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Volumn 33, Issue 23, 2014, Pages 3043-3053

PDK1 controls upstream PI3K expression and PIP 3 generation

Author keywords

Akt; B lymphocytes; PDK1; PI3K; survival

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RAPAMYCIN; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTOME;

EID: 84902197513     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.266     Document Type: Article
Times cited : (32)

References (66)
  • 1
    • 77951568703 scopus 로고    scopus 로고
    • Phosphoinositide signalling in cancer: Beyond PI3K and PTEN
    • Bunney TD, Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 2010; 10: 342-352.
    • (2010) Nat Rev Cancer , vol.10 , pp. 342-352
    • Bunney, T.D.1    Katan, M.2
  • 2
    • 77949452524 scopus 로고    scopus 로고
    • The PKB/AKT pathway in cancer
    • Carnero A. The PKB/AKT pathway in cancer. Curr Pharm Des 2010; 16: 34-44.
    • (2010) Curr Pharm des , vol.16 , pp. 34-44
    • Carnero, A.1
  • 3
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 2009; 4: 127-150.
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 4
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006; 6: 184-192. (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 5
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009; 9: 550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 6
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers I, Vincent EE, Tavare JM. Akt signalling in health and disease. Cell Signal 2011; 23: 1515-1527.
    • (2011) Cell Signal , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 7
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 8
    • 84857875585 scopus 로고    scopus 로고
    • PI3K signalling in B- and T-lymphocytes: New developments and therapeutic advances
    • So L, Fruman DA. PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J 2012; 442: 465-481.
    • (2012) Biochem J , vol.442 , pp. 465-481
    • So, L.1    Fruman, D.A.2
  • 9
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7: 606-619. (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 11
    • 77952107210 scopus 로고    scopus 로고
    • Phosphoinositide phosphatases in cell biology and disease
    • Liu Y, Bankaitis VA. Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res 2010; 49: 201-217.
    • (2010) Prog Lipid Res , vol.49 , pp. 201-217
    • Liu, Y.1    Bankaitis, V.A.2
  • 15
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7: 261-269. (Pubitemid 27176852)
    • (1997) Current Biology , vol.7 , Issue.4 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.J.5    Reese, C.B.6    Cohen, P.7
  • 16
    • 0032518467 scopus 로고    scopus 로고
    • 3-phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    • Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J. 3-Phosphoinositidedependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol 1998; 8: 69-81. (Pubitemid 28104519)
    • (1998) Current Biology , vol.8 , Issue.2 , pp. 69-81
    • Alessi, D.1    Kozlowski, M.T.2    Weng, Q.-P.3    Morrice, N.4    Avruch, J.5
  • 17
    • 0033560707 scopus 로고    scopus 로고
    • Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
    • DOI 10.1042/0264-6021:3390319
    • Kobayashi T, Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 1999; 339: 319-328. (Pubitemid 29209961)
    • (1999) Biochemical Journal , vol.339 , Issue.2 , pp. 319-328
    • Kobayashi, T.1    Cohen, P.2
  • 18
    • 0033571416 scopus 로고    scopus 로고
    • Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
    • Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J 1999; 344: 189-197.
    • (1999) Biochem J , vol.344 , pp. 189-197
    • Kobayashi, T.1    Deak, M.2    Morrice, N.3    Cohen, P.4
  • 19
    • 0033583076 scopus 로고    scopus 로고
    • Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
    • Dong LQ, Zhang RB, Langlais P, He H, Clark M, Zhu L et al. Primary structure, tissue distribution, and expression of mouse phosphoinositide- dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem 1999; 274: 8117-8122.
    • (1999) J Biol Chem , vol.274 , pp. 8117-8122
    • Dong, L.Q.1    Zhang, R.B.2    Langlais, P.3    He, H.4    Clark, M.5    Zhu, L.6
  • 20
    • 0033578776 scopus 로고    scopus 로고
    • 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositidedependent protein kinase-1
    • Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3- phosphoinositidedependent protein kinase-1. J Biol Chem 1999; 274: 27168-27176.
    • (1999) J Biol Chem , vol.274 , pp. 27168-27176
    • Jensen, C.J.1    Buch, M.B.2    Krag, T.O.3    Hemmings, B.A.4    Gammeltoft, S.5    Frodin, M.6
  • 21
    • 0032566691 scopus 로고    scopus 로고
    • Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    • DOI 10.1126/science.281.5385.2042
    • Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998; 281: 2042-2045. (Pubitemid 28475494)
    • (1998) Science , vol.281 , Issue.5385 , pp. 2042-2045
    • Le Good, J.A.1    Ziegler, W.H.2    Parekh, D.B.3    Alessi, D.R.4    Cohen, P.5    Parker, P.J.6
  • 22
    • 0033151832 scopus 로고    scopus 로고
    • Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    • DOI 10.1093/emboj/18.11.3024
    • Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999; 18: 3024-3033. (Pubitemid 29255611)
    • (1999) EMBO Journal , vol.18 , Issue.11 , pp. 3024-3033
    • Park, J.1    Leong, M.L.L.2    Buse, P.3    Maiyar, A.C.4    Firestone, G.L.5    Hemmings, B.A.6
  • 24
    • 79952110243 scopus 로고    scopus 로고
    • PDK1: The major transducer of PI 3-kinase actions
    • Bayascas JR. PDK1: the major transducer of PI 3-kinase actions. Curr Top Microbiol Immunol 2010; 346: 9-29.
    • (2010) Curr Top Microbiol Immunol , vol.346 , pp. 9-29
    • Bayascas, J.R.1
  • 25
    • 0033084143 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3, 4,5-Trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
    • Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP et al. Role of phosphatidylinositol 3,4,5-Trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J 1999; 337: 575-583.
    • (1999) Biochem J , vol.337 , pp. 575-583
    • Currie, R.A.1    Walker, K.S.2    Gray, A.3    Deak, M.4    Casamayor, A.5    Downes, C.P.6
  • 27
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 29
    • 58649092475 scopus 로고    scopus 로고
    • MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 2008; 416: 375-385.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 30
    • 0034617281 scopus 로고    scopus 로고
    • A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC- related kinase 2 by PDK1
    • DOI 10.1074/jbc.M000421200
    • Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC-related kinase 2 by PDK1. J Biol Chem 2000; 275: 20806-20813. (Pubitemid 30457673)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.27 , pp. 20806-20813
    • Balendran, A.1    Biondi, R.M.2    Cheung, P.C.F.3    Casamayor, A.4    Deak, M.5    Alessi, D.R.6
  • 31
    • 0035882103 scopus 로고    scopus 로고
    • The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
    • DOI 10.1093/emboj/20.16.4380
    • Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 2001; 20: 4380-4390. (Pubitemid 32772032)
    • (2001) EMBO Journal , vol.20 , Issue.16 , pp. 4380-4390
    • Biondi, R.M.1    Kieloch, A.2    Currie, R.A.3    Deak, M.4    Alessi, D.R.5
  • 32
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-Talks
    • Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-Talks. Oncogene 2008; 27: 5527-5541.
    • (2008) Oncogene , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 33
    • 37549011707 scopus 로고    scopus 로고
    • IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
    • Shinohara H, Maeda S, Watarai H, Kurosaki T. IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. J Exp Med 2007; 204: 3285-3293.
    • (2007) J Exp Med , vol.204 , pp. 3285-3293
    • Shinohara, H.1    Maeda, S.2    Watarai, H.3    Kurosaki, T.4
  • 35
    • 0028980409 scopus 로고
    • Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis
    • Takata M, Homma Y, Kurosaki T. Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis. J Exp Med 1995; 182: 907-914.
    • (1995) J Exp Med , vol.182 , pp. 907-914
    • Takata, M.1    Homma, Y.2    Kurosaki, T.3
  • 38
    • 79956307046 scopus 로고    scopus 로고
    • Regulation of BCR signaling
    • Kurosaki T. Regulation of BCR signaling. Mol Immunol 2011; 48: 1287-1291.
    • (2011) Mol Immunol , vol.48 , pp. 1287-1291
    • Kurosaki, T.1
  • 40
    • 66449118214 scopus 로고    scopus 로고
    • Switching Akt from survival signaling to deadly response
    • Los M, Maddika S, Erb B, Schulze-Osthoff K. Switching Akt: from survival signaling to deadly response. Bioessays 2009; 31: 492-495.
    • (2009) Bioessays , vol.31 , pp. 492-495
    • Los, M.1    Maddika, S.2    Erb, B.3    Schulze-Osthoff, K.4
  • 41
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008; 14: 458-470.
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6
  • 42
    • 3242886111 scopus 로고    scopus 로고
    • Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40
    • DOI 10.1016/j.dnarep.2004.03.039, PII S1568786404001107
    • Yamazoe M, Sonoda E, Hochegger H, Takeda S. Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) 2004; 3: 1175-1185. (Pubitemid 38997961)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 1175-1185
    • Yamazoe, M.1    Sonoda, E.2    Hochegger, H.3    Takeda, S.4
  • 43
    • 77958127193 scopus 로고    scopus 로고
    • Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: Improvement of fasting glycemia in diabetic db/db mice
    • Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol 2010; 78: 961-970.
    • (2010) Mol Pharmacol , vol.78 , pp. 961-970
    • Nagashima, T.1    Shigematsu, N.2    Maruki, R.3    Urano, Y.4    Tanaka, H.5    Shimaya, A.6
  • 44
    • 0037442448 scopus 로고    scopus 로고
    • Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
    • DOI 10.1016/S0003-2697(02)00607-3
    • Gray A, Olsson H, Batty IH, Priganica L, Peter Downes C. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. Anal Biochem 2003; 313: 234-245. (Pubitemid 36259947)
    • (2003) Analytical Biochemistry , vol.313 , Issue.2 , pp. 234-245
    • Gray, A.1    Olsson, H.2    Batty, I.H.3    Priganica, L.4    Downes, C.P.5
  • 46
    • 77954615408 scopus 로고    scopus 로고
    • MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
    • Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010; 9: 1956-1967.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1956-1967
    • Hirai, H.1    Sootome, H.2    Nakatsuru, Y.3    Miyama, K.4    Taguchi, S.5    Tsujioka, K.6
  • 47
    • 77949430065 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
    • Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 2010; 10: 458-477.
    • (2010) Curr Top Med Chem , vol.10 , pp. 458-477
    • Lindsley, C.W.1
  • 48
    • 67651163588 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol(3, 4,5)trisphosphate in Phosphatidylinositol 3-kinase-induced Oncogenic Transformation
    • Denley A, Gymnopoulos M, Kang S, Mitchell C, Vogt PK. Requirement of phosphatidylinositol( 3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation. Mol Cancer Res 2009; 7: 1132-1138.
    • (2009) Mol Cancer Res , vol.7 , pp. 1132-1138
    • Denley, A.1    Gymnopoulos, M.2    Kang, S.3    Mitchell, C.4    Vogt, P.K.5
  • 50
    • 77952048131 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits
    • Jiang X, Chen S, Asara JM, Balk SP. Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits. J Biol Chem 2010; 285: 14980-14989.
    • (2010) J Biol Chem , vol.285 , pp. 14980-14989
    • Jiang, X.1    Chen, S.2    Asara, J.M.3    Balk, S.P.4
  • 51
    • 84869007032 scopus 로고    scopus 로고
    • Akt is efficiently activated by PIF-pocket- and PtdIns( 3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors
    • Najafov A, Shpiro N, Alessi DR. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors. Biochem J 2012; 448: 285-295.
    • (2012) Biochem J , vol.448 , pp. 285-295
    • Najafov, A.1    Shpiro, N.2    Alessi, D.R.3
  • 53
    • 70450246902 scopus 로고    scopus 로고
    • PIP5K-driven PtdIns(4,5)P2 synthesis: Regulation and cellular functions
    • van den Bout I, Divecha N. PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J Cell Sci 2009; 122: 3837-3850.
    • (2009) J Cell Sci , vol.122 , pp. 3837-3850
    • Van Den Bout, I.1    Divecha, N.2
  • 54
    • 33845340834 scopus 로고    scopus 로고
    • Chronic Protein Kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation
    • DOI 10.1158/0008-5472.CAN-06-1111
    • van Gorp AG, Pomeranz KM, Birkenkamp KU, Hui RC, Lam EW, Coffer PJ. Chronic protein kinase B (PKB/c-Akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res 2006; 66: 10760-10769. (Pubitemid 44876971)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 10760-10769
    • Van Gorp, A.G.M.1    Pomeranz, K.M.2    Birkenkamp, K.U.3    Hui, R.C.-Y.4    Lam, E.W.-F.5    Coffer, P.J.6
  • 55
    • 0037086001 scopus 로고    scopus 로고
    • Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    • DOI 10.1126/science. 1068094
    • Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 2002; 295: 2088-2091. (Pubitemid 34229473)
    • (2002) Science , vol.295 , Issue.5562 , pp. 2088-2091
    • Stocker, H.1    Andjelkovic, M.2    Oldham, S.3    Laffargue, M.4    Wymann, M.P.5    Hemmings, B.A.6    Hafen, E.7
  • 56
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    • DOI 10.1016/S0959-4388(00)00211-7
    • Brunet A, Datta SR, Greenberg ME. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 2001; 11: 297-305. (Pubitemid 32524094)
    • (2001) Current Opinion in Neurobiology , vol.11 , Issue.3 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 57
    • 36249002916 scopus 로고    scopus 로고
    • PKB and the mitochondria: AKTing on apoptosis
    • DOI 10.1016/j.cellsig.2007.07.010, PII S0898656807002252
    • Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 2008; 20: 21-30. (Pubitemid 350138366)
    • (2008) Cellular Signalling , vol.20 , Issue.1 , pp. 21-30
    • Parcellier, A.1    Tintignac, L.A.2    Zhuravleva, E.3    Hemmings, B.A.4
  • 58
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • DOI 10.1016/S0898-6568(01)00271-6, PII S0898656801002716
    • Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-395. (Pubitemid 34214843)
    • (2002) Cellular Signalling , vol.14 , Issue.5 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 59
    • 0032772367 scopus 로고    scopus 로고
    • The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
    • Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol 1999; 19: 6195-6206. (Pubitemid 29399324)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.9 , pp. 6195-6206
    • Wang, J.U.-M.1    Chao, J.-R.2    Chen, W.3    Kuo, M.-L.4    Yen, J.J.-Y.5    Yang-Yen, H.-F.6
  • 60
    • 77951737364 scopus 로고    scopus 로고
    • Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts
    • Bujor AM, Nakerakanti S, Morris E, Hant FN, Trojanowska M. Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Exp Dermatol 2010; 19: 347-354.
    • (2010) Exp Dermatol , vol.19 , pp. 347-354
    • Bujor, A.M.1    Nakerakanti, S.2    Morris, E.3    Hant, F.N.4    Trojanowska, M.5
  • 61
    • 0042838286 scopus 로고    scopus 로고
    • Akt negatively regulates translation of the ternary complex factor Elk-1
    • DOI 10.1038/sj.onc.1206496
    • Figueroa C, Vojtek AB. Akt negatively regulates translation of the ternary complex factor Elk-1. Oncogene 2003; 22: 5554-5561. (Pubitemid 37102690)
    • (2003) Oncogene , vol.22 , Issue.36 , pp. 5554-5561
    • Figueroa, C.1    Vojtek, A.B.2
  • 62
    • 55249085401 scopus 로고    scopus 로고
    • CAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression
    • Song KS, Lee TJ, Kim K, Chung KC, Yoon JH. cAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression. J Biol Chem 2008; 283: 26869-26878.
    • (2008) J Biol Chem , vol.283 , pp. 26869-26878
    • Song, K.S.1    Lee, T.J.2    Kim, K.3    Chung, K.C.4    Yoon, J.H.5
  • 65
    • 33646566510 scopus 로고    scopus 로고
    • Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division
    • DOI 10.1016/j.cub.2006.03.084, PII S0960982206014175
    • Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol 2006; 16: 958-970. (Pubitemid 43728212)
    • (2006) Current Biology , vol.16 , Issue.10 , pp. 958-970
    • Guertin, D.A.1    Guntur, K.V.P.2    Bell, G.W.3    Thoreen, C.C.4    Sabatini, D.M.5


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