-
1
-
-
17044386953
-
Type 2 diabetes: Principles of pathogenesis and therapy
-
M. Stumvoll, B.J. Goldstein, and T.W. van Haeften Type 2 diabetes: principles of pathogenesis and therapy Lancet 365 2005 1333 1346
-
(2005)
Lancet
, vol.365
, pp. 1333-1346
-
-
Stumvoll, M.1
Goldstein, B.J.2
Van Haeften, T.W.3
-
2
-
-
0033046539
-
Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels
-
I. Briaud, C. Rouault, G. Reach, and V. Poitout Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels Metabolism 48 1999 319 323
-
(1999)
Metabolism
, vol.48
, pp. 319-323
-
-
Briaud, I.1
Rouault, C.2
Reach, G.3
Poitout, V.4
-
3
-
-
0026757632
-
Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
-
R.P. Robertson, H.J. Zhang, K.L. Pyzdrowski, and T.F. Walseth Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations J. Clin. Invest. 90 1992 320 325
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 320-325
-
-
Robertson, R.P.1
Zhang, H.J.2
Pyzdrowski, K.L.3
Walseth, T.F.4
-
4
-
-
0032230172
-
Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity
-
L.K. Olson, J. Qian, and V. Poitout Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity Mol. Endocrinol. (Baltimore, Md.) 12 1998 207 219
-
(1998)
Mol. Endocrinol. (Baltimore, Md.)
, vol.12
, pp. 207-219
-
-
Olson, L.K.1
Qian, J.2
Poitout, V.3
-
5
-
-
33947373424
-
Glucotoxicity inhibits late steps of insulin exocytosis
-
M. Dubois, P. Vacher, B. Roger, D. Huyghe, B. Vandewalle, J. Kerr-Conte, F. Pattou, N. Moustaid-Moussa, and J. Lang Glucotoxicity inhibits late steps of insulin exocytosis Endocrinology 148 2007 1605 1614
-
(2007)
Endocrinology
, vol.148
, pp. 1605-1614
-
-
Dubois, M.1
Vacher, P.2
Roger, B.3
Huyghe, D.4
Vandewalle, B.5
Kerr-Conte, J.6
Pattou, F.7
Moustaid-Moussa, N.8
Lang, J.9
-
6
-
-
0036724133
-
Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition
-
G. Patane, M. Anello, S. Piro, R. Vigneri, F. Purrello, and A.M. Rabuazzo Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition Diabetes 51 2002 2749 2756
-
(2002)
Diabetes
, vol.51
, pp. 2749-2756
-
-
Patane, G.1
Anello, M.2
Piro, S.3
Vigneri, R.4
Purrello, F.5
Rabuazzo, A.M.6
-
7
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
P. Marchetti, M. Bugliani, R. Lupi, L. Marselli, M. Masini, U. Boggi, F. Filipponi, G.C. Weir, D.L. Eizirik, and M. Cnop The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients Diabetologia 50 2007 2486 2494
-
(2007)
Diabetologia
, vol.50
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliani, M.2
Lupi, R.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Filipponi, F.7
Weir, G.C.8
Eizirik, D.L.9
Cnop, M.10
-
8
-
-
2542453754
-
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
-
F. Andreozzi, C. D'Alessandris, M. Federici, E. Laratta, S. Del Guerra, S. Del Prato, P. Marchetti, R. Lauro, F. Perticone, and G. Sesti Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells Endocrinology 145 2004 2845 2857
-
(2004)
Endocrinology
, vol.145
, pp. 2845-2857
-
-
Andreozzi, F.1
D'Alessandris, C.2
Federici, M.3
Laratta, E.4
Del Guerra, S.5
Del Prato, S.6
Marchetti, P.7
Lauro, R.8
Perticone, F.9
Sesti, G.10
-
9
-
-
0037341238
-
Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
-
R.P. Robertson, J. Harmon, P.O. Tran, Y. Tanaka, and H. Takahashi Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection Diabetes 52 2003 581 587
-
(2003)
Diabetes
, vol.52
, pp. 581-587
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Tanaka, Y.4
Takahashi, H.5
-
10
-
-
0031025828
-
Long-term effects of aminoguanidine on insulin release and biosynthesis: Evidence that the formation of advanced glycosylation end products inhibits B cell function
-
Y. Tajiri, C. Moller, and V. Grill Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function Endocrinology 138 1997 273 280
-
(1997)
Endocrinology
, vol.138
, pp. 273-280
-
-
Tajiri, Y.1
Moller, C.2
Grill, V.3
-
11
-
-
0032863183
-
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
-
Y. Tanaka, C.E. Gleason, P.O. Tran, J.S. Harmon, and R.P. Robertson Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants Proc. Natl. Acad. Sci. U. S. A. 96 1999 10857 10862
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 10857-10862
-
-
Tanaka, Y.1
Gleason, C.E.2
Tran, P.O.3
Harmon, J.S.4
Robertson, R.P.5
-
12
-
-
0037125997
-
A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
-
Y. Tanaka, P.O. Tran, J. Harmon, and R.P. Robertson A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity Proc. Natl. Acad. Sci. U. S. A. 99 2002 12363 12368
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 12363-12368
-
-
Tanaka, Y.1
Tran, P.O.2
Harmon, J.3
Robertson, R.P.4
-
13
-
-
43549108142
-
Glucolipotoxicity: Fuel excess and beta-cell dysfunction
-
V. Poitout, and R.P. Robertson Glucolipotoxicity: fuel excess and beta-cell dysfunction Endocr. Rev. 29 2008 351 366
-
(2008)
Endocr. Rev.
, vol.29
, pp. 351-366
-
-
Poitout, V.1
Robertson, R.P.2
-
14
-
-
20044390365
-
Functional and molecular defects of pancreatic islets in human type 2 diabetes
-
S. Del Guerra, R. Lupi, L. Marselli, M. Masini, M. Bugliani, S. Sbrana, S. Torri, M. Pollera, U. Boggi, F. Mosca, S. Del Prato, and P. Marchetti Functional and molecular defects of pancreatic islets in human type 2 diabetes Diabetes 54 2005 727 735
-
(2005)
Diabetes
, vol.54
, pp. 727-735
-
-
Del Guerra, S.1
Lupi, R.2
Marselli, L.3
Masini, M.4
Bugliani, M.5
Sbrana, S.6
Torri, S.7
Pollera, M.8
Boggi, U.9
Mosca, F.10
Del Prato, S.11
Marchetti, P.12
-
15
-
-
0037228626
-
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells
-
K. Sakai, K. Matsumoto, T. Nishikawa, M. Suefuji, K. Nakamaru, Y. Hirashima, J. Kawashima, T. Shirotani, K. Ichinose, M. Brownlee, and E. Araki Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells Biochem. Biophys. Res. Commun. 300 2003 216 222
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, pp. 216-222
-
-
Sakai, K.1
Matsumoto, K.2
Nishikawa, T.3
Suefuji, M.4
Nakamaru, K.5
Hirashima, Y.6
Kawashima, J.7
Shirotani, T.8
Ichinose, K.9
Brownlee, M.10
Araki, E.11
-
16
-
-
0842284799
-
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
-
R.P. Robertson, J. Harmon, P.O. Tran, and V. Poitout Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes Diabetes 53 Suppl. 1 2004 S119 S124
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 1
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Poitout, V.4
-
17
-
-
0019852821
-
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
-
K. Grankvist, S.L. Marklund, and I.B. Taljedal CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse Biochem. J. 199 1981 393 398
-
(1981)
Biochem. J.
, vol.199
, pp. 393-398
-
-
Grankvist, K.1
Marklund, S.L.2
Taljedal, I.B.3
-
18
-
-
0029401861
-
Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
-
N. Welsh, B. Margulis, L.A. Borg, H.J. Wiklund, J. Saldeen, M. Flodstrom, M.A. Mello, A. Andersson, D.G. Pipeleers, and C. Hellerstrom Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus Mol. Med. 1 1995 806 820
-
(1995)
Mol. Med.
, vol.1
, pp. 806-820
-
-
Welsh, N.1
Margulis, B.2
Borg, L.A.3
Wiklund, H.J.4
Saldeen, J.5
Flodstrom, M.6
Mello, M.A.7
Andersson, A.8
Pipeleers, D.G.9
Hellerstrom, C.10
-
19
-
-
0030689041
-
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
-
M. Tiedge, S. Lortz, J. Drinkgern, and S. Lenzen Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells Diabetes 46 1997 1733 1742
-
(1997)
Diabetes
, vol.46
, pp. 1733-1742
-
-
Tiedge, M.1
Lortz, S.2
Drinkgern, J.3
Lenzen, S.4
-
20
-
-
77949310048
-
Metabolite profiling of blood plasma of patients with prostate cancer
-
P. Lokhov, M. Dashtiev, S. Moshkovskii, and A. Archakov Metabolite profiling of blood plasma of patients with prostate cancer Metabolomics 6 2010 156 163
-
(2010)
Metabolomics
, vol.6
, pp. 156-163
-
-
Lokhov, P.1
Dashtiev, M.2
Moshkovskii, S.3
Archakov, A.4
-
21
-
-
33748354488
-
Metabolic profiling of CSF: Evidence that early intervention may impact on disease progression and outcome in schizophrenia
-
E. Holmes, T.M. Tsang, J.T. Huang, F.M. Leweke, D. Koethe, C.W. Gerth, B.M. Nolden, S. Gross, D. Schreiber, J.K. Nicholson, and S. Bahn Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia PLoS Med. 3 2006 e327
-
(2006)
PLoS Med.
, vol.3
, pp. 327
-
-
Holmes, E.1
Tsang, T.M.2
Huang, J.T.3
Leweke, F.M.4
Koethe, D.5
Gerth, C.W.6
Nolden, B.M.7
Gross, S.8
Schreiber, D.9
Nicholson, J.K.10
Bahn, S.11
-
22
-
-
60849139445
-
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
-
E.C. Chan, P.K. Koh, M. Mal, P.Y. Cheah, K.W. Eu, A. Backshall, R. Cavill, J.K. Nicholson, and H.C. Keun Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS) J. Proteome Res. 8 2009 352 361
-
(2009)
J. Proteome Res.
, vol.8
, pp. 352-361
-
-
Chan, E.C.1
Koh, P.K.2
Mal, M.3
Cheah, P.Y.4
Eu, K.W.5
Backshall, A.6
Cavill, R.7
Nicholson, J.K.8
Keun, H.C.9
-
23
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, G.D. Lewis, C.S. Fox, P.F. Jacques, C. Fernandez, C.J. O'Donnell, S.A. Carr, V.K. Mootha, J.C. Florez, A. Souza, O. Melander, C.B. Clish, and R.E. Gerszten Metabolite profiles and the risk of developing diabetes Nat. Med. 17 2011 448 453
-
(2011)
Nat. Med.
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
Cheng, S.4
Rhee, E.P.5
McCabe, E.6
Lewis, G.D.7
Fox, C.S.8
Jacques, P.F.9
Fernandez, C.10
O'Donnell, C.J.11
Carr, S.A.12
Mootha, V.K.13
Florez, J.C.14
Souza, A.15
Melander, O.16
Clish, C.B.17
Gerszten, R.E.18
-
24
-
-
80055090409
-
Metabolic regulation in progression to autoimmune diabetes
-
M. Sysi-Aho, A. Ermolov, P.V. Gopalacharyulu, A. Tripathi, T. Seppanen-Laakso, J. Maukonen, I. Mattila, S.T. Ruohonen, L. Vahatalo, L. Yetukuri, T. Harkonen, E. Lindfors, J. Nikkila, J. Ilonen, O. Simell, M. Saarela, M. Knip, S. Kaski, E. Savontaus, and M. Oresic Metabolic regulation in progression to autoimmune diabetes PLoS Comput. Biol. 7 2011 e1002257
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. 1002257
-
-
Sysi-Aho, M.1
Ermolov, A.2
Gopalacharyulu, P.V.3
Tripathi, A.4
Seppanen-Laakso, T.5
Maukonen, J.6
Mattila, I.7
Ruohonen, S.T.8
Vahatalo, L.9
Yetukuri, L.10
Harkonen, T.11
Lindfors, E.12
Nikkila, J.13
Ilonen, J.14
Simell, O.15
Saarela, M.16
Knip, M.17
Kaski, S.18
Savontaus, E.19
Oresic, M.20
more..
-
25
-
-
38649130988
-
Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13)
-
C. Fernandez, U. Fransson, E. Hallgard, P. Spegel, C. Holm, M. Krogh, K. Warell, P. James, and H. Mulder Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13) J. Proteome Res. 7 2008 400 411
-
(2008)
J. Proteome Res.
, vol.7
, pp. 400-411
-
-
Fernandez, C.1
Fransson, U.2
Hallgard, E.3
Spegel, P.4
Holm, C.5
Krogh, M.6
Warell, K.7
James, P.8
Mulder, H.9
-
26
-
-
79952821873
-
Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines
-
P. Spegel, S. Malmgren, V.V. Sharoyko, P. Newsholme, T. Koeck, and H. Mulder Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines Biochem. J. 2011
-
(2011)
Biochem. J.
-
-
Spegel, P.1
Malmgren, S.2
Sharoyko, V.V.3
Newsholme, P.4
Koeck, T.5
Mulder, H.6
-
27
-
-
80054118052
-
Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets
-
I. Goehring, N.S. Sauter, G. Catchpole, A. Assmann, L. Shu, K.S. Zien, M. Moehlig, A.F. Pfeiffer, J. Oberholzer, L. Willmitzer, J. Spranger, and K. Maedler Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets Diabetologia 54 2011 2584 2594
-
(2011)
Diabetologia
, vol.54
, pp. 2584-2594
-
-
Goehring, I.1
Sauter, N.S.2
Catchpole, G.3
Assmann, A.4
Shu, L.5
Zien, K.S.6
Moehlig, M.7
Pfeiffer, A.F.8
Oberholzer, J.9
Willmitzer, L.10
Spranger, J.11
Maedler, K.12
-
28
-
-
0029742094
-
Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion
-
N.H. McClenaghan, C.R. Barnett, E. Ah-Sing, Y.H. Abdel-Wahab, F.P. O'Harte, T.W. Yoon, S.K. Swanston-Flatt, and P.R. Flatt Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion Diabetes 45 1996 1132 1140
-
(1996)
Diabetes
, vol.45
, pp. 1132-1140
-
-
McClenaghan, N.H.1
Barnett, C.R.2
Ah-Sing, E.3
Abdel-Wahab, Y.H.4
O'Harte, F.P.5
Yoon, T.W.6
Swanston-Flatt, S.K.7
Flatt, P.R.8
-
29
-
-
0033560073
-
Free radical modulation of insulin release in INS-1 cells exposed to alloxan
-
D. Janjic, P. Maechler, N. Sekine, C. Bartley, A.S. Annen, and C.B. Wolheim Free radical modulation of insulin release in INS-1 cells exposed to alloxan Biochem. Pharmacol. 57 1999 639 648
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 639-648
-
-
Janjic, D.1
Maechler, P.2
Sekine, N.3
Bartley, C.4
Annen, A.S.5
Wolheim, C.B.6
-
30
-
-
0842291578
-
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells
-
A. Merglen, S. Theander, B. Rubi, G. Chaffard, C.B. Wollheim, and P. Maechler Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Endocrinology 145 2004 667 678
-
(2004)
Endocrinology
, vol.145
, pp. 667-678
-
-
Merglen, A.1
Theander, S.2
Rubi, B.3
Chaffard, G.4
Wollheim, C.B.5
Maechler, P.6
-
31
-
-
33750558924
-
Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism
-
L. Brennan, C. Hewage, J.P. Malthouse, N.H. McClenaghan, P.R. Flatt, and P. Newsholme Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism FEBS J. 273 2006 5160 5168
-
(2006)
FEBS J.
, vol.273
, pp. 5160-5168
-
-
Brennan, L.1
Hewage, C.2
Malthouse, J.P.3
McClenaghan, N.H.4
Flatt, P.R.5
Newsholme, P.6
-
32
-
-
0345548707
-
13C NMR analysis reveals a link between l-glutamine metabolism, d-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line
-
13C NMR analysis reveals a link between l-glutamine metabolism, d-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line Diabetologia 46 2003 1512 1521
-
(2003)
Diabetologia
, vol.46
, pp. 1512-1521
-
-
Brennan, L.1
Corless, M.2
Hewage, C.3
Malthouse, J.P.4
McClenaghan, N.H.5
Flatt, P.R.6
Newsholme, P.7
-
33
-
-
44749087535
-
Effects of homocysteine on metabolic pathways in cultured astrocytes
-
Y. Jin, and L. Brennan Effects of homocysteine on metabolic pathways in cultured astrocytes Neurochem. Int. 52 2008 1410 1415
-
(2008)
Neurochem. Int.
, vol.52
, pp. 1410-1415
-
-
Jin, Y.1
Brennan, L.2
-
35
-
-
77349105487
-
Independent evaluation of a commercial deconvolution reporting software for gas chromatography mass spectrometry analysis of pesticide residues in fruits and vegetables
-
H.R. Norli, A. Christiansen, and B. Holen Independent evaluation of a commercial deconvolution reporting software for gas chromatography mass spectrometry analysis of pesticide residues in fruits and vegetables J. Chromatogr. A 1217 2010 2056 2064
-
(2010)
J. Chromatogr. A
, vol.1217
, pp. 2056-2064
-
-
Norli, H.R.1
Christiansen, A.2
Holen, B.3
-
36
-
-
0033760442
-
Triggering and amplifying pathways of regulation of insulin secretion by glucose
-
J.C. Henquin Triggering and amplifying pathways of regulation of insulin secretion by glucose Diabetes 49 2000 1751 1760
-
(2000)
Diabetes
, vol.49
, pp. 1751-1760
-
-
Henquin, J.C.1
-
37
-
-
70350331458
-
Shortcomings of current models of glucose-induced insulin secretion
-
J.C. Henquin, M. Nenquin, M.A. Ravier, and A. Szollosi Shortcomings of current models of glucose-induced insulin secretion Diabetes Obes. Metab. 11 Suppl. 4 2009 168 179
-
(2009)
Diabetes Obes. Metab.
, vol.11
, Issue.SUPPL. 4
, pp. 168-179
-
-
Henquin, J.C.1
Nenquin, M.2
Ravier, M.A.3
Szollosi, A.4
-
39
-
-
33644872401
-
In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
-
P. Maechler, S. Carobbio, and B. Rubi In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion Int. J. Biochem. Cell Biol. 38 2006 696 709
-
(2006)
Int. J. Biochem. Cell Biol.
, vol.38
, pp. 696-709
-
-
Maechler, P.1
Carobbio, S.2
Rubi, B.3
-
40
-
-
24144490962
-
Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic beta-cells
-
W.H. Kim, J.W. Lee, Y.H. Suh, S.H. Hong, J.S. Choi, J.H. Lim, J.H. Song, B. Gao, and M.H. Jung Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells Diabetes 54 2005 2602 2611
-
(2005)
Diabetes
, vol.54
, pp. 2602-2611
-
-
Kim, W.H.1
Lee, J.W.2
Suh, Y.H.3
Hong, S.H.4
Choi, J.S.5
Lim, J.H.6
Song, J.H.7
Gao, B.8
Jung, M.H.9
-
41
-
-
84873719291
-
Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death
-
S.E. Choi, Y.J. Lee, G.S. Hwang, J.H. Chung, S.J. Lee, J.H. Lee, S.J. Han, H.J. Kim, K.W. Lee, Y. Kim, H.S. Jun, and Y. Kang Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death Arch. Biochem. Biophys. 2010
-
(2010)
Arch. Biochem. Biophys.
-
-
Choi, S.E.1
Lee, Y.J.2
Hwang, G.S.3
Chung, J.H.4
Lee, S.J.5
Lee, J.H.6
Han, S.J.7
Kim, H.J.8
Lee, K.W.9
Kim, Y.10
Jun, H.S.11
Kang, Y.12
-
42
-
-
1542379983
-
Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: Prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle
-
Y.Q. Liu, J.A. Moibi, and J.L. Leahy Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle J. Biol. Chem. 279 2004 7470 7475
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7470-7475
-
-
Liu, Y.Q.1
Moibi, J.A.2
Leahy, J.L.3
-
43
-
-
33646137142
-
Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets
-
J. Xu, J. Han, P.N. Epstein, and Y.Q. Liu Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets Biochem. Biophys. Res. Commun. 344 2006 827 833
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.344
, pp. 827-833
-
-
Xu, J.1
Han, J.2
Epstein, P.N.3
Liu, Y.Q.4
-
44
-
-
0029122615
-
Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats
-
Y.P. Zhou, C.G. Ostenson, Z.C. Ling, and V. Grill Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats Endocrinology 136 1995 3546 3551
-
(1995)
Endocrinology
, vol.136
, pp. 3546-3551
-
-
Zhou, Y.P.1
Ostenson, C.G.2
Ling, Z.C.3
Grill, V.4
-
45
-
-
77954524639
-
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells
-
U. Krus, O. Kotova, P. Spegel, E. Hallgard, V.V. Sharoyko, A. Vedin, T. Moritz, M.C. Sugden, T. Koeck, and H. Mulder Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells Biochem. J. 429 2010 205 213
-
(2010)
Biochem. J.
, vol.429
, pp. 205-213
-
-
Krus, U.1
Kotova, O.2
Spegel, P.3
Hallgard, E.4
Sharoyko, V.V.5
Vedin, A.6
Moritz, T.7
Sugden, M.C.8
Koeck, T.9
Mulder, H.10
-
46
-
-
64249112098
-
Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets
-
J. Pizarro-Delgado, I. Hernandez-Fisac, R. Martin-Del-Rio, and J. Tamarit-Rodriguez Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets Biochem. J. 419 2009 359 368
-
(2009)
Biochem. J.
, vol.419
, pp. 359-368
-
-
Pizarro-Delgado, J.1
Hernandez-Fisac, I.2
Martin-Del-Rio, R.3
Tamarit-Rodriguez, J.4
-
48
-
-
36749050473
-
Amino acid metabolism, insulin secretion and diabetes
-
P. Newsholme, K. Bender, A. Kiely, and L. Brennan Amino acid metabolism, insulin secretion and diabetes Biochem. Soc. Trans. 35 2007 1180 1186
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1180-1186
-
-
Newsholme, P.1
Bender, K.2
Kiely, A.3
Brennan, L.4
-
49
-
-
44649192430
-
Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids
-
H.K. Nyblom, L.I. Nord, R. Andersson, L. Kenne, and P. Bergsten Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids NMR Biomed. 21 2008 357 365
-
(2008)
NMR Biomed.
, vol.21
, pp. 357-365
-
-
Nyblom, H.K.1
Nord, L.I.2
Andersson, R.3
Kenne, L.4
Bergsten, P.5
-
50
-
-
73549091684
-
Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells
-
Y. Coute, Y. Brunner, D. Schvartz, C. Hernandez, A. Masselot, F. Lisacek, C.B. Wollheim, and J.C. Sanchez Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells Proteomics 10 2010 59 71
-
(2010)
Proteomics
, vol.10
, pp. 59-71
-
-
Coute, Y.1
Brunner, Y.2
Schvartz, D.3
Hernandez, C.4
Masselot, A.5
Lisacek, F.6
Wollheim, C.B.7
Sanchez, J.C.8
-
51
-
-
77449141236
-
Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death
-
D. Wei, J. Li, M. Shen, W. Jia, N. Chen, T. Chen, D. Su, H. Tian, S. Zheng, Y. Dai, and A. Zhao Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death Diabetes 59 2010 471 478
-
(2010)
Diabetes
, vol.59
, pp. 471-478
-
-
Wei, D.1
Li, J.2
Shen, M.3
Jia, W.4
Chen, N.5
Chen, T.6
Su, D.7
Tian, H.8
Zheng, S.9
Dai, Y.10
Zhao, A.11
-
52
-
-
0026508490
-
Arachidonic acid-induced insulin secretion from rat islets of Langerhans
-
A.M. Band, P.M. Jones, and S.L. Howell Arachidonic acid-induced insulin secretion from rat islets of Langerhans J. Mol. Endocrinol. 8 1992 95 101
-
(1992)
J. Mol. Endocrinol.
, vol.8
, pp. 95-101
-
-
Band, A.M.1
Jones, P.M.2
Howell, S.L.3
-
53
-
-
33847034426
-
The role of arachidonic acid and its metabolites in insulin secretion from human islets of Langerhans
-
S.J. Persaud, D. Muller, V.D. Belin, I. Kitsou-Mylona, H. Asare-Anane, A. Papadimitriou, C.J. Burns, G.C. Huang, S.A. Amiel, and P.M. Jones The role of arachidonic acid and its metabolites in insulin secretion from human islets of Langerhans Diabetes 56 2007 197 203
-
(2007)
Diabetes
, vol.56
, pp. 197-203
-
-
Persaud, S.J.1
Muller, D.2
Belin, V.D.3
Kitsou-Mylona, I.4
Asare-Anane, H.5
Papadimitriou, A.6
Burns, C.J.7
Huang, G.C.8
Amiel, S.A.9
Jones, P.M.10
-
54
-
-
53849093415
-
Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells
-
D. Keane, and P. Newsholme Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells Biochem. Soc. Trans. 36 2008 955 958
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 955-958
-
-
Keane, D.1
Newsholme, P.2
-
55
-
-
1242284388
-
Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity
-
G. Dixon, J. Nolan, N.H. McClenaghan, P.R. Flatt, and P. Newsholme Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity Clin. Sci. (Lond) 106 2004 191 199
-
(2004)
Clin. Sci. (Lond)
, vol.106
, pp. 191-199
-
-
Dixon, G.1
Nolan, J.2
McClenaghan, N.H.3
Flatt, P.R.4
Newsholme, P.5
-
56
-
-
84861325113
-
Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion
-
E. Gurgul-Convey, K. Hanzelka, and S. Lenzen Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion Endocrinology 153 2012 2612 2622
-
(2012)
Endocrinology
, vol.153
, pp. 2612-2622
-
-
Gurgul-Convey, E.1
Hanzelka, K.2
Lenzen, S.3
-
57
-
-
33744474156
-
Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells
-
T. Tsuboi, M.A. Ravier, L.E. Parton, and G.A. Rutter Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells Diabetes 55 2006 1057 1065
-
(2006)
Diabetes
, vol.55
, pp. 1057-1065
-
-
Tsuboi, T.1
Ravier, M.A.2
Parton, L.E.3
Rutter, G.A.4
-
58
-
-
58249094871
-
Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol
-
J. Vikman, J. Jimenez-Feltstrom, P. Nyman, J. Thelin, and L. Eliasson Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol FASEB J. 23 2009 58 67
-
(2009)
FASEB J.
, vol.23
, pp. 58-67
-
-
Vikman, J.1
Jimenez-Feltstrom, J.2
Nyman, P.3
Thelin, J.4
Eliasson, L.5
|