Endogenous islet uncoupling protein-2 expression and loss of gloucose homeostasis in ob/ob mice

Journal of Endocrinology

Volumn 190, Issue 3, 2006, Pages 659-667

  Saleh, Monique C ^b   Wheeler, Michael B ^a   Chan, Catherine B ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; SMALL INTERFERING RNA; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNOBLOTTING; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; MOUSE STRAIN; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ION CHANNELS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIAL PROTEINS; OBESITY; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 33749873671     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06715     Document Type: Article

References (47)

1. Brun S, Carmona MC, Mampel T, Vinas O, Giralt M, Iglesias R & Villarroya F 1999 Activators of peroxisome proliferator-activated receptor-alpha induce the expression ofthe uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-clependent activation of uncoupling protein-3 gene expression at birth. Diabetes 48 1217-1222.
2. Carlsson C, Borg LA & Welsh N 1999 Sodium pahnitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140 3422-3428.
3. Ceddia RB, Koistinen HA, Zierath JR & Sweeney G 2002 Analysis of paradoxical observations on die association between leptin and insulin resistance. FASEB Journal 16 1163-1176.
4. Chan CB 1995 β-cell stimidus-secretion coupling defects in rodent models of obesity. Canadian Journal of Physiology and Pharmacology 73 1414-1424.
5. ATP channel-dependent and -independent pathways of insulin secretion in isolated islets from fa/fa Zucker rats. Biochemistry and Cell Biology 74 403-410.
6. Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM & Wheeler MB 2001 Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 50 1302-1310.
7. Chavin KD, Yang S, Lin HZ, Chatham J, Chacko VP, Hoek JB, Walajtys-Rode E, Rashid A, Chen C-H, Huang C-C et al. 1999 Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. Journal of Bioligical Chemistry 274 5692-5700.
8. Fink BD, Hong YS, Mathahs MM, Scholz TD, Dillon JS & Sivitz WI 2002 UCP2-dependent proton leak in isolated mammalian mitochondria. Journal of Biological Chemistry 277 3918-3925.
9. Garthwaite TL, Martinson DR, Tseng LF, Hagen TC & Menahan LA 1980 A longitudinal hormonal profile of the generically obese mouse. Endocrinology 107 671-676.
10. Ho PW, Chan DY Kwok KH, Chu AC, Ho JW Kung MH, Ramsden DB & Ho SL 2005 Methyl-4-pherrylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells. Journal of Neuroscience Research 81 261-268.
11. Ito E, Ozawa S, Takahashi K, Tanaka T, Katsuta H, Yamaguchi S, Maruyama M, Takizawa M, Katahira H, Yoshimoto K et al. 2004 PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein. Biochemical and Biophysical Research Communications 324 810-814.
12. Joseph JW, Koshkin V, Zhang CY. Wang J, Lowell BB, Chan CB & Wheeler MB 2002 Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51 3211-3219.
13. Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB & Wheeler MB 2004 Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. Journal of Biological Chemistry 279 51049-51056.
14. Kaplan ML & Leveille GA 1981 Development of lipogenesis and insulin sensitivity in tissues of the oblob mouse. American Journal of Physiology. Endocrinology and Metabolism 240 E101-E107.
15. Kassis N, Bernard C, Pusterla A, Casteilla L, Penicaud L, Richard D, Ricquier D & Ktorza A 2000 Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats. International Journal ofExperimental Diabetes Research 1185-193.
16. Kibenge MT & Chan CB 1995 Identification of biochemical defects in pancreatic islets of fa/fa rats: a developmental study. Obesity Research 3 171-178.
17. Kim M-J, Ryu GR, Kang J-H, Sim SS, Min DS, Rhie D-J, Yoon SH, Hahn SJ, Jeong I-K & Hong K-J 2004 Inhibitory effects of epicatechin on interleukin-1 [beta]-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-[kappa]B activation. Biochemical Pharmacology 68 1775.
18. Kjorholt C, Akerfeldt MC, Biden TJ & Laybutt DR 2005 Chronic hyperglycemia, independent ofplasma lipid levels, is sufficient for the loss of β-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes 54 2755-2763.
19. Koshkin V, Wang X, Scherer PE, Chan CB & Wheeler MB 2003 Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids. Journal of Biological Chemistry 278 19709-19715.
20. Krauss S, Zhang C-Y, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST & Lowell BB 2003 Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. Journal of Clinical Investigation 112 1831-1842.
21. Lakey JR, Young AT, Pardue D, Calvin S, Albertson TE, Jacobson L & Cavanagh TJ 2001 Nonviral transfection of intact pancreatic islets. Cell Transplantation 10 697-708.
22. Lameloise N, Muzzin P, Prentki M & Assimacopoulos-Jeannet F 2001 Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50 803-809.
23. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S & Weir GC 2002 Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. Journal of Biological Chemistry 277 10912-10921.
24. Lee S, Lee H, Kim S, Lee IK & Song DK 2004 Enhancing effect of taurine on glucose response in UCP2-overexpressing beta cells. Diabetes Research and Clinical Practice 66 S69.
25. Medvedev AV, Robidoux J, Bai X, Cao W Floering LM, Daniel KW & Collins S 2002 Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. Journal of Biological Chemistry 277 42639-42644.
26. Menahan LA 1983 Age-related changes in lipid and carbohydrate metabolism of the genetically obese mouse. Metabolism 32 172-178.
27. Milne HM, Burns CJ, Squires PE, Evans ND, Pickup J, Jones PM & Persaud SJ 2005 Uncoupling of nutrient metabolism from insulin secretion by overexpression of cytosolic phospholipase A(2). Diabetes 54 116-124.
28. Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Meneur C, Permutt MA & Imai S-I 2005 Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice. Cell Metabolism 2 105.
29. Patane G, Anello M, Piro S, Vigneri R, Purrello F & Rabuazzo AM 2002 Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 51 2749-2756.
30. Pecqueur C, Alves-Guerra M-C, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F & Miroux B 2001 Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. Journal of Biological Chemistry 276 8705-8712.
31. Pedersen SB, Bruun JM, Kristensen K & Richelsen B 2001 Regulation of UCP1, UCP2 and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen. Biochemical and Biophysical Research Communications 288 191-197.
32. Petersen KF, Dufour S & Shulman GI 2005 Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic patients. PLoS Medicine 2 e233.
33. Poitout V & Robertson RP 2002 Minireview: secondary β-cell failure in type 2 diabetes-A convergence of glucotoxicity and lipotoxicity. Endocrinology 143 339-342.
34. Porter RK, Joyce CJ, Farmer MK, Heneghan R, Tipton KF, Andrews JF, Mc Bennett SM, Lund MD, Jensen CH & Melia HP 1999 Indirect measurement of mitochondrial proton leak and its application. International Journal of Obesity and Related Metabolic Disorders 23 (Suppl 6) S12-S18.
35. Rashid A, Wa TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FY & Diehl AM 1999 Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29 1131-1138.
36. Saleh MC, Wheeler MB & Chan CB 2002 Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia 45 174.
37. Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S et al. 2003 A common polymorphism, in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52 1280-1283.
38. Shimabukuro M, Koyama K, Chen G, Wang M-Y Trieu F, Lee Y, Newgard CB & Unger RH 1997 Direct antidiabetic effect of leptin through triglyceride depletion of tissues. PNAS 94 4637-4641.
39. Sorhede Winzell M, Svensson H, Enerback S, Ravnskjaer K, Mandrup S, Esser V, Arner P, Alves-Guerra M-C, Miroux B, Sundler F et al. 2003 Pancreatic β-cell lipotoxicity induced by overexpression of hormone-sensitive lipase. Diabetes 52 2057-2065.
40. Tassava TM, Okuda T & Romsos DR 1992 Insulin secretion from ob/ob mouse pancreatic islets: effects of neurotransmitters. American Journal of Physiology 262 E338-E343.
41. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP & Semenkovich CF 2002 PPAR alpha suppresses insulin secretion and induces UCP2 in insulinoma cells. Journal of Lipid Research 43 936-943.
42. Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA & Wollheim CB 2000a Hepatocyte nuclear factor 4α regulates the expression ofp ancreatic beta-cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. Journal of Biological Chemistry 275 35953-35959.
43. Wang H, Antinozzi PA, Hagenfeldt KA, Maechler P & Wollheim CB 2000b Molecular targets of a human HNF1α mutation responsible for pancreatic β-cell dysfunction. EMBO Journal 19 4257-4264.
44. Wang X, Li H, De Leo D, Guo W Koshkin V, Fantus IG, Giacca A, Chan CB, Der S & Wheeler MB 2004 Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6. Diabetes 53 129-140.
45. Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M & Kadowaki T 2004 Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology 145 3566-3577.
46. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB et al. 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105 745-755.
47. Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB & Unger RH 1997 Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. PNAS 94 6386-6390.