Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis

Journal of the American Society of Nephrology

Volumn 24, Issue 9, 2013, Pages 1387-1398

  Wei, Xiaofan ^a   Xia, Yang ^b   Li, Feng ^b   Tang, Yan ^b   Nie, Jing ^a   Liu, Youhua ^a   Zhou, Zhanmei ^a   Zhang, Hongquan ^b   Hou, Fan Fan ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BINDING PROTEIN; INTEGRIN BINDING PROTEIN; KINDLIN 2; MESSENGER RNA; MUTANT PROTEIN; SMAD PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY TUBULE EPITHELIUM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUBULOINTERSTITIAL FIBROSIS; WESTERN BLOTTING;

EID: 84884343430     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012101041     Document Type: Article

References (52)

1. ZeisbergM, Neilson EG:Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010
2. Nangaku M: Mechanisms of tubulointerstitial injury in the kidney: Final common pathways to end-stage renal failure. Intern Med 43: 9-17, 2004
3. Liu Y: Cellular and molecular mechanisms of renal fibrosis Nat Rev Nephrol 7: 684-696, 2011
4. Boor P, Ostendorf T, Floege J: Renal fibrosis: Novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 6: 643-656, 2010
5. Okada H, Kalluri R: Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis. Curr Mol Med 5: 467-474, 2005
6. Border WA, Noble NA: TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int 51: 1388-1396, 1997
7. Böttinger EP, Bitzer M: TGF-beta signaling in renal disease. J Am Soc Nephrol 13: 2600-2610, 2002
8. Wang W, Koka V, Lan HY: Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) 10: 48-56, 2005
9. Schmierer B, Hill CS: TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8: 970-982, 2007
10. García-Sánchez O, López-Hernández FJ, López-Novoa JM: An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease. Kidney Int 77: 950-955, 2010
11. Heldin CH, Miyazono K, ten Dijke P: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471, 1997
12. Massagué J: TGF-beta signal transduction.Annu Rev Biochem67: 753-791, 1998
13. Runyan CE, Schnaper HW, Poncelet AC: The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1.JBiol Chem 279: 2632-2639, 2004
14. Hu B, Wu Z, Phan SH: Smad3 mediates transforming growth factorbeta-induced alpha-smooth muscle actin expression. Am J Respir Cell Mol Biol 29: 397-404, 2003
15. Peinado H, Quintanilla M, Cano A: Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines:Mechanisms for epithelial mesenchymal transitions. J Biol Chem 278: 21113-21123, 2003
16. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95: 779-791, 1998
17. Mishra L, Marshall B: Adaptor proteins and ubiquinators in TGF-beta signaling. Cytokine Growth Factor Rev 17: 75-87, 2006
18. Meves A, Stremmel C, Gottschalk K, Fässler R: The Kindlin protein family: New members to the club of focal adhesion proteins. Trends Cell Biol 19: 504-513, 2009
19. Lai-Cheong JE, Parsons M, McGrath JA: The role of kindlins in cell biology and relevance to human disease. Int J BiochemCell Biol 42: 595-603, 2010
20. Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R: Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22: 1325-1330, 2008
21. Larjava H, Plow EF, Wu C: Kindlins: Essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep 9: 1203-1208, 2008
22. Moser M, Legate KR, Zent R, Fässler R: The tail of integrins, talin, and kindlins. Science 324: 895-899, 2009
23. Qu H, Tu Y, Shi X, Larjava H, Saleem MA, Shattil SJ, Fukuda K, Qin J, Kretzler M, Wu C: Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci 124: 879-891, 2011
24. Ussar S, Wang HV, Linder S, Fässler R, Moser M: The Kindlins: Subcellular localization and expression during murine development. Exp Cell Res 312: 3142-3151, 2006
25. Furuhashi M, Yagi K, Yamamoto H, Furukawa Y, Shimada S, Nakamura Y, Kikuchi A, Miyazono K, Kato M: Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol Cell Biol 21: 5132-5141, 2001
26. Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y, Fang W, Zhu WG, Zhang H: Kindlin 2 forms a transcriptional complex with b-catenin and TCF4 to enhance Wnt signalling. EMBO Rep 13: 750-758, 2012
27. Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, Saika S, Flanders KC: Smad3 is key to TGF-beta-mediated epithelial-tomesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev 17: 19-27, 2006
28. Flanders KC: Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 85: 47-64, 2004
29. Yeh YC, Wei WC, Wang YK, Lin SC, Sung JM, Tang MJ: Transforming growth factor-beta1 induces Smad3-dependent beta1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol 177: 1743-1754, 2010
30. Harburger DS, BouaouinaM, Calderwood DA: Kindlin-1 and-2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem 284: 11485-11497, 2009
31. Chevalier RL, Forbes MS, Thornhill BA: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 75: 1145-1152, 2009
32. Leask A, Abraham DJ: TGF-beta signaling and the fibrotic response. FASEB J 18: 816-827, 2004
33. Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L: Disruption of transforming growth factor-beta signaling in ELF beta-spectrindeficient mice. Science 299: 574-577, 2003
34. RazzaqueMS, Taguchi T: Cellular and molecular events leading to renal tubulointerstitial fibrosis. Med Electron Microsc 35: 68-80, 2002
35. Christensen EI, Verroust PJ: Interstitial fibrosis: Tubular hypothesis versus glomerular hypothesis. Kidney Int 74: 1233-1236, 2008
36. Tamaki K, Okuda S: Role of TGF-beta in the progression of renal fibrosis. Contrib Nephrol 139: 44-65, 2003
37. Zeisberg M, Neilson EG: Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437, 2009
38. Gong X, An Z,Wang Y,Guan L, FangW, Strömblad S, Jiang Y, Zhang H: Kindlin-2 controls sensitivity of prostate cancer cells to cisplatininduced cell death. Cancer Lett 299: 54-62, 2010
39. Shi X,Ma YQ, Tu Y, Chen K,Wu S, Fukuda K, Qin J, Plow EF,Wu C: The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem 282: 20455-20466, 2007
40. Li Y, Yang J, Dai C, Wu C, Liu Y: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112: 503-516, 2003
41. An Z, Dobra K, Lock JG, Strömblad S, Hjerpe A, Zhang H: Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Int J Cancer 127: 1999-2008, 2010
42. Zhang H, Berg JS, Li Z, Wang Y, Lång P, Sousa AD, Bhaskar A, Cheney RE, Strömblad S: Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat Cell Biol 6: 523-531, 2004
43. Hamdane M, Bretteville A, Sambo AV, Schindowski K, Bégard S, Delacourte A, Bertrand P, Buée L: p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death. J Cell Sci 118: 1291-1298, 2005
44. Li Y, Cao H, Jiao Z, Pakala SB, Sirigiri DN, Li W, Kumar R, Mishra L: Carcinoembryonic antigen interacts with TGF-beta receptor and inhibits TGF-beta signaling in colorectal cancers. Cancer Res 70: 8159-8168, 2010
45. Yang J, Dai C, Liu Y: Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol 13: 2464-2477, 2002
46. Oda T, Jung YO, Kim HS, Cai X, López-Guisa JM, Ikeda Y, Eddy AA: PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int 60: 587-596, 2001
47. Hamar P, Song E, Kökény G, Chen A, Ouyang N, Lieberman J: Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A 101: 14883-14888, 2004
48. Modlinger P, Chabrashvili T, Gill PS, Mendonca M, Harrison DG, Griendling KK, Li M, Raggio J, Wellstein A, Chen Y, Welch WJ, Wilcox CS: RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension 47: 238-244, 2006
49. Verma UN, Surabhi RM, Schmaltieg A, Becerra C, Gaynor RB: Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 9: 1291-1300, 2003
50. Yoo KH, Thornhill BA, Forbes MS, Coleman CM, Marcinko ES, Liaw L, Chevalier RL: Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. Kidney Int 70: 1735-1741, 2006
51. Wang L, Lyerla T: Histochemical and cellular changes accompanying the appearance of lung fibrosis in an experimental mouse model for Hermansky Pudlak syndrome. Histochem Cell Biol 134: 205-213, 2010
52. Li HY, Hou FF, Zhang X, Chen PY, Liu SX, Feng JX, Liu ZQ, Shan YX, Wang GB, Zhou ZM, Tian JW, Xie D: Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model. J AmSoc Nephrol 18: 528-538, 2007