Toward an optimum system for intervertebral disc organ culture: TGF-β3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-β-R expression and ERK signaling

Spine

Volumn 31, Issue 8, 2006, Pages 884-890

  Risbud, Makarand V ^a   Di Martino, Alberto ^a,b   Guttapalli, Asha ^a   Seghatoleslami, Reza ^c   Denaro, Vincenzo ^b   Vaccaro, Alexander R ^a   Albert, Todd J ^a   Shapiro, Irving M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

ERK; Gene expression; Nucleus pulposus; Organ culture; TGF R; TGF 3

Indexed keywords

AGGRECAN; BIGLYCAN; COLLAGEN TYPE 2; DECORIN; MITOGEN ACTIVATED PROTEIN KINASE; SULFATE; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANNULUS FIBROSUS; ARTICLE; CARTILAGINOUS TISSUE; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EVALUATION; GENE EXPRESSION REGULATION; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTERVERTEBRAL DISK; MALE; NICK END LABELING; NONHUMAN; NUCLEUS PULPOSUS; PHENOTYPE; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SPINE; WESTERN BLOTTING;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; INTERVERTEBRAL DISK; MALE; MAP KINASE SIGNALING SYSTEM; ORGAN CULTURE TECHNIQUES; PROTEOGLYCANS; RATS; RATS, WISTAR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA3;

EID: 33646442480     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000209335.57767.b5     Document Type: Article

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