Smad pathway is activated in the diabetic mouse kidney and smad3 mediates TGF-β-induced fibronectin in mesangial cells

Biochemical and Biophysical Research Communications

Volumn 296, Issue 5, 2002, Pages 1356-1365

  Isono, Motohide ^a   Chen, Sheldon ^a   Won Hong, Soon ^a   Carmen Iglesias de la Cruz, M ^a   Ziyadeh, Fuad N ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Diabetic nephropathies; Extracellular matrix; Kidney glomerulus; Smad7; Streptozotocin

Indexed keywords

FIBRONECTIN; GLUCOSE; INSULIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GLOMERULUS; HYPERGLYCEMIA; IMMUNOBLOTTING; KIDNEY TUBULE; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SOUTHWESTERN BLOTTING; STREPTOZOCIN DIABETES;

ANIMALS; BLOTTING, SOUTHWESTERN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA-BINDING PROTEINS; FEMALE; FIBRONECTINS; GLOMERULAR MESANGIUM; GLUCOSE; KIDNEY; KINETICS; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

GLOMERULUS; VECTORS;

EID: 0036387022     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02084-3     Document Type: Article

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