Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

European Journal of Pharmacology

Volumn 694, Issue 1-3, 2012, Pages 120-126

  Shen, Ning ^a   Huan, Yi ^a   Shen, Zhu Fang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

cell; AMP activated protein kinase; Berberine; Insulin

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; BERBERINE; COMPOUND C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INSULIN; MESSENGER RNA; METFORMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CELL LINE; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN GENE; INSULIN RESISTANCE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BERBERINE; BLOOD GLUCOSE; CELL LINE; DIET, HIGH-FAT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84867337756     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.052     Document Type: Article

References (23)

1. J.M. Brusq, N. Ancellin, P. Grondin, R. Guillard, S. Martin, Y. Saintillan, and M. Issandou Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine J. Lipid Res. 47 2006 1281 1288
2. J. Cameron, T. Ranheim, M.A. Kulseth, T.P. Leren, and K.E. Berge Berberine decreases PCSK9 expression in HepG2 cells Atherosclerosis 201 2008 266 273
3. Q.M. Chen, and M.Z. Xie Studies on the hypoglycemic effect of coptis chinensis and berberine Acta Pharm. Sin. 21 1986 401 406
4. S.G. Fonseca., J. Gromada., and F. Urano. Endoplasmic reticulum stress and pancreatic b-cell death Trends Endocrinol. Metab. 22 2011 266 274
5. K.A. Goodge, and J.C. Hutton Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic β-cell Semin. Cell Dev. Biol. 11 2000 235 243
6. D.G. Hardie AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat. Rev. Mol. Cell Biol. 8 2007 774 785
7. I. Kim, W. Xu, and J.C. Reed Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities Nat. Rev. 7 2008 1013 1030
8. W. Kong, J. Wei, P. Abidi, M. Lin, S. Inaba, C. Li, Y. Wang, Z. Wang, S. Si, H. Pan, S. Wang, J. Wu, Y. Wang, Z. Li, J. Liu, and J.D. Jiang Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Nat. Med. 10 2004 1344 1351
9. N.K. LeBrasseur, M. Kelly, T.S. Tsao, S.R. Farmer, A.K. Saha, N.B. Ruderman, and E. Tomas Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues Am. J. Physiol. Endocrinol. Metab. 175 2006 175 181
10. Y.S. Lee, W.S. Kim, K.H. Kim, M.J. Yoon, H.J. Cho, Y. Shen, J.M. Ye, C.H. Lee, W.K. Oh, C.T. Kim, C. Hohnen-Behrens, A. Gosby, E.W. Kraegen, D.E. James, and J.B. Kim Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states Diabetes 55 2006 2256 2264
11. H.K. Liu, B.D. Green, N.H. McClenaghan, J.T. McCluskey, and P.R. Flatt Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells Pancreas 28 2004 364 368
12. L.J. Luo Experience of berberine in the treatment of diarrhea Chin. J. Med. 41 1955 452 455
13. C. Mhairi, M.C. Towler, and D.G. Hardie AMP-activated protein kinase in metabolic control and insulin signaling Circ. Res. 100 2007 328 341
14. P. Misra AMP activated protein kinase: a next generation target for total metabolic control Expert Opin. Ther. Targets 12 2008 91 100
15. D.M. Muoio, and C.B. Newgard Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes Nat. Rev. Mol. Cell Biol. 9 2008 13 205
16. G. Schimmack, R.A. Defronzo, and N. Musi AMP-activated protein kinase: role in metabolism and therapeutic implications Diabetes Obes. Metab. 8 2006 591 602
17. S. Schinner, R. Krätzner, D. Baun, C. Dickel, R. Blume, and E. Oetjen Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor γ and thiazolidinedione oral antidiabetic drugs Br. J.Pharmacol. 157 2009 736 745
18. UK Prospective Diabetes Study (UKPDS) Group United Kingdom Prospective Diabetes Study Group. Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) Lancet 352 1998 837 853
19. M. Welsh, D.A. Nielsen, A.J. MacKrell, and D.F. Steiner Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability J. Biol. Chem. 260 1985 13590 13594
20. J. Yin, Z. Gao, D. Liu, Z. Liu, and J. Ye Berberine improves glucose metabolism through induction of glycolysis Am. J. Physiol. Endocrinol. Metab. 294 2008 148 156
21. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M.F. Hirshman, L.J. Goodyear, and D.E. Moller Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174
22. J. Zhou, S. Zhou, J. Tang, K. Zhang, L. Guang, Y. Huang, Y. Xu, Y. Ying, L. Zhang, and D. Li Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats Eur. J.Pharmacol. 606 2009 262 268
23. L. Zhou, X. Wang, L. Shao, Y. Yang, W. Shang, G. Yuan, B. Jiang, F. Li, J. Tang, H. Jing, and M. Chen Berberine acutely inhibits insulin secretion from beta-cells through 3′, 5′-cyclic adenosine 5′-monophosphate signaling pathway Endocrinology 149 2008 4510 4518