메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages

Insulin Receptor Substrate 2 Is Required for Testicular Development

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INSULIN RECEPTOR SUBSTRATE 3; INSULIN RECEPTOR SUBSTRATE 4; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84878607044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062103     Document Type: Article
Times cited : (35)

References (55)
  • 1
    • 0034699544 scopus 로고    scopus 로고
    • IRS-2 pathways integrate female reproduction and energy homeostasis
    • Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, et al. (2000) IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407: 377-382.
    • (2000) Nature , vol.407 , pp. 377-382
    • Burks, D.J.1    Font de Mora, J.2    Schubert, M.3    Withers, D.J.4    Myers, M.G.5
  • 2
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon S, Zick Y, (2009) Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 296: E581-591.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Boura-Halfon, S.1    Zick, Y.2
  • 3
    • 0035757603 scopus 로고    scopus 로고
    • Signal integration and the specificity of insulin action
    • Kanzaki M, Pessin JE, (2001) Signal integration and the specificity of insulin action. Cell Biochem Biophys 35: 191-209.
    • (2001) Cell Biochem Biophys , vol.35 , pp. 191-209
    • Kanzaki, M.1    Pessin, J.E.2
  • 4
    • 0031740792 scopus 로고    scopus 로고
    • Genetics of mouse growth
    • Efstratiadis A, (1998) Genetics of mouse growth. Int J Dev Biol 42: 955-976.
    • (1998) Int J Dev Biol , vol.42 , pp. 955-976
    • Efstratiadis, A.1
  • 5
    • 0035719947 scopus 로고    scopus 로고
    • Distinct and overlapping functions of insulin and IGF-I receptors
    • Nakae J, Kido Y, Accili D, (2001) Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 22: 818-835.
    • (2001) Endocr Rev , vol.22 , pp. 818-835
    • Nakae, J.1    Kido, Y.2    Accili, D.3
  • 6
    • 0028085078 scopus 로고
    • The insulin signalling system
    • White MF, Kahn CR, (1994) The insulin signalling system. J Biol Chem 269: 1-4.
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 7
    • 77951891046 scopus 로고    scopus 로고
    • Insulin and IR-beta in pig spermatozoa: A role of the hormone in the acquisition of fertilizing ability
    • Carpino A, Rago V, Guido C, Casaburi I, Aquila S, (2010) Insulin and IR-beta in pig spermatozoa: A role of the hormone in the acquisition of fertilizing ability. Int J Androl 33: 554-562.
    • (2010) Int J Androl , vol.33 , pp. 554-562
    • Carpino, A.1    Rago, V.2    Guido, C.3    Casaburi, I.4    Aquila, S.5
  • 8
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: biological actions
    • Jones JI, Clemmons DR, (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16: 3-34.
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 9
    • 0030748457 scopus 로고    scopus 로고
    • The insulin signalling system and the IRS proteins
    • White MF, (1997) The insulin signalling system and the IRS proteins. Diabetologia 40 Suppl2: S2-17.
    • (1997) Diabetologia 40 , Issue.SUPPL. 2 , pp. 2-17
    • White, M.F.1
  • 10
    • 20044376471 scopus 로고    scopus 로고
    • Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signalling
    • Laviola L, Perrini S, Belsanti G, Natalicchio A, Montrone C, et al. (2005) Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signalling. Endocrinology 146: 1498-1505.
    • (2005) Endocrinology , vol.146 , pp. 1498-1505
    • Laviola, L.1    Perrini, S.2    Belsanti, G.3    Natalicchio, A.4    Montrone, C.5
  • 11
    • 0038575340 scopus 로고    scopus 로고
    • Human 'testicular dysgenesis syndrome': A possible model using in-utero exposure of the rat to dibutyl phthalate
    • Fisher JS, Macpherson S, Marchetti N, Sharpe RM, (2003) Human 'testicular dysgenesis syndrome': A possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 18: 1383-1394.
    • (2003) Hum Reprod , vol.18 , pp. 1383-1394
    • Fisher, J.S.1    Macpherson, S.2    Marchetti, N.3    Sharpe, R.M.4
  • 12
    • 84861321357 scopus 로고    scopus 로고
    • Rodent Models for Human Polycystic Ovary Syndrome
    • Walters KA, Allan CM, Handelsman DJ, (2012) Rodent Models for Human Polycystic Ovary Syndrome. Biol Reprod 149: 1-12.
    • (2012) Biol Reprod , vol.149 , pp. 1-12
    • Walters, K.A.1    Allan, C.M.2    Handelsman, D.J.3
  • 13
    • 0023158859 scopus 로고
    • Somatomedin C/insulin-like growth factor 1 as a possible intratesticular regulator of Leydig cell activity
    • Benahmed M, Morera AM, Chauvin MC, de Peretti E, (1987) Somatomedin C/insulin-like growth factor 1 as a possible intratesticular regulator of Leydig cell activity. Mol Cell Endocrinol 50: 69-77.
    • (1987) Mol Cell Endocrinol , vol.50 , pp. 69-77
    • Benahmed, M.1    Morera, A.M.2    Chauvin, M.C.3    de Peretti, E.4
  • 14
    • 0023140050 scopus 로고
    • Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells
    • Smith EP, Svoboda ME, Van Wyk JJ, Kierszenbaum AL, Tres LL, (1987) Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells. Endocrinology 120: 186-193.
    • (1987) Endocrinology , vol.120 , pp. 186-193
    • Smith, E.P.1    Svoboda, M.E.2    Van Wyk, J.J.3    Kierszenbaum, A.L.4    Tres, L.L.5
  • 15
    • 0027288587 scopus 로고
    • The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
    • Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. Embo J 12: 1929-1936.
    • (1993) Embo J , vol.12 , pp. 1929-1936
    • Skolnik, E.Y.1    Lee, C.H.2    Batzer, A.3    Vicentini, L.M.4    Zhou, M.5
  • 16
    • 0035802863 scopus 로고    scopus 로고
    • Endocrine and paracrine control of sperm production in stallions
    • Roser JF, (2001) Endocrine and paracrine control of sperm production in stallions. Anim Reprod Sci 68: 139-151.
    • (2001) Anim Reprod Sci , vol.68 , pp. 139-151
    • Roser, J.F.1
  • 17
    • 0023916760 scopus 로고
    • Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: An immunohistochemical study
    • Vannelli BG, Barni T, Orlando C, Natali A, Serio M, et al. (1988) Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: An immunohistochemical study. Fertil Steril 49: 666-669.
    • (1988) Fertil Steril , vol.49 , pp. 666-669
    • Vannelli, B.G.1    Barni, T.2    Orlando, C.3    Natali, A.4    Serio, M.5
  • 18
    • 33845910166 scopus 로고    scopus 로고
    • Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development
    • Colon E, Zaman F, Axelson M, Larsson O, Carlsson-Skwirut C, et al. (2007) Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Endocrinology 148: 128-139.
    • (2007) Endocrinology , vol.148 , pp. 128-139
    • Colon, E.1    Zaman, F.2    Axelson, M.3    Larsson, O.4    Carlsson-Skwirut, C.5
  • 19
    • 0029038622 scopus 로고
    • Regulation of Leydig cell function by insulin-like growth factor-I and binding proteins
    • Lin T, (1995) Regulation of Leydig cell function by insulin-like growth factor-I and binding proteins. J Androl 16: 193-196.
    • (1995) J Androl , vol.16 , pp. 193-196
    • Lin, T.1
  • 20
    • 14144250050 scopus 로고    scopus 로고
    • Effect of insulin-like growth factor-1 on apoptosis of rat testicular germ cells induced by testicular torsion
    • Medhi B, Gulati G, (2005) Effect of insulin-like growth factor-1 on apoptosis of rat testicular germ cells induced by testicular torsion. BJU Int 95: 452.
    • (2005) BJU Int , vol.95 , pp. 452
    • Medhi, B.1    Gulati, G.2
  • 21
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
    • Yoon S, Seger R, (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44.
    • (2006) Growth Factors , vol.24 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 22
    • 0030037758 scopus 로고    scopus 로고
    • Effects of an Igf1 gene null mutation on mouse reproduction
    • Baker J, Hardy MP, Zhou J, Bondy C, Lupu F, et al. (1996) Effects of an Igf1 gene null mutation on mouse reproduction. Mol Endocrinol 10: 903-918.
    • (1996) Mol Endocrinol , vol.10 , pp. 903-918
    • Baker, J.1    Hardy, M.P.2    Zhou, J.3    Bondy, C.4    Lupu, F.5
  • 23
  • 24
    • 0032766006 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt
    • Kitamura T, Kitamura Y, Kuroda S, Hino Y, Ando M, et al. (1999) Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol 19: 6286-6296.
    • (1999) Mol Cell Biol , vol.19 , pp. 6286-6296
    • Kitamura, T.1    Kitamura, Y.2    Kuroda, S.3    Hino, Y.4    Ando, M.5
  • 25
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, et al. (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. Embo J 5: 2503-2512.
    • (1986) Embo J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5
  • 26
    • 0034810894 scopus 로고    scopus 로고
    • Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    • Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, et al. (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. Faseb J 15: 2099-2111.
    • (2001) Faseb J , vol.15 , pp. 2099-2111
    • Sesti, G.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Sbraccia, P.5
  • 27
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, et al (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372: 186-190.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag 3rd, B.5
  • 28
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, et al. (1994) Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372: 182-186.
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1    Kadowaki, T.2    Tobe, K.3    Yagi, T.4    Sakura, H.5
  • 29
    • 0033956283 scopus 로고    scopus 로고
    • Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
    • Fantin VR, Wang Q, Lienhard GE, Keller SR, (2000) Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab 278: E127-133.
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Fantin, V.R.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 30
    • 0033581023 scopus 로고    scopus 로고
    • Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
    • Liu SC, Wang Q, Lienhard GE, Keller SR, (1999) Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J Biol Chem 274: 18093-18099.
    • (1999) J Biol Chem , vol.274 , pp. 18093-18099
    • Liu, S.C.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 31
    • 0034917709 scopus 로고    scopus 로고
    • Impact of overweight on the risk of developing common chronic diseases during a 10-year period
    • Field AE, Coakley EH, Must A, Spadano JL, Laird N, et al. (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161: 1581-1586.
    • (2001) Arch Intern Med , vol.161 , pp. 1581-1586
    • Field, A.E.1    Coakley, E.H.2    Must, A.3    Spadano, J.L.4    Laird, N.5
  • 32
    • 77952779297 scopus 로고    scopus 로고
    • Environmental/lifestyle effects on spermatogenesis
    • Sharpe RM, (2010) Environmental/lifestyle effects on spermatogenesis. Philos Trans R Soc Lond B Biol Sci 365: 1697-1712.
    • (2010) Philos Trans R Soc Lond B Biol Sci , vol.365 , pp. 1697-1712
    • Sharpe, R.M.1
  • 33
    • 72449208482 scopus 로고    scopus 로고
    • Obesity and testicular function
    • Mah PM, Wittert GA, (2010) Obesity and testicular function. Mol Cell Endocrinol 316: 180-186.
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 180-186
    • Mah, P.M.1    Wittert, G.A.2
  • 34
    • 84855906431 scopus 로고    scopus 로고
    • Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats
    • Thakur M, Chauhan NS, Sharma V, Dixit VK, Bhargava S, (2012) Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. Int J Impot Res 24: 31-37.
    • (2012) Int J Impot Res , vol.24 , pp. 31-37
    • Thakur, M.1    Chauhan, N.S.2    Sharma, V.3    Dixit, V.K.4    Bhargava, S.5
  • 35
    • 34447538222 scopus 로고    scopus 로고
    • Insulin dependant diabetes mellitus: implications for male reproductive function
    • Agbaje IM, Rogers DA, McVicar CM, McClure N, Atkinson AB, et al. (2007) Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod 22: 1871-1877.
    • (2007) Hum Reprod , vol.22 , pp. 1871-1877
    • Agbaje, I.M.1    Rogers, D.A.2    McVicar, C.M.3    McClure, N.4    Atkinson, A.B.5
  • 36
    • 34249744634 scopus 로고    scopus 로고
    • Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI,et al. (2007) Role of central nervous system and ovarian insulin receptor substrate 2 signalling in female reproductive function in the mouse
    • Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI,et al. (2007) Role of central nervous system and ovarian insulin receptor substrate 2 signalling in female reproductive function in the mouse. Biol Reprod 76: 1045-1053.
    • Biol Reprod , vol.76 , pp. 1045-1053
  • 38
    • 0029787431 scopus 로고    scopus 로고
    • Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium
    • O'Donnell L, McLachlan RI, Wreford NG, de Kretser DM, Robertson DM, (1996) Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium. Biol Reprod 55: 895-901.
    • (1996) Biol Reprod , vol.55 , pp. 895-901
    • O'Donnell, L.1    McLachlan, R.I.2    Wreford, N.G.3    de Kretser, D.M.4    Robertson, D.M.5
  • 39
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 40
    • 0038346008 scopus 로고    scopus 로고
    • Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
    • Sharpe RM, McKinnell C, Kivlin C, Fisher JS, (2003) Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 125: 769-784.
    • (2003) Reproduction , vol.125 , pp. 769-784
    • Sharpe, R.M.1    McKinnell, C.2    Kivlin, C.3    Fisher, J.S.4
  • 41
    • 72749101744 scopus 로고    scopus 로고
    • Androgen action via testicular peritubular myoid cells is essential for male fertility
    • Welsh M, Saunders PT, Atanassova N, Sharpe RM, Smith LB, (2009) Androgen action via testicular peritubular myoid cells is essential for male fertility. Faseb J 23: 4218-4230.
    • (2009) Faseb J , vol.23 , pp. 4218-4230
    • Welsh, M.1    Saunders, P.T.2    Atanassova, N.3    Sharpe, R.M.4    Smith, L.B.5
  • 42
    • 0030757915 scopus 로고    scopus 로고
    • The 60kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells
    • Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, et al. (1997) The 60kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry 36: 8304-8310.
    • (1997) Biochemistry , vol.36 , pp. 8304-8310
    • Smith-Hall, J.1    Pons, S.2    Patti, M.E.3    Burks, D.J.4    Yenush, L.5
  • 44
    • 0043127453 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
    • Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-7092.
    • (2003) J Neurosci , vol.23 , pp. 7084-7092
    • Schubert, M.1    Brazil, D.P.2    Burks, D.J.3    Kushner, J.A.4    Ye, J.5
  • 45
    • 77954194860 scopus 로고    scopus 로고
    • Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?
    • Carew RM, Sadagurski M, Goldschmeding R, Martin F, White MF, et al. (2010) Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol 10: 73.
    • (2010) BMC Dev Biol , vol.10 , pp. 73
    • Carew, R.M.1    Sadagurski, M.2    Goldschmeding, R.3    Martin, F.4    White, M.F.5
  • 46
    • 0023901568 scopus 로고
    • Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development
    • Orth JM, Gunsalus GL, Lamperti AA, (1988) Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology 122: 787-794.
    • (1988) Endocrinology , vol.122 , pp. 787-794
    • Orth, J.M.1    Gunsalus, G.L.2    Lamperti, A.A.3
  • 47
    • 0033721628 scopus 로고    scopus 로고
    • Cell proliferation and hormonal changes during postnatal development of the testis in the pig
    • Franca LR, Silva VA Jr, Chiarini-Garcia H, Garcia SK, Debeljuk L, (2000) Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biol Reprod 63: 1629-1636.
    • (2000) Biol Reprod , vol.63 , pp. 1629-1636
    • Franca, L.R.1    Silva Jr., V.A.2    Chiarini-Garcia, H.3    Garcia, S.K.4    Debeljuk, L.5
  • 48
    • 0025884678 scopus 로고
    • Proliferative activity of gonocytes, Sertoli cells and interstitial cells during testicular development in mice
    • Vergouwen RP, Jacobs SG, Huiskamp R, Davids JA, de Rooij DG, (1991) Proliferative activity of gonocytes, Sertoli cells and interstitial cells during testicular development in mice. J Reprod Fertil 93: 233-243.
    • (1991) J Reprod Fertil , vol.93 , pp. 233-243
    • Vergouwen, R.P.1    Jacobs, S.G.2    Huiskamp, R.3    Davids, J.A.4    de Rooij, D.G.5
  • 50
    • 58849154000 scopus 로고    scopus 로고
    • Sertoli cell Dicer is essential for spermatogenesis in mice
    • Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, et al. (2009) Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol 326: 250-259.
    • (2009) Dev Biol , vol.326 , pp. 250-259
    • Papaioannou, M.D.1    Pitetti, J.L.2    Ro, S.3    Park, C.4    Aubry, F.5
  • 51
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, et al. (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 23: 32-40.
    • (1999) Nat Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5
  • 52
    • 41549147003 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 is expressed in mouse developing testis and regulates somatic cell proliferation
    • (Maywood)
    • Villalpando I, Lira E, Medina G, Garcia-Garcia E, Echeverria O, (2008) Insulin-like growth factor 1 is expressed in mouse developing testis and regulates somatic cell proliferation. Exp Biol Med (Maywood) 233: 419-426.
    • (2008) Exp Biol Med , vol.233 , pp. 419-426
    • Villalpando, I.1    Lira, E.2    Medina, G.3    Garcia-Garcia, E.4    Echeverria, O.5
  • 53
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A, (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 54
    • 3142758618 scopus 로고    scopus 로고
    • The consequences of altered somatotropic system on reproduction
    • Chandrashekar V, Zaczek D, Bartke A, (2004) The consequences of altered somatotropic system on reproduction. Biol Reprod 71: 17-27.
    • (2004) Biol Reprod , vol.71 , pp. 17-27
    • Chandrashekar, V.1    Zaczek, D.2    Bartke, A.3
  • 55
    • 38949149704 scopus 로고    scopus 로고
    • Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis
    • Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, et al. (2008) Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314: 406-417.
    • (2008) Dev Biol , vol.314 , pp. 406-417
    • Gannon, M.1    Ables, E.T.2    Crawford, L.3    Lowe, D.4    Offield, M.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.