Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets

British Journal of Pharmacology

Volumn 171, Issue 13, 2014, Pages 3246-3254

  Liu, Limei ^a   Liu, Jian ^b   Gao, Yuansheng ^a   Yu, Xiaoxing ^a   Xu, Gang ^c   Huang, Yu ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

berberine; INS 1E cells; insulin secretion; islets; oxidative stress; uncoupling protein 2

Indexed keywords

3 NITROTYROSINE; BERBERINE; COPPER ZINC SUPEROXIDE DISMUTASE; GENIPIN; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ION CHANNEL; IRIDOID; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ANTAGONISM; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULINOMA; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CONFOCAL MICROSCOPY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MITOCHONDRION; PANCREAS ISLET; PANCREAS TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BERBERINE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; INSULIN; INSULINOMA; ION CHANNELS; IRIDOIDS; ISLETS OF LANGERHANS; MALE; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84902208521     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12666     Document Type: Article

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