Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Molecular and Cellular Endocrinology

Volumn 375, Issue 1-2, 2013, Pages 89-96

  Zhang, Yongneng ^a   Yamamoto, Tetsuya ^b   Hisatome, Ichiro ^c   Li, Youfeng ^a   Cheng, Weijie ^a   Sun, Ning ^a   Cai, Bozhi ^a   Huang, Tianliang ^a   Zhu, Yuzhang ^a   Li, Zhi ^a   Jing, Xubin ^a   Zhou, Rui ^a   Cheng, Jidong ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

AMPK; ERK; Hyperuricemia; Oxidative stress; Pancreatic cell

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; ORGANIC ANION TRANSPORTER; UNCLASSIFIED DRUG; URATE TRANSPORTER 1; URIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GROWTH INHIBITION; IMMUNOBLOTTING; INSULIN RELEASE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADENYLATE KINASE; ANIMALS; ANION TRANSPORT PROTEINS; CELL LINE; CELL PROLIFERATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; GLUCOSE; HYPERURICEMIA; INSULIN; INSULIN-SECRETING CELLS; MAP KINASE SIGNALING SYSTEM; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; URIC ACID;

EID: 84878932271     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.04.027     Document Type: Article

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