Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts

Experimental Dermatology

Volumn 19, Issue 4, 2010, Pages 347-354

  Bujor, Andreea M ^a,b   Nakerakanti, Sashidar ^a,b   Morris, Erin ^a   Hant, Faye N ^a   Trojanowska, Maria ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; CCN2; Extracellular matrix; MMP1

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C JUN; PROTEIN KINASE B; TRANSCRIPTION FACTOR ETS 1;

ARTICLE; CHRONIC WOUND; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION; WOUND HEALING;

BUTADIENES; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLASTS; GENE EXPRESSION; HUMANS; MATRIX METALLOPROTEINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRILES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-JUN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 77951737364     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01065.x     Document Type: Article

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