN;

ANIMAL TISSUE; ARTICLE; AXIN2 GENE; CYTOPLASM; DOG; DOWN REGULATION; GENE; GENE EXPRESSION PROFILING; IN VITRO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; BIOSYNTHESIS; DNA MICROARRAY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REGENERATION;

ANIMALS; CAVEOLIN 1; DOGS; DOWN-REGULATION; GENE EXPRESSION PROFILING; GUIDED TISSUE REGENERATION; INTERVERTEBRAL DISC DEGENERATION; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WNT SIGNALING PATHWAY;

EID: 84872943178     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4157     Document Type: Article

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