Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway

Spine

Volumn 33, Issue 16, 2008, Pages

  Zhang, Huina ^a,b   Lin, Chia Ying ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

BMP 2; Chondrogenesis; Intervertebral disc; Mevalonate; Simvastatin

Indexed keywords

AGGRECAN; ALGINIC ACID; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; MESSENGER RNA; MEVALONIC ACID; NOGGIN; PROTEOGLYCAN; SIMVASTATIN;

ANIMAL CELL; ARTICLE; BONE CELL; CELL CULTURE; CELL LEVEL; CELL STIMULATION; CHONDROGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IN VITRO STUDY; INTERVERTEBRAL DISC CELL; INTERVERTEBRAL DISK; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN SYNTHESIS INHIBITION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CARTILAGE CELL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHENOTYPE; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; INTERVERTEBRAL DISK; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 58149129547     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31817c561b     Document Type: Article

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