메뉴 건너뛰기




Volumn 1830, Issue 3, 2013, Pages 2583-2590

Metabolomic analysis of pancreatic beta cells following exposure to high glucose

Author keywords

Glucotoxicity; Insulin secretion; Metabolomics

Indexed keywords

AMINO ACID; CALCIUM; GLUCOSE; GLUTATHIONE; INSULIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHORYLCHOLINE; PYRUVATE DEHYDROGENASE KINASE 2;

EID: 84872803257     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.10.025     Document Type: Article
Times cited : (28)

References (58)
  • 1
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • M. Stumvoll, B.J. Goldstein, and T.W. van Haeften Type 2 diabetes: principles of pathogenesis and therapy Lancet 365 2005 1333 1346
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 2
    • 0033046539 scopus 로고    scopus 로고
    • Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels
    • I. Briaud, C. Rouault, G. Reach, and V. Poitout Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels Metabolism 48 1999 319 323
    • (1999) Metabolism , vol.48 , pp. 319-323
    • Briaud, I.1    Rouault, C.2    Reach, G.3    Poitout, V.4
  • 3
    • 0026757632 scopus 로고
    • Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
    • R.P. Robertson, H.J. Zhang, K.L. Pyzdrowski, and T.F. Walseth Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations J. Clin. Invest. 90 1992 320 325
    • (1992) J. Clin. Invest. , vol.90 , pp. 320-325
    • Robertson, R.P.1    Zhang, H.J.2    Pyzdrowski, K.L.3    Walseth, T.F.4
  • 4
    • 0032230172 scopus 로고    scopus 로고
    • Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity
    • L.K. Olson, J. Qian, and V. Poitout Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity Mol. Endocrinol. (Baltimore, Md.) 12 1998 207 219
    • (1998) Mol. Endocrinol. (Baltimore, Md.) , vol.12 , pp. 207-219
    • Olson, L.K.1    Qian, J.2    Poitout, V.3
  • 6
    • 0036724133 scopus 로고    scopus 로고
    • Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition
    • G. Patane, M. Anello, S. Piro, R. Vigneri, F. Purrello, and A.M. Rabuazzo Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition Diabetes 51 2002 2749 2756
    • (2002) Diabetes , vol.51 , pp. 2749-2756
    • Patane, G.1    Anello, M.2    Piro, S.3    Vigneri, R.4    Purrello, F.5    Rabuazzo, A.M.6
  • 8
    • 2542453754 scopus 로고    scopus 로고
    • Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
    • F. Andreozzi, C. D'Alessandris, M. Federici, E. Laratta, S. Del Guerra, S. Del Prato, P. Marchetti, R. Lauro, F. Perticone, and G. Sesti Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells Endocrinology 145 2004 2845 2857
    • (2004) Endocrinology , vol.145 , pp. 2845-2857
    • Andreozzi, F.1    D'Alessandris, C.2    Federici, M.3    Laratta, E.4    Del Guerra, S.5    Del Prato, S.6    Marchetti, P.7    Lauro, R.8    Perticone, F.9    Sesti, G.10
  • 9
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • R.P. Robertson, J. Harmon, P.O. Tran, Y. Tanaka, and H. Takahashi Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection Diabetes 52 2003 581 587
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 10
    • 0031025828 scopus 로고    scopus 로고
    • Long-term effects of aminoguanidine on insulin release and biosynthesis: Evidence that the formation of advanced glycosylation end products inhibits B cell function
    • Y. Tajiri, C. Moller, and V. Grill Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function Endocrinology 138 1997 273 280
    • (1997) Endocrinology , vol.138 , pp. 273-280
    • Tajiri, Y.1    Moller, C.2    Grill, V.3
  • 12
    • 0037125997 scopus 로고    scopus 로고
    • A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    • Y. Tanaka, P.O. Tran, J. Harmon, and R.P. Robertson A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity Proc. Natl. Acad. Sci. U. S. A. 99 2002 12363 12368
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 12363-12368
    • Tanaka, Y.1    Tran, P.O.2    Harmon, J.3    Robertson, R.P.4
  • 13
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and beta-cell dysfunction
    • V. Poitout, and R.P. Robertson Glucolipotoxicity: fuel excess and beta-cell dysfunction Endocr. Rev. 29 2008 351 366
    • (2008) Endocr. Rev. , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 16
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • R.P. Robertson, J. Harmon, P.O. Tran, and V. Poitout Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes Diabetes 53 Suppl. 1 2004 S119 S124
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 17
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • K. Grankvist, S.L. Marklund, and I.B. Taljedal CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse Biochem. J. 199 1981 393 398
    • (1981) Biochem. J. , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Taljedal, I.B.3
  • 18
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
    • N. Welsh, B. Margulis, L.A. Borg, H.J. Wiklund, J. Saldeen, M. Flodstrom, M.A. Mello, A. Andersson, D.G. Pipeleers, and C. Hellerstrom Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus Mol. Med. 1 1995 806 820
    • (1995) Mol. Med. , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.3    Wiklund, H.J.4    Saldeen, J.5    Flodstrom, M.6    Mello, M.A.7    Andersson, A.8    Pipeleers, D.G.9    Hellerstrom, C.10
  • 19
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • M. Tiedge, S. Lortz, J. Drinkgern, and S. Lenzen Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells Diabetes 46 1997 1733 1742
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 20
    • 77949310048 scopus 로고    scopus 로고
    • Metabolite profiling of blood plasma of patients with prostate cancer
    • P. Lokhov, M. Dashtiev, S. Moshkovskii, and A. Archakov Metabolite profiling of blood plasma of patients with prostate cancer Metabolomics 6 2010 156 163
    • (2010) Metabolomics , vol.6 , pp. 156-163
    • Lokhov, P.1    Dashtiev, M.2    Moshkovskii, S.3    Archakov, A.4
  • 22
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
    • E.C. Chan, P.K. Koh, M. Mal, P.Y. Cheah, K.W. Eu, A. Backshall, R. Cavill, J.K. Nicholson, and H.C. Keun Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS) J. Proteome Res. 8 2009 352 361
    • (2009) J. Proteome Res. , vol.8 , pp. 352-361
    • Chan, E.C.1    Koh, P.K.2    Mal, M.3    Cheah, P.Y.4    Eu, K.W.5    Backshall, A.6    Cavill, R.7    Nicholson, J.K.8    Keun, H.C.9
  • 26
    • 79952821873 scopus 로고    scopus 로고
    • Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines
    • P. Spegel, S. Malmgren, V.V. Sharoyko, P. Newsholme, T. Koeck, and H. Mulder Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines Biochem. J. 2011
    • (2011) Biochem. J.
    • Spegel, P.1    Malmgren, S.2    Sharoyko, V.V.3    Newsholme, P.4    Koeck, T.5    Mulder, H.6
  • 30
    • 0842291578 scopus 로고    scopus 로고
    • Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells
    • A. Merglen, S. Theander, B. Rubi, G. Chaffard, C.B. Wollheim, and P. Maechler Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Endocrinology 145 2004 667 678
    • (2004) Endocrinology , vol.145 , pp. 667-678
    • Merglen, A.1    Theander, S.2    Rubi, B.3    Chaffard, G.4    Wollheim, C.B.5    Maechler, P.6
  • 31
    • 33750558924 scopus 로고    scopus 로고
    • Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism
    • L. Brennan, C. Hewage, J.P. Malthouse, N.H. McClenaghan, P.R. Flatt, and P. Newsholme Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism FEBS J. 273 2006 5160 5168
    • (2006) FEBS J. , vol.273 , pp. 5160-5168
    • Brennan, L.1    Hewage, C.2    Malthouse, J.P.3    McClenaghan, N.H.4    Flatt, P.R.5    Newsholme, P.6
  • 33
    • 44749087535 scopus 로고    scopus 로고
    • Effects of homocysteine on metabolic pathways in cultured astrocytes
    • Y. Jin, and L. Brennan Effects of homocysteine on metabolic pathways in cultured astrocytes Neurochem. Int. 52 2008 1410 1415
    • (2008) Neurochem. Int. , vol.52 , pp. 1410-1415
    • Jin, Y.1    Brennan, L.2
  • 35
    • 77349105487 scopus 로고    scopus 로고
    • Independent evaluation of a commercial deconvolution reporting software for gas chromatography mass spectrometry analysis of pesticide residues in fruits and vegetables
    • H.R. Norli, A. Christiansen, and B. Holen Independent evaluation of a commercial deconvolution reporting software for gas chromatography mass spectrometry analysis of pesticide residues in fruits and vegetables J. Chromatogr. A 1217 2010 2056 2064
    • (2010) J. Chromatogr. A , vol.1217 , pp. 2056-2064
    • Norli, H.R.1    Christiansen, A.2    Holen, B.3
  • 36
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • J.C. Henquin Triggering and amplifying pathways of regulation of insulin secretion by glucose Diabetes 49 2000 1751 1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 37
    • 70350331458 scopus 로고    scopus 로고
    • Shortcomings of current models of glucose-induced insulin secretion
    • J.C. Henquin, M. Nenquin, M.A. Ravier, and A. Szollosi Shortcomings of current models of glucose-induced insulin secretion Diabetes Obes. Metab. 11 Suppl. 4 2009 168 179
    • (2009) Diabetes Obes. Metab. , vol.11 , Issue.SUPPL. 4 , pp. 168-179
    • Henquin, J.C.1    Nenquin, M.2    Ravier, M.A.3    Szollosi, A.4
  • 39
    • 33644872401 scopus 로고    scopus 로고
    • In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
    • P. Maechler, S. Carobbio, and B. Rubi In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion Int. J. Biochem. Cell Biol. 38 2006 696 709
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 696-709
    • Maechler, P.1    Carobbio, S.2    Rubi, B.3
  • 40
    • 24144490962 scopus 로고    scopus 로고
    • Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic beta-cells
    • W.H. Kim, J.W. Lee, Y.H. Suh, S.H. Hong, J.S. Choi, J.H. Lim, J.H. Song, B. Gao, and M.H. Jung Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells Diabetes 54 2005 2602 2611
    • (2005) Diabetes , vol.54 , pp. 2602-2611
    • Kim, W.H.1    Lee, J.W.2    Suh, Y.H.3    Hong, S.H.4    Choi, J.S.5    Lim, J.H.6    Song, J.H.7    Gao, B.8    Jung, M.H.9
  • 42
    • 1542379983 scopus 로고    scopus 로고
    • Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: Prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle
    • Y.Q. Liu, J.A. Moibi, and J.L. Leahy Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle J. Biol. Chem. 279 2004 7470 7475
    • (2004) J. Biol. Chem. , vol.279 , pp. 7470-7475
    • Liu, Y.Q.1    Moibi, J.A.2    Leahy, J.L.3
  • 43
    • 33646137142 scopus 로고    scopus 로고
    • Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets
    • J. Xu, J. Han, P.N. Epstein, and Y.Q. Liu Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets Biochem. Biophys. Res. Commun. 344 2006 827 833
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 827-833
    • Xu, J.1    Han, J.2    Epstein, P.N.3    Liu, Y.Q.4
  • 44
    • 0029122615 scopus 로고
    • Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats
    • Y.P. Zhou, C.G. Ostenson, Z.C. Ling, and V. Grill Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats Endocrinology 136 1995 3546 3551
    • (1995) Endocrinology , vol.136 , pp. 3546-3551
    • Zhou, Y.P.1    Ostenson, C.G.2    Ling, Z.C.3    Grill, V.4
  • 46
    • 64249112098 scopus 로고    scopus 로고
    • Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets
    • J. Pizarro-Delgado, I. Hernandez-Fisac, R. Martin-Del-Rio, and J. Tamarit-Rodriguez Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets Biochem. J. 419 2009 359 368
    • (2009) Biochem. J. , vol.419 , pp. 359-368
    • Pizarro-Delgado, J.1    Hernandez-Fisac, I.2    Martin-Del-Rio, R.3    Tamarit-Rodriguez, J.4
  • 49
    • 44649192430 scopus 로고    scopus 로고
    • Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids
    • H.K. Nyblom, L.I. Nord, R. Andersson, L. Kenne, and P. Bergsten Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids NMR Biomed. 21 2008 357 365
    • (2008) NMR Biomed. , vol.21 , pp. 357-365
    • Nyblom, H.K.1    Nord, L.I.2    Andersson, R.3    Kenne, L.4    Bergsten, P.5
  • 50
    • 73549091684 scopus 로고    scopus 로고
    • Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells
    • Y. Coute, Y. Brunner, D. Schvartz, C. Hernandez, A. Masselot, F. Lisacek, C.B. Wollheim, and J.C. Sanchez Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells Proteomics 10 2010 59 71
    • (2010) Proteomics , vol.10 , pp. 59-71
    • Coute, Y.1    Brunner, Y.2    Schvartz, D.3    Hernandez, C.4    Masselot, A.5    Lisacek, F.6    Wollheim, C.B.7    Sanchez, J.C.8
  • 51
    • 77449141236 scopus 로고    scopus 로고
    • Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death
    • D. Wei, J. Li, M. Shen, W. Jia, N. Chen, T. Chen, D. Su, H. Tian, S. Zheng, Y. Dai, and A. Zhao Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death Diabetes 59 2010 471 478
    • (2010) Diabetes , vol.59 , pp. 471-478
    • Wei, D.1    Li, J.2    Shen, M.3    Jia, W.4    Chen, N.5    Chen, T.6    Su, D.7    Tian, H.8    Zheng, S.9    Dai, Y.10    Zhao, A.11
  • 52
    • 0026508490 scopus 로고
    • Arachidonic acid-induced insulin secretion from rat islets of Langerhans
    • A.M. Band, P.M. Jones, and S.L. Howell Arachidonic acid-induced insulin secretion from rat islets of Langerhans J. Mol. Endocrinol. 8 1992 95 101
    • (1992) J. Mol. Endocrinol. , vol.8 , pp. 95-101
    • Band, A.M.1    Jones, P.M.2    Howell, S.L.3
  • 54
    • 53849093415 scopus 로고    scopus 로고
    • Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells
    • D. Keane, and P. Newsholme Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells Biochem. Soc. Trans. 36 2008 955 958
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 955-958
    • Keane, D.1    Newsholme, P.2
  • 55
    • 1242284388 scopus 로고    scopus 로고
    • Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity
    • G. Dixon, J. Nolan, N.H. McClenaghan, P.R. Flatt, and P. Newsholme Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity Clin. Sci. (Lond) 106 2004 191 199
    • (2004) Clin. Sci. (Lond) , vol.106 , pp. 191-199
    • Dixon, G.1    Nolan, J.2    McClenaghan, N.H.3    Flatt, P.R.4    Newsholme, P.5
  • 56
    • 84861325113 scopus 로고    scopus 로고
    • Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion
    • E. Gurgul-Convey, K. Hanzelka, and S. Lenzen Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion Endocrinology 153 2012 2612 2622
    • (2012) Endocrinology , vol.153 , pp. 2612-2622
    • Gurgul-Convey, E.1    Hanzelka, K.2    Lenzen, S.3
  • 57
    • 33744474156 scopus 로고    scopus 로고
    • Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells
    • T. Tsuboi, M.A. Ravier, L.E. Parton, and G.A. Rutter Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells Diabetes 55 2006 1057 1065
    • (2006) Diabetes , vol.55 , pp. 1057-1065
    • Tsuboi, T.1    Ravier, M.A.2    Parton, L.E.3    Rutter, G.A.4
  • 58
    • 58249094871 scopus 로고    scopus 로고
    • Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol
    • J. Vikman, J. Jimenez-Feltstrom, P. Nyman, J. Thelin, and L. Eliasson Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol FASEB J. 23 2009 58 67
    • (2009) FASEB J. , vol.23 , pp. 58-67
    • Vikman, J.1    Jimenez-Feltstrom, J.2    Nyman, P.3    Thelin, J.4    Eliasson, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.