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Volumn 66, Issue 1, 2014, Pages 7-14

Minireview: Metabolic control of the reproductive physiology: Insights from genetic mouse models

Author keywords

Genetic manipulation; Ghrelin; Insulin; Leptin; Reproduction

Indexed keywords

CRE RECOMBINASE; GHRELIN; INSULIN; LEPTIN; LEPTIN RECEPTOR; VIRUS VECTOR;

EID: 84901949131     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2014.04.007     Document Type: Review
Times cited : (15)

References (99)
  • 1
    • 84880197109 scopus 로고    scopus 로고
    • PI3K: an attractive candidate for the central integration of metabolism and reproduction
    • Acosta-Martinez M. PI3K: an attractive candidate for the central integration of metabolism and reproduction. Front. Endocrinol. 2011, 2:110.
    • (2011) Front. Endocrinol. , vol.2 , pp. 110
    • Acosta-Martinez, M.1
  • 7
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • Bates S.H., Myers M.G. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 2003, 14:447-452.
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 447-452
    • Bates, S.H.1    Myers, M.G.2
  • 11
    • 27744573473 scopus 로고    scopus 로고
    • Feedback loops link odor and pheromone signaling with reproduction
    • Boehm U., Zou Z., Buck L.B. Feedback loops link odor and pheromone signaling with reproduction. Cell 2005, 123:683-695.
    • (2005) Cell , vol.123 , pp. 683-695
    • Boehm, U.1    Zou, Z.2    Buck, L.B.3
  • 12
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret S.G., Draper S.J., Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304:108-110.
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 13
    • 69949146039 scopus 로고    scopus 로고
    • Mouse fertility is not dependent on the CREB coactivator Crtc1
    • (author reply 991)
    • Breuillaud L., Halfon O., Magistretti P.J., Pralong F.P., Cardinaux J.R. Mouse fertility is not dependent on the CREB coactivator Crtc1. Nat. Med. 2009, 15:989-990. (author reply 991).
    • (2009) Nat. Med. , vol.15 , pp. 989-990
    • Breuillaud, L.1    Halfon, O.2    Magistretti, P.J.3    Pralong, F.P.4    Cardinaux, J.R.5
  • 17
    • 77649272503 scopus 로고    scopus 로고
    • Distribution of leptin-sensitive cells in the postnatal and adult mouse brain
    • Caron E., Sachot C., Prevot V., Bouret S.G. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J. Comp. Neurol. 2010, 518:459-476.
    • (2010) J. Comp. Neurol. , vol.518 , pp. 459-476
    • Caron, E.1    Sachot, C.2    Prevot, V.3    Bouret, S.G.4
  • 20
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab F.F., Lim M.E., Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 1996, 12:318-320.
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 22
    • 84901834257 scopus 로고    scopus 로고
    • Interface between metabolic balance and reproduction in ruminants: focus on hypothalamus and pituitary
    • Clarke I.J. Interface between metabolic balance and reproduction in ruminants: focus on hypothalamus and pituitary. Horm. Behav. 2014.
    • (2014) Horm. Behav.
    • Clarke, I.J.1
  • 31
    • 84873049395 scopus 로고    scopus 로고
    • The ventral premammillary nucleus links metabolic cues and reproduction
    • Donato J., Elias C.F. The ventral premammillary nucleus links metabolic cues and reproduction. Front. Endocrinol. 2011, 2:57.
    • (2011) Front. Endocrinol. , vol.2 , pp. 57
    • Donato, J.1    Elias, C.F.2
  • 33
    • 78049488476 scopus 로고    scopus 로고
    • Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
    • Donato J., Frazao R., Fukuda M., Vianna C.R., Elias C.F. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology 2010, 151:5415-5427.
    • (2010) Endocrinology , vol.151 , pp. 5415-5427
    • Donato, J.1    Frazao, R.2    Fukuda, M.3    Vianna, C.R.4    Elias, C.F.5
  • 35
    • 84855220278 scopus 로고    scopus 로고
    • Leptin action in pubertal development: recent advances and unanswered questions
    • Elias C.F. Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol. Metab. 2012, 23:9-15.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 9-15
    • Elias, C.F.1
  • 36
    • 84873718098 scopus 로고    scopus 로고
    • Leptin signaling and circuits in puberty and fertility
    • Elias C.F., Purohit D. Leptin signaling and circuits in puberty and fertility. Cell Mol. Life Sci. 2013, 70:841-862.
    • (2013) Cell Mol. Life Sci. , vol.70 , pp. 841-862
    • Elias, C.F.1    Purohit, D.2
  • 37
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996, 274:1704-1707.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 39
    • 0033956283 scopus 로고    scopus 로고
    • Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
    • Fantin V.R., Wang Q., Lienhard G.E., Keller S.R. Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am. J. Physiol. Endocrinol. Metab. 2000, 278:E127-E133.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Fantin, V.R.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 44
    • 0035834586 scopus 로고    scopus 로고
    • Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    • Furuta M., Funabashi T., Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem. Biophys. Res. Commun. 2001, 288:780-785.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 780-785
    • Furuta, M.1    Funabashi, T.2    Kimura, F.3
  • 46
    • 84878607044 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 is required for testicular development
    • Griffeth R.J., Carretero J., Burks D.J. Insulin receptor substrate 2 is required for testicular development. PLoS One 2013, 8:e62103.
    • (2013) PLoS One , vol.8
    • Griffeth, R.J.1    Carretero, J.2    Burks, D.J.3
  • 47
    • 70350317881 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis
    • Hill J.W., Xu Y., Preitner F., Fukuda M., Cho Y.R., Luo J., Balthasar N., Coppari R., Cantley L.C., Kahn B.B., et al. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology 2009, 150:4874-4882.
    • (2009) Endocrinology , vol.150 , pp. 4874-4882
    • Hill, J.W.1    Xu, Y.2    Preitner, F.3    Fukuda, M.4    Cho, Y.R.5    Luo, J.6    Balthasar, N.7    Coppari, R.8    Cantley, L.C.9    Kahn, B.B.10
  • 49
    • 84884185626 scopus 로고    scopus 로고
    • From precocious puberty to infertility: metabolic control of the reproductive function
    • Hill J.W., Alreja M., Elias C.F. From precocious puberty to infertility: metabolic control of the reproductive function. Front. Endocrinol. 2013, 4:43.
    • (2013) Front. Endocrinol. , vol.4 , pp. 43
    • Hill, J.W.1    Alreja, M.2    Elias, C.F.3
  • 50
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls A.M., Dickie M.M., Snell G.D. Obese, a new mutation in the house mouse. J. Hered. 1950, 41:317-318.
    • (1950) J. Hered. , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 51
    • 29344456423 scopus 로고    scopus 로고
    • Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep
    • Iqbal J., Kurose Y., Canny B., Clarke I.J. Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 2006, 147:510-519.
    • (2006) Endocrinology , vol.147 , pp. 510-519
    • Iqbal, J.1    Kurose, Y.2    Canny, B.3    Clarke, I.J.4
  • 53
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    • Kamegai J., Tamura H., Shimizu T., Ishii S., Sugihara H., Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001, 50:2438-2443.
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 54
    • 0027260545 scopus 로고
    • Insulin and IGF-I signaling through the insulin receptor substrate 1
    • (discussion 351-342)
    • Keller S.R., Lamphere L., Lavan B.E., Kuhne M.R., Lienhard G.E. Insulin and IGF-I signaling through the insulin receptor substrate 1. Mol. Reprod. Dev. 1993, 35:346-351. (discussion 351-342).
    • (1993) Mol. Reprod. Dev. , vol.35 , pp. 346-351
    • Keller, S.R.1    Lamphere, L.2    Lavan, B.E.3    Kuhne, M.R.4    Lienhard, G.E.5
  • 55
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 57
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
    • Kowalski T.J., Liu S.M., Leibel R.L., Chua S.C. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 2001, 50:425-435.
    • (2001) Diabetes , vol.50 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.M.2    Leibel, R.L.3    Chua, S.C.4
  • 58
    • 0027417484 scopus 로고
    • The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase
    • Lavan B.E., Lienhard G.E. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. J. Biol. Chem. 1993, 268:5921-5928.
    • (1993) J. Biol. Chem. , vol.268 , pp. 5921-5928
    • Lavan, B.E.1    Lienhard, G.E.2
  • 59
    • 0030995946 scopus 로고    scopus 로고
    • The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
    • Lavan B.E., Lane W.S., Lienhard G.E. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J. Biol. Chem. 1997, 272:11439-11443.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11439-11443
    • Lavan, B.E.1    Lane, W.S.2    Lienhard, G.E.3
  • 60
    • 63849216885 scopus 로고    scopus 로고
    • Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus
    • Leshan R.L., Louis G.W., Jo Y.H., Rhodes C.J., Munzberg H., Myers M.G. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J. Neurosci. Off. J. Soc. Neurosci. 2009, 29:3138-3147.
    • (2009) J. Neurosci. Off. J. Soc. Neurosci. , vol.29 , pp. 3138-3147
    • Leshan, R.L.1    Louis, G.W.2    Jo, Y.H.3    Rhodes, C.J.4    Munzberg, H.5    Myers, M.G.6
  • 61
    • 84860652458 scopus 로고    scopus 로고
    • Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
    • Leshan R.L., Greenwald-Yarnell M., Patterson C.M., Gonzalez I.E., Myers M.G. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat. Med. 2012, 18:820-823.
    • (2012) Nat. Med. , vol.18 , pp. 820-823
    • Leshan, R.L.1    Greenwald-Yarnell, M.2    Patterson, C.M.3    Gonzalez, I.E.4    Myers, M.G.5
  • 63
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S., Perez F.A., Hnasko T.S., Palmiter R.D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 2005, 310:683-685.
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 68
    • 2342584831 scopus 로고    scopus 로고
    • Distribution of estrogen receptor alpha and beta in the mouse central nervous system: in vivo autoradiographic and immunocytochemical analyses
    • Merchenthaler I., Lane M.V., Numan S., Dellovade T.L. Distribution of estrogen receptor alpha and beta in the mouse central nervous system: in vivo autoradiographic and immunocytochemical analyses. J. Comp. Neurol. 2004, 473:270-291.
    • (2004) J. Comp. Neurol. , vol.473 , pp. 270-291
    • Merchenthaler, I.1    Lane, M.V.2    Numan, S.3    Dellovade, T.L.4
  • 69
    • 84869050741 scopus 로고    scopus 로고
    • Central nervous system control of metabolism
    • Myers M.G., Olson D.P. Central nervous system control of metabolism. Nature 2012, 491:357-363.
    • (2012) Nature , vol.491 , pp. 357-363
    • Myers, M.G.1    Olson, D.P.2
  • 70
    • 77950233250 scopus 로고    scopus 로고
    • The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia
    • Nandi A., Wang X., Accili D., Wolgemuth D.J. The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia. Endocrinology 2010, 151:1863-1871.
    • (2010) Endocrinology , vol.151 , pp. 1863-1871
    • Nandi, A.1    Wang, X.2    Accili, D.3    Wolgemuth, D.J.4
  • 72
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
    • Niswender K.D., Morrison C.D., Clegg D.J., Olson R., Baskin D.G., Myers M.G., Seeley R.J., Schwartz M.W. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2003, 52:227-231.
    • (2003) Diabetes , vol.52 , pp. 227-231
    • Niswender, K.D.1    Morrison, C.D.2    Clegg, D.J.3    Olson, R.4    Baskin, D.G.5    Myers, M.G.6    Seeley, R.J.7    Schwartz, M.W.8
  • 73
    • 0032853976 scopus 로고    scopus 로고
    • Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain
    • Numan S., Russell D.S. Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain. Brain Res. Mol. Brain Res. 1999, 72:97-102.
    • (1999) Brain Res. Mol. Brain Res. , vol.72 , pp. 97-102
    • Numan, S.1    Russell, D.S.2
  • 79
    • 84895092552 scopus 로고    scopus 로고
    • Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
    • Sadagurski M., Dong X.C., Myers M.G., White M.F. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol. Metab. 2013, 3:55-63.
    • (2013) Mol. Metab. , vol.3 , pp. 55-63
    • Sadagurski, M.1    Dong, X.C.2    Myers, M.G.3    White, M.F.4
  • 83
    • 0025232316 scopus 로고
    • Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study
    • Simerly R.B., Chang C., Muramatsu M., Swanson L.W. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. Comp. Neurol. 1990, 294:76-95.
    • (1990) J. Comp. Neurol. , vol.294 , pp. 76-95
    • Simerly, R.B.1    Chang, C.2    Muramatsu, M.3    Swanson, L.W.4
  • 84
    • 84879304955 scopus 로고    scopus 로고
    • Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice
    • Singireddy A.V., Inglis M.A., Zuure W.A., Kim J.S., Anderson G.M. Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. Endocrinology 2013, 154:2434-2445.
    • (2013) Endocrinology , vol.154 , pp. 2434-2445
    • Singireddy, A.V.1    Inglis, M.A.2    Zuure, W.A.3    Kim, J.S.4    Anderson, G.M.5
  • 87
    • 84885143632 scopus 로고    scopus 로고
    • An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice
    • Smith J.T., Reichenbach A., Lemus M., Mani B.K., Zigman J.M., Andrews Z.B. An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice. Peptides 2013, 47:45-53.
    • (2013) Peptides , vol.47 , pp. 45-53
    • Smith, J.T.1    Reichenbach, A.2    Lemus, M.3    Mani, B.K.4    Zigman, J.M.5    Andrews, Z.B.6
  • 88
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat. Clin. Pract. Endocrinol. Metab. 2008, 4:666-674.
    • (2008) Nat. Clin. Pract. Endocrinol. Metab. , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 90
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature 2000, 407:908-913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 91
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong L., Ye C., Yang Z., Choi B., Chua S., Lowell B.B. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 2011, 71:142-154.
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua, S.5    Lowell, B.B.6
  • 93
    • 84857374972 scopus 로고    scopus 로고
    • Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility
    • Wu Q., Whiddon B.B., Palmiter R.D. Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:3155-3160.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 3155-3160
    • Wu, Q.1    Whiddon, B.B.2    Palmiter, R.D.3
  • 96
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: from anorexia to obesity-the yin and yang of body weight control
    • Zigman J.M., Elmquist J.K. Minireview: from anorexia to obesity-the yin and yang of body weight control. Endocrinology 2003, 144:3749-3756.
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 99
    • 84887064714 scopus 로고    scopus 로고
    • Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function
    • Zuure W.A., Roberts A.L., Quennell J.H., Anderson G.M. Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function. J. Neurosci. Off. J. Soc. Neurosci. 2013, 33:17874-17883.
    • (2013) J. Neurosci. Off. J. Soc. Neurosci. , vol.33 , pp. 17874-17883
    • Zuure, W.A.1    Roberts, A.L.2    Quennell, J.H.3    Anderson, G.M.4


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