-
1
-
-
33745435247
-
Recapitulation of embryological programmes in renal fibrosis - The importance of epithelial cell plasticity and developmental genes
-
2-s2.0-33745435247 10.1159/000092453
-
Roxburgh S. A., Murphy M., Pollock C. A., Brazil D. P., Recapitulation of embryological programmes in renal fibrosis-the importance of epithelial cell plasticity and developmental genes. Nephron Physiology 2006 103 3 p139 p148 2-s2.0-33745435247 10.1159/000092453
-
(2006)
Nephron Physiology
, vol.103
, Issue.3
-
-
Roxburgh, S.A.1
Murphy, M.2
Pollock, C.A.3
Brazil, D.P.4
-
2
-
-
0034616419
-
IHG-2, a mesangial cell gene induced by high glucose, is human gremlin: Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor- β 1
-
2-s2.0-0034616419 10.1074/jbc.275.14.9901
-
McMahon R., Murphy M., Clarkson M., Taal M., Mackenzie H. S., Godson C., Martin F., Brady H. R., IHG-2, a mesangial cell gene induced by high glucose, is human gremlin: regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor- β 1. The Journal of Biological Chemistry 2000 275 14 9901 9904 2-s2.0-0034616419 10.1074/jbc.275.14.9901
-
(2000)
The Journal of Biological Chemistry
, vol.275
, Issue.14
, pp. 9901-9904
-
-
McMahon, R.1
Murphy, M.2
Clarkson, M.3
Taal, M.4
Mackenzie, H.S.5
Godson, C.6
Martin, F.7
Brady, H.R.8
-
3
-
-
0034708483
-
Biosynthesis, post-translation modification, and functional characterization of Drm/Gremlin
-
2-s2.0-0034708483 10.1074/jbc.275.12.8785
-
Topol L. Z., Bardot B., Zhang Q., Resau J., Huillard E., Marx M., Calothy G., Blair D. G., Biosynthesis, post-translation modification, and functional characterization of Drm/Gremlin. The Journal of Biological Chemistry 2000 275 12 8785 8793 2-s2.0-0034708483 10.1074/jbc.275.12.8785
-
(2000)
The Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 8785-8793
-
-
Topol, L.Z.1
Bardot, B.2
Zhang, Q.3
Resau, J.4
Huillard, E.5
Marx, M.6
Calothy, G.7
Blair, D.G.8
-
4
-
-
4243180526
-
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
-
2-s2.0-4243180526 10.1242/dev.01251
-
Michos O., Panman L., Vintersten K., Beier K., Zeller R., Zuniga A., Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 2004 131 14 3401 3410 2-s2.0-4243180526 10.1242/dev.01251
-
(2004)
Development
, vol.131
, Issue.14
, pp. 3401-3410
-
-
Michos, O.1
Panman, L.2
Vintersten, K.3
Beier, K.4
Zeller, R.5
Zuniga, A.6
-
5
-
-
20444364531
-
Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy
-
2-s2.0-20444364531 10.1053/j.ajkd.2005.03.014
-
Dolan V., Murphy M., Sadlier D., Lappin D., Doran P., Godson C., Martin F., O'Meara Y., Schmid H., Henger A., Kretzler M., Droguett A., Mezzano S., Brady H. R., Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. American Journal of Kidney Diseases 2005 45 6 1034 1039 2-s2.0-20444364531 10.1053/j.ajkd.2005.03.014
-
(2005)
American Journal of Kidney Diseases
, vol.45
, Issue.6
, pp. 1034-1039
-
-
Dolan, V.1
Murphy, M.2
Sadlier, D.3
Lappin, D.4
Doran, P.5
Godson, C.6
Martin, F.7
O'Meara, Y.8
Schmid, H.9
Henger, A.10
Kretzler, M.11
Droguett, A.12
Mezzano, S.13
Brady, H.R.14
-
6
-
-
53849124336
-
Regulation and consequences of differential gene expression in diabetic kidney disease
-
2-s2.0-53849124336 10.1042/BST0360941
-
Murphy M., Crean J., Brazil D. P., Sadlier D., Martin F., Godson C., Regulation and consequences of differential gene expression in diabetic kidney disease. Biochemical Society Transactions 2008 36 5 941 945 2-s2.0-53849124336 10.1042/BST0360941
-
(2008)
Biochemical Society Transactions
, vol.36
, Issue.5
, pp. 941-945
-
-
Murphy, M.1
Crean, J.2
Brazil, D.P.3
Sadlier, D.4
Martin, F.5
Godson, C.6
-
7
-
-
34547851691
-
Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis
-
2-s2.0-34547851691 10.1093/ndt/gfm145
-
Mezzano S., Droguett A., Eugenia M. B., Aros C., Ardiles L., Flores C., Carpio D., Carvajal G., Ruiz-Ortega M., Egido J., Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis. Nephrology Dialysis Transplantation 2007 22 7 1882 1890 2-s2.0-34547851691 10.1093/ndt/gfm145
-
(2007)
Nephrology Dialysis Transplantation
, vol.22
, Issue.7
, pp. 1882-1890
-
-
Mezzano, S.1
Droguett, A.2
Eugenia, M.B.3
Aros, C.4
Ardiles, L.5
Flores, C.6
Carpio, D.7
Carvajal, G.8
Ruiz-Ortega, M.9
Egido, J.10
-
8
-
-
42949143822
-
Gremlin: A novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy
-
2-s2.0-42949143822 10.1016/j.transproceed.2008.02.064
-
Carvajal G., Droguett A., Burgos M. E., Aros C., Ardiles L., Flores C., Carpio D., Ruiz-Ortega M., Egido J., Mezzano S., Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy. Transplantation Proceedings 2008 40 3 734 739 2-s2.0-42949143822 10.1016/j.transproceed.2008.02.064
-
(2008)
Transplantation Proceedings
, vol.40
, Issue.3
, pp. 734-739
-
-
Carvajal, G.1
Droguett, A.2
Burgos, M.E.3
Aros, C.4
Ardiles, L.5
Flores, C.6
Carpio, D.7
Ruiz-Ortega, M.8
Egido, J.9
Mezzano, S.10
-
9
-
-
67650239578
-
Allelic depletion of grem1 attenuates diabetic kidney disease
-
2-s2.0-67650239578 10.2337/db08-1365
-
Roxburgh S. A., Kattla J. J., Curran S. P., O'Meara Y. M., Pollock C. A., Goldschmeding R., Godson C., Martin F., Brazil D. P., Allelic depletion of grem1 attenuates diabetic kidney disease. Diabetes 2009 58 7 1641 1650 2-s2.0-67650239578 10.2337/db08-1365
-
(2009)
Diabetes
, vol.58
, Issue.7
, pp. 1641-1650
-
-
Roxburgh, S.A.1
Kattla, J.J.2
Curran, S.P.3
O'Meara, Y.M.4
Pollock, C.A.5
Goldschmeding, R.6
Godson, C.7
Martin, F.8
Brazil, D.P.9
-
10
-
-
77955411901
-
In vivo delivery of gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7
-
ARTICLE E11709 2-s2.0-77955411901 10.1371/journal.pone.0011709
-
Zhang Q., Shi Y., Wada J., Malakauskas S. M., Liu M., Ren Y., Du C., Duan H., Li Y., Li Y., Zhang Y., In vivo delivery of gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7. PLoS ONE 2010 5 7, article e11709 2-s2.0-77955411901 10.1371/journal.pone.0011709
-
(2010)
PLoS ONE
, vol.5
, Issue.7
-
-
Zhang, Q.1
Shi, Y.2
Wada, J.3
Malakauskas, S.M.4
Liu, M.5
Ren, Y.6
Du, C.7
Duan, H.8
Li, Y.9
Li, Y.10
Zhang, Y.11
-
11
-
-
78149298226
-
Mechanisms of tubulointerstitial fibrosis
-
2-s2.0-78149298226 10.1681/ASN.2010080793
-
Zeisberg M., Neilson E. G., Mechanisms of tubulointerstitial fibrosis. Journal of the American Society of Nephrology 2010 21 11 1819 1834 2-s2.0-78149298226 10.1681/ASN.2010080793
-
(2010)
Journal of the American Society of Nephrology
, vol.21
, Issue.11
, pp. 1819-1834
-
-
Zeisberg, M.1
Neilson, E.G.2
-
12
-
-
77949351029
-
New insights into epithelial-mesenchymal transition in kidney fibrosis
-
2-s2.0-77949351029 10.1681/ASN.2008121226
-
Liu Y., New insights into epithelial-mesenchymal transition in kidney fibrosis. Journal of the American Society of Nephrology 2010 21 2 212 222 2-s2.0-77949351029 10.1681/ASN.2008121226
-
(2010)
Journal of the American Society of Nephrology
, vol.21
, Issue.2
, pp. 212-222
-
-
Liu, Y.1
-
13
-
-
34548175512
-
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
-
2-s2.0-34548175512 10.1111/j.1349-7006.2007.00550.x
-
Moustakas A., Heldin C.-H., Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Science 2007 98 10 1512 1520 2-s2.0-34548175512 10.1111/j.1349-7006.2007. 00550.x
-
(2007)
Cancer Science
, vol.98
, Issue.10
, pp. 1512-1520
-
-
Moustakas, A.1
Heldin, C.-H.2
-
14
-
-
0032842887
-
Transforming growth factor- β regulates tubular epithelial- myofibroblast transdifferentiation in vitro
-
2-s2.0-0032842887 10.1046/j.1523-1755.1999.00656.x
-
Fan J.-M., Yee-Yung N. G., Hill P. A., Nikolic-Paterson D. J., Mu W., Atkins R. C., Lan H. Y., Transforming growth factor- β regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney International 1999 56 4 1455 1467 2-s2.0-0032842887 10.1046/j.1523-1755.1999.00656.x
-
(1999)
Kidney International
, vol.56
, Issue.4
, pp. 1455-1467
-
-
Fan, J.-M.1
Yee-Yung, N.G.2
Hill, P.A.3
Nikolic-Paterson, D.J.4
Mu, W.5
Atkins, R.C.6
Lan, H.Y.7
-
15
-
-
30944466813
-
Smad3 is key to TGF- β -mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
-
2-s2.0-30944466813 10.1016/j.cytogfr.2005.09.008
-
Roberts A. B., Tian F., Byfield S. D., Stuelten C., Ooshima A., Saika S., Flanders K. C., Smad3 is key to TGF- β -mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine & Growth Factor Reviews 2006 17 1-2 19 27 2-s2.0-30944466813 10.1016/j.cytogfr.2005.09. 008
-
(2006)
Cytokine & Growth Factor Reviews
, vol.17
, Issue.1-2
, pp. 19-27
-
-
Roberts, A.B.1
Tian, F.2
Byfield, S.D.3
Stuelten, C.4
Ooshima, A.5
Saika, S.6
Flanders, K.C.7
-
16
-
-
59449090107
-
TGF- β -induced epithelial to mesenchymal transition
-
2-s2.0-59449090107 10.1038/cr.2009.5
-
Xu J., Lamouille S., Derynck R., TGF- β -induced epithelial to mesenchymal transition. Cell Research 2009 19 2 156 172 2-s2.0-59449090107 10.1038/cr.2009.5
-
(2009)
Cell Research
, vol.19
, Issue.2
, pp. 156-172
-
-
Xu, J.1
Lamouille, S.2
Derynck, R.3
-
17
-
-
34047156556
-
TGF- β signaling in vascular fibrosis
-
2-s2.0-34047156556 10.1016/j.cardiores.2007.02.008
-
Ruiz-Ortega M., Rodríguez-Vita J., Sanchez-Lopez E., Carvajal G., Egido J., TGF- β signaling in vascular fibrosis. Cardiovascular Research 2007 74 2 196 206 2-s2.0-34047156556 10.1016/j.cardiores.2007.02.008
-
(2007)
Cardiovascular Research
, vol.74
, Issue.2
, pp. 196-206
-
-
Ruiz-Ortega, M.1
Rodríguez-Vita, J.2
Sanchez-Lopez, E.3
Carvajal, G.4
Egido, J.5
-
18
-
-
84875646745
-
Gremlin is a downstream profibrotic mediator of transforming growth factor-beta in cultured renal cells
-
10.1159/000346575
-
Rodrigues-Diez R., Lavoz C., Carvajal G., Rayego-Mateos S., Rodrigues Diez R. R., Ortiz A., Egido J., Mezzano S., Ruiz-Ortega M., Gremlin is a downstream profibrotic mediator of transforming growth factor-beta in cultured renal cells. Nephron Experimental Nephrology 2012 122 1-2 62 74 10.1159/000346575
-
(2012)
Nephron Experimental Nephrology
, vol.122
, Issue.1-2
, pp. 62-74
-
-
Rodrigues-Diez, R.1
Lavoz, C.2
Carvajal, G.3
Rayego-Mateos, S.4
Rodrigues Diez, R.R.5
Ortiz, A.6
Egido, J.7
Mezzano, S.8
Ruiz-Ortega, M.9
-
19
-
-
18844387660
-
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor- β -independent mechanism
-
2-s2.0-18844387660 10.1161/01.CIR.0000165133.84978.E2
-
Rodríguez-Vita J., Sánchez-López E., Esteban V., Rupérez M., Egido J., Ruiz-Ortega M., Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor- β -independent mechanism. Circulation 2005 111 19 2509 2517 2-s2.0-18844387660 10.1161/01.CIR.0000165133.84978.E2
-
(2005)
Circulation
, vol.111
, Issue.19
, pp. 2509-2517
-
-
Rodríguez-Vita, J.1
Sánchez-López, E.2
Esteban, V.3
Rupérez, M.4
Egido, J.5
Ruiz-Ortega, M.6
-
20
-
-
49749105574
-
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation
-
2-s2.0-49749105574 10.1038/ki.2008.213
-
Carvajal G., Rodríguez-Vita J., Rodrigues-Díez R., Sánchez-López E., Rupérez M., Cartier C., Esteban V., Ortiz A., Egido J., Mezzano S. A., Ruiz-Ortega M., Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. Kidney International 2008 74 5 585 595 2-s2.0-49749105574 10.1038/ki.2008.213
-
(2008)
Kidney International
, vol.74
, Issue.5
, pp. 585-595
-
-
Carvajal, G.1
Rodríguez-Vita, J.2
Rodrigues-Díez, R.3
Sánchez-López, E.4
Rupérez, M.5
Cartier, C.6
Esteban, V.7
Ortiz, A.8
Egido, J.9
Mezzano, S.A.10
Ruiz-Ortega, M.11
-
21
-
-
84881387298
-
Gremlin aggravates hyperglycemia-induced podocyte injury by a TGF β /smad dependent signaling pathway
-
10.1002/jcb.24559
-
Li G., Li Y., Liu S., Shi Y., Chi Y., Liu G., Shan T., Gremlin aggravates hyperglycemia-induced podocyte injury by a TGF β /smad dependent signaling pathway. Journal of Cellular Biochemistry 2013 114 9 2101 2113 10.1002/jcb.24559
-
(2013)
Journal of Cellular Biochemistry
, vol.114
, Issue.9
, pp. 2101-2113
-
-
Li, G.1
Li, Y.2
Liu, S.3
Shi, Y.4
Chi, Y.5
Liu, G.6
Shan, T.7
-
22
-
-
0037498439
-
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
-
2-s2.0-0037498439 10.1097/01.ASN.0000067632.04658.B8
-
Lan H. Y., Mu W., Tomita N., Huang X. R., Li J. H., Zhu H.-J., Morishita R., Johnson R. J., Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. Journal of the American Society of Nephrology 2003 14 6 1535 1548 2-s2.0-0037498439 10.1097/01.ASN.0000067632.04658.B8
-
(2003)
Journal of the American Society of Nephrology
, vol.14
, Issue.6
, pp. 1535-1548
-
-
Lan, H.Y.1
Mu, W.2
Tomita, N.3
Huang, X.R.4
Li, J.H.5
Zhu, H.-J.6
Morishita, R.7
Johnson, R.J.8
-
23
-
-
2942535966
-
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
-
2-s2.0-2942535966 10.1073/pnas.0400035101
-
Fukasawa H., Yamamoto T., Togawa A., Ohashi N., Fujigaki Y., Oda T., Uchida C., Kitagawa K., Hattori T., Suzuki S., Kitagawa M., Hishida A., Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proceedings of the National Academy of Sciences of the United States of America 2004 101 23 8687 8692 2-s2.0-2942535966 10.1073/pnas.0400035101
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.23
, pp. 8687-8692
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
Oda, T.6
Uchida, C.7
Kitagawa, K.8
Hattori, T.9
Suzuki, S.10
Kitagawa, M.11
Hishida, A.12
-
24
-
-
79551599216
-
The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential
-
2-s2.0-79551599216 10.2337/db10-0403
-
Chen H. Y., Huang X. R., Wang W., Li J. H., Heuchel R. L., Chung A. C. K., Lan H. Y., The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 2011 60 2 590 601 2-s2.0-79551599216 10.2337/db10-0403
-
(2011)
Diabetes
, vol.60
, Issue.2
, pp. 590-601
-
-
Chen, H.Y.1
Huang, X.R.2
Wang, W.3
Li, J.H.4
Heuchel, R.L.5
Chung, A.C.K.6
Lan, H.Y.7
-
25
-
-
84884343430
-
Kindlin-2 mediates activation of TGF- β /Smad signaling and renal fibrosis
-
10.1681/ASN.2012101041
-
Wei X., Xia Y., Li F., Tang Y., Nie J., Liu Y., Zhou Z., Zhang H., Hou F. F., Kindlin-2 mediates activation of TGF- β /Smad signaling and renal fibrosis. Journal of the American Society Nephrology 2013 24 9 1387 1398 10.1681/ASN.2012101041
-
(2013)
Journal of the American Society Nephrology
, vol.24
, Issue.9
, pp. 1387-1398
-
-
Wei, X.1
Xia, Y.2
Li, F.3
Tang, Y.4
Nie, J.5
Liu, Y.6
Zhou, Z.7
Zhang, H.8
Hou, F.F.9
-
26
-
-
0036387022
-
Smad pathway is activated in the diabetic mouse kidney and smad3 mediates TGF- β -induced fibronectin in mesangial cells
-
2-s2.0-0036387022 10.1016/S0006-291X(02)02084-3
-
Isono M., Chen S., Hong S. W., Iglesias-de la Cruz M. C., Ziyadeh F. N., Smad pathway is activated in the diabetic mouse kidney and smad3 mediates TGF- β -induced fibronectin in mesangial cells. Biochemical and Biophysical Research Communications 2002 296 5 1356 1365 2-s2.0-0036387022 10.1016/S0006-291X(02)02084-3
-
(2002)
Biochemical and Biophysical Research Communications
, vol.296
, Issue.5
, pp. 1356-1365
-
-
Isono, M.1
Chen, S.2
Hong, S.W.3
Iglesias-De La Cruz, M.C.4
Ziyadeh, F.N.5
-
27
-
-
84884412462
-
Nuclear expression of Smad proteins and its prognostic significance in clear cell renal cell carcinoma
-
10.1016/j.humpath.2013.03.009
-
Park J. H., Lee C., Suh J. H., Chae J. Y., Moon K. C., Nuclear expression of Smad proteins and its prognostic significance in clear cell renal cell carcinoma. Human Pathology 2013 44 10 2047 2054 10.1016/j.humpath.2013.03.009
-
(2013)
Human Pathology
, vol.44
, Issue.10
, pp. 2047-2054
-
-
Park, J.H.1
Lee, C.2
Suh, J.H.3
Chae, J.Y.4
Moon, K.C.5
-
28
-
-
84898772136
-
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension
-
10.1042/CS20130706
-
Liu G. X., Li Y. Q., Huang X. R., Wei L. H., Zhang Y., Feng M., Meng X. M., Chen H. Y., Shi Y. J., Lan H. Y., Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. Clinical Science 2014 127 3 195 208 10.1042/CS20130706
-
(2014)
Clinical Science
, vol.127
, Issue.3
, pp. 195-208
-
-
Liu, G.X.1
Li, Y.Q.2
Huang, X.R.3
Wei, L.H.4
Zhang, Y.5
Feng, M.6
Meng, X.M.7
Chen, H.Y.8
Shi, Y.J.9
Lan, H.Y.10
-
29
-
-
66249114647
-
Bone morphogenetic protein 4 inhibits TGF- β 2 stimulation of extracellular matrix proteins in optic nerve head cells: Role of gremlin in ECM modulation
-
2-s2.0-66249114647 10.1002/glia.20803
-
Zode G. S., Clark A. F., Wordinger R. J., Bone morphogenetic protein 4 inhibits TGF- β 2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation. Glia 2009 57 7 755 766 2-s2.0-66249114647 10.1002/glia.20803
-
(2009)
Glia
, vol.57
, Issue.7
, pp. 755-766
-
-
Zode, G.S.1
Clark, A.F.2
Wordinger, R.J.3
-
30
-
-
84898070133
-
IL-6 trans signalling drives a STAT3 dependant pathway that leads to hyperactive TGF- β signalling promoting SMAD3 activation and fibrosis via gremlin
-
10.1074/jbc.M113.545822
-
O'Reilly S., Ciechomska M., Cant R., van Laar J. M., IL-6 trans signalling drives a STAT3 dependant pathway that leads to hyperactive TGF- β signalling promoting SMAD3 activation and fibrosis via gremlin. The Journal of Biological Chemistry 2014 10.1074/jbc.M113.545822
-
(2014)
The Journal of Biological Chemistry
-
-
O'Reilly, S.1
Ciechomska, M.2
Cant, R.3
Van Laar, J.M.4
-
31
-
-
38849191640
-
Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis
-
2-s2.0-38849191640 10.1164/rccm.200706-945OC
-
Myllärniemi M., Lindholm P., Ryynänen M. J., Kliment C. R., Salmenkivi K., Keski-Oja J., Kinnula V. L., Oury T. D., Koli K., Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine 2008 177 3 321 329 2-s2.0-38849191640 10.1164/rccm.200706-945OC
-
(2008)
American Journal of Respiratory and Critical Care Medicine
, vol.177
, Issue.3
, pp. 321-329
-
-
Myllärniemi, M.1
Lindholm, P.2
Ryynänen, M.J.3
Kliment, C.R.4
Salmenkivi, K.5
Keski-Oja, J.6
Kinnula, V.L.7
Oury, T.D.8
Koli, K.9
-
32
-
-
84857522999
-
Gremlin plays a key role in the pathogenesis of pulmonary hypertension
-
2-s2.0-84857522999 10.1161/CIRCULATIONAHA.111.038125
-
Cahill E., Costello C. M., Rowan S. C., Harkin S., Howell K., Leonard M. O., Southwood M., Cummins E. P., Fitzpatrick S. F., Taylor C. T., Morrell N. W., Martin F., McLoughlin P., Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation 2012 125 7 920 930 2-s2.0-84857522999 10.1161/CIRCULATIONAHA.111.038125
-
(2012)
Circulation
, vol.125
, Issue.7
, pp. 920-930
-
-
Cahill, E.1
Costello, C.M.2
Rowan, S.C.3
Harkin, S.4
Howell, K.5
Leonard, M.O.6
Southwood, M.7
Cummins, E.P.8
Fitzpatrick, S.F.9
Taylor, C.T.10
Morrell, N.W.11
Martin, F.12
McLoughlin, P.13
-
33
-
-
33745203970
-
Transcriptional profiling reveals novel markers of liver fibrogenesis: Gremlin and insulin-like growth factor-binding proteins
-
2-s2.0-33745203970 10.1074/jbc.M600711200
-
Boers W., Aarrass S., Linthorst C., Pinzani M., Elferink R. O., Bosma P., Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins. The Journal of Biological Chemistry 2006 281 24 16289 16295 2-s2.0-33745203970 10.1074/jbc.M600711200
-
(2006)
The Journal of Biological Chemistry
, vol.281
, Issue.24
, pp. 16289-16295
-
-
Boers, W.1
Aarrass, S.2
Linthorst, C.3
Pinzani, M.4
Elferink, R.O.5
Bosma, P.6
-
34
-
-
77951645428
-
Role of gremlin in the lung: Development and disease
-
2-s2.0-77951645428 10.1165/rcmb.2009-0101TR
-
Costello C. M., Cahill E., Martin F., Gaine S., McLoughlin P., Role of gremlin in the lung: development and disease. American Journal of Respiratory Cell and Molecular Biology 2010 42 5 517 523 2-s2.0-77951645428 10.1165/rcmb.2009-0101TR
-
(2010)
American Journal of Respiratory Cell and Molecular Biology
, vol.42
, Issue.5
, pp. 517-523
-
-
Costello, C.M.1
Cahill, E.2
Martin, F.3
Gaine, S.4
McLoughlin, P.5
-
35
-
-
84885912356
-
Gremlin-1 identifies fibrosis and predicts adverse outcome in patients with heart failure undergoing endomyocardial biopsy
-
10.1016/j.cardfail.2013.09.001
-
Mueller K. A., Tavlaki E., Schneider M., Jorbenadze R., Geisler T., Kandolf R., Gawaz M., Mueller I. I., Zuern C. S., Gremlin-1 identifies fibrosis and predicts adverse outcome in patients with heart failure undergoing endomyocardial biopsy. Journal of Cardiac Failure 2013 19 10 678 684 10.1016/j.cardfail.2013.09.001
-
(2013)
Journal of Cardiac Failure
, vol.19
, Issue.10
, pp. 678-684
-
-
Mueller, K.A.1
Tavlaki, E.2
Schneider, M.3
Jorbenadze, R.4
Geisler, T.5
Kandolf, R.6
Gawaz, M.7
Mueller, I.I.8
Zuern, C.S.9
-
36
-
-
84873510031
-
Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway
-
10.1186/1471-2369-14-33
-
Huang H., Huang H., Li Y., Liu M., Shi Y., Chi Y., Zhang T., Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway. BMC Nephrology 2013 14, article 33 10.1186/1471-2369-14-33
-
(2013)
BMC Nephrology
, vol.1433
-
-
Huang, H.1
Huang, H.2
Li, Y.3
Liu, M.4
Shi, Y.5
Chi, Y.6
Zhang, T.7
-
37
-
-
84875024081
-
Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium
-
10.1186/1465-9921-14-36
-
McCormack N., Molloy E. L., O'Dea S., Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium. Respiratory Research 2013 14, article 36 10.1186/1465-9921-14-36
-
(2013)
Respiratory Research
, vol.1436
-
-
McCormack, N.1
Molloy, E.L.2
O'Dea, S.3
-
38
-
-
84883234440
-
Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug
-
10.1038/oncsis.2013.29
-
Tamminen J. A., Parviainen V., Rönty M., Wohl A. P., Murray L., Joenväärä S., Varjosalo M., Leppäranta O., Ritvos O., Sengle G., Renkonen R., Myllärniemi M., Koli K., Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug. Oncogenesis 2013 2, article e66 10.1038/oncsis.2013. 29
-
(2013)
Oncogenesis
, vol.266
-
-
Tamminen, J.A.1
Parviainen, V.2
Rönty, M.3
Wohl, A.P.4
Murray, L.5
Joenväärä, S.6
Varjosalo, M.7
Leppäranta, O.8
Ritvos, O.9
Sengle, G.10
Renkonen, R.11
Myllärniemi, M.12
Koli, K.13
-
39
-
-
55249103431
-
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
-
2-s2.0-55249103431 10.1681/ASN.2008050513
-
Zeisberg E. M., Potenta S. E., Sugimoto H., Zeisberg M., Kalluri R., Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. Journal of the American Society of Nephrology 2008 19 12 2282 2287 2-s2.0-55249103431 10.1681/ASN.2008050513
-
(2008)
Journal of the American Society of Nephrology
, vol.19
, Issue.12
, pp. 2282-2287
-
-
Zeisberg, E.M.1
Potenta, S.E.2
Sugimoto, H.3
Zeisberg, M.4
Kalluri, R.5
-
40
-
-
84882289111
-
Origin and function of myofibroblasts in kidney fibrosis
-
10.1038/nm.3218
-
LeBleu V. S., Taduri G., O'Connell J., Teng Y., Cooke V. G., Woda C., Sugimoto H., Kalluri R., Origin and function of myofibroblasts in kidney fibrosis. Nature Medicine 2013 19 8 1047 1053 10.1038/nm.3218
-
(2013)
Nature Medicine
, vol.19
, Issue.8
, pp. 1047-1053
-
-
Lebleu, V.S.1
Taduri, G.2
O'Connell, J.3
Teng, Y.4
Cooke, V.G.5
Woda, C.6
Sugimoto, H.7
Kalluri, R.8
-
41
-
-
33947673334
-
Cell adhesion molecules in chemically-induced renal injury
-
2-s2.0-33947673334 10.1016/j.pharmthera.2007.01.001
-
Prozialeck W. C., Edwards J. R., Cell adhesion molecules in chemically-induced renal injury. Pharmacology & Therapeutics 2007 114 1 74 93 2-s2.0-33947673334 10.1016/j.pharmthera.2007.01.001
-
(2007)
Pharmacology & Therapeutics
, vol.114
, Issue.1
, pp. 74-93
-
-
Prozialeck, W.C.1
Edwards, J.R.2
-
42
-
-
0038717407
-
BMP-7 counteracts TGF- β 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
-
2-s2.0-0038717407 10.1038/nm888
-
Zeisberg M., Hanai J., Sugimoto H., Mammoto T., Charytan D., Strutz F., Kalluri R., BMP-7 counteracts TGF- β 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nature Medicine 2003 9 7 964 968 2-s2.0-0038717407 10.1038/nm888
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 964-968
-
-
Zeisberg, M.1
Hanai, J.2
Sugimoto, H.3
Mammoto, T.4
Charytan, D.5
Strutz, F.6
Kalluri, R.7
-
43
-
-
84860418956
-
BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition
-
2-s2.0-84860418956 10.1002/jcb.23180
-
Yang Y.-L., Ju H.-Z., Liu S.-F., Lee T.-C., Shih Y.-W., Chuang L.-Y., Guh J.-Y., Yang Y.-Y., Liao T.-N., Hung T.-J., Hung M.-Y., BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition. Journal of Cellular Biochemistry 2011 112 9 2558 2565 2-s2.0-84860418956 10.1002/jcb.23180
-
(2011)
Journal of Cellular Biochemistry
, vol.112
, Issue.9
, pp. 2558-2565
-
-
Yang, Y.-L.1
Ju, H.-Z.2
Liu, S.-F.3
Lee, T.-C.4
Shih, Y.-W.5
Chuang, L.-Y.6
Guh, J.-Y.7
Yang, Y.-Y.8
Liao, T.-N.9
Hung, T.-J.10
Hung, M.-Y.11
-
44
-
-
34047268565
-
Effects of TGF- β 2, BMP-4, and gremlin in the trabecular meshwork: Implications for glaucoma
-
2-s2.0-34047268565 10.1167/iovs.06-0296
-
Wordinger R. J., Fleenor D. L., Hellberg P. E., Pang I.-H., Tovar T. O., Zode G. S., Fuller J. A., Clark A. F., Effects of TGF- β 2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Investigative Ophthalmology & Visual Science 2007 48 3 1191 1200 2-s2.0-34047268565 10.1167/iovs.06-0296
-
(2007)
Investigative Ophthalmology & Visual Science
, vol.48
, Issue.3
, pp. 1191-1200
-
-
Wordinger, R.J.1
Fleenor, D.L.2
Hellberg, P.E.3
Pang, I.-H.4
Tovar, T.O.5
Zode, G.S.6
Fuller, J.A.7
Clark, A.F.8
-
45
-
-
0036346678
-
Drm/Gremlin transcriptionally activates p21Cip1 via a novel mechanism and inhibits neoplastic transformation
-
2-s2.0-0036346678 10.1016/S0006-291X(02)00828-8
-
Chen B., Athanasiou M., Gu Q., Blair D. G., Drm/Gremlin transcriptionally activates p21Cip1 via a novel mechanism and inhibits neoplastic transformation. Biochemical and Biophysical Research Communications 2002 295 5 1135 1141 2-s2.0-0036346678 10.1016/S0006-291X(02)00828-8
-
(2002)
Biochemical and Biophysical Research Communications
, vol.295
, Issue.5
, pp. 1135-1141
-
-
Chen, B.1
Athanasiou, M.2
Gu, Q.3
Blair, D.G.4
-
46
-
-
78149300188
-
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
-
Mitola S., Ravelli C., Moroni E., Salvi V., Leali D., Ballmer-Hofer K., Zammataro L., Presta M., Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 2010 116 18 3677 3680 2-s2.0-78149300188 10.1182/blood-2010-06-291930
-
(2010)
Blood
, vol.116
, Issue.18
, pp. 3677-3680
-
-
Mitola, S.1
Ravelli, C.2
Moroni, E.3
Salvi, V.4
Leali, D.5
Ballmer-Hofer, K.6
Zammataro, L.7
Presta, M.8
|